Class I MHC mediated antigen processing and presentation (Homo sapiens)

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24, 38, 49, 72, 103...5, 99, 101, 121, 138...755, 11228, 75, 12073, 8333, 54, 69, 836833, 10727, 66, 90, 1001, 30, 7317, 31, 46, 82, 132...12, 14, 26, 45, 61...762, 81, 108, 12265, 102101, 120, 125, 12727, 66, 9028, 7511, 1304, 9, 63, 7028, 75, 11725, 40, 48, 58, 1346, 43, 44, 57, 12928, 7558, 94, 98, 131, 134...27, 29, 66, 9028, 751, 7310927, 66, 9083, 8662, 81, 1206, 43, 44, 57, 1293, 71, 9519, 123, 12450, 89, 10735, 64, 9120, 21, 5267792, 10, 77, 79, 114...78, 80, 1267, 2020early endosomerecycling endosomeCOPII-coated ER to Golgi transport vesicleendoplasmic reticulum-Golgi intermediate compartmentcytosolphagolysosomeendoplasmic reticulum lumenGolgi lumenclathrin-coated endocytic vesicleERGICphagocytic vesiclePSMB5 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B50 HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B38 RCHY1 UBA7 E3:K48-polyubiquitinated substrateRNF7 (RBX2) UBE2M HLA class I histocompatibility antigen, A-2 alpha chain CUL1 CHUK HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B15 KBTBD6 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor SHFM1 class I MHC B81 HLA class I histocompatibility antigen, A-36 alpha chain ZBTB16 UBB(1-76) class I MHC B35 SEC22B KBTBD6 ASB13 HLA class I histocompatibility antigen, Cw-8 alpha chain HECTD3 HLA-H KBTBD7 class I MHC B49 (Glc)1 (GlcNAc)2 (Man)9 PSMB2 L-amino acidMRC2 HLA class I histocompatibility antigen, A-80 alpha chain VPRBP TRIM9 HLA-B RNF217 H+UBA7 KLHL5 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B54 PSMD11 HLA class I histocompatibility antigen, A-68 alpha chain SAR1B HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B67 FBXO21 class I MHC B27 SEC24D LRR1 PSMD9 UBC(609-684) class I MHC B51 RNF111 HLA class I histocompatibility antigen, Cw-2 alpha chain DZIP3 antigenic substrate HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B44 RNF217 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ASB9 FBXL4 class I MHC B59 HLA class I histocompatibility antigen, Cw-16 alpha chain PSMD8 HLA-H HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B73 HLA-B UBR1 HLA class I histocompatibility antigen, E alpha chain precursor COPII vesicle withMHC class IPSMD12 TRIM39 TRIM36 class I MHC B46 RLIM HLA class I histocompatibility antigen, A-25 alpha chain PSMB3 class I MHC B27 class I MHC B15 PJA2 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor UBC(153-228) HLA class I histocompatibility antigen, Cw-1 alpha chain UBB(153-228) HLA class I histocompatibility antigen, Cw-18 alpha chain HLA-H UBR4 UBC(1-76) UBC(457-532) TRIM71 MRC2 HLA class I histocompatibility antigen, A-33 alpha chain PSMB8 class I MHC B53 class I MHC B58 UBE2S class I MHC B82 SEC23A HLA class I histocompatibility antigen, Cw-8 alpha chain UBE2G2 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor UBC(229-304) HLA class I histocompatibility antigen, Cw-14 alpha chain RNF217 oligo-MyD88:TIRAP:BTK:activated TLRUBC(153-228) RNF220 RNF138 HLA class I histocompatibility antigen, alpha chain G precursor TRIM21 class I MHC B40 LTN1 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B8 class I MHC B35 ELOB class I MHC B59 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B82 ANAPC1 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain UBC(77-152) HLA-B class I MHC B42 class I MHC B14 PSMB3 MIB2 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain DET1 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain L-amino acidclass I MHC B81 RNF41 KBTBD8 AMPRNF115 class I MHC B13 UBC(1-76) class I MHC B49 RPS27A(1-76) class I MHC B45 class I MHC B44 PARK2 CANX UBE2J1 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain ANAPC4 PJA1 Lipoteichoic acid HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain KLHL13 UBE2V2 HLA class I histocompatibility antigen, A-43 alpha chain FBXL5 RNF6 class I MHC B47 class I MHC B56 TRIM37 KLHL21 class I MHC B42 HLA class I histocompatibility antigen, A-32 alpha chain KLHL25 UBE2W CANX class I MHC B38 SAR1B DTX3L UBE2D4 TRIM32 ERAP1/2ITGAV(31-1048) class I MHC B47 HLA class I histocompatibility antigen, A-29 alpha chain ASB10 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B50 HUWE1 HLA class I histocompatibility antigen, A-29 alpha chain RNF123 FBXW4 PSMD12 IRAP in complex withMHC class IUBB(77-152) class I MHC B58 class I MHC B37 class I MHC B15 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain FBXL15 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B37 UBE2K MEX3C LNPEP KLHL2 FBXL20 class I MHC B27 Antigen peptide UBR2 HLA class I histocompatibility antigen, A-69 alpha chain RNF34 HERC2 FBXL8 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B55 PSMD7 class I MHC B81 RNF19A FBXO40 4xPalmC-CD36 Antigen peptideclass I MHC B54 class I MHC B59 26S proteasomeSEC24B PSMB6 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain ANAPC2 PARK2 RNF14 class I MHC B7 HLA class I histocompatibility antigen, Cw-12 alpha chain FBXO31 VAMP8 (Glc)1 (GlcNAc)2 (Man)9 class I MHC B13 class I MHC B39 FBXL22 RNF19B class I MHC B38 HLA class I histocompatibility antigen, alpha chain G precursor FBXO22 HERC2 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B14 class I MHC B52 HLA class I histocompatibility antigen, alpha chain F precursor FZR1 FBXL12 CYBB HERC2 HLA class I histocompatibility antigen, A-1 alpha chain precursor NEDD4L class I MHC B8 RPS27A(1-76) HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain ASB18 ASB12 HLA class I histocompatibility antigen, E alpha chain precursor ITCH UBA52(1-76) HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor RNF7 (RBX2) FCGR FBXW4 ITGAV(31-1048) HLA-B KLHL42 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor RBBP6 class I MHC B7 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B15 UBR2 ZNRF2 TLR1 class I MHC B18 ASB16 PSMA5 ELOB HLA class I histocompatibility antigen, Cw-16 alpha chain HLA-B CUL5 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain SEC24C HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B44 TAPLONRF1 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B59 UBE2Q2 class I MHC B18 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B67 UBC(1-76) SEC61A1 class I MHC B58 ASB1 UBE2J2 HLA class I histocompatibility antigen, Cw-16 alpha chain SKP2 class I MHC B50 ASB3 class I MHC B58 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ANAPC10 KEAP1 ELOC HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B58 TAP2 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B59 class I MHC B78 LRR1 CDC20 Antigen peptide ExogenousParticulate antigen(Ag)class I MHC B45 class I MHC B41 class I MHC B55 UBAC1 UBE2D3 RNF6 RBBP6 PSMA1 class I MHC B37 class I MHC B82 HLA class I histocompatibility antigen, Cw-8 alpha chain FBXO22 HLA class I histocompatibility antigen, A-11 alpha chain CDC34 Antigen peptide RNF144B HLA class I histocompatibility antigen, A-3 alpha chain precursor CALR UBE2S PSMA2 HLA class I histocompatibility antigen, Cw-17 alpha chain FBXW10 STX4 ASB16 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-17 alpha chain PSME1 PSMB11 BTBD6 E3:Ub:substrateHLA class I histocompatibility antigen, A-11 alpha chain class I MHC B42 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B8 HLA class I histocompatibility antigen, A-25 alpha chain FBXL13 FBXL7 class I MHC B8 RNF6 class I MHC B52 FBXO7 class I MHC B53 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B51 ExogenousParticulate antigen(Ag)PSMC4 RNF213 TRIM9 TRIM69 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B50 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B57 HLA class I histocompatibility antigen, Cw-17 alpha chain SEC22BRCHY1 class I MHC B41 class I MHC B73 class I MHC B15 class I MHC B53 4xPalmC-CD36 FBXO11 RPS27A(1-76) HLA class I histocompatibility antigen, Cw-16 alpha chain B2M(21-119) ASB11 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain UBE3B PSMF1 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor RNF217 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B46 NPEPPS KBTBD13 ADPUBE2E1 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B49 class I MHC B49 class I MHC B44 SPSB1 UBOX5 B2M(21-119) B2M(21-119) FBXO31 FBXO11 HLA class I histocompatibility antigen, Cw-18 alpha chain SAR1B UBA3 HLA class I histocompatibility antigen, A-23 alpha chain STUB1 NEDD4 UBC(305-380) RNF130 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain UBE2E1 KLHL13 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain FBXO9 HLA class I histocompatibility antigen, A-80 alpha chain BTBD1 RNF115 MIB2 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor FBXO44 ASB3 SOCS3 FBXL15 class I MHC B44 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain ASB2 HLA class I histocompatibility antigen, A-68 alpha chain TAP2 class I MHC B44 class I MHC B39 ANAPC2 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain FBXO32 TAPBPDTX3L HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain KLHL5 ASB6 class I MHC B52 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain FBXW12 class I MHC B27 class I MHC B27 class I MHC B44 UBE2G1 TAPPSMC6 PI(4,5)P2 class I MHC B73 class I MHC B13 HLA class I histocompatibility antigen, A-66 alpha chain monoglucosylated MHCclass I HCHLA class I histocompatibility antigen, A-23 alpha chain FBXO4 KCTD7 GLMN HSPA5 FBXO44 class I MHC B42 class I MHC B39 class I MHC B44 HLA class I histocompatibility antigen, Cw-1 alpha chain ZBTB16 HECTD2 KLHL41 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor VAMP8,VAMP3class I MHC B40 TAP1 UBA52(1-76) class I MHC B37 class I MHC B40 class I MHC B81 class I MHC B67 class I MHC B67 class I MHC B45 class I MHC B13 FBXL7 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain PDIA3 VHL UBOX5 class I MHC B18 UBC(381-456) HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B13 class I MHC B47 ANAPC10 FBXW2 UBC(381-456) HLA class I histocompatibility antigen, A-66 alpha chain CUL3 RCHY1 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain RNF19B CDC26 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B78 KLHL9 UBE2R2 class I MHC B50 TRIM37 class I MHC B18 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor CBLB UBE2S HLA class I histocompatibility antigen, Cw-6 alpha chain precursor MEX3C class I MHC B41 HLA class I histocompatibility antigen, A-25 alpha chain PSMC6 4xPalmC-CD36 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, E alpha chain precursor UBE2Z UBC(533-608) CUL3 HLA class I histocompatibility antigen, E alpha chain precursor TRIM32 HLA class I histocompatibility antigen, A-80 alpha chain UBC(1-76) HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor FBXW12 HUWE1 FBXL19 class I MHC B53 class I MHC B8 class I MHC B14 class I MHC B7 KLHL20 class I MHC B67 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B55 ELOC PSMA8 class I MHC B57 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-2 alpha chain UNKL HLA class I histocompatibility antigen, A-26 alpha chain TRIM36 Antigen peptidebound class I MHCclass I MHC B49 UBC(381-456) UBC(305-380) class I MHC B67 RNF7 (RBX2) class I MHC B37 CHUK:IKBKB:IKBKGHLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain FBXO10 UBE2W HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B8 FCGR HUWE1 FBXW5 oligopeptidefragmentclass I MHC B55 HLA class I histocompatibility antigen, A-68 alpha chain 2xN4GlycoAsn-LY96 class I MHC B42 class I MHC B7 HERC3 class I MHC B8 class I MHC B39 Antigen peptidebound class I MHCclass I MHC B13 FBXO11 HECTD3 PSME1 FBXO40 class I MHC B14 HLA class I histocompatibility antigen, Cw-18 alpha chain SPSB1 class I MHC B13 HLA-H UBA7 FBXW12 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B67 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain RNF111 NEDD4L (Glc)1 (GlcNAc)2 (Man)9 class I MHC B37 class I MHC B8 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B47 FBXW5 class I MHC B41 ASB12 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B49 UBE2H KLHL3 class I MHC B47 FBXO4 Class I MHCHC:B2M:Erp57TRIM11 HLA class I histocompatibility antigen, A-24 alpha chain CUL2 class I MHC B35 class I MHC B78 class I MHC B81 HLA class I histocompatibility antigen, Cw-14 alpha chain FBXL5 HLA-H class I MHC B15 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA-H KBTBD6 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain SEC24D (Glc)1 (GlcNAc)2 (Man)9 class I MHC B35 class I MHC B40 PSMD10 STUB1 class I MHC B7 UBE2Q2 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor FBXO21 SIAH2 FBXW5 Antigen peptide class I MHC B73 class I MHC B14 class I MHC B37 RNF114 DZIP3 HLA class I histocompatibility antigen, A-34 alpha chain TAP1 UBE2D1 BTRC KLHL3 class I MHC B73 ARIH2 Antigen peptidebound class I MHCclass I MHC B52 class I MHC B58 HLA class I histocompatibility antigen, Cw-18 alpha chain UBE2F GLMN FBXO17 HERC6 FBXO17 MR:soluble antigenUBB(77-152) ZNF645 class I MHC B38 TRIM36 FBXL18 MYLIP HLA class I histocompatibility antigen, Cw-12 alpha chain PSMD1 MR:soluble antigenCDC34 class I MHC B13 HECTD3 ANAPC2 class I MHC B53 FBXW11 KLHL5 PSMC5 FBXO41 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B40 PSMD2 BTBD1 UBE2Q1 class I MHC B58 TRIM69 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B55 HLA class I histocompatibility antigen, Cw-2 alpha chain IKBKB SMURF2 Ubiquitin:E2conjugating enzymesHERC6 CDC27 RPS27A(1-76) class I MHC B14 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B50 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA-H RNF114 class I MHC B13 LONRF1 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B47 class I MHC B56 class I MHC B41 HLA class I histocompatibility antigen, alpha chain F precursor IKBKG SAR1B:GTPHLA class I histocompatibility antigen, A-23 alpha chain class I MHC B47 HLA class I histocompatibility antigen, A-80 alpha chain UBE2G2 RBCK1 class I MHC B42 PSMB1 SEC13ASB1 RNF111 ASB17 class I MHC B51 ADPUBB(77-152) LRSAM1 UBB(1-76) FBXL5 RNF25 ELOC PJA1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B8 HLA class I histocompatibility antigen, A-3 alpha chain precursor TPP2 UBE2L6 class I MHC B45 HLA class I histocompatibility antigen, A-33 alpha chain RNF123 SAR1B:GDPELOB HLA-H HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ANAPC7 E3 ligases inproteasomaldegradationPSMA6 FBXO44 ANAPC10 HECTD1 TRIM11 TRIM37 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor Diacyl lipopeptide ZNF645 class I MHC B39 PSMA1 HLA class I histocompatibility antigen, A-25 alpha chain UBC(229-304) class I MHC B27 HLA class I histocompatibility antigen, A-24 alpha chain FBXO4 SEC24A ANAPC4 class I MHC B82 ASB7 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain FBXW9 ASB9 class I MHC B52 FBXW2 class I MHC B57 HLA class I histocompatibility antigen, Cw-2 alpha chain SMURF1 VPRBP SPSB4 class I MHC B57 ZBTB16 class I MHC B8 PSMB4 SEC23A HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B40 class I MHC B57 class I MHC B27 FBXW4 class I MHC B50 class I MHC B59 FBXO9 class I MHC B46 class I MHC B15 FBXL19 GLMN PSMA5 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-31 alpha chain AREL1 class I MHC B56 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B35 SOCS1 class I MHC B82 UBE2O PDIA3 UBC(77-152) LRR1 UBB(1-76) HLA class I histocompatibility antigen, Cw-17 alpha chain Triacyl lipopeptide HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B44 ANAPC1 class I MHC B58 HLA class I histocompatibility antigen, A-80 alpha chain ANAPC11 ANAPC13 UBC(609-684) TRIM32 TAPBP RNF144B class I MHC B81 class I MHC B44 FBXO27 FBXL13 class I MHC B39 PSME1 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B39 KEAP1 class I MHC B18 SKP1 TRIM50 HLA class I histocompatibility antigen, A-1 alpha chain precursor RNF144B FBXO6 class I MHC B14 UBE2D3 class I MHC B42 UBB(153-228) class I MHC B45 KLHL42 ATG7 PDIA3 FBXO11 WWP1 class I MHC B78 class I MHC B38 HLA class I histocompatibility antigen, A-69 alpha chain PPiSPSB4 class I MHC B35 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor PSMA7 FBXL7 class I MHC B18 HLA class I histocompatibility antigen, Cw-16 alpha chain ASB18 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B73 UBE4A LMO7 HLA class I histocompatibility antigen, A-30 alpha chain UBA1 SEC23ASEC24B class I MHC B40 HERC4 HERC4 CTSL1(114-288) class I MHC B46 RNF34 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B73 class I MHC B51 class I MHC B45 class I MHC B47 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B47 class I MHC B55 CDC27 FBXL12 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B59 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B56 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B73 class I MHC B13 class I MHC B59 PSMA2 partially digestedAgRNF130 PSMB6 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B54 DZIP3 HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B35 class I MHC B38 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor SPSB1 COPIIHLA class I histocompatibility antigen, A-80 alpha chain ANAPC11 HLA-B HLA class I histocompatibility antigen, E alpha chain precursor SEC24C (Glc)1 (GlcNAc)2 (Man)9 class I MHC B47 CALRUBA6 ANAPC4 KBTBD13 class I MHC B42 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-31 alpha chain ELOC HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PSMC1 FBXO7 class I MHC B57 HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B50 class I MHC B44 HLA class I histocompatibility antigen, A-34 alpha chain HACE1 HLA class I histocompatibility antigen, A-2 alpha chain PSMC2 class I MHC B44 class I MHC B46 RBCK1 SOCS3 ASB8 HECTD2 HLA-H class I MHC B41 FBXO27 PSMB3 SIAH1 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B18 RNF138 FBXO22 class I MHC B56 DTX3L CYBA HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain TRAF7 RNF213 HLA class I histocompatibility antigen, A-26 alpha chain MIB2 LMO7 UBE3B CDC23 class I MHC B73 FBXO6 HLA class I histocompatibility antigen, Cw-12 alpha chain HERC6 HLA class I histocompatibility antigen, Cw-12 alpha chain CUL1 class I MHC B38 ANAPC11 RNF25 class I MHC B37 CANX SEC13 class I MHC B27 HLA class I histocompatibility antigen, A-66 alpha chain FBXL20 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B78 FBXO30 HLA class I histocompatibility antigen, A-80 alpha chain PSMD8 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B81 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor ANAPC13 HLA class I histocompatibility antigen, A-74 alpha chain RNF19A ANAPC7 HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B81 MRC1 class I MHC B18 class I MHC B15 PSMC2 RLIM class I MHC B38 HLA class I histocompatibility antigen, Cw-15 alpha chain FBXO32 UBE2G1 UBE2H DET1 UBE3D HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B39 CD207 HUWE1 class I MHC B40 Major outer membrane protein P TRAF7 HLA class I histocompatibility antigen, A-74 alpha chain B2M(21-119) Antigen peptidebound class I MHCHLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B55 B2M(21-119) class I MHC B35 class I MHC B51 HLA class I histocompatibility antigen, Cw-1 alpha chain RNF138 HLA class I histocompatibility antigen, A-23 alpha chain HLA-H SOCS1 UBB(1-76) HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B40 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B51 CALR HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain FBXL21 PDIA3 HLA class I histocompatibility antigen, Cw-15 alpha chain KCTD6 class I MHC B56 UBC(609-684) class I MHC B39 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ITGAV(31-1048) class I MHC B52 HLA class I histocompatibility antigen, A-29 alpha chain FBXL7 SKP2 class I MHC B73 PiB2M(21-119) AMPHLA class I histocompatibility antigen, A-32 alpha chain TAPBPclass I MHC B14 class I MHC B82 HLA class I histocompatibility antigen, A-31 alpha chain ANAPC13 TRIM69 class I MHC B55 HLA class I histocompatibility antigen, A-23 alpha chain TRIM50 class I MHC B73 GTPSEC61G class I MHC B46 class I MHC B50 RNF25 UBE2D4 LRRC41 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B44 Antigen peptide RLIM class I MHC B39 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B42 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B15 class I MHC B50 AREL1 PSMA4 FBXO30 class I MHC B38 FBXO27 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B38 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-34 alpha chain Exogenous soluble antigen class I MHC B15 HLA class I histocompatibility antigen, Cw-16 alpha chain ZNRF2 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor STUB1 ASB13 class I MHC B81 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-17 alpha chain ASB17 MKRN1 IFN gamma stimulatedaminopeptidasesHLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain TAPASB7 class I MHC B73 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B57 class I MHC B41 UFL1 KLHL11 FBXO22 CUL5 HLA class I histocompatibility antigen, A-31 alpha chain HERC1 SAR1B SOCS1 class I MHC B35 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RPS27A(1-76) HLA class I histocompatibility antigen, A-32 alpha chain FBXO9 KLHL25 class I MHC B67 PSMD9 class I MHC B56 MEX3C TRIM69 class I MHC B73 HLA-B HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B67 UBR4 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B40 class I MHC B45 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain PSME2 class I MHC B8 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B57 PSMB8 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA-H E1 bound ubiquitinGTP class I MHC B47 FBXO7 class I MHC B47 TRIM4 HLA class I histocompatibility antigen, A-2 alpha chain ASB10 WSB1 PSMB9 KLHL41 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B45 class I MHC B40 RNF4 HERC4 CDC26 class I MHC B38 ASB5 class I MHC B49 K48polyUb-partiallydigested AgRNF4 ARIH2 class I MHC B67 PSMD3 class I MHC B73 MGRN1 ASB14 class I MHC B45 HLA class I histocompatibility antigen, Cw-17 alpha chain FBXL16 PSMB7 class I MHC B54 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor KLHL13 ANAPC1 UBE3B class I MHC B47 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B49 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain UBE2V1 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain RNF213 (Glc)1 (GlcNAc)2 (Man)9 TAP2 UBE2N HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B7 SEC31AHLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B13 UBC(533-608) UBE2E3 KLHL20 ASB11 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B38 UBC(153-228) KLHL25 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain UBE2C UBE3D WSB1 CUL5 class I MHC B78 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, alpha chain F precursor HLA-B ATG7 SIAH1 class I MHC B42 HLA class I histocompatibility antigen, A-31 alpha chain KCTD7 MHCclassIHC:Calnexin/BiP:Erp57RNF126 class I MHC B18 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain Antigen peptidebound class IMHC:BAP31 oligomerclass I MHC B57 TRIM36 UBR4 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBB(153-228) TAPBP class I MHC B82 WSB1 ASB17 UBC(229-304) TAP1 class I MHC B27 class I MHC B38 HLA class I histocompatibility antigen, alpha chain F precursor PSMD5 PSMA5 class I MHC B56 UBC(153-228) FBXW8 PSMC1 SEC24D class I MHC B59 ATPclass I MHC B53 HLA class I histocompatibility antigen, A-3 alpha chain precursor SMURF2 DTX3L FBXL3 ARIH2 class I MHC B52 BTBD6 LRSAM1 PSMD13 BAP31 oligomer class I MHC B44 ANAPC1 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PSMD7 ANAPC7 precursor peptidefragment (>16 aa)HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B40 class I MHC B54 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-12 alpha chain UBE2A class I MHC B46 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-1 alpha chain UBE2H RNF220 class I MHC B35 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B82 PSMB10 UBE2J2 class I MHC B8 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B8 B2M(21-119) PSMD14 FBXO10 K48polyUb-antigenic substrate PPiHLA class I histocompatibility antigen, A-66 alpha chain class I MHC B45 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B50 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B39 class I MHC B53 antigenic substrateclass I MHC B38 class I MHC B58 class I MHC B53 class I MHC B37 class I MHC B15 UBE2U PSMD4 PSMD13 TLR2 p-T154,S315-NCF4 BAP31 oligomer class I MHC B39 PJA1 ASB13 class I MHC B82 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B7 HLA class I histocompatibility antigen, A-34 alpha chain CUL3 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B46 class I MHC B46 ZNRF1 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain HECW2 class I MHC B40 PSMC5 KCTD7 SEC22BHLA class I histocompatibility antigen, A-32 alpha chain SEC13 PSMB10 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor CTSL2 class I MHC B50 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B15 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B82 UBAC1 UBC(305-380) HLA class I histocompatibility antigen, A-24 alpha chain RNF41 HLA class I histocompatibility antigen, Cw-17 alpha chain UBE2Q1 FBXL13 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor KEAP1 HLA class I histocompatibility antigen, A-3 alpha chain precursor PSMD3 class I MHC B54 class I MHC B49 UBA52(1-76) UBE2N class I MHC B46 TRIM21 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B57 class I MHC B42 class I MHC B45 class I MHC B57 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain RNF19B KLHL42 MKRN1 class I MHC B47 KCTD7 class I MHC B41 class I MHC B35 class I MHC B42 PARK2 HLA class I histocompatibility antigen, A-29 alpha chain CCNF FBXO6 ADPRBCK1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HECTD2 TAPBP SKP1 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B57 class I MHC B59 WSB1 B2M(21-119) class I MHC B53 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B7 CTSS-like proteinsITGB5 PSMD1 UBA1 ASB4 UBOX5 (Glc)1 (GlcNAc)2 (Man)9 (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, A-1 alpha chain precursor SNAP23PSMD7 HECTD1 ANAPC13 HLA class I histocompatibility antigen, Cw-1 alpha chain MRC1 class I MHC B13 Antigen UBE2U SEC22B UBC(77-152) HLA class I histocompatibility antigen, alpha chain G precursor FBXO32 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B81 ASB3 HLA class I histocompatibility antigen, A-33 alpha chain CTSS class I MHC B78 UBC(533-608) class I MHC B8 TRIM63 ANAPC5 oligopeptidefragment (3-7aa)HLA class I histocompatibility antigen, Cw-12 alpha chain SPSB2 Antigen peptide FBXL18 class I MHC B50 HLA class I histocompatibility antigen, Cw-2 alpha chain TAP1 class I MHC B42 TAP1 class I MHC B42 FBXW8 ExogenousParticulate antigen(Ag)class I MHC B67 UBAC1 HLA class I histocompatibility antigen, Cw-15 alpha chain MHC HC:B2M:Erp57UBE2R2 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain UBE3D RNF34 UBE3D FBXL21 UBE2Z class I MHC B38 RNF123 class I MHC B39 class I MHC B59 class I MHC B46 class I MHC B35 ATPHLA class I histocompatibility antigen, A-30 alpha chain L-amino acidHLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-34 alpha chain TRIM11 HLA class I histocompatibility antigen, A-66 alpha chain MYD88 HLA class I histocompatibility antigen, Cw-12 alpha chain FZR1 RNF182 UBE3A HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B38 ASB14 class I MHC B42 B2M(21-119) HLA class I histocompatibility antigen, E alpha chain precursor TAP2 H2Oclass I MHC B59 HLA-H HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B54 SEC31A HLA class I histocompatibility antigen, Cw-12 alpha chain SEC24A LRRC41 CDC16 KLHL13 CUL3 class I MHC B51 FZR1 HLA class I histocompatibility antigen, Cw-14 alpha chain KBTBD7 ASB9 class I MHC B59 PSMB5 CDC34 RLIM SH3RF1 CD207 class I MHC B15 HLA class I histocompatibility antigen, A-80 alpha chain UBR2 MRC2 PSMB2 RNF182 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B53 TransloconHLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain LRR1 class I MHC B50 RBBP6 ANAPC4 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B13 class I MHC B67 RNF182 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B58 class I MHC B27 HLA class I histocompatibility antigen, A-74 alpha chain KCTD6 class I MHC B53 UBB(153-228) class I MHC B13 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ASB16 CALR:SEC22B:STX4:TAP:TAPBPclass I MHC B37 HLA-H FBXO15 SEC24A HLA-B HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B7 class I MHC B27 PSMA4 HLA class I histocompatibility antigen, Cw-1 alpha chain PSMB4 HLA class I histocompatibility antigen, A-32 alpha chain CUL5 ASB11 RNF115 class I MHC B56 CD36 CUL2 TRIM21 CDC20 class I MHC B78 UBE2C SIAH2 HLA class I histocompatibility antigen, A-26 alpha chain NADP+class I MHC B54 class I MHC B58 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain SEC24A class I MHC B47 UBC(381-456) class I MHC B37 PSMD14 oligopeptidefragment (8-16aa)FBXO4 O2.-PSMA3 class I MHC B44 WWP1 FCGRA HLA class I histocompatibility antigen, A-23 alpha chain DET1 TRIM9 UBC(305-380) HLA class I histocompatibility antigen, Cw-18 alpha chain (Glc)1 (GlcNAc)2 (Man)9 class I MHC B82 PSMD1 UBE4A UNKL class I MHC B78 KCTD6 HLA class I histocompatibility antigen, A-31 alpha chain FBXW8 class I MHC B39 KLHL21 FBXL8 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B37 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-69 alpha chain FZR1 ANAPC5 UFL1 HERC2 DET1 HLA class I histocompatibility antigen, Cw-15 alpha chain KLHL2 class I MHC B73 HLA class I histocompatibility antigen, Cw-17 alpha chain ITCH HLA class I histocompatibility antigen, A-43 alpha chain FBXW9 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B14 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ASB18 VHL HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain SEC24HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B82 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B18 class I MHC B54 class I MHC B54 class I MHC B81 TRIM50 UBE2F HLA class I histocompatibility antigen, alpha chain F precursor UBE2A UBE2N FBXO6 BTRC HSPA5 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B59 PSMA1 HLA class I histocompatibility antigen, B-48 alpha chain HERC1 HLA class I histocompatibility antigen, Cw-14 alpha chain FBXL19 DZIP3 precursor peptidefragment (>16 aa)class I MHC B53 HLA class I histocompatibility antigen, Cw-15 alpha chain FBXW2 class I MHC B45 PSMB2 FBXO44 FBXO40 HLA class I histocompatibility antigen, Cw-18 alpha chain TRIM4 class I MHC B45 PSMD5 UBE2C KLHL21 class I MHC B51 Antigen peptide class I MHC B40 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B7 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B14 MEX3C FBXW10 PSMD14 class I MHC B13 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor GTP KLHL22 LRSAM1 KBTBD7 HLA-H class I MHC B82 oligopeptide fragment HLA class I histocompatibility antigen, A-33 alpha chain Antigenicpeptide:MHC:B2Mpeptide loadingcomplexFBXL16 class I MHC B67 SIAH1 B2M(21-119) UBA52(1-76) PSME4 class I MHC B14 PSMA6 HLA class I histocompatibility antigen, A-3 alpha chain precursor CCNF ASB4 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B52 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B15 class I MHC B18 UBAC1 ASB10 PSME3 class I MHC B54 SOCS1 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B54 ASB4 HECW2 BTRC HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-11 alpha chain PSMD4 class I MHC B39 PSMC4 class I MHC B49 class I MHC B56 class I MHC B45 GLMN class I MHC B15 UBE2D4 class I MHC B46 HLA class I histocompatibility antigen, A-34 alpha chain RNF4 HECTD1 KLHL9 UBE2V2 PSMA2 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor 2xN4GlycoAsn-TLR4 class I MHC B7 ZNF645 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor UBA5 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor DC receptorsrecognizingapoptotic cellsclass I MHC B55 K48polyUb-antigenicsubstrateRNF123 RNF126 HLA class I histocompatibility antigen, A-68 alpha chain PSMB11 class I MHC B41 HLA class I histocompatibility antigen, Cw-18 alpha chain TRAIP TRIM71 HLA class I histocompatibility antigen, alpha chain G precursor TRAIP PSMB1 SEC24C ASB14 class I MHC B58 ASB13 HLA class I histocompatibility antigen, A-34 alpha chain FBXO32 UBC(609-684) FBXW10 NEDD4 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B51 HLA class I histocompatibility antigen, A-26 alpha chain FBXL4 class I MHC B14 FBXO41 AREL1 ASB1 PDIA3 MR:soluble antigenSH3RF1 FBXL5 RNF111 UBC(153-228) class I MHC B45 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B47 class I MHC B8 HLA class I histocompatibility antigen, A-74 alpha chain ZNRF1 TRIM41 class I MHC B8 CBLB class I MHC B51 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B35 WWP1 BTBD1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B82 HLA class I histocompatibility antigen, A-11 alpha chain FBXO2 class I MHC B47 SIAH1 HERC3 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B8 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B41 STUB1 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor FBXL3 HLA class I histocompatibility antigen, A-11 alpha chain SPSB2 FBXO15 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain UBE2Q2 CUL2 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B18 FBXL14 UBOX5 UBC(305-380) UBE2B Unknown hydrolaseclass I MHC B50 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PSME2 HECTD1 class I MHC B35 class I MHC B27 class I MHC B45 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B56 ASB8 UBE2M NEDD4 HLA-B HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B82 TAP1 class I MHC B82 class I MHC B57 class I MHC B18 class I MHC B50 SEC24C FBXO31 UBE2A KLHL5 FBXW10 PSMD2 CUL1 class I MHC B8 class I MHC B78 KBTBD8 CDC26 class I MHC B54 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, Cw-8 alpha chain NEDD4L HLA class I histocompatibility antigen, A-1 alpha chain precursor UBC(229-304) HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain KLHL22 class I MHC B51 HLA-H UBE2R2 class I MHC B54 GDP B2M(21-119) UBE2K UBE2K B2M(21-119) HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B42 RNF19B UBE2E2 HLA class I histocompatibility antigen, B-48 alpha chain UBE2J2 ZNF645 UBE2J1 UBR1 HLA class I histocompatibility antigen, A-11 alpha chain PJA2 HERC6 MRC1 TRIM41 (Glc)1 (GlcNAc)2 (Man)9 FBXL15 BTBD6 class I MHC B52 class I MHC B42 HLA class I histocompatibility antigen, A-34 alpha chain FBXW4 PSMF1 class I MHC B49 MYLIP HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor ASB7 class I MHC B52 MIB2 class I MHC B81 HLA class I histocompatibility antigen, Cw-17 alpha chain SKP2 Class I MHCHC:B2M:Erp57CUL7 (Glc)1 (GlcNAc)2 (Man)9 class I MHC B14 CDC27 ASB2 TRIP12 HLA class I histocompatibility antigen, A-33 alpha chain PSMD6 SIAH2 class I MHC B50 CUL7 PSME2 class I MHC B13 SH3RF1 PSMB7 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B40 L-amino acidclass I MHC B56 class I MHC B27 class I MHC B55 class I MHC B39 RNF130 TRIM71 class I MHC B18 class I MHC B37 PSME3 class I MHC B52 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor RNF220 PiSar1p:GTP:Sec23p:Sec24p:Ag bound MHC class Iclass I MHC B14 ZNRF1 class I MHC B55 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B73 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B56 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B53 KLHL9 UBC(77-152) HLA class I histocompatibility antigen, A-26 alpha chain RNF6 CDC16 class I MHC B67 SEC23:SEC24HERC5 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor FCGR GDPSEC61B SEC24D UBC(457-532) HLA-B class I MHC B51 HLA class I histocompatibility antigen, A-30 alpha chain UBE3A HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B54 PSMB10 KLHL11 Clostridial peptidoglycan UBE3C HLA class I histocompatibility antigen, Cw-4 alpha chain precursor precursor peptidefragment (>16 aa)HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA-B class I MHC B46 HERC1 class I MHC B51 ATPCDC16 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B18 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B54 FCGRA HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor 26S proteasomeHLA class I histocompatibility antigen, A-11 alpha chain TRIM50 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B57 CUL7 class I MHC B51 class I MHC B49 HERC5 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PSMB9 FBXL12 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor UBE2D2 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B78 RNF144B HLA class I histocompatibility antigen, Cw-1 alpha chain BLMH SEC23A PARK2 FBXL16 UBA6 class I MHC B82 p-6S-NCF1 TRIM11 class I MHC B52 KLHL11 HERC5 HLA-B HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B53 class I MHC B49 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain GTP UFL1 ANAPC10 HLA-B ZNRF2 HLA class I histocompatibility antigen, A-29 alpha chain PSMB4 class I MHC B46 ASB1 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain RPS27A(1-76) LRRC41 SOCS3 SHFM1 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B7 class I MHC B49 class I MHC B41 SEC13 class I MHC B57 ASB10 UBE2D1 HLA class I histocompatibility antigen, A-80 alpha chain ASB8 WWP1 Antigen peptidebound class I MHCclass I MHC B13 FBXO15 class I MHC B59 p-S95-SNAP23 HLA class I histocompatibility antigen, Cw-12 alpha chain UBE2J1 HLA class I histocompatibility antigen, A-80 alpha chain TRIM37 KLHL2 UBE2L6 ASB17 HLA class I histocompatibility antigen, A-66 alpha chain ASB15 UBE2G1 KLHL3 UBC(457-532) class I MHC B82 UBB(153-228) UFL1 KLHL21 class I MHC B49 class I MHC B81 class I MHC B39 SEC24C PSMD2 MKRN1 class I MHC B54 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor UBC(381-456) p-S95-SNAP23:VAMP8,VAMP3UBE2Q1 PSMB8 HLA class I histocompatibility antigen, Cw-1 alpha chain CUL2 HLA class I histocompatibility antigen, A-25 alpha chain ASB12 HERC4 CD14(20-345) Ag peptide boundclass I MHCHLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor AREL1 ASB9 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B67 class I MHC B27 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B57 ASB12 RNF41 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain Antigen peptidebound class I MHCHLA class I histocompatibility antigen, A-43 alpha chain LNPEP RNF34 UBE2D1 LTN1 class I MHC B42 class I MHC B37 UBA7 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain CBLB HLA class I histocompatibility antigen, A-30 alpha chain HLA-H HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B50 class I MHC B56 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-32 alpha chain PSMA3 NEDD4 HLA class I histocompatibility antigen, Cw-15 alpha chain RNF19A HLA class I histocompatibility antigen, A-36 alpha chain CCNF HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B47 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain Ag-substrate:E3:E2:UbBAP31 oligomer UNKL HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-66 alpha chain HLA-H class I MHC B56 ANAPC2 MYLIP HLA class I histocompatibility antigen, alpha chain F precursor VHL class I MHC B67 PDIA3 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B59 class I MHC B15 class I MHC B8 FBXL22 KLHL22 LMO7 UBA7 UbHLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain LONRF1 FBXL18 LPS FBXL8 class I MHC B55 FBXW2 FBXW7 SEC24A HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B8 TRIP12 PSMC3 HSPA5 Mg2+class I MHC B55 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B38 PSMC4 STX4class I MHC B41 PSME4 monoglucosylated MHCclass IHC:Calnexin/BiPSKP2 class I MHC B52 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B55 class I MHC B78 LNX1 FBXO2 ASB11 TRIM63 CDC23 CUL1 class I MHC B37 class I MHC B81 CDC27 class I MHC B46 class I MHC B41 class I MHC B38 UBE2G2 class I MHC B14 ASB6 FBXL21 class I MHC B44 BTBD1 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain B2M(21-119) class I MHC B57 TRIM9 class I MHC B81 HLA class I histocompatibility antigen, A-2 alpha chain NOX2 complexHLA class I histocompatibility antigen, A-36 alpha chain SKP1 class I MHC B15 class I MHC B52 RNF126 ASB5 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B55 UBE4A class I MHC B54 class I MHC B82 PSMD13 HACE1 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B35 TAP2 BTRC class I MHC B58 SEC24B MRC2 class I MHC B51 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B39 RNF182 PSME3 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain UBC(533-608) HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B41 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ASB15 SEC24D UBR4 HLA class I histocompatibility antigen, A-31 alpha chain DC receptorsrecognizingapoptotic cellsASB14 ARIH2 class I MHC B73 antigenic substrate FBXW7 MGRN1 UBE2E3 RBBP6 COPII vesicle withMHC class IHLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PJA1 FBXL20 class I MHC B51 HLA class I histocompatibility antigen, A-30 alpha chain FBXL15 FBXO17 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain SMURF2 HLA class I histocompatibility antigen, A-31 alpha chain SPSB2 SMURF1 ASB4 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B51 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBB(1-76) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B37 B2M(21-119) SEC23A ASB8 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B55 Ubiquitin activatingE1 enzymesUBE3C HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B18 FBXW9 HLA class I histocompatibility antigen, E alpha chain precursor FBXW11 ASB6 FBXW11 class I MHC B56 HLA class I histocompatibility antigen, A-2 alpha chain UBC(533-608) class I MHC B78 class I MHC B7 PSMC5 SAR1B RNF41 class I MHC B45 UBE3C RBX1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor Exogenous Particulate antigen (Ag) KBTBD8 class I MHC B58 UBB(77-152) KLHL3 FBXL3 FBXO41 HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B41 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B7 PSMA6 class I MHC B27 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain UBC(533-608) HLA class I histocompatibility antigen, alpha chain G precursor SHFM1 KEAP1 RCHY1 CDC20 UBE2W MRC1 class I MHC B58 BTBD6 class I MHC B57 VAMP8 HLA class I histocompatibility antigen, A-33 alpha chain PSMD9 HLA class I histocompatibility antigen, A-43 alpha chain oligopeptidefragmentLRRC41 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBE2E2 class I MHC B15 class I MHC B13 class I MHC B49 UBC(609-684) class I MHC B13 GAN BAP31 oligomerHLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B78 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor VPRBP GAN class I MHC B73 class I MHC B42 class I MHC B57 HLA-B class I MHC B35 HLA class I histocompatibility antigen, alpha chain F precursor PSMA8 FBXO31 class I MHC B35 class I MHC B57 PSMC2 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor CD207 UBE2L3 SEC24D KLHL42 RNF14 AMPATPSOCS3 HLA class I histocompatibility antigen, A-31 alpha chain partially digestedAgclass I MHC B14 HACE1 TRAF7 class I MHC B35 HLA class I histocompatibility antigen, Cw-15 alpha chain ERAP2 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B59 HLA class I histocompatibility antigen, Cw-14 alpha chain FBXW5 GPIN-CD14(20-345) oligopeptidefragment (8-16aa)RNF130 HLA class I histocompatibility antigen, A-43 alpha chain UBE2V1 class I MHC B73 class I MHC B46 PSMD10 class I MHC B81 class I MHC B53 class I MHC B56 class I MHC B45 PSMD8 Exogenous soluble antigen PSMA7 HLA class I histocompatibility antigen, A-30 alpha chain RNF19A FBXW11 TAPTAP2 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B37 HLA class I histocompatibility antigen, A-36 alpha chain SAR1B LTN1 class I MHC B18 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B53 HLA class I histocompatibility antigen, E alpha chain precursor HERC3 SPSB2 ANAPC5 CALRCCNF HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B18 RNF114 HLA class I histocompatibility antigen, A-66 alpha chain UBE2D2 NEDD4L HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B81 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B14 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-3 alpha chain precursor FBXO10 RNF220 FBXO9 FBXO41 class I MHC B18 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain FBXO10 UBE2B UBE2E1 class I MHC B13 class I MHC B27 ASB5 MGRN1 class I MHC B35 HECW2 MR/other probablereceptorsclass I MHC B49 UBE2V1 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B38 TRIM4 HLA class I histocompatibility antigen, A-26 alpha chain ASB16 SMURF1 class I MHC B67 VAMP3 HLA class I histocompatibility antigen, A-69 alpha chain VPRBP NADPHHLA class I histocompatibility antigen, A-29 alpha chain class I MHC B58 UBC(77-152) SEC31A class I MHC B78 B2M(21-119)HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor TLR6 HLA class I histocompatibility antigen, A-74 alpha chain B2M(21-119) (Glc)1 (GlcNAc)2 (Man)9 class I MHC B56 UBE2L3 class I MHC B13 HLA class I histocompatibility antigen, A-25 alpha chain PSMD5 class I MHC B54 class I MHC B53 Particulate Ag:DCreceptorsHLA class I histocompatibility antigen, Cw-17 alpha chain FBXL19 CALRHLA class I histocompatibility antigen, Cw-8 alpha chain HLA-B HLA class I histocompatibility antigen, A-43 alpha chain UBB(77-152) UBC(457-532) KBTBD7 TRIM71 KBTBD13 FBXW12 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain CALR HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain FBXW8 class I MHC B37 HLA class I histocompatibility antigen, A-29 alpha chain KLHL25 TRAIP HLA-B HLA class I histocompatibility antigen, Cw-16 alpha chain PSMC1 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B52 KLHL2 HLA class I histocompatibility antigen, A-31 alpha chain Exogenous soluble antigen HLA class I histocompatibility antigen, A-1 alpha chain precursor RNF213 HLA class I histocompatibility antigen, A-24 alpha chain PSMC3 HLA class I histocompatibility antigen, A-24 alpha chain HACE1 SEC23A Exogenous solubleantigenCBLB HLA class I histocompatibility antigen, Cw-2 alpha chain UBC(305-380) class I MHC B35 class I MHC B51 SPSB4 HLA class I histocompatibility antigen, A-1 alpha chain precursor KBTBD13 PJA2 HLA class I histocompatibility antigen, A-32 alpha chain TRIM39 KLHL41 KBTBD8 PSMB1 RBX1 Antigen UBR1 HLA class I histocompatibility antigen, A-43 alpha chain FBXO27 class I MHC B51 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain ZBTB16 class I MHC B52 HLA class I histocompatibility antigen, alpha chain F precursor HLA-B HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B59 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B47 class I MHC B46 HECW2 RNF4 class I MHC B58 ANAPC5 HLA class I histocompatibility antigen, Cw-15 alpha chain UBC(457-532) class I MHC B52 class I MHC B55 UBA3 H2OUBC(457-532) PSMD4 PSMA7 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B49 PSMF1 HLA class I histocompatibility antigen, A-33 alpha chain SKP1 ASB7 class I MHC B81 HLA class I histocompatibility antigen, Cw-15 alpha chain FBXL13 PSMA3 HLA class I histocompatibility antigen, Cw-16 alpha chain UBE2D2 class I MHC B58 HLA class I histocompatibility antigen, Cw-15 alpha chain CD207 ATPclass I MHC B49 class I MHC B50 PSMD10 RBX1 KLHL9 HLA class I histocompatibility antigen, A-68 alpha chain FBXO30 THOP1Class I MHC:B2Mclass I MHC B52 class I MHC B40 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain FBXW7 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor CDC16 class I MHC B46 UBE2B HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain PSMB6 class I MHC B7 FBXL8 HLA class I histocompatibility antigen, Cw-18 alpha chain FBXL18 HLA class I histocompatibility antigen, A-25 alpha chain UBC(1-76) HLA class I histocompatibility antigen, alpha chain F precursor ITCH HLA class I histocompatibility antigen, A-23 alpha chain SEC24B class I MHC B56 CDC23 HLA class I histocompatibility antigen, A-2 alpha chain UBE4A HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B38 HLA class I histocompatibility antigen, Cw-2 alpha chain Antigen peptide HLA class I histocompatibility antigen, Cw-17 alpha chain ITCH ZNRF2 class I MHC B44 class I MHC B52 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain SIAH2 HLA-H RNF138 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B49 HLA class I histocompatibility antigen, Cw-1 alpha chain FBXL16 ASB15 HLA class I histocompatibility antigen, A-24 alpha chain SH3RF1 HLA class I histocompatibility antigen, A-1 alpha chain precursor ATPFBXO7 UNKL HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain ASB6 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain UBE3C class I MHC B39 class I MHC B78 PDIA3class I MHC B67 HLA class I histocompatibility antigen, A-30 alpha chain Antigen peptide HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B44 TAPBPHLA class I histocompatibility antigen, A-69 alpha chain KCTD6 TRIM41 HLA class I histocompatibility antigen, A-66 alpha chain KLHL20 PSMB11 CALRHLA class I histocompatibility antigen, E alpha chain precursor FBXL20 HLA-B class I MHC B56 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B27 PSMD11 LTN1 FBXW9 SEC22B:STX4class I MHC B38 KLHL11 class I MHC B14 HLA-C HLA class I histocompatibility antigen, A-30 alpha chain KLHL20 class I MHC B59 FBXO21 HLA class I histocompatibility antigen, A-1 alpha chain precursor LMO7 RNF126 KBTBD6 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-32 alpha chain Exogenous solubleantigenSEC24C HLA class I histocompatibility antigen, A-29 alpha chain LRSAM1 RNF7 (RBX2) HLA class I histocompatibility antigen, A-68 alpha chain SEC24B B2M(21-119) class I MHC B67 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B78 UBE2L6 MKRN1 class I MHC B7 class I MHC B45 H2OHLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B7 O2HLA class I histocompatibility antigen, A-74 alpha chain TRIM63 SEC61A2 UBA52(1-76) class I MHC B81 class I MHC B15 PSMC6 class I MHC B40 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor TRIM39 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B41 class I MHC B39 class I MHC B40 class I MHC B55 ERAP1 class I MHC B54 ASB2 UBC(609-684) class I MHC B81 UBB(153-228) class I MHC B44 class I MHC B52 class I MHC B35 class I MHC B47 FBXL14 UBE2D3 class I MHC B41 HLA class I histocompatibility antigen, Cw-15 alpha chain PSMD6 class I MHC B27 FBXO21 RBCK1 ASB2 class I MHC B55 class I MHC B56 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B49 class I MHC B46 HERC3 HLA class I histocompatibility antigen, A-31 alpha chain CDC20 FBXL12 ASB18 HLA class I histocompatibility antigen, Cw-12 alpha chain MR/other probablereceptorsclass I MHC B37 Chaperonescalnexin/BiPRNF14 SEC31A class I MHC B45 class I MHC B41 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-31 alpha chain LNX1 PSMB7 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B7 HLA class I histocompatibility antigen, A-23 alpha chain TRIM21 class I MHC B73 HLA-H HLA class I histocompatibility antigen, A-11 alpha chain UBE2F HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain UBB(77-152) TRIP12 PSMB9 class I MHC B7 MYLIP class I MHC B39 p-S95-SNAP23HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B44 CUL7 SEC24B HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain UBE2E3 class I MHC B82 UBE2L3 FBXL22 class I MHC B53 FBXO2 class I MHC B7 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B18 class I MHC B82 TRIM4 UBA52(1-76) UBC(153-228) class I MHC B78 RNF114 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B78 class I MHC B54 FBXO40 TRIM39 FBXL14 class I MHC B41 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B55 HLA class I histocompatibility antigen, alpha chain G precursor PSMD3 class I MHC B14 CDC23 VAMP3 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor TAPBPclass I MHC B73 class I MHC B37 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain TRIM41 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B78 UBE2O L-amino acidHLA-H 26S proteasomeclass I MHC B40 E2Ubiquitin-conjugating enzymeclass I MHC B58 class I MHC B59 HLA class I histocompatibility antigen, A-30 alpha chain UBE2O UBE2E2 GAN HLA class I histocompatibility antigen, Cw-2 alpha chain FBXO2 class I MHC B46 HLA class I histocompatibility antigen, A-23 alpha chain SMURF2 class I MHC B27 KLHL41 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B58 HLA class I histocompatibility antigen, Cw-15 alpha chain UBC(381-456) UBE2V2 HLA class I histocompatibility antigen, A-23 alpha chain UBC(77-152) LNX1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-11 alpha chain SPSB4 HLA class I histocompatibility antigen, Cw-18 alpha chain VHL SAR1B TRIP12 HECTD3 SEC24C PJA2 SEC24A FBXO30 HLA class I histocompatibility antigen, A-26 alpha chain Exogenous solubleantigenHLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-25 alpha chain FBXL3 PSMB5 HLA class I histocompatibility antigen, A-29 alpha chain ASB5 UBE2M ITGB5 PPiPSMC3 GAN HLA class I histocompatibility antigen, A-11 alpha chain ANAPC11 class I MHC B40 PSMD6 HLA class I histocompatibility antigen, alpha chain F precursor TRAIP PSMD12 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B8 UbUBE2Z class I MHC B40 B2M(21-119) HLA class I histocompatibility antigen, Cw-2 alpha chain UBA5 MRC1 TAP2 ITGB5 UBR2 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA-H ASB3 class I MHC B52 RNF25 class I MHC B59 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B47 UBC(229-304) class I MHC B27 class I MHC B57 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B58 mip MGRN1 HLA class I histocompatibility antigen, Cw-15 alpha chain ASB15 p-T233-NCF2 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, Cw-12 alpha chain MHC:B2M peptideloading complexclass I MHC B45 FBXL4 CD207 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B51 HLA class I histocompatibility antigen, A-11 alpha chain KLHL22 UBE3A ANAPC7 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain HLA-C FBXL21 SEC24D class I MHC B81 class I MHC B44 HERC1 PSMD11 FBXL14 p-4Y-TIRAP UBR1 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B50 class I MHC B41 PSMA4 class I MHC B53 HLA class I histocompatibility antigen, A-33 alpha chain UBB(1-76) class I MHC B67 HERC5 CDC26 RNF115 UBE3A SMURF1 PSME4 SEC24B HLA class I histocompatibility antigen, Cw-5 alpha chain precursor TRIM32 ZNRF1 class I MHC B14 class I MHC B15 Antigen peptideclass I MHC B41 SPSB1 class I MHC B18 RBX1 class I MHC B42 class I MHC B50 UBC(1-76) GTP class I MHC B51 PSMA8 LNX1 TAP1 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain FBXO15 B2M(21-119) class I MHC B78 class I MHC B53 GTP HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-66 alpha chain UBC(229-304) L-amino acidHLA class I histocompatibility antigen, A-2 alpha chain ELOB FBXW7 class I MHC B15 SEC23A HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor BTK SEC24A class I MHC B53 class I MHC B67 class I MHC B42 class I MHC B55 FBXL22 LONRF1 HLA class I histocompatibility antigen, A-69 alpha chain MRC2 class I MHC B27 class I MHC B7 class I MHC B46 RNF14 HLA class I histocompatibility antigen, A-1 alpha chain precursor FBXO17 UBE3B STX4 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain SAR1B:GTP:SEC23:SEC24UBE2U FBXL4 HLA class I histocompatibility antigen, A-3 alpha chain precursor HECTD2 class I MHC B14 TRAF7 class I MHC B37 TRIM63 10410522123974, 128106411342, 84, 14097326016222236, 9653, 136394112810610574, 1281353, 13682234341541897, 11588938601041313910474, 1281537, 51, 56411041053242, 84, 14097, 11532341281063915139128391353, 136602242, 84, 14010418221392242, 84, 14053, 1361396023, 29, 47, 59, 76...93978104451530, 11034963222106


