NR1D1 (REV-ERBA) represses gene expression (Homo sapiens)

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1-4nucleoplasmNCOR1NR1D1 HDAC3ferriheme bferriheme b NCOR1 ELOVL3 geneNR1D1ELOVL3 gene HDAC3 NR1D1:heme:Corepressors:ELOVL3 gene


Description

REV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thus REV-ERBA and RORA appear to compete to repress or activate genes, repectively. View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 1368071
Reactome-version 
Reactome version: 74
Reactome Author 
Reactome Author: May, Bruce

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Bibliography

  1. Yin L, Wu N, Lazar MA.; ''Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism.''; PubMed Europe PMC Scholia
  2. Phelan CA, Gampe RT, Lambert MH, Parks DJ, Montana V, Bynum J, Broderick TM, Hu X, Williams SP, Nolte RT, Lazar MA.; ''Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.''; PubMed Europe PMC Scholia
  3. Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F.; ''Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.''; PubMed Europe PMC Scholia
  4. Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, Waitt GM, Parks DJ, Pearce KH, Wisely GB, Lazar MA.; ''Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114863view16:37, 25 January 2021ReactomeTeamReactome version 75
113309view11:38, 2 November 2020ReactomeTeamReactome version 74
112520view15:48, 9 October 2020ReactomeTeamReactome version 73
101432view11:30, 1 November 2018ReactomeTeamreactome version 66
100970view21:08, 31 October 2018ReactomeTeamreactome version 65
100507view19:42, 31 October 2018ReactomeTeamreactome version 64
100053view16:25, 31 October 2018ReactomeTeamreactome version 63
99605view14:59, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93993view13:50, 16 August 2017ReactomeTeamreactome version 61
93601view11:28, 9 August 2017ReactomeTeamreactome version 61
88073view08:58, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86708view09:24, 11 July 2016ReactomeTeamreactome version 56
83206view10:22, 18 November 2015ReactomeTeamVersion54
81587view13:07, 21 August 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ELOVL3 gene ProteinENSG00000119915 (Ensembl)
ELOVL3 geneGeneProductENSG00000119915 (Ensembl)
HDAC3 ProteinO15379 (Uniprot-TrEMBL)
HDAC3ProteinO15379 (Uniprot-TrEMBL)
NCOR1 ProteinO75376 (Uniprot-TrEMBL)
NCOR1ProteinO75376 (Uniprot-TrEMBL)
NR1D1 ProteinP20393 (Uniprot-TrEMBL)
NR1D1:heme:Corepressors:ELOVL3 geneComplexR-HSA-5663261 (Reactome)
NR1D1ProteinP20393 (Uniprot-TrEMBL)
ferriheme b MetaboliteCHEBI:36144 (ChEBI)
ferriheme bMetaboliteCHEBI:36144 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ELOVL3 geneR-HSA-5663252 (Reactome)
HDAC3R-HSA-5663252 (Reactome)
NCOR1R-HSA-5663252 (Reactome)
NR1D1:heme:Corepressors:ELOVL3 geneArrowR-HSA-5663252 (Reactome)
NR1D1R-HSA-5663252 (Reactome)
R-HSA-5663252 (Reactome) As inferred from mouse homologs, REV-ERBA (NR1D1) binds the promoter of the ELOVL3 gene and represses transcription, possibly by recruiting corepressors.
ferriheme bR-HSA-5663252 (Reactome)
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