B-WICH complex positively regulates rRNA expression (Homo sapiens)

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3, 5, 10, 11, 13...3, 5, 7, 11, 14...3, 10, 1110, 11nucleoplasmNucleosome (H3K9ac)H3F3A POLR1D POLR1B POLR2H HIST1H2BL TAF1A HIST3H2BB H2BFS CD3EAP SF3B1 BAZ1B MYO1C-3 TAF1D HIST1H2BN RNA Polymerase IHoloenzymeKAT2AHIST1H2BM H2AFX POLR1C HIST3H2BB HIST1H2AC TAF1C B-WICH:rDNAPromoter:KAT2B:KAT2A:EP300Ack10-HIST1H3A TAF1B HIST1H2BB HIST1H2BO POLR2H ZNRD1 HIST2H2AC TWISTNB POLR1E SMARCA5EP300 H2AFZ ERCC6 dimerKAT2A HIST1H2BO H2AFJ AcK10-H3F3A TWISTNB H2AFB1 BAZ1BDEK POLR1C ERCC6 SMARCA5 TAF1D BAZ1B TAF1C ACTB(1-375) NucleosomeHIST1H2AB HIST2H2AA3 MYBBP1A Ack10-HIST2H3A HIST1H2BL Ac-CoAHIST1H2BD TBP HIST1H2AD KAT2BPOLR2E CD3EAP HIST1H2BA HIST1H2BK SF3B1SMARCA5 H2BFS POLR2K HIST1H2AD H2AFX HIST1H4 HIST1H2BJ CoA-SHHIST2H3A POLR1D ERCC6 POLR2F DEK B-WICH:rDNAPromoter:SL1:RNAPol IH2AFB1 ACTB(1-375)HIST1H2AJ HIST1H2AB HIST1H2BH HIST1H2BC H2AFZ POLR1A HIST1H2BD DDX21 POLR1A MYBBP1A POLR2F HIST2H2AC EP300HIST1H2BH H2AFV POLR2E TAF1B HIST1H4 ERCC6 TAF1D HIST1H2BJ HIST2H2AA3 MYBBP1ASL1POLR1E TBP HIST1H3A POLR2K rDNA PromoterPOLR2H HIST1H2BK TAF1A HIST2H2BE POLR1B TAF1A DDX21 H2AFJ TAF1B POLR2F POLR2K TBP POLR1C MYO1C-3 POLR1A POLR2L HIST2H2BE TWISTNB H2AFV HIST1H2BM POLR2L HIST1H2BC GSK3BrDNA Promoter HIST1H2BN DDX21ZNRD1 HIST1H2AC POLR2E POLR1D HIST1H2BA SF3B1 POLR2L POLR1E MYO1C-3 POLR1B KAT2B CD3EAP HIST1H2AJ ZNRD1 HIST1H2BB TAF1C MYO1C:ACTBrDNA Promoter DEK21, 4, 6, 8, 123, 113, 5, 11, 15169


Description

The B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c), SF3B1, DEK, MYBBP1A, and DDX21 (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001, Sarshad et al. 2013, Shen et al. 2013, reviewed in Percipalle and Farrants 2006). B-WICH is found at active rRNA genes as well as at 5S rRNA and 7SL RNA genes. B-WICH appears to remodel chromatin and recruit histone acetyltransferases that modify histones to transcriptionally active states. View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 5250924
Reactome-version 
Reactome version: 73
Reactome Author 
Reactome Author: May, Bruce

