Burn wound healing (Homo sapiens)

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Upregulated GenesPGE2LPS2121, 33PGS238EGFGROA418hsa-miR-4485-3p16CXCL1442TPM3VIM4444PFN144SPARC44TLR4IL82119, 21, 42IL621, 42CCL221MYD8821hsa-miR-181b38PGS238ACHA726ACES26hsa-miR-29a11, 17GAS5HCP51717MIATLINC003381717LN28A17hsa-miR-29b-3p48XIST17, 48hsa-miR-126SCEL1515VEGFA11, 15, 20COL1A211, 15MMP915, 23HOTAIR15TGFB231CNN2TGFB33131FST25COL1A117, 25, 30, 35, 48INHBAAKT12525P28CXCR419, 33CXCL1219, 33SMAD3BRD432P32FN132, 42Col1A1NOX43232TAGLN32IFNA213, 20, 33KLF4MIR1452424BCL26SFRP2SNAI266IFNB1KDR494930PECAM1ACTA1407, 13, 17, 25, 32...SERPINH140NFKB140TGFB1IL1B5, 13, 25, 32, 38...40, 42MIR29B1TNF4040COL1A140MIR29B1MMP134035FBN1TNC18ELN1818ICAM137CXCR28TAGL42IL1A42TNFAIP342NFKBIZ42NFKBIA42ADAM12FOXE14242CD248FILA4227K2C6A27MMP2829MMP123MMP323TIMP123TIMP223MMP223TLR1TLR22121TLR321TLR521TLR621TLR721TLR821TLR921NOD121NOD221LY9621S10A61S10A91S10AB1SLUR126ACh26HMGB126CASP326SFRP24SNAI2PECAM1420SERPINH130bsmA 36F13A136FGFR1FGFR22222FGFR322FGFR4CD3E222IL153Col1a1b35HGF14CXCR419Cspg4PDGFRb77Krt2227TP5334Activin45Sulfate9HEXD39AMBPSequencing Data9Downregulated GenesUp-& Down-regulated GenesNOTCH2MMP710, 43JAG210, 4310, 43


Description

Burn Wound Healing

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Ontology Terms

 

Bibliography

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  1. Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, Weiss ID, Pal B, Wald O, Ad-El D, Fujii N, Arenzana-Seisdedos F, Jung S, Galun E, Gur E, Peled A; ''Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns.''; J Invest Dermatol, 2006 PubMed Europe PMC Scholia
  2. Ali-Bahar M, Bauer B, Tredget EE, Ghahary A; ''Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA.''; Wound Repair Regen, 2004 PubMed Europe PMC Scholia
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  4. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
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  9. Zhu Y, Li Z, Wang Y, Li L, Wang D, Zhang W, Liu L, Jiang H, Yang J, Cheng J; ''Overexpression of miR-29b reduces collagen biosynthesisby inhibiting heat shock protein 47 during skin wound healing.''; Transl Res, 2016 PubMed Europe PMC Scholia
  10. Ghahary A, Marcoux Y, Karimi-Busheri F, Tredget EE; ''Keratinocyte differentiation inversely regulates the expression of involucrin and transforming growth factor beta1.''; J Cell Biochem, 2001 PubMed Europe PMC Scholia
  11. Chen L, Wang Z, Li S, Zhao G, Tian M, Sun Z; ''SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars.''; PLoS One, 2012 PubMed Europe PMC Scholia
  12. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A; ''Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars.''; Am J Pathol, 1999 PubMed Europe PMC Scholia
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  15. Fumagalli M, Musso T, Vermi W, Scutera S, Daniele R, Alotto D, Cambieri I, Ostorero A, Gentili F, Caposio P, Zucca M, Sozzani S, Stella M, Castagnoli C; ''Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin.''; Exp Dermatol, 2007 PubMed Europe PMC Scholia
