Methylation (Gallus gallus)
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SAM synthesis (co-substrate)
O-methylation
S-methylation
N-methylation
N-methylated substrate
MAT1A
NNMT
S-Adenosylmethionine
ATP
O-methylated substrate
TPMT
Substrate
COMT
HNMT
PNMT
INMT
MAT2A
S-methylated substrate
L-Methionine
Phosphate
S-Adenosylmethionine
S-Adenosylhomocysteine
S-Adenosylhomocysteine
S-Adenosylmethionine
S-Adenosylhomocysteine
Phosphate
MAT2B
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP704(r30265)
with a 55% conversion rate.
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Bibliography
Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008
PubMed
Europe PMC
Scholia
Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
118251
view
12:04, 26 May 2021
Eweitz
Modified title
106110
view
12:01, 16 August 2019
MaintBot
HMDB identifier normalization
68791
view
17:13, 8 July 2013
MaintBot
Updated to 2013 gpml schema
58768
view
22:15, 20 February 2013
MaintBot
Updated Ensembl and UniProt data source
40922
view
22:51, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33853
view
17:43, 9 December 2009
MaintBot
Automatic update of empty xrefs
33448
view
14:59, 30 November 2009
MaintBot
Removed group label
30334
view
20:47, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ATP
Metabolite
HMDB0000538 (HMDB)
COMT
GeneProduct
ENSGALG00000002024 (Ensembl)
HNMT
GeneProduct
ENSGALG00000012377 (Ensembl)
INMT
GeneProduct
L-Methionine
Metabolite
HMDB0000696 (HMDB)
MAT1A
GeneProduct
ENSGALG00000002479 (Ensembl)
MAT2A
GeneProduct
MAT2B
GeneProduct
ENSGALG00000001750 (Ensembl)
N-methylated substrate
Metabolite
NNMT
GeneProduct
O-methylated substrate
Metabolite
PNMT
GeneProduct
776803 (Entrez Gene)
Phosphate
Metabolite
HMDB0001429 (HMDB)
S-Adenosylhomocysteine
Metabolite
HMDB0000939 (HMDB)
S-Adenosylmethionine
Metabolite
HMDB0001185 (HMDB)
S-methylated substrate
Metabolite
Substrate
Metabolite
TPMT
GeneProduct
ENSGALG00000012687 (Ensembl)
Annotated Interactions
No annotated interactions
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Discussion
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