Cardiac hypertrophic response (Homo sapiens)
From WikiPathways
Description
Integrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response.
During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Saving...Bibliography
- Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AKT1 | GeneProduct | 207 (Entrez Gene)  | |
| AKT2 | GeneProduct | 208 (Entrez Gene) | |
| ANP | Protein | 4878 (Entrez Gene) | |
| Ang-II | Metabolite | HMDB01035 (HMDB) | |
| BNP | Protein | ||
| CDK 7 | GeneProduct | 1022 (Entrez Gene) | |
| CDK 9 | GeneProduct | 1025 (Entrez Gene) | |
| Ca2+ | Metabolite | HMDB00464 (HMDB) | |
| CaMK | GeneProduct | 817 (Entrez Gene) | |
| Calcineurin | GeneProduct | 5530 (Entrez Gene) | |
| Calmodulin | GeneProduct | 801 (Entrez Gene) | |
| Catecholamines | Metabolite | CHEBI:33567 (ChEBI) | |
| DAG | Metabolite | HMDB07009 (HMDB) | |
| EGF | Protein | 1950 (Entrez Gene) | |
| ERK1 | GeneProduct | 5595 (Entrez Gene) | |
| ERK2 | GeneProduct | 5594 (Entrez Gene) | |
| ERK5 | GeneProduct | 5598 (Entrez Gene) | |
| Endo-1 | Protein | ||
| FGF | Protein | 2247 (Entrez Gene) | |
| FGFR | Protein | 2263 (Entrez Gene) | |
| GC-A | GeneProduct | 2978 (Entrez Gene) | |
| GPCR | Protein | ||
| GSK3-beta | GeneProduct | 2932 (Entrez Gene) | |
| HDAC 4 | GeneProduct | 9759 (Entrez Gene) | |
| HDAC 5 | GeneProduct | 10014 (Entrez Gene) | |
| HDAC 7 | GeneProduct | 51564 (Entrez Gene) | |
| HDAC 9 | GeneProduct | 9734 (Entrez Gene) | |
| I-kappa-B | GeneProduct | 9641 (Entrez Gene) | |
| IGF-I | Protein | 3479 (Entrez Gene) | |
| IKK-alpha | GeneProduct | 1147 (Entrez Gene) | |
| IKK-beta | GeneProduct | 3551 (Entrez Gene) | |
| IKK-gamma | GeneProduct | 8517 (Entrez Gene) | |
| Ins(1,4,5)P3 | Metabolite | HMDB01498 (HMDB) | |
| JNK | GeneProduct | 5599 (Entrez Gene) | |
| MAPKKK | GeneProduct | 4214 (Entrez Gene) | |
| MAPKKKK | GeneProduct | 11184 (Entrez Gene) | |
| MEF2 | GeneProduct | 4205 (Entrez Gene) | |
| MEK1 | GeneProduct | 5604 (Entrez Gene) | |
| MEK2 | GeneProduct | 5605 (Entrez Gene) | |
| MEK3 | GeneProduct | 5606 (Entrez Gene) | |
| MEK4 | GeneProduct | 6416 (Entrez Gene) | |
| MEK5 | GeneProduct | 5607 (Entrez Gene) | |
| MEK6 | GeneProduct | 5608 (Entrez Gene) | |
| MEK7 | GeneProduct | 5609 (Entrez Gene) | |
| NF-kappa-B | GeneProduct | 4790 (Entrez Gene) | |
| NFAT | GeneProduct | 4773 (Entrez Gene) | |
| NIK | GeneProduct | 9020 (Entrez Gene) | |
| Neuregulin | Protein | 3084 (Entrez Gene) | |
| PDK1 | GeneProduct | 5170 (Entrez Gene) | |
| PKC | GeneProduct | 5578 (Entrez Gene) | |
| PKD | GeneProduct | 5587 (Entrez Gene) | |
| PKG-I | GeneProduct | 5592 (Entrez Gene) | |
| PLA2 | GeneProduct | 5320 (Entrez Gene) | |
| PLC | GeneProduct | ||
| Pol II | GeneProduct | ||
| RAC1 | GeneProduct | 5879 (Entrez Gene) | |
| RAF1 | GeneProduct | 5894 (Entrez Gene) | |
| RAS | GeneProduct | ||
| ROH | GeneProduct | ||
| RTKs | Protein | ||
| TAK1 | GeneProduct | 6885 (Entrez Gene) | |
| TGF-beta | Protein | 7040 (Entrez Gene) | |
| TGFR/Activin | Protein | 7046 (Entrez Gene) | |
| TNF-alpha | Protein | 7124 (Entrez Gene) | |
| TNFR | Protein | 7132 (Entrez Gene) | |
| cGMP | Metabolite | HMDB01314 (HMDB) | |
| mTOR | GeneProduct | 2475 (Entrez Gene) | |
| p38 | GeneProduct | 1432 (Entrez Gene) |
Annotated Interactions
No annotated interactions
