FAS pathway and stress induction of HSP regulation (Danio rerio)
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1
Necrosis
Cytoplasm
Activate
Cut
Stress Induction of HSP regulation
Inhibition
3x-P
Extracellular
Apoptosome
DNA presentation
Stress
Self-activation
ROS
Nucleus
3x-P
FAS Pathway
Proteasome
NFK-B Pathway
Cell Survival
Mitochondria Pathway
3x-P
hspb1
mapkapk2a
Phosphate
fadd
actin
rb1
spna2
faf1
apaf1
cflar
Apoptosis
Phosphate
hspb1
TNF
mapkapk3
ripk2
FAP1
parp1
Phosphate
Phosphate
lmnb1
hspb1
casp7
dffb
lmna
casp8l2
casp8
jun
Phosphate
Glutathione
cycsb
casp6
Ceramide
hspb1
Phosphate
mapk8a
IL1A
CASP3
pak2a
LOC100334486
daxx
pak1
arhgdig
faslg
apaf1
hspb1
BCL2
dffb
casp8
hspb1
map2k4a
map3k7
daxx
Phosphate
CASP3
lmnb2
dffa
fas
casp9
hspb1
wu:fa96e12
faf1
Phosphate
hspb1
Description
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info:
BioCarta
.
Comments
GenMAPP remarks
Converted to human by GenMAPP.org.
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP314(r45253)
with a 86% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
116873
view
10:56, 15 May 2021
Eweitz
Modified title
113953
view
06:20, 11 December 2020
Egonw
Another clickable pathway
109415
view
19:00, 16 March 2020
L Dupuis
Fixed interactions
106088
view
11:59, 16 August 2019
MaintBot
HMDB identifier normalization
68680
view
05:39, 6 July 2013
MaintBot
Updated to 2013 gpml schema
67222
view
10:23, 26 June 2013
Christine Chichester
Ontology Term : 'FasL mediated signaling pathway' added !
47922
view
22:18, 18 April 2012
Khanspers
Updating from human to fix xref duplication
40853
view
22:19, 1 March 2011
MaintBot
Removed redundant pathway information and comments
38239
view
21:17, 27 August 2010
Khanspers
Removed receptor and protein complex graphics
35563
view
15:03, 12 February 2010
Thomas
added literature
35561
view
15:02, 12 February 2010
Thomas
Modified description
34235
view
21:39, 9 December 2009
MaintBot
Automatic update of empty xrefs
32450
view
17:22, 15 August 2009
MaintBot
Fixed text labels
32130
view
13:55, 14 August 2009
MaintBot
Fixed group labels
31467
view
21:18, 13 August 2009
MaintBot
Fixed text labels
31062
view
01:26, 30 July 2009
MaintBot
Converted from Homo sapiens
21754
view
11:32, 14 November 2008
MaintBot
[[Pathway:Danio rerio:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP511]]: Moved to stable identifier
12012
view
08:43, 15 May 2008
MaintBot
Added to category $category
12010
view
08:43, 15 May 2008
MaintBot
Uploaded new pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
Apoptosis
Pathway
WP254 (WikiPathways)
BCL2
GeneProduct
CASP3
GeneProduct
Ceramide
Metabolite
104404-17-3 (CAS)
FAP1
GeneProduct
Glutathione
Metabolite
HMDB0000125 (HMDB)
IL1A
GeneProduct
LOC100334486
GeneProduct
100334486 (Entrez Gene)
Phosphate
Metabolite
HMDB0001429 (HMDB)
TNF
GeneProduct
actin
GeneProduct
apaf1
GeneProduct
58131 (Entrez Gene)
arhgdig
GeneProduct
394132 (Entrez Gene)
Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
casp6
GeneProduct
552927 (Entrez Gene)
casp7
GeneProduct
553634 (Entrez Gene)
casp8
GeneProduct
58022 (Entrez Gene)
casp8l2
GeneProduct
557302 (Entrez Gene)
casp9
GeneProduct
492763 (Entrez Gene)
cflar
GeneProduct
373114 (Entrez Gene)
cycsb
GeneProduct
415158 (Entrez Gene)
daxx
GeneProduct
561006 (Entrez Gene)
dffa
GeneProduct
436904 (Entrez Gene)
dffb
GeneProduct
373130 (Entrez Gene)
fadd
GeneProduct
562317 (Entrez Gene)
faf1
GeneProduct
406243 (Entrez Gene)
fas
GeneProduct
768248 (Entrez Gene)
faslg
GeneProduct
735295 (Entrez Gene)
hspb1
GeneProduct
368243 (Entrez Gene)
jun
GeneProduct
335916 (Entrez Gene)
lmna
GeneProduct
195815 (Entrez Gene)
lmnb1
GeneProduct
195816 (Entrez Gene)
lmnb2
GeneProduct
30196 (Entrez Gene)
map2k4a
GeneProduct
403052 (Entrez Gene)
map3k7
GeneProduct
553788 (Entrez Gene)
mapk8a
GeneProduct
562720 (Entrez Gene)
mapkapk2a
GeneProduct
327321 (Entrez Gene)
mapkapk3
GeneProduct
790934 (Entrez Gene)
pak1
GeneProduct
373103 (Entrez Gene)
pak2a
GeneProduct
266749 (Entrez Gene)
parp1
GeneProduct
560788 (Entrez Gene)
rb1
GeneProduct
777733 (Entrez Gene)
ripk2
GeneProduct
373874 (Entrez Gene)
receptor (TNFRSF)-interacting serine-threonine kinase 2
spna2
GeneProduct
553383 (Entrez Gene)
Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
wu:fa96e12
GeneProduct
562283 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions