Endochondral Ossification (Pan troglodytes)

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1, 2HypertrophyintegrinsBMPsWNT signalingcanonical / non-canonicalCartilageRemoval of extracellular matrixand invasion by bone cellsOsteoblasticdifferentiation?GsChondrocyte deathDyingChondrocyte (pre)hypertrophyChondrocyte proliferationProliferationBoneVascular invastionCathepsinsand CalpainsFull differentiationMineralisationRemoval of cartilage matrixBMPR1APTCH1SOX9MMP13COL10A1ADAMTS5SOX5THRAKIF3APTHTHRAHDAC4Growth hormonePTHLHPLATRUNX2COL2A1CarminerinDDR2PTCHADAMTS4IFT88RUNX3MMP9Thyroid hormoneSCINVEGFAAKT1TNAPPTH1RIHHSTAT1FGFR1TriiodothyroninePLAUTGFB1MEF2CENPP1SLC38A2FGFR3FRZBCALM1CDKN1CIGF2cAMPTIMP3SERPINH1BMP7HMGCS1RUNX2GHRADAMTS1PRKACAMGPSOX6IGF1RSPP1Bapx1CHST11CTSL2OxygenSTAT5BAKP2RUNX2TGFB2FGF18Thyroid hormoneIGF1BMP6AggrecanFGF2TGFB1GLI3CAB39


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 71% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia
  2. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
107228view14:32, 17 September 2019MaintBotChEBI identifier normalization
106942view13:40, 17 September 2019MaintBotHMDB identifier normalization
87980view13:20, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72219view12:56, 27 October 2013EgonwFixed the ChEBI database name.
72179view22:20, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
69274view18:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
41583view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
34311view22:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33596view09:55, 1 December 2009MaintBotRemoved group label
31617view22:17, 13 August 2009MaintBotFixed text labels
30516view21:48, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAMTS1GeneProduct473934 (Entrez Gene)
ADAMTS4GeneProduct457453 (Entrez Gene)
ADAMTS5GeneProduct473935 (Entrez Gene)
AKP2GeneProduct
AKT1GeneProduct740898 (Entrez Gene)
AggrecanGeneProduct
BMP6GeneProduct471851 (Entrez Gene)
BMP7GeneProduct458357 (Entrez Gene)
BMPR1AGeneProduct450572 (Entrez Gene)
Bapx1GeneProduct
CAB39GeneProduct470672 (Entrez Gene)
CALM1GeneProduct738819 (Entrez Gene)
CDKN1CGeneProduct
CHST11GeneProduct467113 (Entrez Gene)
COL10A1GeneProduct742603 (Entrez Gene)
COL2A1GeneProduct451860 (Entrez Gene)
CTSL2GeneProduct464593 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
CarminerinGeneProduct
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
DDR2GeneProduct457467 (Entrez Gene)
ENPP1GeneProduct463002 (Entrez Gene)
FGF18GeneProduct739611 (Entrez Gene)
FGF2GeneProduct641462 (Entrez Gene)
FGFR1GeneProduct464122 (Entrez Gene)
FGFR3GeneProduct461067 (Entrez Gene)
FRZBGeneProduct742552 (Entrez Gene)
GHRGeneProduct471560 (Entrez Gene)
GLI3GeneProduct463369 (Entrez Gene)
Growth hormoneGeneProduct
HDAC4GeneProduct
HMGCS1GeneProduct461892 (Entrez Gene)
IFT88GeneProduct452461 (Entrez Gene)
IGF1GeneProduct741055 (Entrez Gene)
IGF1RGeneProduct453676 (Entrez Gene)
IGF2GeneProduct742381 (Entrez Gene)
IHHGeneProduct470652 (Entrez Gene)
KIF3AGeneProduct450168 (Entrez Gene)
MEF2CGeneProduct461760 (Entrez Gene)
MGPGeneProduct465310 (Entrez Gene)
MMP13GeneProduct451513 (Entrez Gene)
MMP9GeneProduct458294 (Entrez Gene)
OxygenMetaboliteHMDB0001377 (HMDB)
PLATGeneProduct472748 (Entrez Gene)
PLAUGeneProduct738078 (Entrez Gene)
PRKACAGeneProduct455776 (Entrez Gene)
PTCHGeneProduct
PTCH1GeneProduct465254 (Entrez Gene)
PTH1RGeneProduct461008 (Entrez Gene)
PTHGeneProduct466447 (Entrez Gene)
PTHLHGeneProduct473393 (Entrez Gene)
RUNX2GeneProduct472017 (Entrez Gene)
RUNX3GeneProduct456633 (Entrez Gene)
SCINGeneProduct472296 (Entrez Gene) PMID: 17097081
SERPINH1GeneProduct466899 (Entrez Gene)
SLC38A2GeneProduct451851 (Entrez Gene)
SOX5GeneProduct740110 (Entrez Gene)
SOX6GeneProduct
SOX9GeneProduct450101 (Entrez Gene)
SPP1GeneProduct461366 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT5BGeneProduct454679 (Entrez Gene)
TGFB1GeneProduct456060 (Entrez Gene)
TGFB2GeneProduct457742 (Entrez Gene)
THRAGeneProduct
TIMP3GeneProduct458784 (Entrez Gene)
TNAPGeneProduct
Thyroid hormoneMetabolite60311 (ChEBI)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetabolite24864 (ChEBI)
VEGFAGeneProduct
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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