Description

Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface. View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 983169
Reactome-version 
Reactome version: 73
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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Bibliography

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  1. Rodriguez A, Regnault A, Kleijmeer M, Ricciardi-Castagnoli P, Amigorena S.; ''Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells.''; PubMed Europe PMC Scholia
  2. York IA, Rock KL.; ''Antigen processing and presentation by the class I major histocompatibility complex.''; PubMed Europe PMC Scholia
  3. Howarth M, Williams A, Tolstrup AB, Elliott T.; ''Tapasin enhances MHC class I peptide presentation according to peptide half-life.''; PubMed Europe PMC Scholia
  4. Stephens DJ, Lin-Marq N, Pagano A, Pepperkok R, Paccaud JP.; ''COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites.''; PubMed Europe PMC Scholia
  5. Glick BS, Nakano A.; ''Membrane traffic within the Golgi apparatus.''; PubMed Europe PMC Scholia
  6. Lee I, Schindelin H.; ''Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.''; PubMed Europe PMC Scholia
  7. da Silva Correia J, Ulevitch RJ.; ''MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.''; PubMed Europe PMC Scholia
  8. Ohmura-Hoshino M, Goto E, Matsuki Y, Aoki M, Mito M, Uematsu M, Hotta H, Ishido S.; ''A novel family of membrane-bound E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  9. Zhao X, Xu B, Bhattacharjee A, Oldfield CM, Wientjes FB, Feldman GM, Cathcart MK.; ''Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes.''; PubMed Europe PMC Scholia
  10. Ye Y, Rape M.; ''Building ubiquitin chains: E2 enzymes at work.''; PubMed Europe PMC Scholia
  11. Tao N, Wagner SJ, Lublin DM.; ''CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.''; PubMed Europe PMC Scholia
  12. Plafker SM, Plafker KS, Weissman AM, Macara IG.; ''Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.''; PubMed Europe PMC Scholia
  13. Rock KL, Farfán-Arribas DJ, Shen L.; ''Proteases in MHC class I presentation and cross-presentation.''; PubMed Europe PMC Scholia
  14. Purcell AW, Elliott T.; ''Molecular machinations of the MHC-I peptide loading complex.''; PubMed Europe PMC Scholia
  15. Pfeifer JD, Wick MJ, Roberts RL, Findlay K, Normark SJ, Harding CV.; ''Phagocytic processing of bacterial antigens for class I MHC presentation to T cells.''; PubMed Europe PMC Scholia
  16. Matsuzawa K, Izawa S, Ohkura T, Ohkura H, Ishiguro K, Yoshida A, Takiyama Y, Haneda M, Shigemasa C, Yamamoto K, Taniguchi S.; ''Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms.''; PubMed Europe PMC Scholia
  17. Karim ZA, Zhang J, Banerjee M, Chicka MC, Al Hawas R, Hamilton TR, Roche PA, Whiteheart SW.; ''IκB kinase phosphorylation of SNAP-23 controls platelet secretion.''; PubMed Europe PMC Scholia
  18. Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL, Bhardwaj N.; ''Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes.''; PubMed Europe PMC Scholia
  19. Lakadamyali M, Rust MJ, Zhuang X.; ''Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes.''; PubMed Europe PMC Scholia
  20. Garstka M, Borchert B, Al-Balushi M, Praveen PV, Kühl N, Majoul I, Duden R, Springer S.; ''Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes.''; PubMed Europe PMC Scholia
  21. Tector M, Salter RD.; ''Calnexin influences folding of human class I histocompatibility proteins but not their assembly with beta 2-microglobulin.''; PubMed Europe PMC Scholia
  22. Mitaksov V, Fremont DH.; ''Structural definition of the H-2Kd peptide-binding motif.''; PubMed Europe PMC Scholia
  23. Stoltze L, Schirle M, Schwarz G, Schröter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H.; ''Two new proteases in the MHC class I processing pathway.''; PubMed Europe PMC Scholia
  24. Putilina T, Jaworski C, Gentleman S, McDonald B, Kadiri M, Wong P.; ''Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain.''; PubMed Europe PMC Scholia
  25. Kleijmeer MJ, Escola JM, UytdeHaag FG, Jakobson E, Griffith JM, Osterhaus AD, Stoorvogel W, Melief CJ, Rabouille C, Geuze HJ.; ''Antigen loading of MHC class I molecules in the endocytic tract.''; PubMed Europe PMC Scholia
  26. Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A.; ''Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.''; PubMed Europe PMC Scholia
  27. Kuang Z, Lewis RS, Curtis JM, Zhan Y, Saunders BM, Babon JJ, Kolesnik TB, Low A, Masters SL, Willson TA, Kedzierski L, Yao S, Handman E, Norton RS, Nicholson SE.; ''The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation.''; PubMed Europe PMC Scholia
  28. Wearsch PA, Cresswell P.; ''The quality control of MHC class I peptide loading.''; PubMed Europe PMC Scholia
  29. Kawai T, Akira S.; ''TLR signaling.''; PubMed Europe PMC Scholia
  30. Lee PC, Sowa ME, Gygi SP, Harper JW.; ''Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.''; PubMed Europe PMC Scholia
  31. Simone LC, Wang X, Solheim JC.; ''A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule.''; PubMed Europe PMC Scholia
  32. Koch J, Tampé R.; ''The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation.''; PubMed Europe PMC Scholia
  33. Spiliotis ET, Manley H, Osorio M, Zúñiga MC, Edidin M.; ''Selective export of MHC class I molecules from the ER after their dissociation from TAP.''; PubMed Europe PMC Scholia
  34. Schulman BA, Harper JW.; ''Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.''; PubMed Europe PMC Scholia
  35. Schölz C, Tampé R.; ''The peptide-loading complex--antigen translocation and MHC class I loading.''; PubMed Europe PMC Scholia
  36. Krappmann D, Hatada EN, Tegethoff S, Li J, Klippel A, Giese K, Baeuerle PA, Scheidereit C.; ''The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.''; PubMed Europe PMC Scholia
  37. Jackson CL.; ''Mechanisms of transport through the Golgi complex.''; PubMed Europe PMC Scholia
  38. Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL.; ''An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.''; PubMed Europe PMC Scholia
  39. Rock KL, York IA, Goldberg AL.; ''Post-proteasomal antigen processing for major histocompatibility complex class I presentation.''; PubMed Europe PMC Scholia
  40. Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM.; ''TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.''; PubMed Europe PMC Scholia
  41. Suzuki K, Verma IM.; ''Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.''; PubMed Europe PMC Scholia
  42. Dong G, Wearsch PA, Peaper DR, Cresswell P, Reinisch KM.; ''Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.''; PubMed Europe PMC Scholia
  43. Watanabe K, Yumimoto K, Nakayama KI.; ''FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.''; PubMed Europe PMC Scholia
  44. Kim DT, Mitchell DJ, Brockstedt DG, Fong L, Nolan GP, Fathman CG, Engleman EG, Rothbard JB.; ''Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide.''; PubMed Europe PMC Scholia
  45. Vyas JM, Van der Veen AG, Ploegh HL.; ''The known unknowns of antigen processing and presentation.''; PubMed Europe PMC Scholia
  46. Costoya JA, Hobbs RM, Pandolfi PP.; ''Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation.''; PubMed Europe PMC Scholia
  47. Motshwene PG, Moncrieffe MC, Grossmann JG, Kao C, Ayaluru M, Sandercock AM, Robinson CV, Latz E, Gay NJ.; ''An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.''; PubMed Europe PMC Scholia
  48. York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL.; ''Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.''; PubMed Europe PMC Scholia
  49. Kovacsovics-Bankowski M, Rock KL.; ''A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules.''; PubMed Europe PMC Scholia
  50. Segura E, Albiston AL, Wicks IP, Chai SY, Villadangos JA.; ''Different cross-presentation pathways in steady-state and inflammatory dendritic cells.''; PubMed Europe PMC Scholia
  51. Park Y, Yoon SK, Yoon JB.; ''TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.''; PubMed Europe PMC Scholia
  52. Rodriguez-Boulan E, Müsch A.; ''Protein sorting in the Golgi complex: shifting paradigms.''; PubMed Europe PMC Scholia
  53. Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW.; ''Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.''; PubMed Europe PMC Scholia
  54. Hewitt EW, Lehner PJ.; ''The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP.''; PubMed Europe PMC Scholia
  55. Kanaseki T, Blanchard N, Hammer GE, Gonzalez F, Shastri N.; ''ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  56. el Benna J, Faust LP, Babior BM.; ''The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.''; PubMed Europe PMC Scholia
  57. Starostina NG, Simpliciano JM, McGuirk MA, Kipreos ET.; ''CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.''; PubMed Europe PMC Scholia
  58. Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P.; ''IRAP identifies an endosomal compartment required for MHC class I cross-presentation.''; PubMed Europe PMC Scholia
  59. Amigorena S, Savina A.; ''Intracellular mechanisms of antigen cross presentation in dendritic cells.''; PubMed Europe PMC Scholia
  60. Mantegazza AR, Savina A, Vermeulen M, Pérez L, Geffner J, Hermine O, Rosenzweig SD, Faure F, Amigorena S.; ''NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.''; PubMed Europe PMC Scholia
  61. Nillegoda NB, Theodoraki MA, Mandal AK, Mayo KJ, Ren HY, Sultana R, Wu K, Johnson J, Cyr DM, Caplan AJ.; ''Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.''; PubMed Europe PMC Scholia
  62. Hammond AT, Glick BS.; ''Dynamics of transitional endoplasmic reticulum sites in vertebrate cells.''; PubMed Europe PMC Scholia
  63. Ding W, Li C, Hu T, Graves-Deal R, Fotia AB, Weissman AM, Coffey RJ.; ''EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.''; PubMed Europe PMC Scholia
  64. Winchester JF, Salsberg JA, Levin NW.; ''Beta-2 microglobulin in ESRD: an in-depth review.''; PubMed Europe PMC Scholia
  65. Basha G, Lizée G, Reinicke AT, Seipp RP, Omilusik KD, Jefferies WA.; ''MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells.''; PubMed Europe PMC Scholia
  66. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
  67. Rogers LD, Foster LJ.; ''Contributions of proteomics to understanding phagosome maturation.''; PubMed Europe PMC Scholia
  68. Grenfell SJ, Trausch-Azar JS, Handley-Gearhart PM, Ciechanover A, Schwartz AL.; ''Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent.''; PubMed Europe PMC Scholia
  69. Neumann L, Tampé R.; ''Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding.''; PubMed Europe PMC Scholia
  70. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
  71. Houde M, Bertholet S, Gagnon E, Brunet S, Goyette G, Laplante A, Princiotta MF, Thibault P, Sacks D, Desjardins M.; ''Phagosomes are competent organelles for antigen cross-presentation.''; PubMed Europe PMC Scholia
  72. Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF.; ''NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.''; PubMed Europe PMC Scholia
  73. Hu Q, Guo C, Li Y, Aronow BJ, Zhang J.; ''LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.''; PubMed Europe PMC Scholia
  74. Huang AY, Bruce AT, Pardoll DM, Levitsky HI.; ''In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter.''; PubMed Europe PMC Scholia
  75. Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C.; ''CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.''; PubMed Europe PMC Scholia
  76. Ladasky JJ, Boyle S, Seth M, Li H, Pentcheva T, Abe F, Steinberg SJ, Edidin M.; ''Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules.''; PubMed Europe PMC Scholia
  77. Ohnishi T, Muroi M, Tanamoto K.; ''N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.''; PubMed Europe PMC Scholia
  78. Kloetzel PM, Ossendorp F.; ''Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.''; PubMed Europe PMC Scholia
  79. Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL.; ''Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.''; PubMed Europe PMC Scholia
  80. Franz J, Jerome J, Lear T, Gong Q, Weathington NM.; ''The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.''; PubMed Europe PMC Scholia
  81. Burgdorf S, Kurts C.; ''Endocytosis mechanisms and the cell biology of antigen presentation.''; PubMed Europe PMC Scholia
  82. Craiu A, Akopian T, Goldberg A, Rock KL.; ''Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.''; PubMed Europe PMC Scholia
  83. Beninga J, Rock KL, Goldberg AL.; ''Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase.''; PubMed Europe PMC Scholia
  84. Mulherkar SA, Sharma J, Jana NR.; ''The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.''; PubMed Europe PMC Scholia
  85. Aderem A, Underhill DM.; ''Mechanisms of phagocytosis in macrophages.''; PubMed Europe PMC Scholia
  86. Loureiro J, Ploegh HL.; ''Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.''; PubMed Europe PMC Scholia
  87. Vendeville A, Rayne F, Bonhoure A, Bettache N, Montcourrier P, Beaumelle B.; ''HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.''; PubMed Europe PMC Scholia
  88. Elliott T, Neefjes J.; ''The complex route to MHC class I-peptide complexes.''; PubMed Europe PMC Scholia
  89. Palmowski MJ, Gileadi U, Salio M, Gallimore A, Millrain M, James E, Addey C, Scott D, Dyson J, Simpson E, Cerundolo V.; ''Role of immunoproteasomes in cross-presentation.''; PubMed Europe PMC Scholia
  90. Neefjes JJ, Momburg F, Hämmerling GJ.; ''Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.''; PubMed Europe PMC Scholia
  91. Michelle C, Vourc'h P, Mignon L, Andres CR.; ''What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?''; PubMed Europe PMC Scholia
  92. Fortier JM, Kornbluth J.; ''NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.''; PubMed Europe PMC Scholia
  93. Hatakeyama S, Nakayama KI.; ''U-box proteins as a new family of ubiquitin ligases.''; PubMed Europe PMC Scholia
  94. Nakano A, Luini A.; ''Passage through the Golgi.''; PubMed Europe PMC Scholia
  95. Ulbrecht M, Couturier A, Martinozzi S, Pla M, Srivastava R, Peterson PA, Weiss EH.; ''Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences.''; PubMed Europe PMC Scholia
  96. van Wijk SJ, Timmers HT.; ''The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.''; PubMed Europe PMC Scholia
  97. Van Hateren A, James E, Bailey A, Phillips A, Dalchau N, Elliott T.; ''The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding.''; PubMed Europe PMC Scholia
  98. Saper MA, Bjorkman PJ, Wiley DC.; ''Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution.''; PubMed Europe PMC Scholia
  99. Hochman JH, Shimizu Y, DeMars R, Edidin M.; ''Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin.''; PubMed Europe PMC Scholia
  100. Procko E, Gaudet R.; ''Antigen processing and presentation: TAPping into ABC transporters.''; PubMed Europe PMC Scholia
  101. Ackerman AL, Kyritsis C, Tampé R, Cresswell P.; ''Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells.''; PubMed Europe PMC Scholia
  102. Diedrich G, Bangia N, Pan M, Cresswell P.; ''A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  103. Harris MR, Yu YY, Kindle CS, Hansen TH, Solheim JC.; ''Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.''; PubMed Europe PMC Scholia
  104. Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J.; ''G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.''; PubMed Europe PMC Scholia
  105. Lührig S, Kolb S, Mellies N, Nolte J.; ''The novel BTB-kelch protein, KBTBD8, is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis.''; PubMed Europe PMC Scholia
  106. Stronge VS, Saito Y, Ihara Y, Williams DB.; ''Relationship between calnexin and BiP in suppressing aggregation and promoting refolding of protein and glycoprotein substrates.''; PubMed Europe PMC Scholia
  107. Bouin AP, Grandvaux N, Vignais PV, Fuchs A.; ''p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process.''; PubMed Europe PMC Scholia
  108. Howe C, Garstka M, Al-Balushi M, Ghanem E, Antoniou AN, Fritzsche S, Jankevicius G, Kontouli N, Schneeweiss C, Williams A, Elliott T, Springer S.; ''Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules.''; PubMed Europe PMC Scholia
  109. Lange S, Perera S, Teh P, Chen J.; ''Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.''; PubMed Europe PMC Scholia
  110. Lin ML, Zhan Y, Villadangos JA, Lew AM.; ''The cell biology of cross-presentation and the role of dendritic cell subsets.''; PubMed Europe PMC Scholia
  111. Vieira OV, Botelho RJ, Grinstein S.; ''Phagosome maturation: aging gracefully.''; PubMed Europe PMC Scholia
  112. Paulsson KM, Wang P.; ''Quality control of MHC class I maturation.''; PubMed Europe PMC Scholia
  113. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES.; ''Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate.''; PubMed Europe PMC Scholia
  114. Katayama K, Noguchi K, Sugimoto Y.; ''FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.''; PubMed Europe PMC Scholia
  115. Kloetzel PM.; ''Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.''; PubMed Europe PMC Scholia
  116. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO.; ''Mechanisms of ubiquitin transfer by the anaphase-promoting complex.''; PubMed Europe PMC Scholia
  117. Grommé M, Uytdehaag FG, Janssen H, Calafat J, van Binnendijk RS, Kenter MJ, Tulp A, Verwoerd D, Neefjes J.; ''Recycling MHC class I molecules and endosomal peptide loading.''; PubMed Europe PMC Scholia
  118. Ramachandra L, Simmons D, Harding CV.; ''MHC molecules and microbial antigen processing in phagosomes.''; PubMed Europe PMC Scholia
  119. Hotton SK, Callis J.; ''Regulation of cullin RING ligases.''; PubMed Europe PMC Scholia
  120. Rothwarf DM, Zandi E, Natoli G, Karin M.; ''IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.''; PubMed Europe PMC Scholia
  121. Kong Q, Zeng W, Wu J, Hu W, Li C, Mao B.; ''RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination.''; PubMed Europe PMC Scholia
  122. Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL.; ''26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.''; PubMed Europe PMC Scholia
  123. Abe F, Van Prooyen N, Ladasky JJ, Edidin M.; ''Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  124. Deshaies RJ, Joazeiro CA.; ''RING domain E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  125. Kloetzel PM.; ''The proteasome and MHC class I antigen processing.''; PubMed Europe PMC Scholia
  126. Doherty GJ, McMahon HT.; ''Mechanisms of endocytosis.''; PubMed Europe PMC Scholia
  127. York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL.; ''The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.''; PubMed Europe PMC Scholia
  128. Burgdorf S, Lukacs-Kornek V, Kurts C.; ''The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.''; PubMed Europe PMC Scholia
  129. Crotzer VL, Blum JS.; ''Autophagy and its role in MHC-mediated antigen presentation.''; PubMed Europe PMC Scholia
  130. Li ZH, Zhang XH, Li GY.; ''[Study on the fusion expression of FBXO30: a novel member of F-box protein family].''; PubMed Europe PMC Scholia
  131. Antoniou AN, Powis SJ, Elliott T.; ''Assembly and export of MHC class I peptide ligands.''; PubMed Europe PMC Scholia
  132. Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S.; ''Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.''; PubMed Europe PMC Scholia
  133. Danilczyk UG, Cohen-Doyle MF, Williams DB.; ''Functional relationship between calreticulin, calnexin, and the endoplasmic reticulum luminal domain of calnexin.''; PubMed Europe PMC Scholia
  134. Norbury CC, Chambers BJ, Prescott AR, Ljunggren HG, Watts C.; ''Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells.''; PubMed Europe PMC Scholia
  135. Meroni G, Diez-Roux G.; ''TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  136. Ware FE, Vassilakos A, Peterson PA, Jackson MR, Lehrman MA, Williams DB.; ''The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteins.''; PubMed Europe PMC Scholia
  137. D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, Dynlacht B, Pagano M.; ''SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.''; PubMed Europe PMC Scholia
  138. Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y.; ''E6AP promotes the degradation of the PML tumor suppressor.''; PubMed Europe PMC Scholia
  139. Tokgöz Z, Bohnsack RN, Haas AL.; ''Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.''; PubMed Europe PMC Scholia
  140. Ebstein F, Lange N, Urban S, Seifert U, Krüger E, Kloetzel PM.; ''Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.''; PubMed Europe PMC Scholia
  141. Sato K, Nakano A.; ''Mechanisms of COPII vesicle formation and protein sorting.''; PubMed Europe PMC Scholia
  142. Kallijärvi J, Lahtinen U, Hämäläinen R, Lipsanen-Nyman M, Palvimo JJ, Lehesjoki AE.; ''TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117684view12:08, 22 May 2021EweitzModified title
114758view16:24, 25 January 2021ReactomeTeamReactome version 75
113202view11:26, 2 November 2020ReactomeTeamReactome version 74
112427view15:37, 9 October 2020ReactomeTeamReactome version 73
101331view11:21, 1 November 2018ReactomeTeamreactome version 66
100869view20:55, 31 October 2018ReactomeTeamreactome version 65
100410view19:28, 31 October 2018ReactomeTeamreactome version 64
99959view16:13, 31 October 2018ReactomeTeamreactome version 63
99514view14:45, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99156view12:41, 31 October 2018ReactomeTeamreactome version 62
94507view09:31, 14 September 2017Mkutmonreactome version 61
87162view19:18, 18 July 2016MkutmonOntology Term : 'adaptive immune response pathway' added !
87068view11:35, 18 July 2016ReactomeTeamReactome version 56
83467view12:31, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Glc)1 (GlcNAc)2 (Man)9 MetaboliteCHEBI:59080 (ChEBI)
26S proteasomeComplexR-HSA-68819 (Reactome)
2xN4GlycoAsn-LY96 ProteinQ9Y6Y9 (Uniprot-TrEMBL)
2xN4GlycoAsn-TLR4 ProteinO00206 (Uniprot-TrEMBL)
4xPalmC-CD36 ProteinP16671 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:456216 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANAPC1 ProteinQ9H1A4 (Uniprot-TrEMBL)
ANAPC10 ProteinQ9UM13 (Uniprot-TrEMBL)
ANAPC11 ProteinQ9NYG5 (Uniprot-TrEMBL)
ANAPC13 ProteinQ9BS18 (Uniprot-TrEMBL)
ANAPC2 ProteinQ9UJX6 (Uniprot-TrEMBL)
ANAPC4 ProteinQ9UJX5 (Uniprot-TrEMBL)
ANAPC5 ProteinQ9UJX4 (Uniprot-TrEMBL)
ANAPC7 ProteinQ9UJX3 (Uniprot-TrEMBL)
AREL1 ProteinO15033 (Uniprot-TrEMBL)
ARIH2 ProteinO95376 (Uniprot-TrEMBL)
ASB1 ProteinQ9Y576 (Uniprot-TrEMBL)
ASB10 ProteinQ8WXI3 (Uniprot-TrEMBL)
ASB11 ProteinQ8WXH4 (Uniprot-TrEMBL)
ASB12 ProteinQ8WXK4 (Uniprot-TrEMBL)
ASB13 ProteinQ8WXK3 (Uniprot-TrEMBL)
ASB14 ProteinA6NK59 (Uniprot-TrEMBL)
ASB15 ProteinQ8WXK1 (Uniprot-TrEMBL)
ASB16 ProteinQ96NS5 (Uniprot-TrEMBL)
ASB17 ProteinQ8WXJ9 (Uniprot-TrEMBL)
ASB18 ProteinQ6ZVZ8 (Uniprot-TrEMBL)
ASB2 ProteinQ96Q27 (Uniprot-TrEMBL)
ASB3 ProteinQ9Y575 (Uniprot-TrEMBL)
ASB4 ProteinQ9Y574 (Uniprot-TrEMBL)
ASB5 ProteinQ8WWX0 (Uniprot-TrEMBL)
ASB6 ProteinQ9NWX5 (Uniprot-TrEMBL)
ASB7 ProteinQ9H672 (Uniprot-TrEMBL)
ASB8 ProteinQ9H765 (Uniprot-TrEMBL)
ASB9 ProteinQ96DX5 (Uniprot-TrEMBL)
ATG7 ProteinO95352 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:30616 (ChEBI)
Ag peptide bound class I MHCComplexR-HSA-1236931 (Reactome)
Ag-substrate:E3:E2:UbComplexR-HSA-983126 (Reactome)
Antigen R-ALL-173548 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ComplexR-HSA-983132 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-1236934 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-198904 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983114 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983412 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983416 (Reactome)
Antigen peptide MetaboliteCHEBI:25676 (ChEBI)
Antigen peptide R-ALL-983324 (Reactome)
Antigen peptide R-ALL-983326 (Reactome)
Antigen peptideMetaboliteCHEBI:25676 (ChEBI)
Antigenic

