ErbB signaling pathway (Rattus norvegicus)

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Ca+2Migration / Invasion+p+p+p+pPIP3GliomaCellular targetsCalcium signaling pathwayProteinsynthesisDNAmTor signaling pathwayERDG+pPancreaticCancerDifferentiationProliferation+p(HER2/Neu)MAPK signalingpathwaySurvival+pDNADNACell cycle+pEndometrialcancer+pCell cycleprogressionAdhesion+pCell survivalMetabolismAdhesionMigration+pActivation by ErbB2overexpression (cancers)+p+pReceptor ubiquitylation+pDNA+p+pNon-smallcell lungcancerIP3+pCellular targets+p+pAngiogenesisDegradationNo signalingERBB SIGNALING PATHWAY(EGFR)Stat5aPrkcaEgfrErbb3BtcGsk3bErbb2Nrg4Nck1Erbb3Plcg1Erbb2Rps6kb1BadMtorGrb2Map2k1Elk1AREGShc2Erbb4Mapk1Erbb2Nrg3Mapk8Erbb4Cdkn1aCamk2aAkt3Nrg1Grb2EgfStat5aGab1Erbb4Cdkn1bTgfaMap2k7Pik3r5MycEregHbegfEif4ebp1Erbb2CrkArafErbb2SrcHrasEgfrNrg2Erbb3JunEgfrPtk2Pak4Sos1Abl1CblcElk1


Description

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP673(r29836) with a 98% conversion rate.

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History

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CompareRevisionActionTimeUserComment
108381view10:38, 15 December 2019Marvin M2Converted dashed lines into graphical lines
108360view14:43, 12 December 2019Marvin M2Connected lines, removed invisible box that made some lines connected while they weren't
108317view20:37, 6 December 2019L DupuisConnected some unconnected lines
108187view10:54, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
108186view10:54, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
108185view10:54, 29 November 2019FehrhartOntology Term : 'cancer' added !
72057view17:16, 24 October 2013Mkutmonupdated annotations for Camk2a and Akt3
69395view18:59, 8 July 2013MaintBotUpdated to 2013 gpml schema
67204view10:20, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41713view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
34092view19:16, 9 December 2009MaintBotAutomatic update of empty xrefs
31337view20:24, 13 August 2009MaintBotFixed text labels
30984view00:54, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AREGGeneProduct29183 (Entrez Gene)
Abl1GeneProduct311860 (Entrez Gene)
Akt3GeneProductENSRNOG00000021497 (Ensembl)
ArafGeneProduct64363 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene)
BtcGeneProduct64022 (Entrez Gene)
Camk2aGeneProductENSRNOG00000018712 (Ensembl)
CblcGeneProduct292699 (Entrez Gene)
Cdkn1aGeneProduct114851 (Entrez Gene)
Cdkn1bGeneProduct83571 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
EgfGeneProduct25313 (Entrez Gene)
EgfrGeneProduct24329 (Entrez Gene)
Eif4ebp1GeneProduct116636 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
Erbb2GeneProduct24337 (Entrez Gene)
Erbb3GeneProduct29496 (Entrez Gene)
Erbb4GeneProduct59323 (Entrez Gene)
EregGeneProduct59325 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
HbegfGeneProduct25433 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k7GeneProduct363855 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
MtorGeneProduct56718 (Entrez Gene)
MycGeneProduct24577 (Entrez Gene)
Nck1GeneProduct300955 (Entrez Gene)
Nrg1GeneProduct112400 (Entrez Gene)
Nrg2GeneProduct432361 (Entrez Gene)
Nrg3GeneProduct498596 (Entrez Gene)
Nrg4GeneProduct690919 (Entrez Gene)
Pak4GeneProduct292756 (Entrez Gene)
Pik3r5GeneProduct497931 (Entrez Gene)
Plcg1GeneProduct25738 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
Ptk2GeneProduct25614 (Entrez Gene)
Rps6kb1GeneProduct83840 (Entrez Gene)
Shc2GeneProduct314612 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
TgfaGeneProduct24827 (Entrez Gene)

Annotated Interactions

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