MAP3K1 role in promoting and blocking gonadal determination (Homo sapiens)

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1normalphosphorylationMale developmentFemale developmenthyper phosphorylationMale developmentFemale developmentCatenin beta-1SOX9MAPK11ROCK1FGF9MAP3K4Catenin beta-1MAP3K1WNT4GSK3BAXIN1MAPK1GADD45GFGFR2MAP3K4AXIN1SRYGSK3BMAPK1MAP3K1FOXL2RHOARHOAAXIN1SOX9FRAT1MAPK11ROCK1


Description

This pathway summarizes the differential signaling in sex development in the human fetus. Disorders of sex development can derive from dysfunction of one or more genes in this pathway.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ostrer H; ''Disorders of sex development (DSDs): an update.''; J Clin Endocrinol Metab, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129657view00:28, 22 May 2024EweitzOntology Term : 'signaling pathway pertinent to development' added !
129656view00:26, 22 May 2024EweitzEconomize layout
110081view09:11, 16 April 2020FehrhartModified description
110080view09:10, 16 April 2020FehrhartOntology Term : 'signaling pathway' added !
110079view09:09, 16 April 2020FehrhartAdded reference and connected unconnected line
109745view11:35, 30 March 2020TilmansModified title
109744view11:34, 30 March 2020TilmansOntology Term : '46 XY gonadal dysgenesis' added !
109743view11:33, 30 March 2020TilmansOntology Term : 'gonadal dysgenesis' added !
109742view11:33, 30 March 2020TilmansOntology Term : '46 XX gonadal dysgenesis' added !
109741view11:28, 30 March 2020TilmansNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AXIN1GeneProductENSG00000103126 (Ensembl)
Catenin beta-1ProteinB4DGU4 (Uniprot-TrEMBL)
FGF9GeneProductENSG00000102678 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FOXL2GeneProductENSG00000183770 (Ensembl)
FRAT1GeneProductENSG00000165879 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCK1GeneProductENSG00000067900 (Ensembl)
SOX9GeneProductENSG00000125398 (Ensembl)
SRYGeneProductENSG00000184895 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)

Annotated Interactions

No annotated interactions

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