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  17. Ding J, Hori K, Zhang R, Marcoux Y, Honardoust D, Shankowsky HA, Tredget EE; ''Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in the formation of postburn hypertrophic scar (HTS).''; Wound Repair Regen, 2011 PubMed Europe PMC Scholia
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  19. Colwell AS, Phan TT, Kong W, Longaker MT, Lorenz PH; ''Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation.''; Plast Reconstr Surg, 2005 PubMed Europe PMC Scholia
  20. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE; ''Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor.''; J Interferon Cytokine Res, 2008 PubMed Europe PMC Scholia
  21. Kwan P, Ding J, Tredget EE; ''MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar.''; PLoS One, 2015 PubMed Europe PMC Scholia
  22. Nedelec B, Shankowsky H, Scott PG, Ghahary A, Tredget EE; ''Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b.''; Surgery, 2001 PubMed Europe PMC Scholia
  23. Ijaz T, Jamaluddin M, Zhao Y, Zhang Y, Jay J, Finnerty CC, Herndon DN, Tilton RG, Brasier AR; ''Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation.''; Cell Death Dis, 2017 PubMed Europe PMC Scholia
  24. Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R, Figueiredo C; ''miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity.''; Mol Med, 2015 PubMed Europe PMC Scholia
  25. Wu J, Ma B, Yi S, Wang Z, He W, Luo G, Chen X, Wang X, Chen A, Barisoni D; ''Gene expression of early hypertrophic scar tissue screened by means of cDNA microarrays.''; J Trauma, 2004 PubMed Europe PMC Scholia
  26. Hermanns-Lê T, Piérard GE, Jennes S, Piérard-Franchimont C; ''Protomyofibroblast Pathway in Early Thermal Burn Healing.''; Skin Pharmacol Physiol, 2015 PubMed Europe PMC Scholia
  27. Rong HT, Liu DW; ''Identification of differentially expressed miRNAs associated with thermal injury in epidermal stem cells based on RNA-sequencing.''; Exp Ther Med, 2020 PubMed Europe PMC Scholia
  28. Chan RK, Zamora DO, Wrice NL, Baer DG, Renz EM, Christy RJ, Natesan S; ''Development of a vascularized skin construct using adipose-derived stem cells from debrided burned skin.''; Stem Cells Int, 2012 PubMed Europe PMC Scholia
  29. Cao W, Feng Y; ''LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury.''; Biol Res, 2019 PubMed Europe PMC Scholia
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  34. Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, Tredget EE; ''Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring.''; J Cell Physiol, 2011 PubMed Europe PMC Scholia
  35. Neely AN, Brown RL, Clendening CE, Orloff MM, Gardner J, Greenhalgh DG; ''Proteolytic activity in human burn wounds.''; Wound Repair Regen, 1997 PubMed Europe PMC Scholia
  36. Nanney LB, Mueller SG, Bueno R, Peiper SC, Richmond A; ''Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair.''; Am J Pathol, 1995 PubMed Europe PMC Scholia
  37. Zhu Y, Li Z, Wang Y, Li L, Wang D, Zhang W, Liu L, Jiang H, Yang J, Cheng J; ''Overexpression of miR-29b reduces collagen biosynthesisby inhibiting heat shock protein 47 during skin wound healing.''; Transl Res, 2016 PubMed Europe PMC Scholia
  38. ''''; , PubMed Europe PMC Scholia
