Glycolysis in senescence (Homo sapiens)

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3959817492Oxygen ConsumptionRateInflammatorysignalling cascadeCellenlargementStressWoundhealingEvading immuneresponseReplicativesenescenceTumorigenesisIrradiationAcidification ofcellular environmentLDHAPGK1AldolaseOxidativestressNF-kBsignallingTP53GlutaminePyruvate kinaseProteinsGlycolysisPGMPKMRB1PyruvateGAPDHLactateSASPSerineTCAcycleHexokinaseAMPKOncogene inducedsenescenceLipidsG6PDEnolaseOncogene inducedsenescence6


Description

Influencing factors of glycolysis during senescence

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Birgit Veldman; ''Metabolic hallmarks of cellular senescence: highlighting the role of intracellular pathways in various senescent phenotypes''; Unpublished, 2020
  2. Wiley CD, Campisi J; ''From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.''; Cell Metab, 2016 PubMed Europe PMC Scholia
  3. Mazurek S, Zwerschke W, Jansen-Dürr P, Eigenbrodt E; ''Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.''; Oncogene, 2001 PubMed Europe PMC Scholia
  4. Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X; ''p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.''; Nat Cell Biol, 2011 PubMed Europe PMC Scholia
  5. Nacarelli T, Sell C; ''Targeting metabolism in cellular senescence, a role for intervention''; https://doi.org/10.1016/j.mce.2016.08.049, 2017 PubMed Europe PMC Scholia
  6. Gu J, Wang S, Guo H, Tan Y, Liang Y, Feng A, Liu Q, Damodaran C, Zhang Z, Keller BB, Zhang C, Cai L; ''Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis.''; Cell Death Dis, 2018 PubMed Europe PMC Scholia
  7. Sabbatinelli J, Prattichizzo F, Olivieri F, Procopio AD, Rippo MR, Giuliani A; ''Where Metabolism Meets Senescence: Focus on Endothelial Cells.''; Front Physiol, 2019 PubMed Europe PMC Scholia
  8. Dörr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Däbritz JH, Lisec J, Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfürst B, Walenta S, Mueller-Klieser W, Gräler M, Hummel M, Keller U, Buck AK, Dörken B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA; ''Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.''; Nature, 2013 PubMed Europe PMC Scholia
  9. Zwerschke W, Mazurek S, Stöckl P, Hütter E, Eigenbrodt E, Jansen-Dürr P; ''Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence.''; Biochem J, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127659view19:17, 14 November 2023KhanspersReverted to version '21:30, 11 December 2022' by Khanspers
127655view23:33, 13 November 2023KhanspersModified description
127654view23:32, 13 November 2023KhanspersReverted to version '21:30, 11 December 2022' by Khanspers
127630view22:41, 9 November 2023KhanspersModified description
124803view21:30, 11 December 2022AlexanderPicofixed citations
120508view10:38, 10 December 2021EweitzPad containers for readability, copyedit
120504view01:57, 10 December 2021EweitzOntology Term : 'glycolysis pathway' added !
118985view06:45, 7 June 2021Fehrhartconnected unconnected connection
115339view14:07, 14 February 2021EgonwMade a few more pathway clickable
115220view20:15, 5 February 2021AlexanderPicoOntology Term : 'classic metabolic pathway' added !
115219view20:14, 5 February 2021AlexanderPicoOntology Term : 'cellular senescence pathway' added !
115113view08:58, 26 January 2021WayanM0
115111view08:54, 26 January 2021WayanM0New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AMPKProteinQ13131 (Uniprot-TrEMBL)
AldolaseProteinA0A024QZ64 (Uniprot-TrEMBL)
EnolaseProteinA0A024R4F1 (Uniprot-TrEMBL)
G6PDGeneProductENSG00000160211 (Ensembl)
GAPDHGeneProductENSG00000111640 (Ensembl)
GlutamineMetaboliteCHEBI:28300 (ChEBI)
GlycolysisPathwayWP534 (WikiPathways)
HexokinaseProteinA0A024QZK7 (Uniprot-TrEMBL)
LDHAGeneProductENSG00000134333 (Ensembl)
LactateMetaboliteCHEBI:24996 (ChEBI)
LipidsMetaboliteCHEBI:18059 (ChEBI)
NF-kB signallingPathwayWP4562 (WikiPathways)
Oncogene induced senescencePathwayWP3308 (WikiPathways)
Oxidative stressPathwayWP3404 (WikiPathways)
PGK1GeneProductENSG00000102144 (Ensembl)
PGMMetaboliteCHEBI:33365 (ChEBI)
PKMGeneProductENSG00000067225 (Ensembl)
ProteinsMetaboliteCHEBI:36080 (ChEBI)
Pyruvate kinaseProteinA0A024R5Z9 (Uniprot-TrEMBL)
PyruvateMetaboliteCHEBI:15361 (ChEBI)
RB1GeneProductENSG00000139687 (Ensembl)
SASPPathwayWP3391 (WikiPathways)
SerineMetaboliteCHEBI:17822 (ChEBI)
TCA cyclePathwayWP78 (WikiPathways)
TP53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

No annotated interactions

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