Mevalonate pathway (Homo sapiens)

From WikiPathways

Revision as of 00:00, 20 October 2019 by AlexanderPico (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
1MVDGeranyl diphosphateCholesterolAcetyl-CoAAcetoacetyl-CoAUbiquinoneHMGCRPMVKDimethylallyl diphosphateMVK(R)-5-phosphomevalonateHMGCS1HMG-CoAACAT2mevalonateDolichol(R)-5-diphosphomevalonateFDPS


Description

The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria. The pathway produces two five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholesterol, vitamin K, coenzyme Q10, and all steroid hormones. (Wikipedia)

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ; ''the interplay between cell signalling and the mevalonate pathway in cancer''; ,

History

View all...
CompareRevisionActionTimeUserComment
107557view00:00, 20 October 2019AlexanderPicoModified description
106770view13:25, 17 September 2019MaintBotHMDB identifier normalization
103308view00:19, 22 February 2019AlexanderPicostandard node sizes and less empty space
97112view22:53, 29 April 2018AlexanderPicoReverted to version '01:07, 1 April 2018' by AlexanderPico
97111view22:20, 29 April 2018WpblockedModified title
96733view08:07, 1 April 2018EgonwReplaced another secondary ChEBI identifier with a primary identifier.
96717view13:52, 30 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94743view15:10, 5 October 2017Mkutmonfix unconnected line
91920view04:43, 6 April 2017KhanspersOntology Term : 'isoprenoid metabolic pathway' added !
91361view14:13, 10 February 2017JacobwindsorNew pathway
91351view21:29, 6 February 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)-5-diphosphomevalonateMetaboliteCHEBI:15899 (ChEBI)
(R)-5-phosphomevalonateMetaboliteCHEBI:17436 (ChEBI)
ACAT2GeneProductENSG00000120437 (Ensembl)
Acetoacetyl-CoAMetaboliteCHEBI:15345 (ChEBI)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
CholesterolMetaboliteHMDB0000067 (HMDB)
Dimethylallyl diphosphateMetaboliteCHEBI:16057 (ChEBI)
DolicholMetaboliteCHEBI:88766 (ChEBI)
FDPSGeneProductENSG00000160752 (Ensembl)
Geranyl diphosphateMetaboliteCHEBI:17211 (ChEBI)
HMG-CoAMetaboliteCHEBI:15467 (ChEBI)
HMGCRGeneProductENSG00000113161 (Ensembl)
HMGCS1GeneProductENSG00000112972 (Ensembl)
MVDGeneProductENSG00000167508 (Ensembl)
MVKGeneProductENSG00000110921 (Ensembl)
PMVKGeneProductENSG00000163344 (Ensembl)
UbiquinoneMetaboliteCHEBI:16389 (ChEBI)
mevalonateMetaboliteQ27109878 (Wikidata)

Annotated Interactions

No annotated interactions

Personal tools