peptide:MHC:B2M peptide loading

complex		ComplexR-HSA-8951496 (Reactome)
B2M(21-119) ProteinP61769 (Uniprot-TrEMBL)
B2M(21-119)ProteinP61769 (Uniprot-TrEMBL)
BAP31 oligomer R-HSA-983323 (Reactome)
BAP31 oligomerR-HSA-983323 (Reactome)
BLMH ProteinQ13867 (Uniprot-TrEMBL)
BTBD1 ProteinQ9H0C5 (Uniprot-TrEMBL)
BTBD6 ProteinQ96KE9 (Uniprot-TrEMBL)
BTK ProteinQ06187 (Uniprot-TrEMBL)
BTRC ProteinQ9Y297 (Uniprot-TrEMBL)
CALR ProteinP27797 (Uniprot-TrEMBL)
CALR:SEC22B:STX4:TAP:TAPBPComplexR-HSA-8951594 (Reactome)
CALRProteinP27797 (Uniprot-TrEMBL)
CANX ProteinP27824 (Uniprot-TrEMBL)
CBLB ProteinQ13191 (Uniprot-TrEMBL)
CCNF ProteinP41002 (Uniprot-TrEMBL)
CD14(20-345) ProteinP08571 (Uniprot-TrEMBL)
CD207 ProteinQ9UJ71 (Uniprot-TrEMBL)
CD36 ProteinP16671 (Uniprot-TrEMBL)
CDC16 ProteinQ13042 (Uniprot-TrEMBL)
CDC20 ProteinQ12834 (Uniprot-TrEMBL)
CDC23 ProteinQ9UJX2 (Uniprot-TrEMBL)
CDC26 ProteinQ8NHZ8 (Uniprot-TrEMBL)
CDC27 ProteinP30260 (Uniprot-TrEMBL)
CDC34 ProteinP49427 (Uniprot-TrEMBL)
CHUK ProteinO15111 (Uniprot-TrEMBL)
CHUK:IKBKB:IKBKGComplexR-HSA-168113 (Reactome) Co-immunoprecipitation studies and size exclusion chromatography analysis indicate that the high molecular weight (around 700 to 900 kDa) IKK complex is composed of two kinase subunits (IKK1/CHUK/IKBKA and/or IKK2/IKBKB/IKKB) bound to a regulatory gamma subunit (IKBKG/NEMO) (Rothwarf DMet al. 1998; Krappmann D et al. 2000; Miller BS & Zandi E 2001). Variants of the IKK complex containing IKBKA or IKBKB homodimers associated with NEMO may also exist. Crystallographic and quantitative analyses of the binding interactions between N-terminal NEMO and C-terminal IKBKB fragments showed that IKBKB dimers would interact with NEMO dimers resulting in 2:2 stoichiometry (Rushe M et al. 2008). Chemical cross-linking and equilibrium sedimentation analyses of IKBKG (NEMO) suggest a tetrameric oligomerization (dimers of dimers) (Tegethoff S et al. 2003). The tetrameric NEMO could sequester four kinase molecules, yielding an 2xIKBKA:2xIKBKB:4xNEMO stoichiometry (Tegethoff S et al. 2003). The above data suggest that the core IKK complex consists of an IKBKA:IKBKB heterodimer associated with an IKBKG dimer or higher oligomeric assemblies. However, the exact stoichiometry of the IKK complex remains unclear.
COPII vesicle with MHC class IComplexR-HSA-983414 (Reactome)
COPII vesicle with MHC class IComplexR-HSA-983418 (Reactome)
COPIIComplexR-HSA-204019 (Reactome)
CTSL1(114-288) ProteinP07711 (Uniprot-TrEMBL)
CTSL2 ProteinO60911 (Uniprot-TrEMBL)
CTSS ProteinP25774 (Uniprot-TrEMBL)
CTSS-like proteinsComplexR-HSA-4127472 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CUL1 ProteinQ13616 (Uniprot-TrEMBL)
CUL2 ProteinQ13617 (Uniprot-TrEMBL)
CUL3 ProteinQ13618 (Uniprot-TrEMBL)
CUL5 ProteinQ93034 (Uniprot-TrEMBL)
CUL7 ProteinQ14999 (Uniprot-TrEMBL)
CYBA ProteinP13498 (Uniprot-TrEMBL)
CYBB ProteinP04839 (Uniprot-TrEMBL)
Chaperones calnexin/BiPComplexR-HSA-983129 (Reactome)
Class I MHC HC:B2M:Erp57ComplexR-HSA-1236922 (Reactome)
Class I MHC HC:B2M:Erp57ComplexR-HSA-8863933 (Reactome)
Class I MHC:B2MComplexR-HSA-1236930 (Reactome)
Clostridial peptidoglycan MetaboliteCHEBI:8005 (ChEBI)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236899 (Reactome)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236904 (Reactome)
DET1 ProteinQ7L5Y6 (Uniprot-TrEMBL)
DTX3L ProteinQ8TDB6 (Uniprot-TrEMBL)
DZIP3 ProteinQ86Y13 (Uniprot-TrEMBL)
Diacyl lipopeptide MetaboliteCHEBI:46896 (ChEBI)
E1 bound ubiquitinComplexR-HSA-976164 (Reactome)
E2 Ubiquitin-conjugating enzymeComplexR-HSA-947628 (Reactome)
E3 ligases in

