XBP1(S) activates chaperone genes (Homo sapiens)

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1, 2, 10, 13, 1510101010101010101110101010107-9103, 410104, 121010101010101010101013106, 14101010101015105101010101010Golgi lumenlysosomal lumenendoplasmic reticulum membranemitochondrial matrixendosomeendoplasmic reticulum lumennucleoplasmcytosolHYOU1DDX11GFPT1PDIA5 geneTLN1PDIA5ATP6V0D1 geneGOSR2 geneSHC1DCTN1 genePPP2R5BDNAJB9GOSR2KLHDC3 geneFKBP14WFS1CXXC1C19orf10SEC31AFKBP14 geneTSPYL2 geneSULT1A3GSK3AEDEM1 geneWIPI1TATDN2 geneWIPI1 geneEXTL3 geneSYVN1(1-617)KLHDC3ZBTB17 geneSHC1 geneEXTL1 geneDNAJB9 geneTPP1 geneDNAJB11KDELR3 geneSULT1A3 geneATP6V0D1SEC31A geneLMNA geneSSR1TPP1CUL7 geneTSPYL2SERP1 geneGFPT1 geneDNAJC3YIF1A geneSRPRB geneCXXC1 geneTATDN2C19orf10 geneSRPRBEXTL3CUL7ADD1TLN1 genePREB geneEXTL2 geneCTDSP2 geneARFGAP1 geneSYVN1 geneCTDSP2HDGFSSR1 geneEDEM1SRPR geneSERP1PPP2R5B geneARFGAP1WFS1 geneLMNA(1-664)HYOU1 geneDCTN1GSK3A geneHDGF geneACADVL geneZBTB17SRPRADD1 genePREBACADVLDDX11 genePLA2G4B geneYIF1APDIA6 geneEXTL1KDELR3EXTL2DNAJB11 geneXBP1-2PDIA6PLA2G4BDNAJC3 gene


Description

Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER. View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 381038
Reactome-version 
Reactome version: 75
Reactome Author 
Reactome Author: May, Bruce

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Bibliography

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  1. Lee AH, Iwakoshi NN, Glimcher LH.; ''XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.''; PubMed Europe PMC Scholia
  2. Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD.; ''XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.''; PubMed Europe PMC Scholia
  3. Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ.; ''Identification and characterization of a novel member of the EXT gene family, EXTL2.''; PubMed Europe PMC Scholia
  4. Saito T, Seki N, Yamauchi M, Tsuji S, Hayashi A, Kozuma S, Hori T.; ''Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.''; PubMed Europe PMC Scholia
  5. Yu M, Haslam RH, Haslam DB.; ''HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells.''; PubMed Europe PMC Scholia
  6. Yamaguchi A, Hori O, Stern DM, Hartmann E, Ogawa S, Tohyama M.; ''Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.''; PubMed Europe PMC Scholia
  7. Jordan PA, Stevens JM, Hubbard GP, Barrett NE, Sage T, Authi KS, Gibbins JM.; ''A role for the thiol isomerase protein ERP5 in platelet function.''; PubMed Europe PMC Scholia
  8. Hayano T, Kikuchi M.; ''Cloning and sequencing of the cDNA encoding human P5.''; PubMed Europe PMC Scholia
  9. Kikuchi M, Doi E, Tsujimoto I, Horibe T, Tsujimoto Y.; ''Functional analysis of human P5, a protein disulfide isomerase homologue.''; PubMed Europe PMC Scholia
  10. Kakiuchi C, Ishiwata M, Hayashi A, Kato T.; ''XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.''; PubMed Europe PMC Scholia
  11. Korth MJ, Lyons CN, Wambach M, Katze MG.; ''Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase.''; PubMed Europe PMC Scholia
  12. Wise CA, Clines GA, Massa H, Trask BJ, Lovett M.; ''Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family.''; PubMed Europe PMC Scholia
  13. Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K.; ''Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds.''; PubMed Europe PMC Scholia
  14. Li G, Luna C, Qiu J, Epstein DL, Gonzalez P.; ''Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells.''; PubMed Europe PMC Scholia
  15. Yoshida H, Oku M, Suzuki M, Mori K.; ''pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114932view16:45, 25 January 2021ReactomeTeamReactome version 75
113377view11:45, 2 November 2020ReactomeTeamReactome version 74
112582view15:55, 9 October 2020ReactomeTeamReactome version 73
101497view11:36, 1 November 2018ReactomeTeamreactome version 66
101034view21:17, 31 October 2018ReactomeTeamreactome version 65
100567view19:51, 31 October 2018ReactomeTeamreactome version 64
100116view16:36, 31 October 2018ReactomeTeamreactome version 63
99666view15:06, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99264view12:45, 31 October 2018ReactomeTeamreactome version 62
94043view13:53, 16 August 2017ReactomeTeamreactome version 61
93668view11:30, 9 August 2017ReactomeTeamreactome version 61
88353view16:23, 1 August 2016FehrhartOntology Term : 'protein folding pathway' added !