  39. ''''; , PubMed Europe PMC Scholia
  40. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
  41. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A; ''Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars.''; Am J Pathol, 1999 PubMed Europe PMC Scholia
  42. ''''; , PubMed Europe PMC Scholia
  43. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE; ''Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor.''; J Interferon Cytokine Res, 2008 PubMed Europe PMC Scholia
  44. ''''; , PubMed Europe PMC Scholia
  45. ''''; , PubMed Europe PMC Scholia
  46. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
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  49. Jiang B, Tang Y, Wang H, Chen C, Yu W, Sun H, Duan M, Lin X, Liang P; ''Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing.''; Cell Death Dis, 2020 PubMed Europe PMC Scholia
  50. Evdokiou A, Kanisicak O, Gierek S, Barry A, Ivey MJ, Zhang X, Bodnar RJ, Satish L; ''Characterization of Burn Eschar Pericytes.''; J Clin Med, 2020 PubMed Europe PMC Scholia
  51. Castagnoli C, Stella M, Magliacani G, Ferrone S, Richiardi PM; ''Similar ectopic expression of ICAM-1 and HLA class II molecules in hypertrophic scars following thermal injury.''; Burns, 1994 PubMed Europe PMC Scholia
  52. Guo L, Huang X, Liang P, Zhang P, Zhang M, Ren L, Zeng J, Cui X; ''Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury.''; J Cell Biochem, 2018 PubMed Europe PMC Scholia
  53. Holmes CJ, Plichta JK, Gamelli RL, Radek KA; ''Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin.''; Shock, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135209view01:57, 8 August 2024EweitzReduce node-interaction occlusion
135208view01:55, 8 August 2024EweitzAlign nodes, economize layout
135207view01:51, 8 August 2024EweitzEconomize layout
135206view01:48, 8 August 2024EweitzTailor node widths, economize layout
135205view01:39, 8 August 2024EweitzTailor node width, alignment
135204view01:37, 8 August 2024EweitzEconomize layout
135203view01:34, 8 August 2024EweitzEconomize layout
135202view01:25, 8 August 2024EweitzEconomize layout
135201view01:15, 8 August 2024EweitzEconomize layout
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135199view01:07, 8 August 2024EweitzEconomize layout
135198view00:59, 8 August 2024EweitzStandardize case, refine font size
135197view00:57, 8 August 2024EweitzGroup formally not only graphically, economize layout
135196view00:51, 8 August 2024EweitzAdjust background color contrast for readability
134364view06:06, 21 July 2024EgonwCleaned up the references
134363view06:01, 21 July 2024EgonwRemoved template comments
122621view08:42, 22 April 2022ExperiMeddeleted a wrong node
122620view08:41, 22 April 2022ExperiMedupdated/added nodes, edges and references
120278view13:44, 23 November 2021EgonwClean up of two references
119583view07:17, 21 July 2021ExperiMedModified description
119552view10:47, 15 July 2021ExperiMedOntology Term : 'immune response pathway' added !
119551view10:47, 15 July 2021ExperiMedOntology Term : 'keratinocyte' added !
119550view10:46, 15 July 2021ExperiMedOntology Term : 'endothelial cell' added !
