DNA mismatch repair (Homo sapiens)

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11C45GTC3T2CTCCCRFC1MLH1PCNAEXO1PCNARPA1PCNAMSH6EXO1MSH2MSH6POLD1LIG1MSH2


Description

DNA mismatch repair is a system for recognizing and repairing erroneous insertion, deletion and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage

Source: wikipedia.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Iyer RR, Pluciennik A, Burdett V, Modrich PL; ''DNA mismatch repair: functions and mechanisms.''; Chem Rev, 2006 PubMed Europe PMC Scholia
  2. Hsieh P, Zhang Y; ''The Devil is in the details for DNA mismatch repair.''; Proc Natl Acad Sci U S A, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141136view13:51, 3 November 2025EweitzClear deprecated metadata rendering
137038view21:23, 26 February 2025KhanspersModified description
136385view01:36, 1 February 2025Khanspersinteractions
136384view01:34, 1 February 2025KhanspersModified description
117702view12:23, 22 May 2021EweitzModified title
113644view18:17, 9 November 2020EgonwReplaced old HMDB identifiers.
110621view18:03, 21 May 2020Khanspersclearer diagram
110620view17:13, 21 May 2020KhanspersModified description
110610view05:39, 21 May 2020KhanspersAdded more 3' MMR
110609view00:11, 21 May 2020Khanspersadded 3' MMR
110608view00:04, 21 May 2020Khansperswork in progress
110607view23:35, 20 May 2020Khansperswork in progress
110606view23:15, 20 May 2020Khansperswork in progress
108607view05:19, 10 January 2020Khanspersfixed ordering
108606view05:18, 10 January 2020KhanspersModified description
108605view05:12, 10 January 2020KhanspersOntology Term : 'mismatch repair pathway' added !
108604view05:12, 10 January 2020KhanspersOntology Term : 'DNA repair pathway' added !
108603view05:11, 10 January 2020Khanspersclarified complexes
108602view03:32, 10 January 2020Khanspersoverhaul
108598view23:56, 9 January 2020Khanspersupdated layout, style etc
106649view21:11, 12 September 2019Khanspersfixed interaction
106648view21:09, 12 September 2019KhanspersModified description
105502view05:55, 8 August 2019KhanspersModified description
102350view17:05, 20 December 2018KhanspersModified title
102349view17:05, 20 December 2018KhanspersModified title
102348view17:04, 20 December 2018Khanspersconverted interactions to graphical lines
69021view17:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
59206view19:50, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
41198view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
36296view23:21, 17 March 2010KhanspersModified categories
35172view14:57, 11 February 2010Thomasadded literature ref
35171view14:54, 11 February 2010Thomascolor fix
35170view14:53, 11 February 2010ThomasModified description
35169view14:52, 11 February 2010Thomassolid shapes
29611view12:09, 23 May 2009MartijnVanIerselUpdated ensembl references
21796view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Mismatch repair]] moved to [[Pathway:WP531]]: Moved to stable identifier
20396view21:16, 3 November 2008AlexanderPicofixed species info
10357view03:01, 23 January 2008AlexanderPicoModified categories
9590view10:51, 9 January 2008Thomasadded mismatch repair pathway

External references

DataNodes

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NameTypeDatabase referenceComment
EXO1GeneProductENSG00000174371 (Ensembl)
LIG1GeneProductENSG00000105486 (Ensembl)
MLH1GeneProductENSG00000076242 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MSH6GeneProductENSG00000116062 (Ensembl)
PCNAGeneProductENSG00000132646 (Ensembl)
POLD1GeneProductENSG00000062822 (Ensembl)
RFC1GeneProductENSG00000035928 (Ensembl)
RPA1GeneProductENSG00000132383 (Ensembl)

Annotated Interactions

No annotated interactions

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