Endoplasmic reticulum stress response in coronavirus infection (Homo sapiens)

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1, 324UnfoldedproteinNucleusGolgiProsurvival genesMERS 4aER-associatedmRNAER lumenSSplicingER protein chaperonesdsRNAGlobal proteintranslationAmino acid synthesisAntioxidant responseApoptosisER protein chaperonesLipid biosynthesisER-associated degradationMVH infectionCRES1PPPP1CBS2PApoptosisHRIERN1ATF6nsp15ATF4SARS 8abMAPK8PKRRIDDBCL2GCN2XBP1PPP1CCPEIF2APPGADD34CHOPPERKSARS, IBV infectionSARS, OC43,MHV, IBV infectionERN1PUnfoldedproteinERN1PXBP1uHSPA5ATF6UnfoldedproteinATF6ATF6-p50SARS EHSPA5HSPA5HSPA5CytosolHSPA5HSPA5PERKPPERKPEIF2APKRCHOPXBP1dsRNAOC43 infectionSARS, 229E, MHVPKRPC/EBPUPREERSEERSE-IIERSEPPP1CA


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, Garcia-Sastre A, Shokat KM, Shoichet BK, Krogan NJ; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.''; Nature, 2020 PubMed Europe PMC Scholia
  2. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  3. Cui W, Li J, Ron D, Sha B; ''The structure of the PERK kinase domain suggests the mechanism for its activation.''; Acta Crystallogr D Biol Crystallogr, 2011 PubMed Europe PMC Scholia
  4. Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL; ''ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  5. DeDiego ML, Nieto-Torres JL, Jiménez-Guardeño JM, Regla-Nava JA, Alvarez E, Oliveros JC, Zhao J, Fett C, Perlman S, Enjuanes L; ''Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.''; PLoS Pathog, 2011 PubMed Europe PMC Scholia
  6. Sung SC, Chao CY, Jeng KS, Yang JY, Lai MM; ''The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6.''; Virology, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135076view21:11, 5 August 2024Khanspersadded PMIDs from description to bibliography
124658view13:34, 18 November 2022NhungPupdate viral protein shapes
124631view12:25, 18 November 2022NhungPchange shape of viral proteins
124630view12:25, 18 November 2022NhungPchange shape of SARS-COV 2 viral proteins
118973view12:51, 5 June 2021EgonwGave dsRNA an identifier
118972view12:47, 5 June 2021EgonwA protein family is also a gene product, I guess
116305view10:15, 29 April 2021EweitzModified description
116304view10:14, 29 April 2021EweitzModified title
116211view13:23, 20 April 2021EgonwUpdated two data sources
115877view10:13, 19 March 2021FinterlyFixed some weird symbol characters.
115863view16:03, 18 March 2021LaurentUpdated some annotations for DataNodes
114110view08:04, 23 December 2020EgonwConverted two Labels to a DataNode
114083view08:03, 21 December 2020EgonwConverted a few more interacting labels into DataNodes.
112228view07:40, 4 October 2020EgonwModified title
112166view18:34, 29 September 2020Khanspersfixed ptm state comments
111617view20:42, 29 August 2020EgonwModified title
111114view09:24, 13 July 2020EgonwMade a pathway clickable
110816view23:31, 9 June 2020KhanspersModified description
110815view22:49, 9 June 2020KhanspersModified title
110810view10:07, 9 June 2020AndraModified title
110793view00:13, 6 June 2020KhanspersModified description
110792view22:17, 5 June 2020Khanspersupdated lit ref for Gordon et al
110767view12:36, 3 June 2020Fehrhartfixed unconnected line fixed stimulation of transcription/translation
110763view21:36, 2 June 2020Khanspersremoved duplicated label
110762view21:35, 2 June 2020Khanspersminor placement change
110761view21:31, 2 June 2020Khanspersadded legend
110760view21:22, 2 June 2020Khanspersnucleus details
110759view21:11, 2 June 2020Khanspersadded PP1 subunits
110677view23:52, 27 May 2020KhanspersModified title
110676view23:51, 27 May 2020KhanspersModified description
110675view23:51, 27 May 2020Khanspersadded S1P, S2P and missing xrefs
110674view23:27, 27 May 2020KhanspersAdded phospho sites
110673view22:22, 27 May 2020Khanspersfixed typo
110672view22:16, 27 May 2020Khanspersadded details and viral proteins
110670view18:45, 27 May 2020KhanspersModified title
110669view18:40, 27 May 2020Khanspersupdated to protein ids, fixed ER
110665view00:29, 27 May 2020KhanspersModified title
110664view00:28, 27 May 2020Khanspersadded third arm, location etc
110630view23:33, 22 May 2020Khanspersspecified interactions
110629view23:19, 22 May 2020Khanspersadded content
110451view22:43, 12 May 2020Khansperscleared up names, added interactions
110198view20:38, 23 April 2020EgonwTyped proteins as Type="Protein"
109971view18:17, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109855view13:41, 2 April 2020MaintBotThe label just black.
109854view13:40, 2 April 2020MaintBotStyled the virus node.
109726view21:10, 29 March 2020EgonwAdded a Wikidata identifier for nsp15
109643view19:23, 27 March 2020AlexanderPicoOntology Term : 'viral infectious disease' added !
109632view18:27, 27 March 2020AlexanderPicoOntology Term : 'stress response pathway' added !
109631view18:27, 27 March 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
109630view18:26, 27 March 2020AlexanderPicoOntology Term : 'disease pathway' added !

External references

DataNodes

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NameTypeDatabase referenceComment
ATF4ProteinP18848 (Uniprot-TrEMBL)
ATF6-p50ProteinP18850 (Uniprot-TrEMBL)
ATF6ProteinP18850 (Uniprot-TrEMBL)
ApoptosisPathwayWP354 (WikiPathways)
BCL2ProteinP10415 (Uniprot-TrEMBL)
CHOPProteinP35638 (Uniprot-TrEMBL)
EIF2AProteinQ53XC0 (Uniprot-TrEMBL)
ERN1ProteinO75460 (Uniprot-TrEMBL)
GADD34ProteinO75807 (Uniprot-TrEMBL)
GCN2ProteinQ9H492 (Uniprot-TrEMBL)
HRIProteinQ9BQI3 (Uniprot-TrEMBL)
HSPA5ProteinP11021 (Uniprot-TrEMBL)
MAPK8ProteinP45983 (Uniprot-TrEMBL)
MERS 4aProtein
PERKProteinQ9NZJ5 (Uniprot-TrEMBL)
PKRProteinP19525 (Uniprot-TrEMBL)
PPP1CAProteinP62136 (Uniprot-TrEMBL)
PPP1CBProteinP62140 (Uniprot-TrEMBL)
PPP1CCProteinP36873 (Uniprot-TrEMBL)
RIDDPathway
SProtein
S1PProteinQ14703 (Uniprot-TrEMBL)
S2PProteinO43462 (Uniprot-TrEMBL)
SARS 8abGeneProduct
SARS EGeneProduct
XBP1ProteinP17861 (Uniprot-TrEMBL)
XBP1uProteinP17861 (Uniprot-TrEMBL)
nsp15ProteinQ87917579 (Wikidata)

Annotated Interactions

No annotated interactions

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