88352view16:23, 1 August 2016FehrhartOntology Term : 'transcription pathway' added !
86791view09:26, 11 July 2016ReactomeTeamreactome version 56
83243view10:28, 18 November 2015ReactomeTeamVersion54
82409view13:10, 29 September 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACADVL geneGeneProductENSG00000072778 (Ensembl)
ACADVLProteinP49748 (Uniprot-TrEMBL)
ADD1 geneGeneProductENSG00000087274 (Ensembl)
ADD1ProteinP35611 (Uniprot-TrEMBL)
ARFGAP1 geneGeneProductENSG00000101199 (Ensembl)
ARFGAP1ProteinQ8N6T3 (Uniprot-TrEMBL)
ATP6V0D1 geneGeneProductENSG00000159720 (Ensembl)
ATP6V0D1ProteinP61421 (Uniprot-TrEMBL)
C19orf10 geneGeneProductENSG00000074842 (Ensembl)
C19orf10ProteinQ969H8 (Uniprot-TrEMBL)
CTDSP2 geneGeneProductENSG00000175215 (Ensembl)
CTDSP2ProteinO14595 (Uniprot-TrEMBL)
CUL7 geneGeneProductENSG00000044090 (Ensembl)
CUL7ProteinQ14999 (Uniprot-TrEMBL)
CXXC1 geneGeneProductENSG00000154832 (Ensembl)
CXXC1ProteinQ9P0U4 (Uniprot-TrEMBL)
DCTN1 geneGeneProductENSG00000204843 (Ensembl)
DCTN1ProteinQ14203 (Uniprot-TrEMBL)
DDX11 geneGeneProductENSG00000013573 (Ensembl)
DDX11ProteinQ96FC9 (Uniprot-TrEMBL)
DNAJB11 geneGeneProductENSG00000090520 (Ensembl)
DNAJB11ProteinQ9UBS4 (Uniprot-TrEMBL)
DNAJB9 geneGeneProductENSG00000128590 (Ensembl)
DNAJB9ProteinQ9UBS3 (Uniprot-TrEMBL)
DNAJC3 geneGeneProductENSG00000102580 (Ensembl)
DNAJC3ProteinQ13217 (Uniprot-TrEMBL)
EDEM1 geneGeneProductENSG00000134109 (Ensembl)
EDEM1ProteinQ92611 (Uniprot-TrEMBL)
EXTL1 geneGeneProductENSG00000158008 (Ensembl)
EXTL1ProteinQ92935 (Uniprot-TrEMBL)
EXTL2 geneGeneProductENSG00000162694 (Ensembl)
EXTL2ProteinQ9UBQ6 (Uniprot-TrEMBL)
EXTL3 geneGeneProductENSG00000012232 (Ensembl)
EXTL3ProteinO43909 (Uniprot-TrEMBL)
FKBP14 geneGeneProductENSG00000106080 (Ensembl)
FKBP14ProteinQ9NWM8 (Uniprot-TrEMBL)
GFPT1 geneGeneProductENSG00000198380 (Ensembl)
GFPT1ProteinQ06210 (Uniprot-TrEMBL)
GOSR2 geneGeneProductENSG00000108433 (Ensembl)
GOSR2ProteinO14653 (Uniprot-TrEMBL)
GSK3A geneGeneProductENSG00000105723 (Ensembl)
GSK3AProteinP49840 (Uniprot-TrEMBL)
HDGF geneGeneProductENSG00000143321 (Ensembl)
HDGFProteinP51858 (Uniprot-TrEMBL)
HYOU1 geneGeneProductENSG00000149428 (Ensembl)
HYOU1ProteinQ9Y4L1 (Uniprot-TrEMBL)
KDELR3 geneGeneProductENSG00000100196 (Ensembl)
KDELR3ProteinO43731 (Uniprot-TrEMBL)
KLHDC3 geneGeneProductENSG00000124702 (Ensembl)
KLHDC3ProteinQ9BQ90 (Uniprot-TrEMBL)
LMNA geneGeneProductENSG00000160789 (Ensembl)
LMNA(1-664)ProteinP02545 (Uniprot-TrEMBL)
PDIA5 geneGeneProductENSG00000065485 (Ensembl)
PDIA5ProteinQ14554 (Uniprot-TrEMBL)
PDIA6 geneGeneProductENSG00000143870 (Ensembl)
PDIA6ProteinQ15084 (Uniprot-TrEMBL)
PLA2G4B geneGeneProductENSG00000243708 (Ensembl)