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Bibliography

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  1. Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Lamont D, Visa N, Percipalle P.; ''Glycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells.''; PubMed Europe PMC Scholia
  2. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R.; ''Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits.''; PubMed Europe PMC Scholia
  3. Russell J, Zomerdijk JC.; ''The RNA polymerase I transcription machinery.''; PubMed Europe PMC Scholia
  4. Comai L, Tanese N, Tjian R.; ''The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1.''; PubMed Europe PMC Scholia
  5. Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P, Grummt I.; ''Nuclear actin and myosin I are required for RNA polymerase I transcription.''; PubMed Europe PMC Scholia
  6. Cavellán E, Asp P, Percipalle P, Farrants AK.; ''The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.''; PubMed Europe PMC Scholia
  7. Gorski JJ, Pathak S, Panov K, Kasciukovic T, Panova T, Russell J, Zomerdijk JC.; ''A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription.''; PubMed Europe PMC Scholia
  8. Christiansen M, Thorslund T, Jochimsen B, Bohr VA, Stevnsner T.; ''The Cockayne syndrome group B protein is a functional dimer.''; PubMed Europe PMC Scholia
  9. Vintermist A, Böhm S, Sadeghifar F, Louvet E, Mansén A, Percipalle P, Ostlund Farrants AK.; ''The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes.''; PubMed Europe PMC Scholia
  10. Bell SP, Pikaard CS, Reeder RH, Tjian R.; ''Molecular mechanisms governing species-specific transcription of ribosomal RNA.''; PubMed Europe PMC Scholia
  11. Sarshad AA, Percipalle P.; ''New insight into role of myosin motors for activation of RNA polymerases.''; PubMed Europe PMC Scholia
  12. Shen M, Zhou T, Xie W, Ling T, Zhu Q, Zong L, Lyu G, Gao Q, Zhang F, Tao W.; ''The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation.''; PubMed Europe PMC Scholia
  13. Pijnappel WP, Kolkman A, Baltissen MP, Heck AJ, Timmers HM.; ''Quantitative mass spectrometry of TATA binding protein-containing complexes and subunit phosphorylations during the cell cycle.''; PubMed Europe PMC Scholia
  14. Percipalle P, Fomproix N, Cavellán E, Voit R, Reimer G, Krüger T, Thyberg J, Scheer U, Grummt I, Farrants AK.; ''The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.''; PubMed Europe PMC Scholia
  15. Sarshad A, Sadeghifar F, Louvet E, Mori R, Böhm S, Al-Muzzaini B, Vintermist A, Fomproix N, Östlund AK, Percipalle P.; ''Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.''; PubMed Europe PMC Scholia
  16. Percipalle P, Farrants AK.; ''Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114698view16:17, 25 January 2021ReactomeTeamReactome version 75
113143view11:20, 2 November 2020ReactomeTeamReactome version 74
112373view15:30, 9 October 2020ReactomeTeamReactome version 73
101276view11:16, 1 November 2018ReactomeTeamreactome version 66
100813view20:46, 31 October 2018ReactomeTeamreactome version 65
100354view19:22, 31 October 2018ReactomeTeamreactome version 64
99899view16:05, 31 October 2018ReactomeTeamreactome version 63
99456view14:38, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93900view13:43, 16 August 2017ReactomeTeamreactome version 61
93473view11:24, 9 August 2017ReactomeTeamreactome version 61
87091view14:27, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87090view14:27, 18 July 2016MkutmonOntology Term : 'non-coding RNA pathway' added !
86570view09:21, 11 July 2016ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTB(1-375) ProteinP60709 (Uniprot-TrEMBL)
ACTB(1-375)ProteinP60709 (Uniprot-TrEMBL)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
AcK10-H3F3A ProteinP84243 (Uniprot-TrEMBL)
Ack10-HIST1H3A ProteinP68431 (Uniprot-TrEMBL)
Ack10-HIST2H3A ProteinQ71DI3 (Uniprot-TrEMBL)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300ComplexR-HSA-5250942 (Reactome)
B-WICH:rDNA