119549view10:46, 15 July 2021ExperiMedOntology Term : 'myofibroblast cell' added !
119548view10:46, 15 July 2021ExperiMedOntology Term : 'fibroblast' added !
119547view10:28, 15 July 2021ExperiMedOntology Term : 'cell-extracellular matrix signaling pathway' added !
119546view10:19, 15 July 2021ExperiMedFixed Interaction
117667view11:58, 22 May 2021EweitzModified title
116240view17:07, 21 April 2021EgonwUse Uniprot-TrEMBL instead of Uniprot-SwissProt
115827view23:10, 15 March 2021Khanspersminor change to trigger update
115639view10:08, 3 March 2021ExperiMedadded full references
115373view16:29, 16 February 2021ExperiMedNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACESProteinP22303 (Uniprot-SwissProt)
ACHA7ProteinP36544 (Uniprot-SwissProt)
ACTA1ProteinP68133 (Uniprot-SwissProt)
AChMetaboliteHMDB0000895 (HMDB)
ADAM12RnaENSG00000148848 (Ensembl) pericytes
AKT1ProteinP31749 (Uniprot-SwissProt)
AMBPProteinP02760 (Uniprot-SwissProt)
  • Uronic acid
  • Type your comment here
ActivinProtein
  • Fibroblasts, Histiocytes, Endothelial cells, Lymphocytes
  • Type your comment here
BCL2ProteinP10415 (Uniprot-SwissProt)
BRD4ProteinO60885 (Uniprot-SwissProt)
CASP3ProteinP42574 (Uniprot-SwissProt)
CCL2ProteinP13500 (Uniprot-SwissProt) pericytes
CD248RnaENSG00000174807 (Ensembl) pericytes
CD3EProteinP07766 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
CNN2RnaENSG00000064666 (Ensembl)
COL1A1ProteinP02452 (Uniprot-SwissProt)
COL1A2ProteinP08123 (Uniprot-SwissProt)
CXCL12ProteinP48061 (Uniprot-SwissProt)
  • SDF1
  • Type your comment here
CXCL14RnaENSG00000145824 (Ensembl) pericytes
CXCR2ProteinP25025 (Uniprot-SwissProt)
CXCR4ProteinP61073 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
Col1A1RnaENSG00000108821 (Ensembl)
Col1a1bRnaENSDARG00000035809 (Ensembl)
  • Fibroblasts
  • Type your comment here
Cspg4ProteinQ8VHY0 (Uniprot-SwissProt)
EGFProteinP01133 (Uniprot-SwissProt)
ELNProteinP15502 (Uniprot-SwissProt)
F13A1ProteinP00488 (Uniprot-SwissProt)
FBN1ProteinP35555 (Uniprot-SwissProt)
FGFR1ProteinP11362 (Uniprot-SwissProt)
FGFR2ProteinP21802 (Uniprot-SwissProt)
FGFR3ProteinP22607 (Uniprot-SwissProt)
FGFR4ProteinP22455 (Uniprot-SwissProt)
FILAProteinP20930 (Uniprot-SwissProt) pericytes
FN1RnaENSG00000115414 (Ensembl)
FOXE1ProteinO00358 (Uniprot-SwissProt) pericytes
FSTGeneProductP19883 (Uniprot-SwissProt)
GAS5RnaENSG00000234741 (Ensembl) pericytes
GROAProteinP09341 (Uniprot-SwissProt)
HCP5RnaENSG00000237105 (Ensembl) pericytes
HEXDProteinQ8WVB3 (Uniprot-SwissProt)
HGFProteinP14210 (Uniprot-SwissProt)
HMGB1ProteinP09429 (Uniprot-SwissProt)
HOTAIRRnaENSG00000228630 (Ensembl) pericytes
ICAM1ProteinP05362 (Uniprot-SwissProt)
IFNA2ProteinP01563 (Uniprot-SwissProt)
IFNB1ProteinP01574 (Uniprot-SwissProt)
IL15ProteinP40933 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
IL1ARnaENSG00000115008 (Ensembl) pericytes
IL1BProteinP01584 (Uniprot-SwissProt)
IL6ProteinP05231 (Uniprot-SwissProt) pericytes
IL8ProteinP10145 (Uniprot-SwissProt) pericytes
INHBAProteinP08476 (Uniprot-SwissProt)
  • = Activin A = EDF
  • Type your comment here
JAG2ProteinP97607 (Uniprot-SwissProt)
K2C6AProteinP02538 (Uniprot-SwissProt) pericytes
KDRRnaENSG00000128052 (Ensembl)
