From WikiPathways
Degradation Chemotaxis NO induction CXCL5 GNB2 HRAS SHC3 ADCY5 NCF1 HCK CXCL3 SHC4 Cytokine-cytokine receptor interaction GRK2 IKBKB D-myo-Inositol 1,4,5-trisphosphate CCR9 PXN NFKBIA NFKBIB AKT1 GNG10 MAPK signaling pathway CCL7 PPBP TIAM1 PRKCZ CCL24 PIK3CA LYN CXCR3 CXCL11 MAPK3 CCR10 ITK CX3CR1 STAT1 PLCB1 SHC1 Gm12844 CCL28 CCL19 CXCR4 CXCR2 MAP2K1 Phosphatidylinositol-3,4,5-trisphosphate CCL21 PIK3CG GNG2 Diacylglycerol NRAS PIK3R2 NFKB1 CXCL12 ADCY4 SOS1 Regulation of actin cytoskeleton CCL17 DOCK2 PLCB4 PIK3R3 Gm5741 ADCY9 RAP1A VAV1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like CCL20 CSK RAP1B MAPK1 Gm4356 KRAS PAK1 PRKACB Gm11787 Cxcl15 CCR7 GSK3B CCL15 PLCB3 CCR1 GNAI1 GNGT1 CCR2 CCR4 CXCR5 FGR RELA Leukocyte transendothelial migration GRK6 ADCY2 JAK2 GRK1 GNB5 CCL22 ARRB1 Ccl2 ADCY3 PLCB2 PTK2 GRK4 BCAR1 BRAF GNG4 AC006486.9 RASGRP2 CCR6 CXCL14 XCL1 WASL CCL26 ADCY7 PRKX ADCY6 FOXO3 PRKCD PIK3CD CCR1 GNAI3 Rhoa CXCL3 RAF1 PREX1 CCR3 WAS PF4 CCL27 STAT3 ROCK2 CCL4 ARRB2 SOS2 CCL21 GNB4 STAT2 CXCL13 IKBKG GNB1 CCL7 Jak-STAT signaling pathway CXCL10 GNG8 PRKCZ XCR1 VAV3 c-C motif chemokine 12-like CCL1 STAT5B VAV2 GNAI2 PIK3CB ADCY8 PARD3 CRKL AKT2 PRKCB GRB2 GNG12 CCL5 CCL3 CXCL9 CCL27 ROCK1 CRK CX3CL1 GNG5 RAC1 GNGT2 CCL15 Ubiquitin mediated proteolysis PIK3R1 GNB3 CCR8 CCL25 GNG11 CXCR6 GNG13 CCL19 Ccl8 GNG5 ELMO1 Calcium PTK2B GNG3 PRKACG CXCL16 CCR2 ADCY1 GNG7 GRK5 TIAM2 CHUK CDC42 RAC2 PIK3R5 SHC2 JAK3 3',5'-Cyclic AMP CXCR2 CCL11 AKT3 Gm3785 ROS production Receptor internalization Migration Chemotaxis Cellular shape changes Metestasis Degranulation ROS production Cytokine production Cellular growth and differentiation Cell survival Migration Apoptosis
Description
Chemokines are small cytokines, or signaling proteins, secreted by cells. A major rol of chemokines is to act as chemoattractants in guiding migration of cells. Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization.
This pathway was adapted from KEGG
Proteins on this pathway have targeted assays available via the
CPTAC Assay Portal
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