PLA2G4BProteinP0C869 (Uniprot-TrEMBL)
PPP2R5B geneGeneProductENSG00000068971 (Ensembl)
PPP2R5BProteinQ15173 (Uniprot-TrEMBL)
PREB geneGeneProductENSG00000138073 (Ensembl)
PREBProteinQ9HCU5 (Uniprot-TrEMBL)
SEC31A geneGeneProductENSG00000138674 (Ensembl)
SEC31AProteinO94979 (Uniprot-TrEMBL)
SERP1 geneGeneProductENSG00000120742 (Ensembl)
SERP1ProteinQ9Y6X1 (Uniprot-TrEMBL)
SHC1 geneGeneProductENSG00000160691 (Ensembl)
SHC1ProteinP29353 (Uniprot-TrEMBL)
SRPR geneGeneProductENSG00000182934 (Ensembl)
SRPRB geneGeneProductENSG00000144867 (Ensembl)
SRPRBProteinQ9Y5M8 (Uniprot-TrEMBL)
SRPRProteinP08240 (Uniprot-TrEMBL)
SSR1 geneGeneProductENSG00000124783 (Ensembl)
SSR1ProteinP43307 (Uniprot-TrEMBL)
SULT1A3 geneGeneProductENSG00000261052 (Ensembl)
SULT1A3ProteinP0DMM9 (Uniprot-TrEMBL)
SYVN1 geneGeneProductENSG00000162298 (Ensembl)
SYVN1(1-617)ProteinQ86TM6 (Uniprot-TrEMBL)
TATDN2 geneGeneProductENSG00000157014 (Ensembl)
TATDN2ProteinQ93075 (Uniprot-TrEMBL)
TLN1 geneGeneProductENSG00000137076 (Ensembl)
TLN1ProteinQ9Y490 (Uniprot-TrEMBL)
TPP1 geneGeneProductENSG00000166340 (Ensembl)
TPP1ProteinO14773 (Uniprot-TrEMBL)
TSPYL2 geneGeneProductENSG00000184205 (Ensembl)
TSPYL2ProteinQ9H2G4 (Uniprot-TrEMBL)
WFS1 geneGeneProductENSG00000109501 (Ensembl)
WFS1ProteinO76024 (Uniprot-TrEMBL)
WIPI1 geneGeneProductENSG00000070540 (Ensembl)
WIPI1ProteinQ5MNZ9 (Uniprot-TrEMBL)
XBP1-2ProteinP17861-2 (Uniprot-TrEMBL)
YIF1A geneGeneProductENSG00000174851 (Ensembl)
YIF1AProteinO95070 (Uniprot-TrEMBL)
ZBTB17 geneGeneProductENSG00000116809 (Ensembl)
ZBTB17ProteinQ13105 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ACADVL geneR-HSA-1791069 (Reactome)
ACADVLArrowR-HSA-1791069 (Reactome)
ADD1 geneR-HSA-1791076 (Reactome)
ADD1ArrowR-HSA-1791076 (Reactome)
ARFGAP1 geneR-HSA-1791064 (Reactome)
ARFGAP1ArrowR-HSA-1791064 (Reactome)
ATP6V0D1 geneR-HSA-1791184 (Reactome)
ATP6V0D1ArrowR-HSA-1791184 (Reactome)
C19orf10 geneR-HSA-1791102 (Reactome)
C19orf10ArrowR-HSA-1791102 (Reactome)
CTDSP2 geneR-HSA-1791130 (Reactome)
CTDSP2ArrowR-HSA-1791130 (Reactome)
CUL7 geneR-HSA-1791058 (Reactome)
CUL7ArrowR-HSA-1791058 (Reactome)
CXXC1 geneR-HSA-1791158 (Reactome)
CXXC1ArrowR-HSA-1791158 (Reactome)
DCTN1 geneR-HSA-1791092 (Reactome)
DCTN1ArrowR-HSA-1791092 (Reactome)
DDX11 geneR-HSA-1791116 (Reactome)
DDX11ArrowR-HSA-1791116 (Reactome)
DNAJB11 geneR-HSA-1791075 (Reactome)
DNAJB11ArrowR-HSA-1791075 (Reactome)
DNAJB9 geneR-HSA-1791124 (Reactome)
DNAJB9ArrowR-HSA-1791124 (Reactome)
DNAJC3 geneR-HSA-1791157 (Reactome)
DNAJC3ArrowR-HSA-1791157 (Reactome)
EDEM1 geneR-HSA-1791155 (Reactome)
EDEM1ArrowR-HSA-1791155 (Reactome)
EXTL1 geneR-HSA-8953336 (Reactome)
