Downregulation of ACE2 by SARS-CoV-2 spike protein (Homo sapiens)

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Amber Koning, Eric Weitz, Egon Willighagen, Friederike Ehrhart, Alexander Pico, et al.

Description

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Ontology Terms

Pathway Ontology : disease pathway

Disease : viral infectious disease COVID-19 respiratory failure

Bibliography

Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM; ''A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.''; Nat Med, 2005 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
129018	view	23:10, 6 March 2024	Eweitz	Ontology Term : 'respiratory failure' added !
120793	view	20:55, 8 January 2022	AlexanderPico	Reverted to version '11:32, 22 December 2021' by AlexanderPico
120657	view	18:35, 22 December 2021	Eweitz	Modified description
120656	view	18:34, 22 December 2021	Eweitz	Modified description
120655	view	18:32, 22 December 2021	Eweitz	Ontology Term : 'COVID-19' added !
120654	view	18:31, 22 December 2021	Eweitz	Use standard height, font size
120653	view	18:22, 22 December 2021	Eweitz	Modified title
120652	view	18:21, 22 December 2021	Eweitz	Horizontally align
120651	view	18:20, 22 December 2021	Eweitz	Change "SARS-CoV" to "SAR-CoV-2" per Uniprot
120649	view	16:34, 22 December 2021	Eweitz	Refine case
120648	view	16:33, 22 December 2021	Eweitz	Tighten graphics
120247	view	11:49, 20 November 2021	Egonw	Made the pathway clickable
120030	view	13:40, 16 October 2021	Egonw	Link to the lung injury AOP
116362	view	12:35, 4 May 2021	Eweitz	Modified title
114111	view	08:05, 23 December 2020	Egonw	Converted a Label into a pathway DataNode
113785	view	08:40, 21 November 2020	Egonw	Undo revision 113774 by [[Special:Contributions/NhungP\|NhungP]] ([[User talk:NhungP\|Talk]])
113774	view	11:12, 20 November 2020	NhungP	Change AngII identifier and source databases of nodes
111615	view	20:41, 29 August 2020	Egonw	Modified title
110803	view	09:33, 8 June 2020	Fehrhart	Updated protein S ID
110802	view	09:32, 8 June 2020	Fehrhart	Updated protein S ID
110245	view	17:54, 29 April 2020	Egonw	The neutral form
110244	view	17:50, 29 April 2020	Egonw	Not a mim-conversion
110243	view	17:49, 29 April 2020	Egonw	Not a mim-conversion
109976	view	18:19, 8 April 2020	AlexanderPico	updated sars nodes per #covidpathways guidelines
109852	view	11:43, 2 April 2020	Fehrhart	changed virus protein visualization
109440	view	13:54, 17 March 2020	Fehrhart	Graphical adjustments
109439	view	13:38, 17 March 2020	Fehrhart	Added literature reference
109161	view	13:43, 21 February 2020	Amber	Ontology Term : 'CL:0001034' removed !
109160	view	13:43, 21 February 2020	Amber	Modified description
109159	view	13:41, 21 February 2020	Amber	Modified title
108981	view	20:15, 12 February 2020	Amber	Modified title
108980	view	20:12, 12 February 2020	Amber	Ontology Term : 'cell in vitro' added !
108979	view	20:11, 12 February 2020	Amber	Ontology Term : 'viral infectious disease' added !
108978	view	20:10, 12 February 2020	Amber	Ontology Term : 'disease pathway' added !
108977	view	20:07, 12 February 2020	Amber	Modified description
108976	view	19:59, 12 February 2020	Amber	New pathway

External references

DataNodes

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Name	Type	Database reference
ACE2	Protein	Q9BYF1 (Uniprot-TrEMBL)
ACE	Protein	A0A0A0MSN4 (Uniprot-TrEMBL)
AT1R	Protein	P30556 (Uniprot-TrEMBL)
AT2R	Protein	P50052 (Uniprot-TrEMBL)
Ang II	Metabolite	CHEBI:58506 (ChEBI)
SARS-CoV Spike	Protein	694009 (NCBI Protein)