Portal:Disease/COVIDPathways

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Welcome to the COVID-19 Pathway Collection

This special subset of disease pathways is being highlighted during the current COVID-19 crisis. This content is released under a CC0 waiver to be freely used, reused and distributed. Let us know if you add a new pathway or want to recommend one for this collection.

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SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

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Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

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Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with muliple members of the Cullin 2 ubiquitin ligase complex.

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Autophagy during CoV infection
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Integrative stress response in SARS-CoV-2 infection
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Host-pathogen interaction of human corona viruses - autophagy
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Host-pathogen interaction of human corona viruses - apoptosis
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Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

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Host-pathogen interaction of human corona viruses - ER stress
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Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
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Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

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Host-pathogen interaction of human corona viruses - MAPK signaling
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Host-pathogen interaction of human corona viruses - Interferon induction
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SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target
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COVID-19 AOP

Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways

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nsp9/nsp10-mediated SARS-CoV-2 pathogenesis

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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LDLRAD4 pathway in COVID-19
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SARS coronavirus and innate immunity
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COVID-19, thrombosis and anticoagulation


More about ACE2

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ACE Inhibitor Pathway
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Metabolism of Angiotensinogen to Angiotensins (Reactome)
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