EXTL1ArrowR-HSA-8953336 (Reactome)
EXTL2 geneR-HSA-8953356 (Reactome)
EXTL2ArrowR-HSA-8953356 (Reactome)
EXTL3 geneR-HSA-1791144 (Reactome)
EXTL3ArrowR-HSA-1791144 (Reactome)
FKBP14 geneR-HSA-1791114 (Reactome)
FKBP14ArrowR-HSA-1791114 (Reactome)
GFPT1 geneR-HSA-1791088 (Reactome)
GFPT1ArrowR-HSA-1791088 (Reactome)
GOSR2 geneR-HSA-1791154 (Reactome)
GOSR2ArrowR-HSA-1791154 (Reactome)
GSK3A geneR-HSA-1791054 (Reactome)
GSK3AArrowR-HSA-1791054 (Reactome)
HDGF geneR-HSA-1791112 (Reactome)
HDGFArrowR-HSA-1791112 (Reactome)
HYOU1 geneR-HSA-1791066 (Reactome)
HYOU1ArrowR-HSA-1791066 (Reactome)
KDELR3 geneR-HSA-1791123 (Reactome)
KDELR3ArrowR-HSA-1791123 (Reactome)
KLHDC3 geneR-HSA-1791177 (Reactome)
KLHDC3ArrowR-HSA-1791177 (Reactome)
LMNA geneR-HSA-1791128 (Reactome)
LMNA(1-664)ArrowR-HSA-1791128 (Reactome)
PDIA5 geneR-HSA-1791122 (Reactome)
PDIA5ArrowR-HSA-1791122 (Reactome)
PDIA6 geneR-HSA-1791131 (Reactome)
PDIA6ArrowR-HSA-1791131 (Reactome)
PLA2G4B geneR-HSA-1791071 (Reactome)
PLA2G4BArrowR-HSA-1791071 (Reactome)
PPP2R5B geneR-HSA-1791096 (Reactome)
PPP2R5BArrowR-HSA-1791096 (Reactome)
PREB geneR-HSA-1791083 (Reactome)
PREBArrowR-HSA-1791083 (Reactome)
R-HSA-1791054 (Reactome) The GSK3A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791057 (Reactome) The TSPYL2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791058 (Reactome) The Cullin-7 (CUL7) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791060 (Reactome) The SRPRB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791064 (Reactome) The GAP gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791066 (Reactome) The HYOU1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791069 (Reactome) The ACADVL gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791071 (Reactome) The PLA2GB4B gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791075 (Reactome) The DNAJB11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791076 (Reactome) The ADD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791083 (Reactome) The Sec12 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791084 (Reactome) The SYVN1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791088 (Reactome) The GFPT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791092 (Reactome) The DCTN1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791096 (Reactome) The PPP2R5B gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791102 (Reactome) The C19orf10 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791108 (Reactome) The SULT1A3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791112 (Reactome) The HDGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791114 (Reactome) The FKBP14 