Phosphodiesterases in neuronal function (Homo sapiens)

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2413nucleus accumbens/caudate-putamenPKAsynaptic gapPDEsAMPA receptorDopamine receptor D1glutamergic neuron nucleusA2AnAChR (nicotine alpha 7 receptor)frontal cortexNMDA receptorLegendrelease of neurotransmitters into synaptic gapbindingstimulationinhibitionmainly responsibleGuanylat cyclases (GC)(soluble)PDE4CCyclic GMPGRIN1GRIN2CCilostazolDRD1ADCY7CaffeinePDE6GADCY9PDE3ADRD2ADCY8PDE4BDARPP-32GRIN2APDE6HADCY4PDE1ASildenafilPDE9AADORA2AADCY5PDE6CADCY6PDE8APDE6BGUCY1A3PDE3BGUCY1B3GUCY1A2AMPRolipramPDE3ACREBPDE5APDE12L-GlutamatePDEGUCY1B2GRIN2BCyclic AMPPDE4DPDE5ANOS1PDE7AGMPNitric oxideADCY10ADCY2PDE10APDE1BPDE2APDE11APDE6DPKGGRIA1PDE?CaMKADCY1PDE4ACHRNA7GRIN2DPDE6APDE7BADCY3PDE8BPDE1CCalciumDopaminePKAPDE3BL-GlutamateL-GlutamateCyclic AMPDopamineneuron dopamergic neuron from substantianigra pars compacta (SNc)and/or ventral tegmental areaDopaminePDE10APDE4DPDE1BPDE4DL-GlutamateDopaminePKADRD2GRIN1GRIN2DGRIN2CGRIN2AGRIN2BAMPAspiny neuronD1 direct pathwayspiny neuron D2 indirect pathwaystriatal interneuronGMPCyclic GMPGUCY1A3GUCY1A2GUCY1B2GUCY1B3GMPCyclic GMPPDE1BnucleusCREBPKGAMPAGRIN1GRIN2DGRIN2CGRIN2AGRIN2BDRD1nucleusCREBPKGGUCY1A2GUCY1B3GUCY1A3GUCY1B2GRIN2AGRIN2CGRIN1GRIN2BGRIN2DDRD1DRD2Dopamine receptor D2GRIA1ADORA2AGUCY1B2GUCY1A3GUCY1B3GUCY1A2Adenylat cyclases (AC)PDE1BPDE10APDE4DADCY2ADCY1AMPCyclic AMPADCY2ADCY1AMPADCY2ADCY1DARPP-32PKAADCY2ADCY1AMPCyclic AMPPKADARPP-32


