mBDNF and proBDNF regulation of GABA neurotransmission (Homo sapiens)

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1, 2NucleusNeuron?Endocytosis?GABA gene expressionPLCG1CREB1MAPKCREMproBDNFRHOAAP2A1STAT3GABRA1PKCSLC12A5NTRK2NGFRPTENPIK3CAPIK3CBPIK3R1PIK3R2PIK3R3PIK3CGAP2A2AP2B1SLC12A5mBDNFSLC12A5ROCK1JAK2?SHC1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG1GABRG2GABRG3GABRDGABREGABRPGABRQ


Description

draft

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kittler JT, Delmas P, Jovanovic JN, Brown DA, Smart TG, Moss SJ; ''Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.''; J Neurosci, 2000 PubMed Europe PMC Scholia
  2. Porcher C, Medina I, Gaiarsa JL; ''Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains.''; Front Cell Neurosci, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
109219view00:38, 28 February 2020KhanspersModified description
109218view00:34, 28 February 2020Khanspersupdated layout
109217view00:23, 28 February 2020KhanspersOntology Term : 'epilepsy' added !
109216view00:21, 28 February 2020KhanspersOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
109215view00:15, 28 February 2020KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AP2A1GeneProductENSG00000196961 (Ensembl)
AP2A2GeneProductENSG00000183020 (Ensembl)
AP2B1GeneProductENSG00000006125 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CREMGeneProductENSG00000095794 (Ensembl)
GABRA1GeneProductENSG00000022355 (Ensembl)
GABRA2GeneProductENSG00000151834 (Ensembl)
GABRA3GeneProductENSG00000011677 (Ensembl)
GABRA4GeneProductENSG00000109158 (Ensembl)
GABRA5GeneProductENSG00000186297 (Ensembl)
GABRA6GeneProductENSG00000145863 (Ensembl)
GABRB1GeneProductENSG00000163288 (Ensembl)
GABRB2GeneProductENSG00000145864 (Ensembl)
GABRB3GeneProductENSG00000166206 (Ensembl)
GABRDGeneProductENSG00000187730 (Ensembl)
GABREGeneProductENSG00000102287 (Ensembl)
GABRG1GeneProductENSG00000163285 (Ensembl)
GABRG2GeneProductENSG00000113327 (Ensembl)
GABRG3GeneProductENSG00000182256 (Ensembl)
GABRPGeneProductENSG00000094755 (Ensembl)
GABRQGeneProductENSG00000268089 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
  • CAV2; caveolin 2
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
MAPKPathwayWP382 (WikiPathways)
NGFRGeneProductENSG00000064300 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PKCGeneProduct
PLCG1GeneProductENSG00000124181 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCK1GeneProductENSG00000067900 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SLC12A5GeneProductENSG00000124140 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
mBDNFGeneProductENSG00000176697 (Ensembl)
proBDNFGeneProductENSG00000176697 (Ensembl)

Annotated Interactions

No annotated interactions

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