HIPK2 in kidney fibrosis (Homo sapiens)

Revision as of 21:10, 22 November 2019 by AgustinGV (Talk | contribs)

Description

This pathway was adapted from Figure 6i of PMID: 22406746

View approved pathways at the new wikipathways.org.

Review changes for Approved

Pathway Ontology : kidney disease pathway

Disease : renal fibrosis

Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, Mazloom AR, Chen EY, D'Agati V, Xiong H, Ross MJ, Chen N, Ma'ayan A, He JC; ''A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.''; Nat Med, 2012 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
137915 Approved	view	17:37, 10 March 2025	Khanspers	Modified description
123418	view	06:12, 26 July 2022	Egonw	Made five pathways clickable
120779	view	22:23, 4 January 2022	Khanspers	updated layout and pathway labels
120775	view	21:27, 4 January 2022	Khanspers	Modified description
120774	view	20:16, 4 January 2022	Khanspers	Modified description
108288	view	16:55, 4 December 2019	AgustinGV
108287	view	16:54, 4 December 2019	AgustinGV
108286	view	16:52, 4 December 2019	AgustinGV
108025	view	21:15, 22 November 2019	AgustinGV
108024	view	21:13, 22 November 2019	AgustinGV
108023	view	21:10, 22 November 2019	AgustinGV
108022	view	20:59, 22 November 2019	AgustinGV	Ontology Term : 'renal fibrosis' added !
108021	view	20:58, 22 November 2019	AgustinGV	Ontology Term : 'kidney disease pathway' added !
108019	view	20:55, 22 November 2019	AgustinGV	New pathway

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Name	Type	Database reference
Apoptosis
ETM markers
HIPK2	GeneProduct	28996 (Entrez Gene)
Inflammation
KIDNEY FIBROSIS
NF-kB	Pathway	WP4562 (WikiPathways)
Notch	Pathway	WP268 (WikiPathways)
ROS DNA damage
SIAH1	GeneProduct	6477 (Entrez Gene)
TGF-B	Pathway	WP3874 (WikiPathways)
Wnt_B-catenin	Pathway	WP4150 (WikiPathways)
p53	Pathway	WP707 (WikiPathways)

No annotated interactions