Description

Phosphodiesterases are enzymes which break phosphodiester bonds and play an importan role in signaling pathways, especially in second messenger pathways which involve cyclic AMP or GMP.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, Jones BA, Howard ML, McAllister-Lucas LM, Sonnenburg WK, Francis SH, Corbin JD, Beavo JA, Ferguson K; ''Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.''; Gene, 1998 PubMed Europe PMC Scholia
  2. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, Kimura Y, Ikeda Y, Shiku H, Nishikawa M.; ''Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo.''; Life Sci. , 1997 PubMed Europe PMC Scholia
  3. Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG; ''Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.''; Cell, 2015 PubMed Europe PMC Scholia
  4. Heckman PR, van Duinen MA, Bollen EP, Nishi A, Wennogle LP, Blokland A, Prickaerts J; ''''; , PubMed Europe PMC Scholia
  5. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, Deschepper CF, Petrof BJ, Des Rosiers C.; ''Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency.''; Proc Natl Acad Sci U S A., 2008 PubMed Europe PMC Scholia
  6. Kitabchi AE, Wilson DB, Sharma RK.; ''Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE).''; vBiochem Biophys Res Commun. , 1971 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
132625view17:31, 7 June 2024Khanspersupdated incorrect mim-modification to mim-binding
124530view14:17, 5 November 2022EgonwMade a pathway clickable
124484view13:48, 31 October 2022Cenna Doornbos
124483view13:46, 31 October 2022Cenna DoornbosUppdated non-annotated nodes
124482view13:06, 31 October 2022Cenna DoornbosUpdated sildenafil pathway and protein names.
107160view14:24, 17 September 2019MaintBotChEBI identifier normalization
106137view12:03, 16 August 2019MaintBotHMDB identifier normalization
105135view12:00, 10 July 2019EgonwFixed the identifier for L-glutamate (a more accurate record)
96808view11:35, 9 April 2018Fehrhartfixed data node annotation
96231view13:22, 1 March 2018FehrhartOntology Term : 'attention deficit hyperactivity disorder' added !
96230view13:22, 1 March 2018FehrhartOntology Term : 'obsessive-compulsive disorder' added !
96229view13:22, 1 March 2018FehrhartOntology Term : 'Gilles de la Tourette syndrome' added !
96228view13:22, 1 March 2018FehrhartOntology Term : 'Huntington's disease' added !
96227view13:21, 1 March 2018FehrhartOntology Term : 'Parkinson's disease' added !
96226view13:21, 1 March 2018FehrhartOntology Term : 'schizophrenia' added !
96225view13:20, 1 March 2018FehrhartOntology Term : 'Alzheimer's disease' added !
96224view13:19, 1 March 2018FehrhartOntology Term : 'glutamate signaling pathway' added !
96223view13:19, 1 March 2018FehrhartOntology Term : 'dopamine signaling pathway' added !
96222view13:18, 1 March 2018FehrhartOntology Term : 'neuron-to-neuron signaling pathways' added !
96221view13:18, 1 March 2018FehrhartOntology Term : 'neuron' added !
96220view13:17, 1 March 2018Fehrhartwork in progress
96219view11:02, 1 March 2018Fehrhartwork in progress
96218view10:15, 1 March 2018FehrhartModified title
96216view15:31, 28 February 2018Fehrhartwork in progress
96215view15:00, 28 February 2018Fehrhartwork in progress
96214view14:21, 28 February 2018FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCY10GeneProductENSG00000143199 (Ensembl)
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY2GeneProductENSG00000078295 (Ensembl)
ADCY3GeneProductENSG00000138031 (Ensembl)
ADCY4GeneProductENSG00000129467 (Ensembl)
ADCY5GeneProductENSG00000173175 (Ensembl)
ADCY6GeneProductENSG00000174233 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADCY8GeneProductENSG00000155897 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
ADORA2AGeneProductENSG00000128271 (Ensembl)
AMPAGeneProductENSG00000155511 (Ensembl)
AMPMetaboliteHMDB0003540 (HMDB)
CHRNA7GeneProductENSG00000175344 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
CaMK GeneProduct
CaffeineMetaboliteHMDB0001847 (HMDB)
CalciumMetaboliteHMDB0000464 (HMDB)
CilostazolMetaboliteHMDB0015297 (HMDB)
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
Cyclic GMPMetaboliteHMDB0001314 (HMDB)
DARPP-32GeneProductENSG00000131771 (Ensembl)
DRD1GeneProductENSG00000184845 (Ensembl)
DRD2GeneProductENSG00000149295 (Ensembl)
DopamineMetaboliteHMDB0000073 (HMDB)
GMPMetaboliteHMDB0001397 (HMDB)
GRIA1GeneProductENSG00000155511 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
L-GlutamateMetaboliteCHEBI:16015 (ChEBI)
NOS1GeneProductENSG00000089250 (Ensembl)
Nitric oxideMetaboliteHMDB0003378 (HMDB)
PDEGeneProduct
PDE10AGeneProductENSG00000112541 (Ensembl)
PDE11AGeneProductENSG00000128655 (Ensembl)
PDE12GeneProductENSG00000174840 (Ensembl)
PDE1AGeneProductENSG00000115252 (Ensembl)
PDE1BGeneProductENSG00000123360 (Ensembl)
PDE1CGeneProductENSG00000154678 (Ensembl)
PDE2AGeneProductENSG00000186642 (Ensembl)
PDE3AGeneProductENSG00000172572 (Ensembl)
PDE3BGeneProductENSG00000152270 (Ensembl)
PDE4AGeneProductENSG00000065989 (Ensembl)
PDE4BGeneProductENSG00000184588 (Ensembl)
PDE4CGeneProductENSG00000105650 (Ensembl)
PDE4DGeneProductENSG00000113448
PDE4DGeneProductENSG00000113448 (Ensembl)
PDE5AGeneProductENSG00000138735 (Ensembl)
PDE6AGeneProductENSG00000132915 (Ensembl)
PDE6BGeneProductENSG00000133256 (Ensembl)
PDE6CGeneProductENSG00000095464 (Ensembl)
PDE6DGeneProductENSG00000156973 (Ensembl)
PDE6GGeneProductENSG00000185527 (Ensembl)
PDE6HGeneProductENSG00000139053 (Ensembl)
PDE7AGeneProductENSG00000205268 (Ensembl)
PDE7BGeneProductENSG00000171408 (Ensembl)
PDE8AGeneProductENSG00000073417 (Ensembl)
PDE8BGeneProductENSG00000113231 (Ensembl)
PDE9AGeneProductENSG00000160191 (Ensembl)
PDE?GeneProduct
PKAGeneProduct
PKGGeneProduct
RolipramMetabolite104872 (ChEBI)
SildenafilMetaboliteHMDB0005039 (HMDB)

Annotated Interactions

No annotated interactions

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