Keap1-Nrf2 (Gallus gallus)
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1
Phase II enzymes
T-P
Nucleus
CCAAT/XRE
T-P
S-P
S-P
ARE
Curcumin
KEAP1
HMOX1
GSTA2
NFE2L2
AIMP2
PIK3CA
Caffeic acid phenethyl ester
CEBPB
MAF
MAPK8
EPHB2
RCJMB04_5a10
GCLM
Sulforaphane
GCLC
NFE2L2
6-HITC
KEAP1
NFE2L2
CEBPB
NQO1
Description
Based on
Surh, 2003, figure 4
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP3(r29720)
with a 77% conversion rate.
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Quality Tags
Ontology Terms
Saving...
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Bibliography
Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
106109
view
12:01, 16 August 2019
MaintBot
HMDB identifier normalization
88685
view
15:48, 12 August 2016
Jmelius
Ontology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
88684
view
15:48, 12 August 2016
Jmelius
Ontology Term : 'oxidative stress response pathway' added !
74391
view
05:42, 16 April 2014
Egonw
Removed a data source where no ID was given.
74176
view
15:40, 2 April 2014
Egonw
Updated the PubChem-compound data source.
68834
view
17:18, 8 July 2013
MaintBot
Updated to 2013 gpml schema
40970
view
22:54, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33895
view
17:58, 9 December 2009
MaintBot
Automatic update of empty xrefs
33445
view
14:59, 30 November 2009
MaintBot
Removed group label
30331
view
20:46, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
6-HITC
Metabolite
Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
AIMP2
GeneProduct
769030 (Entrez Gene)
CEBPB
GeneProduct
396185 (Entrez Gene)
Caffeic acid phenethyl ester
Metabolite
Curcumin
Metabolite
HMDB0002269 (HMDB)
EPHB2
GeneProduct
396513 (Entrez Gene)
GCLC
GeneProduct
421894 (Entrez Gene)
GCLM
GeneProduct
424492 (Entrez Gene)
GSTA2
GeneProduct
HMOX1
GeneProduct
396287 (Entrez Gene)
KEAP1
GeneProduct
MAF
GeneProduct
693248 (Entrez Gene)
MAPK8
GeneProduct
423778 (Entrez Gene)
NFE2L2
GeneProduct
396014 (Entrez Gene)
NQO1
GeneProduct
769737 (Entrez Gene)
PIK3CA
GeneProduct
424971 (Entrez Gene)
RCJMB04_5a10
GeneProduct
417430 (Entrez Gene)
Sulforaphane
Metabolite
5350 (PubChem-compound)
Annotated Interactions
No annotated interactions
Views
Pathway
Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions