Oxidation by cytochrome P450 (Mus musculus)

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1Cytochrome P450 genesCyp20a1SubstrateCYP4A11Cyp27a1CYPCyb5bFe2+CYP3A4CYPCYPNADP+Cyp19a1CYP4F11SubstrateSubstrateCYP4Z1Cyb5Cyp7a1Cyp4f39NAD+Cyp4f18Substrateactivated O2Cyp51CYP2C19Cyp39a1Cyp7b1CYP4A22Cyb5r3CYP2G1PCYP2C18PorCYP2B6Cyp4b1Cyp2r1Cyb5bCYP3A43Cyb5CYPCyp2u1Cyp4x1AC161058.2-1Cyp2f2Cyb5r4Fe3+Fe3+O2Cyp26b1Cyp8b1Cyp2e1Fe2+O2Cyp24a1Cyp46a1Fe2+NADPHCyp1b1CYP27C1CYP2A6Cyp1a2Cyp1a1Cyp11b1Cyp21a1Cyp27b1Cyp11a1Cyb5bFe3+CYP4F2SubstrateCyp51CYP2C8CYP2A13Cyp2s1Fe3+CYP3A5CYP2J2Cyp11b2Fe2+Cyp26a1Cyb5r2Cyp26c1NADHCYPCyb5Cyp17a1CYP2A7Substrate-OHCYP2D6Cyb5r1CYP4F8CYP4F12Cyp4v3WaterCYP3A7CYP2C9


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP43(r29608) with a 53% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996

History

View all...
CompareRevisionActionTimeUserComment
125273view16:01, 31 January 2023LarsgwAdd ISBN to publication
124778view06:28, 11 December 2022AlexanderPicofixed citations
117931view10:42, 23 May 2021EweitzModified title
107196view14:28, 17 September 2019MaintBotChEBI identifier normalization
106852view13:33, 17 September 2019MaintBotHMDB identifier normalization
73502view23:10, 29 January 2014KhanspersModified title
69207view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67126view10:10, 26 June 2013Christine ChichesterOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
59077view21:45, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58511view19:12, 14 February 2013MaintBotModified title
48227view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
42733view22:36, 24 April 2011MaintBot
42732view22:23, 24 April 2011MaintBot
41397view00:30, 2 March 2011MaintBotRemoved redundant pathway information and comments
34430view18:04, 10 December 2009MaintBotAutomatic update of empty xrefs
32843view20:49, 14 September 2009MaintBotadded xrefs
31874view12:39, 14 August 2009MaintBotFixed group labels
30909view00:27, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC161058.2-1GeneProductENSMUSG00000029541 (Ensembl)
CYPGeneProduct
CYP27C1GeneProduct
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2D6GeneProduct
CYP2G1PGeneProduct
CYP2J2GeneProduct
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP4A11GeneProduct
CYP4A22GeneProduct
CYP4F11GeneProduct
CYP4F12GeneProduct
CYP4F2GeneProduct
CYP4F8GeneProduct
CYP4Z1GeneProduct
Cyb5GeneProductENSMUSG00000024646 (Ensembl)
Cyb5bGeneProductENSMUSG00000031924 (Ensembl)
Cyb5r1GeneProductENSMUSG00000026456 (Ensembl)
Cyb5r2GeneProductENSMUSG00000048065 (Ensembl)
Cyb5r3GeneProductENSMUSG00000018042 (Ensembl)
Cyb5r4GeneProductENSMUSG00000032872 (Ensembl)
Cyp11a1GeneProductENSMUSG00000032323 (Ensembl)
Cyp11b1GeneProduct110115 (Entrez Gene)
Cyp11b2GeneProduct13072 (Entrez Gene)
Cyp17a1GeneProductENSMUSG00000003555 (Ensembl)
Cyp19a1GeneProductENSMUSG00000032274 (Ensembl)
Cyp1a1GeneProductENSMUSG00000032315 (Ensembl)
Cyp1a2GeneProductENSMUSG00000032310 (Ensembl)
Cyp1b1GeneProductENSMUSG00000024087 (Ensembl)
Cyp20a1GeneProductENSMUSG00000049439 (Ensembl)
Cyp21a1GeneProductENSMUSG00000024365 (Ensembl)
Cyp24a1GeneProductENSMUSG00000038567 (Ensembl)
Cyp26a1GeneProductENSMUSG00000024987 (Ensembl)
Cyp26b1GeneProductENSMUSG00000063415 (Ensembl)
Cyp26c1GeneProductENSMUSG00000062432 (Ensembl)
Cyp27a1GeneProductENSMUSG00000026170 (Ensembl)
Cyp27b1GeneProductENSMUSG00000006724 (Ensembl)
Cyp2e1GeneProductENSMUSG00000025479 (Ensembl)
Cyp2f2GeneProductENSMUSG00000052974 (Ensembl)
Cyp2r1GeneProductENSMUSG00000030670 (Ensembl)
Cyp2s1GeneProductENSMUSG00000040703 (Ensembl)
Cyp2u1GeneProductENSMUSG00000027983 (Ensembl)
Cyp39a1GeneProductENSMUSG00000023963 (Ensembl)
Cyp46a1GeneProductENSMUSG00000021259 (Ensembl)
Cyp4b1GeneProductENSMUSG00000028713 (Ensembl)
Cyp4f18GeneProductENSMUSG00000003484 (Ensembl)
Cyp4f39GeneProductENSMUSG00000061126 (Ensembl)
Cyp4v3GeneProductENSMUSG00000079057 (Ensembl)
Cyp4x1GeneProductENSMUSG00000047155 (Ensembl)
Cyp51GeneProductENSMUSG00000001467 (Ensembl)
Cyp7a1GeneProductENSMUSG00000028240 (Ensembl)
Cyp7b1GeneProductENSMUSG00000039519 (Ensembl)
Cyp8b1GeneProductENSMUSG00000050445 (Ensembl)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
Fe3+MetaboliteCHEBI:29034 (ChEBI)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
O2MetaboliteHMDB0001377 (HMDB)
PorGeneProductENSMUSG00000005514 (Ensembl)
SubstrateGeneProduct
Substrate-OHGeneProduct
WaterMetaboliteHMDB0002111 (HMDB)
activated O2Metabolite

Annotated Interactions

No annotated interactions
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