proteasomal

degradation		ComplexR-HSA-976075 (Reactome)
E3:K48-polyubiquitinated substrateComplexR-HSA-983134 (Reactome)
E3:Ub:substrateComplexR-HSA-983131 (Reactome)
ELOB ProteinQ15370 (Uniprot-TrEMBL)
ELOC ProteinQ15369 (Uniprot-TrEMBL)
ERAP1 ProteinQ9NZ08 (Uniprot-TrEMBL)
ERAP1/2ComplexR-HSA-983125 (Reactome)
ERAP2 ProteinQ6P179 (Uniprot-TrEMBL)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236714 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236716 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236726 (Reactome)
Exogenous Particulate antigen (Ag) R-ALL-1236726 (Reactome)
Exogenous soluble antigenMetaboliteCHEBI:16670 (ChEBI)
Exogenous soluble antigen MetaboliteCHEBI:16670 (ChEBI)
FBXL12 ProteinQ9NXK8 (Uniprot-TrEMBL)
FBXL13 ProteinQ8NEE6 (Uniprot-TrEMBL)
FBXL14 ProteinQ8N1E6 (Uniprot-TrEMBL)
FBXL15 ProteinQ9H469 (Uniprot-TrEMBL)
FBXL16 ProteinQ8N461 (Uniprot-TrEMBL)
FBXL18 ProteinQ96ME1 (Uniprot-TrEMBL)
FBXL19 ProteinQ6PCT2 (Uniprot-TrEMBL)
FBXL20 ProteinQ96IG2 (Uniprot-TrEMBL)
FBXL21 ProteinQ9UKT6 (Uniprot-TrEMBL)
FBXL22 ProteinQ6P050 (Uniprot-TrEMBL)
FBXL3 ProteinQ9UKT7 (Uniprot-TrEMBL)
FBXL4 ProteinQ9UKA2 (Uniprot-TrEMBL)
FBXL5 ProteinQ9UKA1 (Uniprot-TrEMBL)
FBXL7 ProteinQ9UJT9 (Uniprot-TrEMBL)
FBXL8 ProteinQ96CD0 (Uniprot-TrEMBL)
FBXO10 ProteinQ9UK96 (Uniprot-TrEMBL)
FBXO11 ProteinQ86XK2 (Uniprot-TrEMBL)
FBXO15 ProteinQ8NCQ5 (Uniprot-TrEMBL)
FBXO17 ProteinQ96EF6 (Uniprot-TrEMBL)
FBXO2 ProteinQ9UK22 (Uniprot-TrEMBL)
FBXO21 ProteinO94952 (Uniprot-TrEMBL)
FBXO22 ProteinQ8NEZ5 (Uniprot-TrEMBL)
FBXO27 ProteinQ8NI29 (Uniprot-TrEMBL)
FBXO30 ProteinQ8TB52 (Uniprot-TrEMBL)
FBXO31 ProteinQ5XUX0 (Uniprot-TrEMBL)
FBXO32 ProteinQ969P5 (Uniprot-TrEMBL)
FBXO4 ProteinQ9UKT5 (Uniprot-TrEMBL)
FBXO40 ProteinQ9UH90 (Uniprot-TrEMBL)
FBXO41 ProteinQ8TF61 (Uniprot-TrEMBL)
FBXO44 ProteinQ9H4M3 (Uniprot-TrEMBL)
FBXO6 ProteinQ9NRD1 (Uniprot-TrEMBL)
FBXO7 ProteinQ9Y3I1 (Uniprot-TrEMBL)
FBXO9 ProteinQ9UK97 (Uniprot-TrEMBL)
FBXW10 ProteinQ5XX13 (Uniprot-TrEMBL)
FBXW11 ProteinQ9UKB1 (Uniprot-TrEMBL)
FBXW12 ProteinQ6X9E4 (Uniprot-TrEMBL)
FBXW2 ProteinQ9UKT8 (Uniprot-TrEMBL)
FBXW4 ProteinP57775 (Uniprot-TrEMBL)
FBXW5 ProteinQ969U6 (Uniprot-TrEMBL)
FBXW7 ProteinQ969H0 (Uniprot-TrEMBL)
FBXW8 ProteinQ8N3Y1 (Uniprot-TrEMBL)
FBXW9 ProteinQ5XUX1 (Uniprot-TrEMBL)
FCGR R-HSA-1236898 (Reactome)
FCGR R-HSA-1236905 (Reactome)
FCGRA R-HSA-1031694 (Reactome)
FZR1 ProteinQ9UM11 (Uniprot-TrEMBL)
GAN ProteinQ9H2C0 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GLMN ProteinQ92990 (Uniprot-TrEMBL)
GPIN-CD14(20-345) ProteinP08571 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HACE1 ProteinQ8IYU2 (Uniprot-TrEMBL)
HECTD1 ProteinQ9ULT8 (Uniprot-TrEMBL)
HECTD2 ProteinQ5U5R9 (Uniprot-TrEMBL)
HECTD3 ProteinQ5T447 (Uniprot-TrEMBL)
HECW2 ProteinQ9P2P5 (Uniprot-TrEMBL)
HERC1 ProteinQ15751 (Uniprot-TrEMBL)
HERC2 ProteinO95714 (Uniprot-TrEMBL)
HERC3 ProteinQ15034 (Uniprot-TrEMBL)
HERC4 ProteinQ5GLZ8 (Uniprot-TrEMBL)
HERC5 ProteinQ9UII4 (Uniprot-TrEMBL)
HERC6 ProteinQ8IVU3 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-1 alpha chain precursor ProteinP30443 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-11 alpha chain ProteinP13746 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-23 alpha chain ProteinP30447 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-24 alpha chain ProteinP05534 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-25 alpha chain ProteinP18462 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-26 alpha chain ProteinP30450 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-29 alpha chain ProteinP30512 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-3 alpha chain precursor ProteinP04439 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-30 alpha chain ProteinP16188 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-31 alpha chain ProteinP16189 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-32 alpha chain ProteinP10314 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-33 alpha chain ProteinP16190 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-34 alpha chain ProteinP30453 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-36 alpha chain ProteinP30455 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-43 alpha chain ProteinP30456 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-66 alpha chain ProteinP30457 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-68 alpha chain ProteinP01891 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-69 alpha chain ProteinP10316 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-74 alpha chain ProteinP30459 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-80 alpha chain ProteinQ09160 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, B-48 alpha chain ProteinP30486 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-1 alpha chain ProteinP30499 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-12 alpha chain ProteinP30508 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-14 alpha chain ProteinP30510 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-15 alpha chain ProteinQ07000 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-16 alpha chain ProteinQ29960 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-17 alpha chain ProteinQ95604 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-18 alpha chain ProteinQ29865 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-2 alpha chain ProteinP30501 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ProteinP04222 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ProteinP30504 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ProteinQ9TNN7 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ProteinQ29963 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ProteinP10321 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-8 alpha chain ProteinP30505 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, E alpha chain precursor ProteinP13747 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain F precursor ProteinP30511 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain G precursor ProteinP17693 (Uniprot-TrEMBL)
HLA-B ProteinP30486 (Uniprot-TrEMBL)
HLA-C ProteinP10321 (Uniprot-TrEMBL)
HLA-H ProteinP01893 (Uniprot-TrEMBL)
HSPA5 ProteinP11021 (Uniprot-TrEMBL)
HUWE1 ProteinQ7Z6Z7 (Uniprot-TrEMBL)
IFN gamma stimulated aminopeptidasesComplexR-HSA-983128 (Reactome)
IKBKB ProteinO14920 (Uniprot-TrEMBL)
IKBKG ProteinQ9Y6K9 (Uniprot-TrEMBL)
IRAP in complex with MHC class IComplexR-HSA-1236916 (Reactome)
ITCH ProteinQ96J02 (Uniprot-TrEMBL)
ITGAV(31-1048) ProteinP06756 (Uniprot-TrEMBL)
ITGB5 ProteinP18084 (Uniprot-TrEMBL)
K48polyUb-antigenic substrateR-ALL-983123 (Reactome)
K48polyUb-antigenic substrate R-ALL-983123 (Reactome)
K48polyUb-partially digested AgR-ALL-1236918 (Reactome)
KBTBD13 ProteinC9JR72 (Uniprot-TrEMBL)
KBTBD6 ProteinQ86V97 (Uniprot-TrEMBL)
KBTBD7 ProteinQ8WVZ9 (Uniprot-TrEMBL)
KBTBD8 ProteinQ8NFY9 (Uniprot-TrEMBL)
KCTD6 ProteinQ8NC69 (Uniprot-TrEMBL)
KCTD7 ProteinQ96MP8 (Uniprot-TrEMBL)
KEAP1 ProteinQ14145 (Uniprot-TrEMBL)
KLHL11 ProteinQ9NVR0 (Uniprot-TrEMBL)
KLHL13 ProteinQ9P2N7 (Uniprot-TrEMBL)
KLHL2 ProteinO95198 (Uniprot-TrEMBL)
KLHL20 ProteinQ9Y2M5 (Uniprot-TrEMBL)
KLHL21 ProteinQ9UJP4 (Uniprot-TrEMBL)
KLHL22 ProteinQ53GT1 (Uniprot-TrEMBL)
KLHL25 ProteinQ9H0H3 (Uniprot-TrEMBL)
KLHL3 ProteinQ9UH77 (Uniprot-TrEMBL)
KLHL41 ProteinO60662 (Uniprot-TrEMBL)
KLHL42 ProteinQ9P2K6 (Uniprot-TrEMBL)
KLHL5 ProteinQ96PQ7 (Uniprot-TrEMBL)
KLHL9 ProteinQ9P2J3 (Uniprot-TrEMBL)
L-amino acidMetaboliteCHEBI:59869 (ChEBI)
LMO7 ProteinQ8WWI1 (Uniprot-TrEMBL)
LNPEP ProteinQ9UIQ6 (Uniprot-TrEMBL)
LNX1 ProteinQ8TBB1 (Uniprot-TrEMBL)
LONRF1 ProteinQ17RB8 (Uniprot-TrEMBL)
LPS MetaboliteCHEBI:16412 (ChEBI)
LRR1 ProteinQ96L50 (Uniprot-TrEMBL)
LRRC41 ProteinQ15345 (Uniprot-TrEMBL)
LRSAM1 ProteinQ6UWE0 (Uniprot-TrEMBL)
LTN1 ProteinO94822 (Uniprot-TrEMBL)
Lipoteichoic acid MetaboliteCHEBI:28640 (ChEBI)
MEX3C ProteinQ5U5Q3 (Uniprot-TrEMBL)
MGRN1 ProteinO60291 (Uniprot-TrEMBL)
MHC

class I

HC:Calnexin/BiP:Erp57		ComplexR-HSA-983119 (Reactome)
MHC HC:B2M:Erp57ComplexR-HSA-983136 (Reactome)
MHC:B2M peptide loading complexComplexR-HSA-983121 (Reactome)
MIB2 ProteinQ96AX9 (Uniprot-TrEMBL)
MKRN1 ProteinQ9UHC7 (Uniprot-TrEMBL)
MR/other probable receptorsComplexR-HSA-1236909 (Reactome)
MR/other probable receptorsComplexR-HSA-1236911 (Reactome)
MR:soluble antigenComplexR-HSA-1236923 (Reactome)
MR:soluble antigenComplexR-HSA-1236926 (Reactome)
MR:soluble antigenComplexR-HSA-1236929 (Reactome)
MRC1 ProteinP22897 (Uniprot-TrEMBL)
MRC2 ProteinQ9UBG0 (Uniprot-TrEMBL)
MYD88 ProteinQ99836 (Uniprot-TrEMBL)
MYLIP ProteinQ8WY64 (Uniprot-TrEMBL)
Major outer membrane protein P ProteinP30690 (Uniprot-TrEMBL)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEDD4 ProteinP46934 (Uniprot-TrEMBL)
NEDD4L ProteinQ96PU5 (Uniprot-TrEMBL)
NOX2 complexComplexR-HSA-1996217 (Reactome)
NPEPPS ProteinP55786 (Uniprot-TrEMBL)
O2.-MetaboliteCHEBI:18421 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
PARK2 ProteinO60260 (Uniprot-TrEMBL)
PDIA3 ProteinP30101 (Uniprot-TrEMBL)
PDIA3ProteinP30101 (Uniprot-TrEMBL)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PJA1 ProteinQ8NG27 (Uniprot-TrEMBL)
PJA2 ProteinO43164 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
Particulate Ag:DC receptorsComplexR-HSA-1236920 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RBBP6 ProteinQ7Z6E9 (Uniprot-TrEMBL)
RBCK1 ProteinQ9BYM8 (Uniprot-TrEMBL)
RBX1 ProteinP62877 (Uniprot-TrEMBL)
RCHY1 ProteinQ96PM5 (Uniprot-TrEMBL)
RLIM ProteinQ9NVW2 (Uniprot-TrEMBL)
RNF111 ProteinQ6ZNA4 (Uniprot-TrEMBL)
RNF114 ProteinQ9Y508 (Uniprot-TrEMBL)
RNF115 ProteinQ9Y4L5 (Uniprot-TrEMBL)
RNF123 ProteinQ5XPI4 (Uniprot-TrEMBL)
RNF126 ProteinQ9BV68 (Uniprot-TrEMBL)
RNF130 ProteinQ86XS8 (Uniprot-TrEMBL)
RNF138 ProteinQ8WVD3 (Uniprot-TrEMBL)
RNF14 ProteinQ9UBS8 (Uniprot-TrEMBL)
RNF144B ProteinQ7Z419 (Uniprot-TrEMBL)
RNF182 ProteinQ8N6D2 (Uniprot-TrEMBL)
RNF19A ProteinQ9NV58 (Uniprot-TrEMBL)
RNF19B ProteinQ6ZMZ0 (Uniprot-TrEMBL)
RNF213 ProteinQ63HN8 (Uniprot-TrEMBL)
RNF217 ProteinQ8TC41 (Uniprot-TrEMBL)
RNF220 ProteinQ5VTB9 (Uniprot-TrEMBL)
RNF25 ProteinQ96BH1 (Uniprot-TrEMBL)
RNF34 ProteinQ969K3 (Uniprot-TrEMBL)
RNF4 ProteinP78317 (Uniprot-TrEMBL)
RNF41 ProteinQ9H4P4 (Uniprot-TrEMBL)
RNF6 ProteinQ9Y252 (Uniprot-TrEMBL)
RNF7 (RBX2) ProteinQ9UBF6 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SAR1B ProteinQ9Y6B6 (Uniprot-TrEMBL)
SAR1B:GDPComplexR-HSA-203989 (Reactome)
SAR1B:GTP:SEC23:SEC24ComplexR-HSA-203997 (Reactome)
SAR1B:GTPComplexR-HSA-204003 (Reactome)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEC13ProteinP55735 (Uniprot-TrEMBL)
SEC22B ProteinO75396 (Uniprot-TrEMBL)
SEC22B:STX4ComplexR-HSA-8863847 (Reactome)
SEC22BProteinO75396 (Uniprot-TrEMBL)
SEC23:SEC24ComplexR-HSA-203975 (Reactome)
SEC23A ProteinQ15436 (Uniprot-TrEMBL)
SEC23AProteinQ15436 (Uniprot-TrEMBL)
SEC24A ProteinO95486 (Uniprot-TrEMBL)
SEC24B ProteinO95487 (Uniprot-TrEMBL)
SEC24C ProteinP53992 (Uniprot-TrEMBL)
SEC24D ProteinO94855 (Uniprot-TrEMBL)
SEC24ComplexR-HSA-203991 (Reactome)
SEC31A ProteinO94979 (Uniprot-TrEMBL)
SEC31AProteinO94979 (Uniprot-TrEMBL)
SEC61A1 ProteinP61619 (Uniprot-TrEMBL)
SEC61A2 ProteinQ9H9S3 (Uniprot-TrEMBL)
SEC61B ProteinP60468 (Uniprot-TrEMBL)
SEC61G ProteinP60059 (Uniprot-TrEMBL)
SH3RF1 ProteinQ7Z6J0 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SIAH1 ProteinQ8IUQ4 (Uniprot-TrEMBL)
SIAH2 ProteinO43255 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SKP2 ProteinQ13309 (Uniprot-TrEMBL)
SMURF1 ProteinQ9HCE7 (Uniprot-TrEMBL)
SMURF2 ProteinQ9HAU4 (Uniprot-TrEMBL)
SNAP23ProteinO00161 (Uniprot-TrEMBL)
SOCS1 ProteinO15524 (Uniprot-TrEMBL)
SOCS3 ProteinO14543 (Uniprot-TrEMBL)
SPSB1 ProteinQ96BD6 (Uniprot-TrEMBL)
SPSB2 ProteinQ99619 (Uniprot-TrEMBL)
SPSB4 ProteinQ96A44 (Uniprot-TrEMBL)
STUB1 ProteinQ9UNE7 (Uniprot-TrEMBL)
STX4 ProteinQ12846 (Uniprot-TrEMBL)
STX4ProteinQ12846 (Uniprot-TrEMBL)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IComplexR-HSA-983413 (Reactome)
TAP1 ProteinQ03518 (Uniprot-TrEMBL)
TAP2 ProteinQ03519 (Uniprot-TrEMBL)
TAPBP ProteinO15533 (Uniprot-TrEMBL)
TAPBPProteinO15533 (Uniprot-TrEMBL)
TAPComplexR-HSA-1236915 (Reactome)
TAPComplexR-HSA-8863936 (Reactome)
TAPComplexR-HSA-983113 (Reactome)
THOP1ProteinP52888 (Uniprot-TrEMBL)
TLR1 ProteinQ15399 (Uniprot-TrEMBL)
TLR2 ProteinO60603 (Uniprot-TrEMBL)
TLR6 ProteinQ9Y2C9 (Uniprot-TrEMBL)
TPP2 ProteinP29144 (Uniprot-TrEMBL)
TRAF7 ProteinQ6Q0C0 (Uniprot-TrEMBL)
TRAIP ProteinQ9BWF2 (Uniprot-TrEMBL)
TRIM11 ProteinQ96F44 (Uniprot-TrEMBL)
TRIM21 ProteinP19474 (Uniprot-TrEMBL)
TRIM32 ProteinQ13049 (Uniprot-TrEMBL)
TRIM36 ProteinQ9NQ86 (Uniprot-TrEMBL)
TRIM37 ProteinO94972 (Uniprot-TrEMBL)
TRIM39 ProteinQ9HCM9 (Uniprot-TrEMBL)
TRIM4 ProteinQ9C037 (Uniprot-TrEMBL)
TRIM41 ProteinQ8WV44 (Uniprot-TrEMBL)
TRIM50 ProteinQ86XT4 (Uniprot-TrEMBL)
TRIM63 ProteinQ969Q1 (Uniprot-TrEMBL)
TRIM69 ProteinQ86WT6 (Uniprot-TrEMBL)
TRIM71 ProteinQ2Q1W2 (Uniprot-TrEMBL)
TRIM9 ProteinQ9C026 (Uniprot-TrEMBL)
TRIP12 ProteinQ14669 (Uniprot-TrEMBL)
TransloconComplexR-HSA-1236927 (Reactome)
Triacyl lipopeptide MetaboliteCHEBI:60192 (ChEBI)
UBA1 ProteinP22314 (Uniprot-TrEMBL)
UBA3 ProteinQ8TBC4 (Uniprot-TrEMBL)
UBA5 ProteinQ9GZZ9 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBA6 ProteinA0AVT1 (Uniprot-TrEMBL)
UBA7 ProteinP41226 (Uniprot-TrEMBL)
UBAC1 ProteinQ9BSL1 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UBE2A ProteinP49459 (Uniprot-TrEMBL)
UBE2B ProteinP63146 (Uniprot-TrEMBL)
UBE2C ProteinO00762 (Uniprot-TrEMBL)
UBE2D1 ProteinP51668 (Uniprot-TrEMBL)
UBE2D2 ProteinP62837 (Uniprot-TrEMBL)
UBE2D3 ProteinP61077 (Uniprot-TrEMBL)
UBE2D4 ProteinQ9Y2X8 (Uniprot-TrEMBL)
UBE2E1 ProteinP51965 (Uniprot-TrEMBL)
UBE2E2 ProteinQ96LR5 (Uniprot-TrEMBL)
UBE2E3 ProteinQ969T4 (Uniprot-TrEMBL)
UBE2F ProteinQ969M7 (Uniprot-TrEMBL)
UBE2G1 ProteinP62253 (Uniprot-TrEMBL)
UBE2G2 ProteinP60604 (Uniprot-TrEMBL)
UBE2H ProteinP62256 (Uniprot-TrEMBL)
UBE2J1 ProteinQ9Y385 (Uniprot-TrEMBL)
UBE2J2 ProteinQ8N2K1 (Uniprot-TrEMBL)
UBE2K ProteinP61086 (Uniprot-TrEMBL)
UBE2L3 ProteinP68036 (Uniprot-TrEMBL)
UBE2L6 ProteinO14933 (Uniprot-TrEMBL)
UBE2M ProteinP61081 (Uniprot-TrEMBL)
UBE2N ProteinP61088 (Uniprot-TrEMBL)
UBE2O ProteinQ9C0C9 (Uniprot-TrEMBL)
UBE2Q1 ProteinQ7Z7E8 (Uniprot-TrEMBL)
UBE2Q2 ProteinQ8WVN8 (Uniprot-TrEMBL)
UBE2R2 ProteinQ712K3 (Uniprot-TrEMBL)
UBE2S ProteinQ16763 (Uniprot-TrEMBL)
UBE2U ProteinQ5VVX9 (Uniprot-TrEMBL)
UBE2V1 ProteinQ13404 (Uniprot-TrEMBL)
UBE2V2 ProteinQ15819 (Uniprot-TrEMBL)
UBE2W ProteinQ96B02 (Uniprot-TrEMBL)
UBE2Z ProteinQ9H832 (Uniprot-TrEMBL)
UBE3A ProteinQ05086 (Uniprot-TrEMBL)
UBE3B ProteinQ7Z3V4 (Uniprot-TrEMBL)
UBE3C ProteinQ15386 (Uniprot-TrEMBL)
UBE3D ProteinQ7Z6J8 (Uniprot-TrEMBL)
UBE4A ProteinQ14139 (Uniprot-TrEMBL)
UBOX5 ProteinO94941 (Uniprot-TrEMBL)
UBR1 ProteinQ8IWV7 (Uniprot-TrEMBL)
UBR2 ProteinQ8IWV8 (Uniprot-TrEMBL)
UBR4 ProteinQ5T4S7 (Uniprot-TrEMBL)
UFL1 ProteinO94874 (Uniprot-TrEMBL)
UNKL ProteinQ9H9P5 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
Ubiquitin activating E1 enzymesComplexR-HSA-947695 (Reactome)
Ubiquitin:E2 conjugating enzymesComplexR-HSA-976165 (Reactome)
Unknown hydrolaseR-HSA-8939794 (Reactome)
VAMP3 ProteinQ15836 (Uniprot-TrEMBL)
VAMP8 ProteinQ9BV40 (Uniprot-TrEMBL)
VAMP8,VAMP3ComplexR-HSA-8863861 (Reactome)
VHL ProteinP40337 (Uniprot-TrEMBL)
VPRBP ProteinQ9Y4B6 (Uniprot-TrEMBL)
WSB1 ProteinQ9Y6I7 (Uniprot-TrEMBL)
WWP1 ProteinQ9H0M0 (Uniprot-TrEMBL)
ZBTB16 ProteinQ05516 (Uniprot-TrEMBL)
ZNF645 ProteinQ8N7E2 (Uniprot-TrEMBL)
ZNRF1 ProteinQ8ND25 (Uniprot-TrEMBL)
ZNRF2 ProteinQ8NHG8 (Uniprot-TrEMBL)
antigenic substrate R-ALL-983035 (Reactome)
antigenic substrateR-ALL-983035 (Reactome)
class I MHC B13 ProteinP30461 (Uniprot-TrEMBL)
class I MHC B14 ProteinP30462 (Uniprot-TrEMBL)
class I MHC B15 ProteinP30464 (Uniprot-TrEMBL)
class I MHC B18 ProteinP30466 (Uniprot-TrEMBL)
class I MHC B27 ProteinP03989 (Uniprot-TrEMBL)
class I MHC B35 ProteinP30685 (Uniprot-TrEMBL)
class I MHC B37 ProteinP18463 (Uniprot-TrEMBL)
class I MHC B38 ProteinQ95365 (Uniprot-TrEMBL)
class I MHC B39 ProteinP30475 (Uniprot-TrEMBL)
class I MHC B40 ProteinQ04826 (Uniprot-TrEMBL)
class I MHC B41 ProteinP30479 (Uniprot-TrEMBL)
class I MHC B42 ProteinP30480 (Uniprot-TrEMBL)
class I MHC B44 ProteinP30481 (Uniprot-TrEMBL)
class I MHC B45 ProteinP30483 (Uniprot-TrEMBL)
class I MHC B46 ProteinP30484 (Uniprot-TrEMBL)
class I MHC B47 ProteinP30485 (Uniprot-TrEMBL)
class I MHC B49 ProteinP30487 (Uniprot-TrEMBL)
class I MHC B50 ProteinP30488 (Uniprot-TrEMBL)
class I MHC B51 ProteinP18464 (Uniprot-TrEMBL)
class I MHC B52 ProteinP30490 (Uniprot-TrEMBL)
class I MHC B53 ProteinP30491 (Uniprot-TrEMBL)
class I MHC B54 ProteinP30492 (Uniprot-TrEMBL)
class I MHC B55 ProteinP30493 (Uniprot-TrEMBL)
class I MHC B56 ProteinP30495 (Uniprot-TrEMBL)
class I MHC B57 ProteinP18465 (Uniprot-TrEMBL)
class I MHC B58 ProteinP10319 (Uniprot-TrEMBL)
class I MHC B59 ProteinQ29940 (Uniprot-TrEMBL)
class I MHC B67 ProteinQ29836 (Uniprot-TrEMBL)
class I MHC B7 ProteinP01889 (Uniprot-TrEMBL)
class I MHC B73 ProteinQ31612 (Uniprot-TrEMBL)
class I MHC B78 ProteinP30498 (Uniprot-TrEMBL)
class I MHC B8 ProteinP30460 (Uniprot-TrEMBL)
class I MHC B81 ProteinQ31610 (Uniprot-TrEMBL)
class I MHC B82 ProteinQ29718 (Uniprot-TrEMBL)
mip ProteinP26623 (Uniprot-TrEMBL)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ComplexR-HSA-983116 (Reactome)
monoglucosylated MHC class I HCComplexR-HSA-983120 (Reactome)
oligo-MyD88:TIRAP:BTK:activated TLRComplexR-HSA-937033 (Reactome)
oligopeptide fragment (3-7aa)MetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragment (8-16aa)MetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragmentMetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragmentR-ALL-1236721 (Reactome)
oligopeptide fragment R-ALL-1236721 (Reactome)
p-4Y-TIRAP ProteinP58753 (Uniprot-TrEMBL)
p-6S-NCF1 ProteinP14598 (Uniprot-TrEMBL)
p-S95-SNAP23 ProteinO00161 (Uniprot-TrEMBL)
p-S95-SNAP23:VAMP8,VAMP3ComplexR-HSA-8863972 (Reactome)
p-S95-SNAP23ProteinO00161 (Uniprot-TrEMBL)
p-T154,S315-NCF4 ProteinQ15080 (Uniprot-TrEMBL)
p-T233-NCF2 ProteinP19878 (Uniprot-TrEMBL)
partially digested AgR-ALL-1236713 (Reactome)
partially digested AgR-ALL-1236718 (Reactome)
precursor peptide fragment (>16 aa)MetaboliteCHEBI:25676 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-1236935 (Reactome)
26S proteasomemim-catalysisR-HSA-1236970 (Reactome)
26S proteasomemim-catalysisR-HSA-983150 (Reactome)
ADPArrowR-HSA-1236949 (Reactome)
ADPArrowR-HSA-8863895 (Reactome)
ADPArrowR-HSA-983144 (Reactome)
AMPArrowR-HSA-983140 (Reactome)
AMPArrowR-HSA-983153 (Reactome)
AMPArrowR-HSA-983156 (Reactome)
ATPR-HSA-1236949 (Reactome)
ATPR-HSA-8863895 (Reactome)
ATPR-HSA-983140 (Reactome)
ATPR-HSA-983144 (Reactome)
ATPR-HSA-983153 (Reactome)
ATPR-HSA-983156 (Reactome)
Ag peptide bound class I MHCArrowR-HSA-1236971 (Reactome)
Ag peptide bound class I MHCR-HSA-1236965 (Reactome)
Ag-substrate:E3:E2:UbArrowR-HSA-983157 (Reactome)
Ag-substrate:E3:E2:UbR-HSA-983140 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ArrowR-HSA-983161 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		R-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236943 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236965 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983422 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983427 (Reactome)
Antigen peptide bound class I MHCR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCR-HSA-983426 (Reactome)
Antigen peptide bound class I MHCR-HSA-983427 (Reactome)
Antigen peptideArrowR-HSA-1236954 (Reactome)
Antigen peptideArrowR-HSA-983158 (Reactome)
Antigen peptideR-HSA-1236943 (Reactome)
Antigen peptideR-HSA-8951499 (Reactome)
Antigenic