Promoter:SL1:RNA

Pol I
ComplexR-HSA-5250923 (Reactome)
BAZ1B ProteinQ9UIG0 (Uniprot-TrEMBL)
BAZ1BProteinQ9UIG0 (Uniprot-TrEMBL)
CD3EAP ProteinO15446 (Uniprot-TrEMBL)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
DDX21 ProteinQ9NR30 (Uniprot-TrEMBL)
DDX21ProteinQ9NR30 (Uniprot-TrEMBL)
DEK ProteinP35659 (Uniprot-TrEMBL)
DEKProteinP35659 (Uniprot-TrEMBL)
EP300 ProteinQ09472 (Uniprot-TrEMBL)
EP300ProteinQ09472 (Uniprot-TrEMBL)
ERCC6 ProteinQ03468 (Uniprot-TrEMBL)
ERCC6 dimerComplexR-HSA-5365864 (Reactome)
GSK3BProteinP49841 (Uniprot-TrEMBL)
H2AFB1 ProteinP0C5Y9 (Uniprot-TrEMBL)
H2AFJ ProteinQ9BTM1 (Uniprot-TrEMBL)
H2AFV ProteinQ71UI9 (Uniprot-TrEMBL)
H2AFX ProteinP16104 (Uniprot-TrEMBL)
H2AFZ ProteinP0C0S5 (Uniprot-TrEMBL)
H2BFS ProteinP57053 (Uniprot-TrEMBL)
H3F3A ProteinP84243 (Uniprot-TrEMBL)
HIST1H2AB ProteinP04908 (Uniprot-TrEMBL)
HIST1H2AC ProteinQ93077 (Uniprot-TrEMBL)
HIST1H2AD ProteinP20671 (Uniprot-TrEMBL)
HIST1H2AJ ProteinQ99878 (Uniprot-TrEMBL)
HIST1H2BA ProteinQ96A08 (Uniprot-TrEMBL)
HIST1H2BB ProteinP33778 (Uniprot-TrEMBL)
HIST1H2BC ProteinP62807 (Uniprot-TrEMBL)
HIST1H2BD ProteinP58876 (Uniprot-TrEMBL)
HIST1H2BH ProteinQ93079 (Uniprot-TrEMBL)
HIST1H2BJ ProteinP06899 (Uniprot-TrEMBL)
HIST1H2BK ProteinO60814 (Uniprot-TrEMBL)
HIST1H2BL ProteinQ99880 (Uniprot-TrEMBL)
HIST1H2BM ProteinQ99879 (Uniprot-TrEMBL)
HIST1H2BN ProteinQ99877 (Uniprot-TrEMBL)
HIST1H2BO ProteinP23527 (Uniprot-TrEMBL)
HIST1H3A ProteinP68431 (Uniprot-TrEMBL)
HIST1H4 ProteinP62805 (Uniprot-TrEMBL)
HIST2H2AA3 ProteinQ6FI13 (Uniprot-TrEMBL)
HIST2H2AC ProteinQ16777 (Uniprot-TrEMBL)
HIST2H2BE ProteinQ16778 (Uniprot-TrEMBL)
HIST2H3A ProteinQ71DI3 (Uniprot-TrEMBL)
HIST3H2BB ProteinQ8N257 (Uniprot-TrEMBL)
KAT2A ProteinQ92830 (Uniprot-TrEMBL)
KAT2AProteinQ92830 (Uniprot-TrEMBL)
KAT2B ProteinQ92831 (Uniprot-TrEMBL)
KAT2BProteinQ92831 (Uniprot-TrEMBL)
MYBBP1A ProteinQ9BQG0 (Uniprot-TrEMBL)
MYBBP1AProteinQ9BQG0 (Uniprot-TrEMBL)
MYO1C-3 ProteinO00159-3 (Uniprot-TrEMBL)
MYO1C:ACTBComplexR-HSA-5250916 (Reactome)
Nucleosome (H3K9ac)ComplexR-HSA-5250919 (Reactome)
NucleosomeComplexR-HSA-427402 (Reactome)
POLR1A ProteinO95602 (Uniprot-TrEMBL)
POLR1B ProteinQ9H9Y6 (Uniprot-TrEMBL)
POLR1C ProteinO15160 (Uniprot-TrEMBL)
POLR1D ProteinP0DPB5 (Uniprot-TrEMBL)
POLR1E ProteinQ9GZS1 (Uniprot-TrEMBL)
POLR2E ProteinP19388 (Uniprot-TrEMBL)
POLR2F ProteinP61218 (Uniprot-TrEMBL)
POLR2H ProteinP52434 (Uniprot-TrEMBL)
POLR2K ProteinP53803 (Uniprot-TrEMBL)
POLR2L ProteinP62875 (Uniprot-TrEMBL)
RNA Polymerase I HoloenzymeComplexR-HSA-73859 (Reactome)
SF3B1 ProteinO75533 (Uniprot-TrEMBL)
SF3B1ProteinO75533 (Uniprot-TrEMBL)
SL1ComplexR-HSA-73692 (Reactome)
SMARCA5 ProteinO60264 (Uniprot-TrEMBL)
SMARCA5ProteinO60264 (Uniprot-TrEMBL)
TAF1A ProteinQ15573 (Uniprot-TrEMBL)
TAF1B ProteinQ53T94 (Uniprot-TrEMBL)
TAF1C ProteinQ15572 (Uniprot-TrEMBL)
TAF1D ProteinQ9H5J8 (Uniprot-TrEMBL)
TBP ProteinP20226 (Uniprot-TrEMBL)
TWISTNB ProteinQ3B726 (Uniprot-TrEMBL)
ZNRD1 ProteinQ9P1U0 (Uniprot-TrEMBL)
rDNA Promoter R-ALL-73682 (Reactome)
rDNA PromoterR-ALL-73682 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ACTB(1-375)ArrowR-HSA-5250947 (Reactome)
Ac-CoAR-HSA-5250938 (Reactome)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300ArrowR-HSA-5250930 (Reactome)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300mim-catalysisR-HSA-5250938 (Reactome)
B-WICH:rDNA