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791116 (Reactome) The DDX11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791122 (Reactome) The PDIA5 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791123 (Reactome) The KDELR3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791124 (Reactome) The DNAJB9 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791128 (Reactome) The LMNA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791130 (Reactome) The CTDSP2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791131 (Reactome) The PDIA6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791133 (Reactome) The Sec31A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791134 (Reactome) The SHC1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791137 (Reactome) The Talin-1 (TLN1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791138 (Reactome) The TPP1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791139 (Reactome) The SRPR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791143 (Reactome) The YIF1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791144 (Reactome) The EXTL3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791154 (Reactome) The GOSR2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791155 (Reactome) The EDEM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791156 (Reactome) The TATDN2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791157 (Reactome) The p58IPK (DNAJC3) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791158 (Reactome) The CXXC1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791164 (Reactome) The SSR1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791167 (Reactome) The RAMP4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791169 (Reactome) The WFS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791172 (Reactome) The WIPI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791177 (Reactome) The KLHDC3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791184 (Reactome) The ATP6VOD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791186 (Reactome) The ZBTB17 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-8953336 (Reactome) The EXTL1 gene is transcribed to yield mRNA and the mRNA is translated to yield exostosin-like 1 (EXTL1) protein (Wise et al. 1997, Saito et al. 1998).
R-HSA-8953356 (Reactome) The EXTL2 gene is transcribed to yield mRNA and the mRNA is translated to yield exostosin-like 2 (EXTL2) protein (Wuyts et al. 1997, Saito et al. 1998).
SEC31A geneR-HSA-1791133 (Reactome)
SEC31AArrowR-HSA-1791133 (Reactome)
SERP1 geneR-HSA-1791167 (Reactome)
SERP1ArrowR-HSA-1791167 (Reactome)
SHC1 geneR-HSA-1791134 (Reactome)
SHC1ArrowR-HSA-1791134 (Reactome)
