Unfolded protein response (Homo sapiens)

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Regulated IRE1-dependent decaymRNAsmiRNAsERNLRP3inflammasomemiRNAsXBP1(s) activated chaperone genesCytosolSterileinflammationATF6 activated chaperone genesIL1BCaspase-8BIDATF6EIF2S1ATF4Caspase-2TXNIPTNFRSF10BMBTPS1PERKApoptosisp53IRE1αCHOPXBP1RTCBBBC3ATF4PMAIP1NFE2L2BiPGADD35ROSBCL2Caspase-1MBTPS2BCL2L11ATF6GADD35PMAIP1BBC3BCL2L11TNFRSF10BTNFRSF10B


Description

The Unfolded Protein Response (UPR) pathway regulates and protects the cell from improperly folded protein overload in the Endoplasmic Reticulum (ER). The UPR can result in the slowing of protein synthesis, which gives the cell time to translate more chaperones to help process the proteins. If the stress is too high, the UPR can eventually trigger apoptosis.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hetz C, Papa FR; ''The Unfolded Protein Response and Cell Fate Control.''; Mol Cell, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123438view04:38, 27 July 2022EgonwMade two pathways clickable
112845view05:24, 12 October 2020EgonwNot a conversion. Needs curation.
110553view10:18, 18 May 2020Fehrhartfixed unconnected lines
110415view11:55, 9 May 2020EgonwNot a mim-conversion
110414view11:30, 9 May 2020Egonw
110410view08:33, 9 May 2020AnnabayaAdd reference
110409view08:31, 9 May 2020AnnabayaOntology Term : 'endoplasmic reticulum stress - the unfolded protein response pathway' added !
110408view08:30, 9 May 2020AnnabayaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF4GeneProductENSG00000128272 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BBC3GeneProductENSG00000105327 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BiPGeneProductENSG00000044574 (Ensembl)
CHOPGeneProductENSG00000175197 (Ensembl)
Caspase-1ProteinA0A1W2PRX7 (Uniprot-TrEMBL)
Caspase-2ProteinA0A087WYM1 (Uniprot-TrEMBL)
Caspase-8ProteinA0A0A0MS31 (Uniprot-TrEMBL)
EIF2S1GeneProductENSG00000134001 (Ensembl)
GADD35GeneProductENSG00000087074 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IRE1αGeneProductENSG00000178607 (Ensembl)
MBTPS1GeneProductENSG00000140943 (Ensembl)
MBTPS2GeneProductENSG00000012174 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
PERKGeneProductENSG00000172071 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
ROSPathwayWP3941 (WikiPathways)
RTCBGeneProductENSG00000100220 (Ensembl)
TNFRSF10BGeneProductENSG00000120889 (Ensembl)
TXNIPGeneProductENSG00000265972 (Ensembl)
XBP1GeneProductENSG00000100219 (Ensembl)
p53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

No annotated interactions

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