Promoter:SL1:RNA

Pol I
ArrowR-HSA-5250947 (Reactome)
B-WICH:rDNA

Promoter:SL1:RNA

Pol I
R-HSA-5250930 (Reactome)
BAZ1BR-HSA-5250947 (Reactome)
CoA-SHArrowR-HSA-5250938 (Reactome)
DDX21R-HSA-5250947 (Reactome)
DEKR-HSA-5250947 (Reactome)
EP300R-HSA-5250930 (Reactome)
ERCC6 dimerR-HSA-5250947 (Reactome)
GSK3BArrowR-HSA-5250947 (Reactome)
KAT2AR-HSA-5250930 (Reactome)
KAT2BR-HSA-5250930 (Reactome)
MYBBP1AR-HSA-5250947 (Reactome)
MYO1C:ACTBR-HSA-5250947 (Reactome)
Nucleosome (H3K9ac)ArrowR-HSA-5250938 (Reactome)
NucleosomeR-HSA-5250938 (Reactome)
R-HSA-5250930 (Reactome) Direct interactions between BAZ1B (WSTF) and histone acetyltransferases KAT2B, KAT2A, and EP300 are weak (Vintermist et al. 2011) so the acetyltransferases may interact with other subunits of B‑WICH or with proteins not in the B‑WICH complex. The ERCC6 (CSB) component of B‑WICH and MYOIC interact with KAT2B (PCAF) (Sarshad et al. 2013, Shen et al. 2013). The histone acetyltransferases are believed to acetylate histone H3 at lysine‑9 in rDNA since this modification is reduced in WSTF and MYOIC knockdown cells (Vintermist et al. 2011, Sarshad et al. 2013). Knockdown of KAT2B causes loss of acetylation on histone H4 and on histone H3 at lysine‑9 (Shen et al. 2013).
R-HSA-5250938 (Reactome) Histone acetyltransferases recruited by the B‑WICH complex acetylate histone H3 at lysine‑9. Knockdown of the BAZ1B (WSTF) and MYOIC components of B‑WICH cause a loss of histone acetyltransferases KAT2B (PCAF), KAT2A (GCN5), and EP300 (p300) and a reduction of acetylated histone H3. Knockdown of KAT2B (PCAF) causes a reduction in acetylation of histone H3 at lysine‑9, leading to reduced rRNA synthesis levels (Sarshad et al. 2013, Shen et al. 2013).
R-HSA-5250947 (Reactome) Active rRNA genes are bound by the B‑WICH multiprotein complex (Cavellan et al. 2006, Percipalle et al. 2006). B-WICH binds the promoter region of the gene (Percipalle et al. 2006, Sarshad et al. 2013). The MYO1C component of the B-WICH complex binds chromatin and interacts with SMARCA5. Binding causes 200 bp of chromatin at the promoter to adopt a more open configuration and contributes to epigenetic modifications compatible with transcription activation (Vintermist et al. 2011, Sarshad et al. 2013). At the rRNA gene promoter the SMARCA5-MYOIC interaction is excluded when MYOIC interacts with actin in complex with RNA polymerase I (Sarshad et al. 2013). Binding of MYOIC to chromatin is regulated by GSK3beta-dependent phosphorylation that targets the MYOIC chromatin binding domain (Sarshad et al. 2014). Binding of MYOIC to the RNA polymerase I is partly mediated via phosphorylated TIF1A (Philimonenko et al. 2004). Binding of B‑WICH to rRNA genes requires MYOIC to be recruited to active rRNA genes and this mechanism appears to be a requirement to activate and maintain transcription by RNA polymerase I (Percipalle et al. 2006, Sarshad et al. 2013, Sarshad et al. 2014, reviewed in Sarshad and Percipalle 2014).
RNA Polymerase I HoloenzymeR-HSA-5250947 (Reactome)
SF3B1R-HSA-5250947 (Reactome)
SL1R-HSA-5250947 (Reactome)
SMARCA5R-HSA-5250947 (Reactome)
rDNA PromoterR-HSA-5250947 (Reactome)
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