Protein alkylation leading to liver fibrosis (Homo sapiens)

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1KER 269KE244: Protein alkylationCCl4ApoptosisDimethylnitrosamineretinolallyl alcoholthioacetamideTNF alpha Signaline PathwayCollagen biosynthesis and modifying enzymesApoptosis Modulation and SignalingKE55: Cell injury/deathKE134: Increased activation and recruitment of Kupffer CellsKER 67KE276: TGFbeta1 expression up regulationKER 147KE265: Stellate cell activationKER 304KE68: Collagen accumulationKER 295KE344: Liver FibrosisKER 68KER 82


Description

Protein alkylation leading to liver fibrosis This pathway is based on descriptive text of the adverse outcome pathway (AOP) on https://aopwiki.org/aops/38

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Quality Tags

Ontology Terms

 

Bibliography

  1. Horvat T, Landesmann B, Lostia A, Vinken M, Munn S, Whelan M; ''Adverse outcome pathway development from protein alkylation to liver fibrosis.''; Arch Toxicol, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125572view13:09, 28 February 2023Marvin M2created event nodes
125571view13:07, 28 February 2023Marvin M2added KE nodes
125570view12:50, 28 February 2023Marvin M2Added tgf-beta pathway
114317view16:15, 6 January 2021Marvin M2Updated layout
114316view16:06, 6 January 2021Marvin M2Renewed and removed molecular entities to follow AOP guidelines
96718view16:23, 30 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96693view15:51, 27 March 2018Marvin M2Added references to Key Events and Key Event Relationships
93134view13:39, 31 July 2017Marvin M2Added the main reference for this AOP
92321view11:11, 22 May 2017Marvin M2Ontology Term : 'liver disease pathway' added !
92320view11:04, 22 May 2017Marvin M2Ontology Term : 'liver disease' added !
92296view12:59, 19 May 2017Marvin M2Modified description
92294view12:47, 19 May 2017Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Apoptosis Modulation and SignalingPathwayWP1772 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
CCl4MetaboliteCHEBI:27385 (ChEBI)
Collagen biosynthesis and modifying enzymesPathwayWP2725 (WikiPathways)
DimethylnitrosamineMetaboliteCHEBI:35807 (ChEBI)
TNF alpha Signaline PathwayPathwayWP231 (WikiPathways)
allyl alcoholMetaboliteCHEBI:16605 (ChEBI)
retinolMetaboliteCHEBI:50211 (ChEBI)
thioacetamideMetaboliteQ416253 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3980"
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