  • VEGFR2
  • Type your comment here
KLF4ProteinO43474 (Uniprot-SwissProt)
Krt222ProteinQ8N1A0 (Uniprot-SwissProt)
LINC00338RnaENSG00000234912 (Ensembl) pericytes
LN28AProteinQ9H9Z2 (Uniprot-SwissProt)
LPSMetabolite53481794 (PubChem-substance)
LY96RnaENSG00000154589 (Ensembl) pericytes
MIATRnaENSG00000225783 (Ensembl) pericytes
MIR145RnaENSG00000276365 (Ensembl)
MIR29B1ProteinENSG00000283797 (Ensembl)
MMP13RnaENSG00000137745 (Ensembl)
  • Fibroblasts
  • Type your comment here
MMP1RnaENSG00000196611 (Ensembl) pericytes
MMP28ProteinQ9H239 (Uniprot-SwissProt) pericytes
MMP2ProteinP08253 (Uniprot-SwissProt) pericytes
MMP3RnaENSG00000149968 (Ensembl) pericytes
MMP7ProteinP50280 (Uniprot-SwissProt)
MMP9ProteinP14780 (Uniprot-SwissProt)
MYD88ProteinQ99836 (Uniprot-SwissProt) pericytes
NFKB1ProteinP19838 (Uniprot-SwissProt)
NFKBIARnaENSG00000100906 (Ensembl) pericytes
NFKBIZRnaENSG00000144802 (Ensembl) pericytes
NOD1RnaENSG00000106100 (Ensembl) pericytes
NOD2RnaENSG00000167207 (Ensembl) pericytes
NOTCH2ProteinQ9QW30 (Uniprot-SwissProt)
NOX4ProteinQ9NPH5 (Uniprot-SwissProt)
PDGFRbProteinP09619 (Uniprot-SwissProt)
PECAM1ProteinP16284 (Uniprot-SwissProt)
PFN1RnaENSG00000108518 (Ensembl) pericytes
PGE2MetaboliteHMDB0060041 (HMDB)
PGS2ProteinP07585 (Uniprot-SwissProt)
S10A6ProteinP06703 (Uniprot-SwissProt)
S10A9ProteinP06702 (Uniprot-SwissProt)
S10ABProteinP31949 (Uniprot-SwissProt)
SCELProteinO95171 (Uniprot-SwissProt)
SERPINH1ProteinP50454 (Uniprot-SwissProt) HSP47
SFRP2ProteinQ96HF1 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
SLUR1ProteinP55000 (Uniprot-SwissProt)
SMAD3ProteinP84022 (Uniprot-SwissProt)
SNAI2ProteinO43623 (Uniprot-SwissProt)
  • Fibroblasts
  • Type your comment here
SPARCRnaENSG00000113140 (Ensembl) pericytes
SulfateMetaboliteHMDB0001448 (HMDB)
TAGLNRnaENSG00000149591 (Ensembl)
TAGLProteinQ01995 (Uniprot-SwissProt) pericytes
TGFB1ProteinP01137 (Uniprot-SwissProt)
TGFB2ProteinP61812 (Uniprot-SwissProt)
TGFB3ProteinP10600 (Uniprot-SwissProt)
TIMP1RnaENSG00000102265 (Ensembl) pericytes
TIMP2RnaENSG00000035862 (Ensembl) pericytes
TLR1RnaENSG00000174125 (Ensembl) pericytes
TLR2RnaENSG00000137462 (Ensembl) pericytes
TLR3RnaENSG00000164342 (Ensembl) pericytes
TLR4ProteinO00206 (Uniprot-SwissProt) pericytes
TLR5RnaENSG00000187554 (Ensembl) pericytes
TLR6RnaENSG00000174130 (Ensembl) pericytes
TLR7RnaENSG00000196664 (Ensembl) pericytes
TLR8RnaENSG00000101916 (Ensembl) pericytes
TLR9RnaENSG00000239732 (Ensembl) pericytes
TNCProteinP24821 (Uniprot-SwissProt)
TNFAIP3RnaENSG00000118503 (Ensembl) pericytes
TNFProteinP01375 (Uniprot-SwissProt)
TP53ProteinP04637 (Uniprot-SwissProt)
TPM3RnaENSG00000174807 (Ensembl) pericytes
VEGFAProteinP15692 (Uniprot-SwissProt)
VIMRnaENSG00000026025 (Ensembl) pericytes
XISTRnaENSG00000229807 (Ensembl) pericytes
bsmA ProteinP39297 (Uniprot-SwissProt)
hsa-miR-126RnaMI0000471 (miRBase Sequence)
hsa-miR-181bRnaMI0003331 (miRBase Sequence)
hsa-miR-29aRnaMI0000087 (miRBase Sequence)
hsa-miR-29b-3pRnaMIMAT0000100 (miRBase Sequence)
hsa-miR-4485-3pRnaMI0016846 (miRBase Sequence)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5055"
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