Mevalonate pathway (Homo sapiens)
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Description
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria. The pathway produces two five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholesterol, vitamin K, coenzyme Q10, and all steroid hormones. (Wikipedia)
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Ontology Terms
Saving...Bibliography
- Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ; ''the interplay between cell signalling and the mevalonate pathway in cancer''; ,
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| (R)-5-diphosphomevalonate | Metabolite | CHEBI:15899 (ChEBI)  | |
| (R)-5-phosphomevalonate | Metabolite | CHEBI:17436 (ChEBI) | |
| ACAT2 | GeneProduct | ENSG00000120437 (Ensembl) | |
| Acetoacetyl-CoA | Metabolite | CHEBI:15345 (ChEBI) | |
| Acetyl-CoA | Metabolite | CHEBI:15351 (ChEBI) | |
| Cholesterol | Metabolite | HMDB0000067 (HMDB) | |
| Dimethylallyl diphosphate | Metabolite | CHEBI:16057 (ChEBI) | |
| Dolichol | Metabolite | CHEBI:88766 (ChEBI) | |
| FDPS | GeneProduct | ENSG00000160752 (Ensembl) | |
| Geranyl diphosphate | Metabolite | CHEBI:17211 (ChEBI) | |
| HMG-CoA | Metabolite | CHEBI:15467 (ChEBI) | |
| HMGCR | GeneProduct | ENSG00000113161 (Ensembl) | |
| HMGCS1 | GeneProduct | ENSG00000112972 (Ensembl) | |
| MVD | GeneProduct | ENSG00000167508 (Ensembl) | |
| MVK | GeneProduct | ENSG00000110921 (Ensembl) | |
| PMVK | GeneProduct | ENSG00000163344 (Ensembl) | |
| Ubiquinone | Metabolite | CHEBI:16389 (ChEBI) | |
| mevalonate | Metabolite | Q27109878 (Wikidata) |
Annotated Interactions
No annotated interactions