SRPR geneR-HSA-1791139 (Reactome)
SRPRArrowR-HSA-1791139 (Reactome)
SRPRB geneR-HSA-1791060 (Reactome)
SRPRBArrowR-HSA-1791060 (Reactome)
SSR1 geneR-HSA-1791164 (Reactome)
SSR1ArrowR-HSA-1791164 (Reactome)
SULT1A3 geneR-HSA-1791108 (Reactome)
SULT1A3ArrowR-HSA-1791108 (Reactome)
SYVN1 geneR-HSA-1791084 (Reactome)
SYVN1(1-617)ArrowR-HSA-1791084 (Reactome)
TATDN2 geneR-HSA-1791156 (Reactome)
TATDN2ArrowR-HSA-1791156 (Reactome)
TLN1 geneR-HSA-1791137 (Reactome)
TLN1ArrowR-HSA-1791137 (Reactome)
TPP1 geneR-HSA-1791138 (Reactome)
TPP1ArrowR-HSA-1791138 (Reactome)
TSPYL2 geneR-HSA-1791057 (Reactome)
TSPYL2ArrowR-HSA-1791057 (Reactome)
WFS1 geneR-HSA-1791169 (Reactome)
WFS1ArrowR-HSA-1791169 (Reactome)
WIPI1 geneR-HSA-1791172 (Reactome)
WIPI1ArrowR-HSA-1791172 (Reactome)
XBP1-2ArrowR-HSA-1791054 (Reactome)
XBP1-2ArrowR-HSA-1791057 (Reactome)
XBP1-2ArrowR-HSA-1791058 (Reactome)
XBP1-2ArrowR-HSA-1791060 (Reactome)
XBP1-2ArrowR-HSA-1791064 (Reactome)
XBP1-2ArrowR-HSA-1791066 (Reactome)
XBP1-2ArrowR-HSA-1791069 (Reactome)
XBP1-2ArrowR-HSA-1791071 (Reactome)
XBP1-2ArrowR-HSA-1791075 (Reactome)
XBP1-2ArrowR-HSA-1791076 (Reactome)
XBP1-2ArrowR-HSA-1791083 (Reactome)
XBP1-2ArrowR-HSA-1791084 (Reactome)
XBP1-2ArrowR-HSA-1791088 (Reactome)
XBP1-2ArrowR-HSA-1791092 (Reactome)
XBP1-2ArrowR-HSA-1791096 (Reactome)
XBP1-2ArrowR-HSA-1791102 (Reactome)
XBP1-2ArrowR-HSA-1791108 (Reactome)
XBP1-2ArrowR-HSA-1791112 (Reactome)
XBP1-2ArrowR-HSA-1791114 (Reactome)
XBP1-2ArrowR-HSA-1791116 (Reactome)
XBP1-2ArrowR-HSA-1791122 (Reactome)
XBP1-2ArrowR-HSA-1791123 (Reactome)
XBP1-2ArrowR-HSA-1791124 (Reactome)
XBP1-2ArrowR-HSA-1791128 (Reactome)
XBP1-2ArrowR-HSA-1791130 (Reactome)
XBP1-2ArrowR-HSA-1791131 (Reactome)
XBP1-2ArrowR-HSA-1791133 (Reactome)
XBP1-2ArrowR-HSA-1791134 (Reactome)
XBP1-2ArrowR-HSA-1791137 (Reactome)
XBP1-2ArrowR-HSA-1791138 (Reactome)
XBP1-2ArrowR-HSA-1791139 (Reactome)
XBP1-2ArrowR-HSA-1791143 (Reactome)
XBP1-2ArrowR-HSA-1791144 (Reactome)
XBP1-2ArrowR-HSA-1791154 (Reactome)
XBP1-2ArrowR-HSA-1791155 (Reactome)
XBP1-2ArrowR-HSA-1791156 (Reactome)
XBP1-2ArrowR-HSA-1791157 (Reactome)
XBP1-2ArrowR-HSA-1791158 (Reactome)
XBP1-2ArrowR-HSA-1791164 (Reactome)
XBP1-2ArrowR-HSA-1791167 (Reactome)
XBP1-2ArrowR-HSA-1791169 (Reactome)
XBP1-2ArrowR-HSA-1791172 (Reactome)
XBP1-2ArrowR-HSA-1791177 (Reactome)
XBP1-2ArrowR-HSA-1791184 (Reactome)
XBP1-2ArrowR-HSA-1791186 (Reactome)
XBP1-2ArrowR-HSA-8953336 (Reactome)
XBP1-2ArrowR-HSA-8953356 (Reactome)
YIF1A geneR-HSA-1791143 (Reactome)
YIF1AArrowR-HSA-1791143 (Reactome)
ZBTB17 geneR-HSA-1791186 (Reactome)
ZBTB17ArrowR-HSA-1791186 (Reactome)
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