peptide:MHC:B2M peptide loading

complex		ArrowR-HSA-8951499 (Reactome)
Antigenic

peptide:MHC:B2M peptide loading

complex		R-HSA-983161 (Reactome)
B2M(21-119)R-HSA-983146 (Reactome)
BAP31 oligomerArrowR-HSA-983138 (Reactome)
BAP31 oligomerR-HSA-983142 (Reactome)
CALR:SEC22B:STX4:TAP:TAPBPArrowR-HSA-8863858 (Reactome)
CALR:SEC22B:STX4:TAP:TAPBPR-HSA-8951595 (Reactome)
CALRArrowR-HSA-8863914 (Reactome)
CALRArrowR-HSA-8951595 (Reactome)
CALRArrowR-HSA-983161 (Reactome)
CALRR-HSA-8863858 (Reactome)
CALRR-HSA-8863914 (Reactome)
CALRR-HSA-983142 (Reactome)
CHUK:IKBKB:IKBKGmim-catalysisR-HSA-8863895 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983424 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983425 (Reactome)
COPII vesicle with MHC class IR-HSA-983422 (Reactome)
COPII vesicle with MHC class IR-HSA-983424 (Reactome)
COPIImim-catalysisR-HSA-983422 (Reactome)
CTSS-like proteinsmim-catalysisR-HSA-1236948 (Reactome)
Chaperones calnexin/BiPArrowR-HSA-983146 (Reactome)
Chaperones calnexin/BiPR-HSA-983145 (Reactome)
Class I MHC HC:B2M:Erp57ArrowR-HSA-8863973 (Reactome)
Class I MHC HC:B2M:Erp57R-HSA-1236971 (Reactome)
Class I MHC HC:B2M:Erp57R-HSA-8863973 (Reactome)
Class I MHC:B2MR-HSA-1236943 (Reactome)
DC receptors

recognizing

apoptotic cells		ArrowR-HSA-1236956 (Reactome)
DC receptors

recognizing

apoptotic cells		R-HSA-1236958 (Reactome)
E1 bound ubiquitinArrowR-HSA-983153 (Reactome)
E1 bound ubiquitinR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983140 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983156 (Reactome)
E2 Ubiquitin-conjugating enzymeR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymemim-catalysisR-HSA-983152 (Reactome)
E3 ligases in

proteasomal

degradation		ArrowR-HSA-983147 (Reactome)
E3 ligases in

proteasomal

degradation		R-HSA-983157 (Reactome)
E3 ligases in

proteasomal

degradation		mim-catalysisR-HSA-983140 (Reactome)
E3:K48-polyubiquitinated substrateArrowR-HSA-983156 (Reactome)
E3:K48-polyubiquitinated substrateR-HSA-983147 (Reactome)
E3:Ub:substrateArrowR-HSA-983140 (Reactome)
E3:Ub:substrateR-HSA-983156 (Reactome)
E3:Ub:substratemim-catalysisR-HSA-983156 (Reactome)
ERAP1/2mim-catalysisR-HSA-983158 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236956 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236963 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236938 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236958 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236963 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236940 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236939 (Reactome)
Exogenous soluble antigenR-HSA-1236948 (Reactome)
Exogenous soluble antigenR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236970 (Reactome)
GDPR-HSA-983422 (Reactome)
GTPArrowR-HSA-983422 (Reactome)
H+ArrowR-HSA-1236967 (Reactome)
H2OR-HSA-1236949 (Reactome)
H2OR-HSA-983144 (Reactome)
H2OR-HSA-983422 (Reactome)
IFN gamma stimulated aminopeptidasesmim-catalysisR-HSA-983162 (Reactome)
IRAP in complex with MHC class Imim-catalysisR-HSA-1236954 (Reactome)
K48polyUb-antigenic substrateArrowR-HSA-983147 (Reactome)
K48polyUb-antigenic substrateR-HSA-983150 (Reactome)
K48polyUb-partially digested AgR-HSA-1236935 (Reactome)
L-amino acidArrowR-HSA-1236935 (Reactome)
L-amino acidArrowR-HSA-1236948 (Reactome)
L-amino acidArrowR-HSA-1236954 (Reactome)
L-amino acidArrowR-HSA-1236970 (Reactome)
L-amino acidArrowR-HSA-983150 (Reactome)
L-amino acidArrowR-HSA-983158 (Reactome)
L-amino acidArrowR-HSA-983162 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		ArrowR-HSA-983148 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		R-HSA-983146 (Reactome)
MHC HC:B2M:Erp57ArrowR-HSA-983146 (Reactome)
MHC HC:B2M:Erp57R-HSA-983142 (Reactome)
MHC:B2M peptide loading complexArrowR-HSA-983142 (Reactome)
MHC:B2M peptide loading complexR-HSA-8951499 (Reactome)
MR/other probable receptorsArrowR-HSA-1236940 (Reactome)
MR/other probable receptorsR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236941 (Reactome)
MR:soluble antigenArrowR-HSA-1236955 (Reactome)
MR:soluble antigenR-HSA-1236940 (Reactome)
MR:soluble antigenR-HSA-1236941 (Reactome)
MR:soluble antigenR-HSA-1236955 (Reactome)
Mg2+ArrowR-HSA-983153 (Reactome)
Mg2+R-HSA-983153 (Reactome)
NADP+ArrowR-HSA-1236967 (Reactome)
NADPHR-HSA-1236967 (Reactome)
NOX2 complexmim-catalysisR-HSA-1236967 (Reactome)
O2.-ArrowR-HSA-1236967 (Reactome)
O2R-HSA-1236967 (Reactome)
PDIA3ArrowR-HSA-983161 (Reactome)
PDIA3R-HSA-983148 (Reactome)
PPiArrowR-HSA-983140 (Reactome)
PPiArrowR-HSA-983153 (Reactome)
PPiArrowR-HSA-983156 (Reactome)
Particulate Ag:DC receptorsArrowR-HSA-1236958 (Reactome)
Particulate Ag:DC receptorsR-HSA-1236956 (Reactome)
PiArrowR-HSA-1236949 (Reactome)
PiArrowR-HSA-983144 (Reactome)
R-HSA-1236935 (Reactome) Proteasomes are usually localized to the cytoplasm but are also present in the nucleus and ER. Houde et al. (2003) investigated the distribution of proteasomes in J774 macrophages and observed them on phagosomes. The proteasomes present on phagosomes may not come directly from ER, but instead assemble on phagosomes to play a function at a precise point during phagolysosomal biogenesis. Houde et al. also observed polyubiquitinated proteins on the cytoplasmic side of phagosomes and highlighted the link between the ubiquitination process and proteasomal degradation; translocated peptides are ubiquitinated and processed by the proteasome complex assembled on the cytoplasmic side of phagosomes, leading to the generation of MHC class I binding peptides.
R-HSA-1236938 (Reactome) Phagocytosed particulate antigens are partially digested in the lumen of phagolysosomes by various lysosomal hydrolases.
R-HSA-1236939 (Reactome) Soluble antigens are presented to dendritic cells (DCs) in some cases by receptor mediated endocytosis or fluid-phase endocytosis. Burgdorf et al. (2008) suggest that there are two different endocytic compartments for antigen processing: one dedicated to MHC class I (early endosomes) and the other one for MHC class II presentation (lysosomes). Sorting of cargo into these different compartments occurs at the plasma membrane and is likely to depend on the type of endocytic receptor the cargo is interacting with (Burgdorf et al. 2008, Zhuang et al. 2006). The mannose receptor (MR) is the best studied receptor that targets soluble antigens to early endosomes but not to lysosomes (Burgdorf et al. 2006). Antigens taken up by the MR are targeted towards a mildly acidic stable early endosomal compartment for exclusive presentation on MHC I molecules (Burgdorf et al. 2008).
R-HSA-1236940 (Reactome) Within the endosome the receptor and cargo separate and the receptor recycles back to the cell surface. Soluble antigens are targeted into the stable early endosome lumen for efficient cross presentation. Early endosomes are mildly acidic and relatively poor in proteases.
R-HSA-1236941 (Reactome) Receptor-bound exogenous antigens in coated pits on the cell surface are internalized into clathrin-coated vesicles.
R-HSA-1236943 (Reactome) Peptides generated by Cathepsin S or IRAP-mediated proteolysis in the endosomes are loaded onto MHC class I molecules, which are internalized and transported to early and late endosomal compartments where antigenic peptides can be loaded. A fraction of the internalized cell surface class I molecules enter MHC class II compartments (MIICs) within endocytic vesicles (Gromme et al. 1999, Kleijmeer et al. 2001). Microscopic analysis has revealed that surface MHC-I molecules are internalized and transported to early and late endosomal compartments (Basha et al. 2008, Lizee et al. 2003). A tyrosine-based endocytic trafficking motif (YXXA) is required for the constitutive internalization of MHC-I molecules from the cell surface into early/late endosomes for peptide loading (Basha et al. 2008, Lizee et al. 2003). Upon entry in to these endosomal compartments the MHC class I complexes exchange their pre-bound peptides with exogenously derived antigenic peptides.
R-HSA-1236947 (Reactome) Fusion of the maturing phagosome with the ER mediates the exchange of materials resulting in the formation of a hybrid ER-phagosome compartment (Gagnon et al. 2002, Guermonprez et al. 2003, Houde et al. 2003, Ackerman et al. 2003, Blanchard et al. 2010). This hybrid contains the retrotranslocon factor Sec61 that mediates the access of proteasomes on the cytosolic surface of the phagosome. Using fluorescence imaging, Houde et al. (2003) provided evidence for the role of Sec61 in the retrotranslocation of internalized exogenous proteins from phagosomes to the cytoplasmic face of J774 macrophages. Sec61 factor is a heterotrimeric complex composed of alpha, beta and gamma subunits forming the core of the mammalian ER translocon (Greenfield et al. 1999). Oligomers of the Sec61 complex form a transmembrane channel involved in the retrotranslocation of misfolded proteins from ER to the cytosol for degradation, and thus it has been proposed that Sec61 might be involved in the translocation of proteins in phagosomes to the cytosol (Kasturi et al. 2008).
R-HSA-1236948 (Reactome) Endocytic compartments contain many cysteine proteases such as cathepsin S that can generate cross-presented peptides. Cathepsins may participate in the generation of MHC class II-presentated peptides (Villadangos et al. 1999). Shen et al. (2004) demonstrated that cathepsin S contributes to TAP-independent cross-presentation in vivo, showing that ovalbumin was cross-presented by denritic cells (DCs) through both TAP-dependent and TAP-independent pathways. The TAP-independent pathway was sensitive to the cystine protease inhibitor leupeptin, but not to proteasome inhibitors. Further experiments with knockout mice showed that cathepsin S contributed to cross-presentation. DCs lacking cathepsin S lack the TAP-independent pathway (Khor et al. 2008, Shen et al. 2004).
R-HSA-1236949 (Reactome) After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.
R-HSA-1236954 (Reactome) While it is established that cathepsin S is involved in antigen processing in endocytotic vesicles, it is less certain whether other proteases present in endocytic vesicles are also involved in generating the peptide fragments. Insulin regulated aminopeptidase (IRAP) is an epitope-trimming zinc-dependent aminopeptidase closely related to ERAP1 and ERAP2. IRAP may be involved in vacuolar processing of the peptide fragments within endosomes (Saveanu et al. 2009, Segura et al. 2009). IRAP is detected predominantly in the early and recycling endosome fractions. Saveanu et al. (2009) observed the physical association of IRAP with internalized class I MHC molecules and suggested that this may favour a direct linkage between peptide trimming and MHC class I loading. They also showed that IRAP-dependent processing of antigens requires active proteasome but not lysosomal proteases, which suggests that this pathway utilizes cytosolic degradation followed by peptide transport into IRAP-containing endosomes.
R-HSA-1236955 (Reactome) The antigen:receptor complex moves from clathrin-coated vesicles to the early endosome membrane.
R-HSA-1236956 (Reactome) After internalization, F-actin is depolymerized from the phagosome, and the newly denuded vacuole membrane becomes accessible to early endosomes (Aderem & Underhill. 1999).
R-HSA-1236958 (Reactome) Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
R-HSA-1236963 (Reactome) Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.

fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.
R-HSA-1236964 (Reactome) Peptide-loaded MHC class I complexes are transported by an undefined mechanism back to the cell surface for cross-presentation to T cells.
R-HSA-1236965 (Reactome) Exogenous antigen loaded class I MHC molecules in phagosomes may be delivered to the surface by membrane recycling machinery.
R-HSA-1236967 (Reactome) After the fusion of phagosome and lysosome lumen acidity rises and the activity of lysosomal proteases increases, conferring proteolytic ability. However antigens must be spared from complete proteolytic destruction. Dendritic cells (DCs) achieve this by regulating the level of proteolysis and phagosomal acidification. DCs recruit the NADPH oxidase NOX2 to the phagosome and mediate sustained production of low levels of reactive oxygen species (ROS), causing active alkalization of the phagosomal lumen (Savina et al. 2006, Ramachandra et al. 2009). NOX2 consumes oxygen and protons (pumped by V-ATPase or other H+ voltage-gated channels) to produce ROS and this lowers phagosome acidity. This apparently reduces antigen proteolysis to a level that allows processing but does not fully destroy the antigenic peptides, favouring increased MHC-I cross presentation (Ramachandra et al. 2009). Rab27a controls the recruitment of NOX2 to DC phagosomes (Savina et al. 2007).
R-HSA-1236968 (Reactome) Endocytosed antigens must leave the endocytic structure to enter into the MHC I pathway before exhaustive degradation within lysosomes. The canonical pathway is the transporter associated with antigen processing (TAP)-dependent cytosolic pathway, which involves the translocation of endocytosed antigens into the cytosol where they are degraded into antigenic peptides by the proteasome and transported to ER through TAP. This hypothesis comes from indirect evidences showing that proteasome inhibitors block cross presentation of certain antigens (Amigorena et al. 2010, Burgdorf et al. 2008) . According to this model antigens are translocated into the cytosol by an undefined mechanism.
There are less well-characterized mechanisms for the delivery of exogenous antigens into the cytosol. Certain peptides with highly positively charged sequences derived from HIV tat protein or the Antennapedia homeodomain (AntHD) protein seem to penetrate into the cytosol directly across the plasma membrane (Monu et al. 2007, Vendeville et al. 2004). It is also proposed that some exogenous antigens can be exchanged between neighboring cells through gap junctions, leading to cross presentation by the recipient cell (Monu et al. 2007, Neijssen et al. 2005).
Once internalized antigens are routed into the cytosol, they follow the conventional pathway of proteasome digestion and TAP mediated transport of peptides into the ER lumen.
R-HSA-1236970 (Reactome) Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.
R-HSA-1236971 (Reactome) Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen.
R-HSA-1236972 (Reactome) Upon phagolysosomal proteolysis the phagocytosed proteins still need to gain access to the cytosol for proteasomal access, transport into the ER and loading onto MHC class I. The mechanism for this escape of phagocytosed antigens remain unknown.
R-HSA-203979 (Reactome) Sar1p-GTP recruits the cytoplasmic Sec23p-Sec24p complex. (Though not represented in the subsequent steps, Sec23p-Sec24p would bind to members of the p24 protein family of possible cargo receptors, and together with Sar1p bind the appropiate v-SNARE, and Rab-GTP.)



R-HSA-8863858 (Reactome) The interaction between the two compartments could involve either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
R-HSA-8863895 (Reactome) A major reserve of MHC-I in dendritic cells reside within the endocytic recycling compartments (ERC). MHC-I trafficking to the ERC is regulated by the activity of Rab11a and subsequent trafficking from ERC to phagosomes is controlled by TLR-MyD88-IKK2-dependent phosphorylation of phagosomal SNAP23. Toll-like receptor (TLR) signalling regulate cross-presentation as they regulate phagocytosis and phagolysosomal fusion (Nair et al. 2011). MHC-I bearing ERC are enriched with R-SNAREs like RAB11a, VAMP3, and VAMP8. These SNARE molecules can interact with Q-SNARE SNAP23 present on phagosomes and this mediates membrane fusion. This interaction of SNAP23 with R-SNAREs require phosphorylation of SNAP23 (on Ser-95) by IKK2, and IKK2 is activated by TLR signalling. SNAP23 phosphorylation may increase SNAP23 binding to SNAREs. It may also regulate platelet and mast cell secretion (Karim et al. 2013, Suziki & Verma 2008).
R-HSA-8863914 (Reactome) In DCs subset of ER proteins including MHC-I peptide loading complex (PLC) and transporter associated with antigen processing (TAP) transit to phagosomes via the intermediate compartment ER-Golgi intermediate compartment (ERGIC) (Cebrian et al. 2011). TAP exits the ER in COPII vesicles in association with MHC class I, and that peptide translocation by TAP and binding to class I can occur in post-ER compartments (Ghanem et al. 2010). SEC22B, an ER-resident SNARE is required for the transport of PLC from ERGIC (Cebrian et al. 2011), but this step does not deliver MHC-I (Nair-Gupta et al. 2014). Instead, MHC-I are recruited from an endosomal recycling compartment (ERC), which is marked by Rab11a, VAMP3/cellubrevin, and VAMP8/endobrevin that holds large reserves of MHC-I. This step is dependent on TLR signalling (Nair-Gupta et al. 2014).
R-HSA-8863973 (Reactome) Recycling endosome-localized R-SNARE protein like RAB11a, VAMP3, and VAMP8 dock with target phagosome membrane Q-SNARE protein SNAP23. MHC-I present on the recycling endosomes would be delivered to phagosomes during this process.
R-HSA-8940641 (Reactome) Thimet oligopeptidase (THOP1, EP24.15) is a zinc-dependent peptidase of the metallopeptidase M3 family (Pierotti et al. 1990). It was first described as a neuropeptide-degrading enzyme present in the soluble fraction of brain homogenates (Orlowski et al. 1983). However, its predominant location in the cytosol and nucleus suggests that extracellular degradation of neuropeptides and hormones is not its primary function (Fontenele-Neto et al. 2001). THOP1 can metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. It was shown in vivo to participate in antigen presentation through MHC-I (Silva et al. 1999, Kim et al. 2003, Yorl et al. 2003) and in vitro to bind (Portaro et al. 1999) or degrade (Saric et al. 2001) some MHC-I associated peptides. THOP1 can degrade a broad range of intracellular peptides containing 5–17 amino acids (Oliveira et al. 2001, Berti et al. 2009). Substrate size is restricted because its catalytic center is located in a deep channel (Ray et al. 2004). THOP1 can both degrade existing peptides and generate new peptides, making it a versatile enzyme for regulating intracellular peptide function including antigen presentation (Berti et al. 2009, Russo et al. 2012).

Cytotoxic T lymphocytes (CTLs) recognize peptides presented by HLA class I molecules on the cell surface. The C terminus of these CTL epitopes is considered to be produced by the proteasome, but is complemented by THOP1 and other cytosolic endopeptidases such as Nardilysin (Kessler et al. 2011, Oliveira & van Hall 2015).
R-HSA-8951499 (Reactome) MHC class I heterodimers are only stable in peptide bound form and only as a trimer (with bound peptide) present on the cell surface. Class I MHC molecules prefer nonapeptides, and less frequently use octa- or deca-peptides. The peptide binding groove in MHC class I molecules is formed by the intimate association of the alpha1 and alpha2 domains of the heavy chain. Structural studies have revealed that the alpha1:alpha2 domains form a single peptide binding groove consisting of 2 parallel helices on a floor of 8 beta-strands. Hydrogen bonding networks are established in the binding groove with the antigenic peptide main chain and terminal atoms that enable largely sequence independent ligation. Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al, 2009; Garstka et al, 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al, 2009).
R-HSA-8951595 (Reactome) The interaction between the two compartments involves either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
R-HSA-983138 (Reactome) When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.
R-HSA-983140 (Reactome) Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).
R-HSA-983142 (Reactome) Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptor–associated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules.
R-HSA-983144 (Reactome) Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.
R-HSA-983145 (Reactome) The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation.
R-HSA-983146 (Reactome) Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.
R-HSA-983147 (Reactome) K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.
R-HSA-983148 (Reactome) Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.
R-HSA-983150 (Reactome) The 26S proteasome complex consists of the 20S catalytic core particle which harbours the proteolytically active sites and the regulatory 19S particle which is responsible for substrate interaction. This process generates a vast number (perhaps hundreds) of different peptides, depending on the length and sequence of the substrate protein. Only a small fraction of these peptides (nearly 10%) form the exact length to be presented by class I MHC; most (approximately 70%) are too short to bind. The remaining proteasome products (10-20%) are N-terminally extended precursors that require additional cleavage by cytosolic aminopeptidases for presentation by MHC class I molecules.
R-HSA-983152 (Reactome) Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002).
R-HSA-983153 (Reactome) Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here.
R-HSA-983156 (Reactome) Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).
R-HSA-983157 (Reactome) Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).
R-HSA-983158 (Reactome) Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
R-HSA-983161 (Reactome) Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al. 2009, Garstka et al. 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al. 2009).
R-HSA-983162 (Reactome) Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).
R-HSA-983421 (Reactome) Cargo must pass through the various compartments of the Golgi complex to reach the plasma membrane. This may occur through either of the two well known models, cisternal maturation or vesicular transport (Refer to review articles Glick et al. 2009, Jackson 2009, Nakano et al. 2010).
R-HSA-983422 (Reactome) Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.
R-HSA-983424 (Reactome) Once the entire COPII coat has been assembled, the bud is separated from the ER membrane in the form of a COPII coated vesicle.
R-HSA-983425 (Reactome) Sec13-Sec31 binds the prebudding complex and this Sec13-Sec31 heterotetramer forms the outer structural scaffold of the coat. Sec13-Sec31 is likely to crosslink the prebudding complexes generating COPII-coated vesicles.
R-HSA-983426 (Reactome) The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.
R-HSA-983427 (Reactome) After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane. There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat.
SAR1B:GDPArrowR-HSA-983422 (Reactome)
SAR1B:GTP:SEC23:SEC24ArrowR-HSA-203979 (Reactome)
SAR1B:GTP:SEC23:SEC24R-HSA-983426 (Reactome)
SAR1B:GTPR-HSA-203979 (Reactome)
SEC13ArrowR-HSA-983422 (Reactome)
SEC13R-HSA-983425 (Reactome)
SEC22B:STX4ArrowR-HSA-8951595 (Reactome)
SEC22BArrowR-HSA-8863914 (Reactome)
SEC22BR-HSA-8863858 (Reactome)
SEC22BR-HSA-8863914 (Reactome)
SEC23:SEC24R-HSA-203979 (Reactome)
SEC23AArrowR-HSA-983422 (Reactome)
SEC24ArrowR-HSA-983422 (Reactome)
SEC31AArrowR-HSA-983422 (Reactome)
SEC31AR-HSA-983425 (Reactome)
SNAP23R-HSA-8863895 (Reactome)
STX4R-HSA-8863858 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IArrowR-HSA-983426 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IR-HSA-983425 (Reactome)
TAPArrowR-HSA-8863914 (Reactome)
TAPArrowR-HSA-8951595 (Reactome)
TAPArrowR-HSA-983161 (Reactome)
TAPBPArrowR-HSA-8863914 (Reactome)
TAPBPArrowR-HSA-8951595 (Reactome)
TAPBPArrowR-HSA-983161 (Reactome)
TAPBPR-HSA-8863858 (Reactome)
TAPBPR-HSA-8863914 (Reactome)
TAPBPR-HSA-983142 (Reactome)
TAPR-HSA-8863858 (Reactome)
TAPR-HSA-8863914 (Reactome)
TAPR-HSA-983142 (Reactome)
TAPmim-catalysisR-HSA-1236949 (Reactome)
TAPmim-catalysisR-HSA-983144 (Reactome)
THOP1mim-catalysisR-HSA-8940641 (Reactome)
Transloconmim-catalysisR-HSA-1236947 (Reactome)
UbArrowR-HSA-1236935 (Reactome)
UbArrowR-HSA-983150 (Reactome)
UbR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin activating E1 enzymesR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesmim-catalysisR-HSA-983153 (Reactome)
Ubiquitin:E2 conjugating enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983156 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983157 (Reactome)
Unknown hydrolasemim-catalysisR-HSA-1236938 (Reactome)
VAMP8,VAMP3R-HSA-8863973 (Reactome)
antigenic substrateR-HSA-983157 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ArrowR-HSA-983145 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		R-HSA-983148 (Reactome)
monoglucosylated MHC class I HCR-HSA-983145 (Reactome)
oligo-MyD88:TIRAP:BTK:activated TLRArrowR-HSA-8863895 (Reactome)
oligopeptide fragment (3-7aa)ArrowR-HSA-8940641 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-1236935 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983150 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983162 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-1236949 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-8940641 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-983144 (Reactome)
oligopeptide fragmentArrowR-HSA-1236949 (Reactome)
oligopeptide fragmentArrowR-HSA-983144 (Reactome)
oligopeptide fragmentR-HSA-1236971 (Reactome)
oligopeptide fragmentR-HSA-983158 (Reactome)
p-S95-SNAP23:VAMP8,VAMP3ArrowR-HSA-8863973 (Reactome)
p-S95-SNAP23ArrowR-HSA-8863895 (Reactome)
p-S95-SNAP23R-HSA-8863973 (Reactome)
partially digested AgArrowR-HSA-1236938 (Reactome)
partially digested AgArrowR-HSA-1236947 (Reactome)
partially digested AgArrowR-HSA-1236972 (Reactome)
partially digested AgR-HSA-1236947 (Reactome)
partially digested AgR-HSA-1236972 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236948 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236970 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-983150 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-1236954 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-983162 (Reactome)
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