Burn wound healing (Homo sapiens)

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Upregulated GenesPGE2LPS3535, 44PGS222EGFGROA1242hsa-miR-4485-3p6CXCL1413TPM3VIM1111PFN111SPARC11TLR4IL83513, 15, 35IL613, 35CCL235MYD8835hsa-miR-181b22PGS222ACHA748ACES48hsa-miR-29a10, 17GAS5HCP51717MIATLINC003381717LN28A17hsa-miR-29b-3p49XIST17, 49hsa-miR-126SCEL3636VEGFA10, 36, 40COL1A210, 36MMP936, 43HOTAIR36TGFB227CNN2TGFB32727FST45COL1A117, 23, 45, 47, 49INHBAAKT14545P7CXCR415, 44CXCL1215, 44SMAD3BRD429P29FN113, 29Col1A1NOX42929TAGLN29IFNA240, 44, 46KLF4MIR1453030BCL23SFRP2SNAI233IFNB1KDR262647PECAM1ACTA14117, 19, 25, 29, 37...SERPINH141NFKB141TGFB1IL1B12, 13, 19, 22, 29...13, 41MIR29B1TNF4141COL1A141MIR29B1MMP134123FBN1TNC24ELN2424ICAM15CXCR242TAGL13IL1A13TNFAIP313NFKBIZ13NFKBIA13ADAM12FOXE11313CD248FILA131K2C6A1MMP2828MMP143MMP343TIMP143TIMP243MMP243TLR1TLR23535TLR335TLR535TLR635TLR735TLR835TLR935NOD135NOD235LY9635S10A621S10A921S10AB21SLUR148ACh48HMGB148CASP348SFRP216SNAI2PECAM11640SERPINH147bsmA 37F13A137FGFR1FGFR244FGFR34FGFR4CD3E432IL1514Col1a1b23HGF8CXCR415Cspg4PDGFRb3939Krt22239TP5331Activin2Sulfate33HEXD20AMBPSequencing Data33Downregulated GenesUp-& Down-regulated GenesNOTCH2MMP79, 18JAG29, 189, 18


Description

Burn Wound Healing

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Ontology Terms

 

Bibliography

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  1. Nedelec B, Shankowsky H, Scott PG, Ghahary A, Tredget EE; ''Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b.''; Surgery, 2001 PubMed Europe PMC Scholia
  2. Ali-Bahar M, Bauer B, Tredget EE, Ghahary A; ''Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA.''; Wound Repair Regen, 2004 PubMed Europe PMC Scholia
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  4. Ding J, Hori K, Zhang R, Marcoux Y, Honardoust D, Shankowsky HA, Tredget EE; ''Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in the formation of postburn hypertrophic scar (HTS).''; Wound Repair Regen, 2011 PubMed Europe PMC Scholia
  5. Ijaz T, Jamaluddin M, Zhao Y, Zhang Y, Jay J, Finnerty CC, Herndon DN, Tilton RG, Brasier AR; ''Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation.''; Cell Death Dis, 2017 PubMed Europe PMC Scholia
  6. Nanney LB, Mueller SG, Bueno R, Peiper SC, Richmond A; ''Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair.''; Am J Pathol, 1995 PubMed Europe PMC Scholia
  7. Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, Tredget EE; ''Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring.''; J Cell Physiol, 2011 PubMed Europe PMC Scholia
  8. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE; ''Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor.''; J Interferon Cytokine Res, 2008 PubMed Europe PMC Scholia
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  10. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A; ''Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars.''; Am J Pathol, 1999 PubMed Europe PMC Scholia
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  25. Neely AN, Brown RL, Clendening CE, Orloff MM, Gardner J, Greenhalgh DG; ''Proteolytic activity in human burn wounds.''; Wound Repair Regen, 1997 PubMed Europe PMC Scholia
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  29. Ghahary A, Marcoux Y, Karimi-Busheri F, Tredget EE; ''Keratinocyte differentiation inversely regulates the expression of involucrin and transforming growth factor beta1.''; J Cell Biochem, 2001 PubMed Europe PMC Scholia
  30. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
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  32. Castagnoli C, Stella M, Magliacani G, Ferrone S, Richiardi PM; ''Similar ectopic expression of ICAM-1 and HLA class II molecules in hypertrophic scars following thermal injury.''; Burns, 1994 PubMed Europe PMC Scholia
  33. Holmes CJ, Plichta JK, Gamelli RL, Radek KA; ''Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin.''; Shock, 2017 PubMed Europe PMC Scholia
  34. Fumagalli M, Musso T, Vermi W, Scutera S, Daniele R, Alotto D, Cambieri I, Ostorero A, Gentili F, Caposio P, Zucca M, Sozzani S, Stella M, Castagnoli C; ''Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin.''; Exp Dermatol, 2007 PubMed Europe PMC Scholia
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  37. Evdokiou A, Kanisicak O, Gierek S, Barry A, Ivey MJ, Zhang X, Bodnar RJ, Satish L; ''Characterization of Burn Eschar Pericytes.''; J Clin Med, 2020 PubMed Europe PMC Scholia
  38. Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, Weiss ID, Pal B, Wald O, Ad-El D, Fujii N, Arenzana-Seisdedos F, Jung S, Galun E, Gur E, Peled A; ''Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns.''; J Invest Dermatol, 2006 PubMed Europe PMC Scholia
  39. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
  40. Guo L, Huang X, Liang P, Zhang P, Zhang M, Ren L, Zeng J, Cui X; ''Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury.''; J Cell Biochem, 2018 PubMed Europe PMC Scholia
  41. Zhu Y, Li Z, Wang Y, Li L, Wang D, Zhang W, Liu L, Jiang H, Yang J, Cheng J; ''Overexpression of miR-29b reduces collagen biosynthesisby inhibiting heat shock protein 47 during skin wound healing.''; Transl Res, 2016 PubMed Europe PMC Scholia
  42. Chen L, Wang Z, Li S, Zhao G, Tian M, Sun Z; ''SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars.''; PLoS One, 2012 PubMed Europe PMC Scholia
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  45. Kwan P, Ding J, Tredget EE; ''MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar.''; PLoS One, 2015 PubMed Europe PMC Scholia
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  50. Chan RK, Zamora DO, Wrice NL, Baer DG, Renz EM, Christy RJ, Natesan S; ''Development of a vascularized skin construct using adipose-derived stem cells from debrided burned skin.''; Stem Cells Int, 2012 PubMed Europe PMC Scholia
  51. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
  52. Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R, Figueiredo C; ''miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity.''; Mol Med, 2015 PubMed Europe PMC Scholia
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History

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141012view12:52, 1 November 2025EweitzRemove deprecated metadata rendering
135209view01:57, 8 August 2024EweitzReduce node-interaction occlusion
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135204view01:37, 8 August 2024EweitzEconomize layout
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135198view00:59, 8 August 2024EweitzStandardize case, refine font size
135197view00:57, 8 August 2024EweitzGroup formally not only graphically, economize layout
135196view00:51, 8 August 2024EweitzAdjust background color contrast for readability
134364view06:06, 21 July 2024EgonwCleaned up the references
134363view06:01, 21 July 2024EgonwRemoved template comments
122621view08:42, 22 April 2022ExperiMeddeleted a wrong node
122620view08:41, 22 April 2022ExperiMedupdated/added nodes, edges and references
120278view13:44, 23 November 2021EgonwClean up of two references
119583view07:17, 21 July 2021ExperiMedModified description
119552view10:47, 15 July 2021ExperiMedOntology Term : 'immune response pathway' added !
119551view10:47, 15 July 2021ExperiMedOntology Term : 'keratinocyte' added !
119550view10:46, 15 July 2021ExperiMedOntology Term : 'endothelial cell' added !
119549view10:46, 15 July 2021ExperiMedOntology Term : 'myofibroblast cell' added !
119548view10:46, 15 July 2021ExperiMedOntology Term : 'fibroblast' added !
119547view10:28, 15 July 2021ExperiMedOntology Term : 'cell-extracellular matrix signaling pathway' added !
119546view10:19, 15 July 2021ExperiMedFixed Interaction
117667view11:58, 22 May 2021EweitzModified title
116240view17:07, 21 April 2021EgonwUse Uniprot-TrEMBL instead of Uniprot-SwissProt
115827view23:10, 15 March 2021Khanspersminor change to trigger update
115639view10:08, 3 March 2021ExperiMedadded full references
115373view16:29, 16 February 2021ExperiMedNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACESProteinP22303 (Uniprot-SwissProt)
ACHA7ProteinP36544 (Uniprot-SwissProt)
ACTA1ProteinP68133 (Uniprot-SwissProt)
AChMetaboliteHMDB0000895 (HMDB)
ADAM12RnaENSG00000148848 (Ensembl) pericytes
AKT1ProteinP31749 (Uniprot-SwissProt)
AMBPProteinP02760 (Uniprot-SwissProt)
  • Uronic acid
  • Type your comment here
ActivinProtein
  • Fibroblasts, Histiocytes, Endothelial cells, Lymphocytes
  • Type your comment here
BCL2ProteinP10415 (Uniprot-SwissProt)
BRD4ProteinO60885 (Uniprot-SwissProt)
CASP3ProteinP42574 (Uniprot-SwissProt)
CCL2ProteinP13500 (Uniprot-SwissProt) pericytes
CD248RnaENSG00000174807 (Ensembl) pericytes
CD3EProteinP07766 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
CNN2RnaENSG00000064666 (Ensembl)
COL1A1ProteinP02452 (Uniprot-SwissProt)
COL1A2ProteinP08123 (Uniprot-SwissProt)
CXCL12ProteinP48061 (Uniprot-SwissProt)
  • SDF1
  • Type your comment here
CXCL14RnaENSG00000145824 (Ensembl) pericytes
CXCR2ProteinP25025 (Uniprot-SwissProt)
CXCR4ProteinP61073 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
Col1A1RnaENSG00000108821 (Ensembl)
Col1a1bRnaENSDARG00000035809 (Ensembl)
  • Fibroblasts
  • Type your comment here
Cspg4ProteinQ8VHY0 (Uniprot-SwissProt)
EGFProteinP01133 (Uniprot-SwissProt)
ELNProteinP15502 (Uniprot-SwissProt)
F13A1ProteinP00488 (Uniprot-SwissProt)
FBN1ProteinP35555 (Uniprot-SwissProt)
FGFR1ProteinP11362 (Uniprot-SwissProt)
FGFR2ProteinP21802 (Uniprot-SwissProt)
FGFR3ProteinP22607 (Uniprot-SwissProt)
FGFR4ProteinP22455 (Uniprot-SwissProt)
FILAProteinP20930 (Uniprot-SwissProt) pericytes
FN1RnaENSG00000115414 (Ensembl)
FOXE1ProteinO00358 (Uniprot-SwissProt) pericytes
FSTGeneProductP19883 (Uniprot-SwissProt)
GAS5RnaENSG00000234741 (Ensembl) pericytes
GROAProteinP09341 (Uniprot-SwissProt)
HCP5RnaENSG00000237105 (Ensembl) pericytes
HEXDProteinQ8WVB3 (Uniprot-SwissProt)
HGFProteinP14210 (Uniprot-SwissProt)
HMGB1ProteinP09429 (Uniprot-SwissProt)
HOTAIRRnaENSG00000228630 (Ensembl) pericytes
ICAM1ProteinP05362 (Uniprot-SwissProt)
IFNA2ProteinP01563 (Uniprot-SwissProt)
IFNB1ProteinP01574 (Uniprot-SwissProt)
IL15ProteinP40933 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
IL1ARnaENSG00000115008 (Ensembl) pericytes
IL1BProteinP01584 (Uniprot-SwissProt)
IL6ProteinP05231 (Uniprot-SwissProt) pericytes
IL8ProteinP10145 (Uniprot-SwissProt) pericytes
INHBAProteinP08476 (Uniprot-SwissProt)
  • = Activin A = EDF
  • Type your comment here
JAG2ProteinP97607 (Uniprot-SwissProt)
K2C6AProteinP02538 (Uniprot-SwissProt) pericytes
KDRRnaENSG00000128052 (Ensembl)
  • VEGFR2
  • Type your comment here
KLF4ProteinO43474 (Uniprot-SwissProt)
Krt222ProteinQ8N1A0 (Uniprot-SwissProt)
LINC00338RnaENSG00000234912 (Ensembl) pericytes
LN28AProteinQ9H9Z2 (Uniprot-SwissProt)
LPSMetabolite53481794 (PubChem-substance)
LY96RnaENSG00000154589 (Ensembl) pericytes
MIATRnaENSG00000225783 (Ensembl) pericytes
MIR145RnaENSG00000276365 (Ensembl)
MIR29B1ProteinENSG00000283797 (Ensembl)
MMP13RnaENSG00000137745 (Ensembl)
  • Fibroblasts
  • Type your comment here
MMP1RnaENSG00000196611 (Ensembl) pericytes
MMP28ProteinQ9H239 (Uniprot-SwissProt) pericytes
MMP2ProteinP08253 (Uniprot-SwissProt) pericytes
MMP3RnaENSG00000149968 (Ensembl) pericytes
MMP7ProteinP50280 (Uniprot-SwissProt)
MMP9ProteinP14780 (Uniprot-SwissProt)
MYD88ProteinQ99836 (Uniprot-SwissProt) pericytes
NFKB1ProteinP19838 (Uniprot-SwissProt)
NFKBIARnaENSG00000100906 (Ensembl) pericytes
NFKBIZRnaENSG00000144802 (Ensembl) pericytes
NOD1RnaENSG00000106100 (Ensembl) pericytes
NOD2RnaENSG00000167207 (Ensembl) pericytes
NOTCH2ProteinQ9QW30 (Uniprot-SwissProt)
NOX4ProteinQ9NPH5 (Uniprot-SwissProt)
PDGFRbProteinP09619 (Uniprot-SwissProt)
PECAM1ProteinP16284 (Uniprot-SwissProt)
PFN1RnaENSG00000108518 (Ensembl) pericytes
PGE2MetaboliteHMDB0060041 (HMDB)
PGS2ProteinP07585 (Uniprot-SwissProt)
S10A6ProteinP06703 (Uniprot-SwissProt)
S10A9ProteinP06702 (Uniprot-SwissProt)
S10ABProteinP31949 (Uniprot-SwissProt)
SCELProteinO95171 (Uniprot-SwissProt)
SERPINH1ProteinP50454 (Uniprot-SwissProt) HSP47
SFRP2ProteinQ96HF1 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
SLUR1ProteinP55000 (Uniprot-SwissProt)
SMAD3ProteinP84022 (Uniprot-SwissProt)
SNAI2ProteinO43623 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
SPARCRnaENSG00000113140 (Ensembl) pericytes
SulfateMetaboliteHMDB0001448 (HMDB)
TAGLNRnaENSG00000149591 (Ensembl)
TAGLProteinQ01995 (Uniprot-SwissProt) pericytes
TGFB1ProteinP01137 (Uniprot-SwissProt)
TGFB2ProteinP61812 (Uniprot-SwissProt)
TGFB3ProteinP10600 (Uniprot-SwissProt)
TIMP1RnaENSG00000102265 (Ensembl) pericytes
TIMP2RnaENSG00000035862 (Ensembl) pericytes
TLR1RnaENSG00000174125 (Ensembl) pericytes
TLR2RnaENSG00000137462 (Ensembl) pericytes
TLR3RnaENSG00000164342 (Ensembl) pericytes
TLR4ProteinO00206 (Uniprot-SwissProt) pericytes
TLR5RnaENSG00000187554 (Ensembl) pericytes
TLR6RnaENSG00000174130 (Ensembl) pericytes
TLR7RnaENSG00000196664 (Ensembl) pericytes
TLR8RnaENSG00000101916 (Ensembl) pericytes
TLR9RnaENSG00000239732 (Ensembl) pericytes
TNCProteinP24821 (Uniprot-SwissProt)
TNFAIP3RnaENSG00000118503 (Ensembl) pericytes
TNFProteinP01375 (Uniprot-SwissProt)
TP53ProteinP04637 (Uniprot-SwissProt)
TPM3RnaENSG00000174807 (Ensembl) pericytes
VEGFAProteinP15692 (Uniprot-SwissProt)
VIMRnaENSG00000026025 (Ensembl) pericytes
XISTRnaENSG00000229807 (Ensembl) pericytes
bsmA ProteinP39297 (Uniprot-SwissProt)
hsa-miR-126RnaMI0000471 (miRBase Sequence)
hsa-miR-181bRnaMI0003331 (miRBase Sequence)
hsa-miR-29aRnaMI0000087 (miRBase Sequence)
hsa-miR-29b-3pRnaMIMAT0000100 (miRBase Sequence)
hsa-miR-4485-3pRnaMI0016846 (miRBase Sequence)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5055"
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