Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome (Homo sapiens)

From WikiPathways

Revision as of 11:16, 6 July 2020 by Marvin M2 (Talk | contribs)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)Assembly of mitochondrial complex IKE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)Kidney injuryMitochondrial dysfunctionAutophagyNecrosisApoptosisFerroptosisKE55: N/A, Cell injury/deathDeguelinDecreased proximal tubule vectorial transportKE1563: Decreased proximal tubular vectorial transportDecreased mitochondrial oxidative phosphorylationKE1477: Decrease, OXPHOSOxidative stress responseKE1562: Decreased Na/K ATPase activityImpaired proteostasisUnfolded Protein ResponseKE889: Impaired, ProteostasisRotenoneKE1564: Chemical induced Fanconi syndromeName: Mitochondrial Complex I inhibition leading to chemical induced fanconi syndromeOrganism: Homo sapiens


Description

New pathway of type Adverse Outcome Pathway

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:NeedsRef.pngAdd references
Image:Curated.pngReview changes for Approved
Image:Wplogo_31.pngCommunity: Adverse Outcome Pathways

Ontology Terms

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
129304
Approved
view13:46, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
118493view08:55, 28 May 2021FinterlyIn Previous edit, replaced DataNode type "Stressor" and "Key Event" with "Event" (Comment)
118492view08:49, 28 May 2021FinterlyReplaced
116640view11:29, 9 May 2021EweitzModified title
115232
AOP
view07:21, 6 February 2021EgonwRedirected a pathway node, after deletion of the previous linked pathway
111509view09:57, 21 August 2020Marvin M2ungrouped groups for better network merging
111508view09:53, 21 August 2020Marvin M2Aligned layout better
111506view09:44, 21 August 2020Marvin M2Changed connections in groups to test for merging
111424view11:23, 7 August 2020Marvin M2Ontology Term : 'altered metabolic pathway' added !
111077view11:36, 6 July 2020Marvin M2Modified description
111076view11:27, 6 July 2020Marvin M2Ontology Term : 'Fanconi syndrome' added !
111075view11:26, 6 July 2020Marvin M2
111074view11:23, 6 July 2020Marvin M2Modified description
111073view11:16, 6 July 2020Marvin M2
111072view11:13, 6 July 2020Marvin M2
111071view11:12, 6 July 2020Marvin M2
111070view11:10, 6 July 2020Marvin M2
111069view11:03, 6 July 2020Marvin M2New pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ApoptosisPathwayWP1772 (WikiPathways)
Assembly of mitochondrial complex IPathwayWP4324 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
Decreased mitochondrial oxidative phosphorylationPathwayWP111 (WikiPathways)
Decreased proximal tubule vectorial transportPathwayWP4917 (WikiPathways)
DeguelinMetaboliteCHEBI:4357 (ChEBI)
FerroptosisPathwayWP4313 (WikiPathways)
Impaired proteostasisPathwayWP4918 (WikiPathways)
KE1477: Decrease, OXPHOSKey Event1477 (AOP-Wiki KE)
KE1562: Decreased Na/K ATPase activity Key Event1562 (AOP-Wiki KE)
KE1563: Decreased proximal tubular vectorial transport Key Event1563 (AOP-Wiki KE)
KE1564: Chemical induced Fanconi syndrome Key Event1564 (AOP-Wiki KE)
KE55: N/A, Cell injury/death Key Event55 (AOP-Wiki KE)
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)Key Event887 (AOP-Wiki KE)
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)Key Event888 (AOP-Wiki KE)
KE889: Impaired, Proteostasis Key Event889 (AOP-Wiki KE)
NecrosisPathwayWP3383 (WikiPathways)
Oxidative stress responsePathwayWP3941 (WikiPathways)
RotenoneMetaboliteCHEBI:28201 (ChEBI)
Unfolded Protein ResponsePathwayWP4925 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4944"
Personal tools