FAS pathway and stress induction of HSP regulation (Canis familiaris)
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1
Proteasome
Apoptosome
Nucleus
3x-P
ROS
Extracellular
Stress Induction of HSP regulation
Self-activation
FAS Pathway
3x-P
3x-P
Cell Survival
Activate
NFK-B Pathway
Cut
DNA presentation
Mitochondria Pathway
Necrosis
Cytoplasm
Stress
Inhibition
Phosphate
MAPKAPK3
SPTAN1
RB1
JUN
HSPB1
LMNB2
CASP3
Phosphate
MAP2K4
FAF1
LMNA
IL1A
HSPB1
Glutathione
Ceramide
CYCS
CASP3
HSPB1
FAF1
DAXX
PAK1
DAXX
DFFB
MAPK8
ARHGDIB
HSPB1
Phosphate
PARP1
HSPB1
PAK2
HSPB1
CASP7
FAS
CASP8
CASP6
RIPK2
PRKDC
CASP9
TNF
DFFA
MAPKAPK2
FADD
Apoptosis
CASP8
Phosphate
Phosphate
HSPB1
HSPB1
CASP10
APAF1
APAF1
Phosphate
MAP3K1
actin
Phosphate
CFLAR
FASLG
Phosphate
LMNB1
FAP1
DFFB
BCL2
MAP3K7
Description
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info:
BioCarta
.
Comments
GenMAPP remarks
Converted to human by GenMAPP.org.
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP314(r45253)
with a 88% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117076
view
14:45, 16 May 2021
Eweitz
Modified title
114231
view
21:45, 27 December 2020
Andra
connect unconnected line
114091
view
08:46, 22 December 2020
Egonw
Made a pathway clickable
106047
view
11:56, 16 August 2019
MaintBot
HMDB identifier normalization
68520
view
22:03, 5 July 2013
MaintBot
Updated to 2013 gpml schema
67220
view
10:22, 26 June 2013
Christine Chichester
Ontology Term : 'FasL mediated signaling pathway' added !
48166
view
20:25, 9 May 2012
MaintBot
Updating from human to fix xrefs
40674
view
21:49, 1 March 2011
MaintBot
Removed redundant pathway information and comments
38227
view
21:07, 27 August 2010
Khanspers
Removed receptors and Protein Complex graphics
35555
view
14:59, 12 February 2010
Thomas
Modified description
35552
view
14:57, 12 February 2010
Thomas
added literature
33964
view
18:26, 9 December 2009
MaintBot
Automatic update of empty xrefs
32567
view
13:11, 17 August 2009
MaintBot
Fixed text labels
32246
view
12:54, 15 August 2009
MaintBot
Fixed text labels
31759
view
12:05, 14 August 2009
MaintBot
Fixed group labels
31265
view
19:56, 13 August 2009
MaintBot
Fixed text labels
30707
view
22:51, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
APAF1
GeneProduct
482620 (Entrez Gene)
ARHGDIB
GeneProduct
486666 (Entrez Gene)
Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
Apoptosis
Pathway
WP254 (WikiPathways)
BCL2
GeneProduct
403416 (Entrez Gene)
CASP10
GeneProduct
488472 (Entrez Gene)
CASP3
GeneProduct
403567 (Entrez Gene)
CASP6
GeneProduct
487899 (Entrez Gene)
CASP7
GeneProduct
CASP8
GeneProduct
488473 (Entrez Gene)
CASP9
GeneProduct
487432 (Entrez Gene)
CFLAR
GeneProduct
488471 (Entrez Gene)
CYCS
GeneProduct
475258 (Entrez Gene)
Ceramide
Metabolite
104404-17-3 (CAS)
DAXX
GeneProduct
474873 (Entrez Gene)
DFFA
GeneProduct
487449 (Entrez Gene)
DFFB
GeneProduct
489623 (Entrez Gene)
FADD
GeneProduct
FAF1
GeneProduct
608231 (Entrez Gene)
FAP1
GeneProduct
FAS
GeneProduct
486469 (Entrez Gene)
FASLG
GeneProduct
442968 (Entrez Gene)
Glutathione
Metabolite
HMDB0000125 (HMDB)
HSPB1
GeneProduct
403979 (Entrez Gene)
IL1A
GeneProduct
403782 (Entrez Gene)
JUN
GeneProduct
609429 (Entrez Gene)
LMNA
GeneProduct
480124 (Entrez Gene)
LMNB1
GeneProduct
474663 (Entrez Gene)
LMNB2
GeneProduct
485070 (Entrez Gene)
MAP2K4
GeneProduct
MAP3K1
GeneProduct
478061 (Entrez Gene)
MAP3K7
GeneProduct
MAPK8
GeneProduct
477746 (Entrez Gene)
MAPKAPK2
GeneProduct
490263 (Entrez Gene)
MAPKAPK3
GeneProduct
484756 (Entrez Gene)
PAK1
GeneProduct
607885 (Entrez Gene)
PAK2
GeneProduct
612814 (Entrez Gene)
PARP1
GeneProduct
490385 (Entrez Gene)
PRKDC
GeneProduct
474176 (Entrez Gene)
Phosphate
Metabolite
HMDB0001429 (HMDB)
RB1
GeneProduct
476915 (Entrez Gene)
RIPK2
GeneProduct
477936 (Entrez Gene)
receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1
GeneProduct
403484 (Entrez Gene)
Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNF
GeneProduct
403922 (Entrez Gene)
actin
GeneProduct
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions