ACE2 inhibition leads to pulmonary fibrosis (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Clerbaux LA, Amigó N, Amorim MJ, Bal-Price A, Batista Leite S, Beronius A, Bezemer GFG, Bostroem AC, Carusi A, Coecke S, Concha R, Daskalopoulos EP, De Bernardi F, Edrosa E, Edwards SW, Filipovska J, Garcia-Reyero N, Gavins FNE, Halappanavar S, Hargreaves AJ, Hogberg HT, Huynh MT, Jacobson D, Josephs-Spaulding J, Kim YJ, Kong HJ, Krebs CE, Lam A, Landesmann B, Layton A, Lee YO, Macmillan DS, Mantovani A, Margiotta-Casaluci L, Martens M, Masereeuw R, Mayasich SA, Mei LM, Mortensen H, Munoz Pineiro A, Nymark P, Ohayon E, Ojasi J, Paini A, Parissis N, Parvatam S, Pistollato F, Sachana M, Sørli JB, Sullivan KM, Sund J, Tanabe S, Tsaioun K, Vinken M, Viviani L, Waspe J, Willett C, Wittwehr C; ''COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop.''; ALTEX, 2022 PubMed Europe PMC Scholia
2. Wittwehr C, Amorim MJ, Clerbaux LA, Krebs C, Landesmann B, Macmillan DS, Nymark P, Ram R, Garcia-Reyero N, Sachana M, Sullivan K, Sund J, Willett C; ''Understanding COVID-19 through adverse outcome pathways - 2nd CIAO AOP Design Workshop.''; ALTEX, 2021 PubMed Europe PMC Scholia
3. Nymark P, Sachana M, Leite SB, Sund J, Krebs CE, Sullivan K, Edwards S, Viviani L, Willett C, Landesmann B, Wittwehr C; ''Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework.''; Front Public Health, 2021 PubMed Europe PMC Scholia

History

View all...

Compare	Revision	Action	Time	User	Comment
	134596	view	01:07, 23 July 2024	Eweitz	Ontology Term : 'kallikrein-kinin cascade pathway' added !
	125622	view	20:00, 5 March 2023	AlexanderPico	Modified description
	125577	view	13:33, 28 February 2023	Marvin M2	Replaced 2 Event notes with labels since these do not exist in AOP-Wiki
	125576	view	13:28, 28 February 2023	Marvin M2	Added references
	125575	view	13:25, 28 February 2023	Marvin M2	Ontology Term : 'CL:0000057' removed !
	118508	view	09:17, 28 May 2021	Finterly	Replace DataNode Type "Key Event" with "Event"
	116869	view	20:52, 14 May 2021	Marvin M2	Added KE pathway and connected line
	116321	view	11:36, 30 April 2021	Marvin M2	added KE pathways
	116261	view	12:51, 22 April 2021	Marvin M2	added chain of bradykinin and prostaglandin
	116260	view	11:17, 22 April 2021	Marvin M2	corrected WP IDs
	116232	view	14:38, 21 April 2021	Marvin M2	Ontology Term : 'fibroblast' added !
	116231	view	14:38, 21 April 2021	Marvin M2	Ontology Term : 'angiotensin II signaling pathway via AT1 receptor' added !
	116230	view	14:36, 21 April 2021	Marvin M2	Ontology Term : 'pulmonary fibrosis' added !
	116229	view	14:36, 21 April 2021	Marvin M2	Ontology Term : 'COVID-19' added !
	116227	view	13:16, 21 April 2021	Marvin M2
	116226	view	13:15, 21 April 2021	Marvin M2	typo in database
	116225	view	13:15, 21 April 2021	Marvin M2
	116224	view	13:10, 21 April 2021	Marvin M2	Added KEs for AOP382
	114326	view	08:52, 7 January 2021	Marvin M2
	114325	view	08:51, 7 January 2021	Marvin M2
	114321	view	17:37, 6 January 2021	Marvin M2	New pathway

External references

DataNodes

View all...

Name	Type	Database reference	Comment
Collagen biosynthesis and modifying enzymes	Pathway	WP2725 (WikiPathways)
KE1276: Lung Fibrosis
KE1740: ACE2 inhibition
KE1743: Increased plasma Angiotensin II
KE1752: Increased Angiotensin II
KE68: Collagen Accumulation
Metabolism of Angiotensinogen to Angiotensins	Pathway	WP2729 (WikiPathways)
Renin Angiotensin Aldosterone System	Pathway	WP4756 (WikiPathways)

Annotated Interactions

No annotated interactions