Prostaglandin signaling (Homo sapiens)

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1PGI2+IP activated pathwaysProtection against viral infectionDecreased recruitment of CCR2 expressing monocytes and macrophagesDecreased platelet activationfibroblastcAMPCa2+ effluxProstaglandin E2 receptor EP2 subtypeIRF7Prostaglandin E2Prostaglandin E receptor 4IFNA1VEGFAIL6Prostaglandin E receptor 4CSF1IL6IL8COX2Prostaglandin E2MMP9IL17AIL6IL8IL1BMonocytes, Macrophages, fibroblasts, airway epithelial cellsTh17 cellsProstaglandin E2 receptor EP2 subtypeCCL2CXCL1MacrophageAREGVEGFATGFB1M2 MacrophageTissue repair, potential lung fibrosisProstaglandin E2 receptor EP2 subtypeProstaglandin E receptor 4Neutrophil Extracellular Trap formationProstaglandin E2 receptor EP2 subtypeProstaglandin E receptor 4PKAT cell activation and proliferationTh17 cellsIL17AIL17FIL22AHR cytokine stormIFNGIL12AProstaglandin E receptor 4Natural killer cells antigen CD94NK and CD8+ T cell cytolytic activityCXCL9CXCL10NK cell migrationcAMPcAMPNFKB1cytokine storm, hyperinflammation (postive feedback loop)IL1BInflammasome activation(positive feedback loop)Prostaglandin I2IFNA1NFKB1IL1BIL6TNFTNFCCL2Th17 cellsTh1 cellsIL17AIFNGIP-activated cAMP


Description

Prostaglandin Signalling in Homo Sapiens in COVID-19

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Bibliography

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  5. Honda T, Segi-Nishida E, Miyachi Y, Narumiya S; ''Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis.''; J Exp Med, 2006 PubMed Europe PMC Scholia
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  8. Kothari P, Pestana R, Mesraoua R, Elchaki R, Khan KM, Dannenberg AJ, Falcone DJ; ''IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages.''; J Immunol, 2014 PubMed Europe PMC Scholia
  9. Li T, Qi J, Cowley EA; ''Activation of the EP₄ prostanoid receptor induces prostaglandin E₂ and pro-inflammatory cytokine production in human airway epithelial cells.''; Pulm Pharmacol Ther, 2011 PubMed Europe PMC Scholia
  10. Paulissen SM, van Hamburg JP, Davelaar N, Asmawidjaja PS, Hazes JM, Lubberts E; ''Synovial fibroblasts directly induce Th17 pathogenicity via the cyclooxygenase/prostaglandin E2 pathway, independent of IL-23.''; J Immunol, 2013 PubMed Europe PMC Scholia
  11. Nakajima S, Honda T, Sakata D, Egawa G, Tanizaki H, Otsuka A, Moniaga CS, Watanabe T, Miyachi Y, Narumiya S, Kabashima K; ''Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.''; J Immunol, 2010 PubMed Europe PMC Scholia
  12. Inoue H, Takamori M, Shimoyama Y, Ishibashi H, Yamamoto S, Koshihara Y; ''Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts.''; Br J Pharmacol, 2002 PubMed Europe PMC Scholia
  13. Kumei S, Yuhki KI, Kojima F, Kashiwagi H, Imamichi Y, Okumura T, Narumiya S, Ushikubi F; ''Prostaglandin I2suppresses the development of diet-induced nonalcoholic steatohepatitis in mice.''; FASEB J, 2018 PubMed Europe PMC Scholia
  14. Liao M, Liu Y, Yuan J, Wen Y, Xu G, Zhao J, Cheng L, Li J, Wang X, Wang F, Liu L, Amit I, Zhang S, Zhang Z; ''Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.''; Nat Med, 2020 PubMed Europe PMC Scholia
  15. Shishikura K, Horiuchi T, Sakata N, Trinh DA, Shirakawa R, Kimura T, Asada Y, Horiuchi H; ''Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP.''; Br J Pharmacol, 2016 PubMed Europe PMC Scholia
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  19. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; ''COVID-19: consider cytokine storm syndromes and immunosuppression.''; Lancet, 2020 PubMed Europe PMC Scholia
  20. Zeddou M, Greimers R, de Valensart N, Nayjib B, Tasken K, Boniver J, Moutschen M, Rahmouni S; ''Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes bya cAMP-dependent protein kinase A type I pathway.''; Biochem Pharmacol, 2005 PubMed Europe PMC Scholia
  21. Robb CT, Goepp M, Rossi AG, Yao C; ''Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.''; Br J Pharmacol, 2020 PubMed Europe PMC Scholia
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  23. Robb CT, McSorley HJ, Lee J, Aoki T, Yu C, Crittenden S, Astier A, Felton JM, Parkinson N, Ayele A, Breyer RM, Anderton SM, Narumiya S, Rossi AG, Howie SE, Guttman-Yassky E, Weller RB, Yao C; ''Prostaglandin E2stimulates adaptive IL-22 production and promotes allergic contact dermatitis.''; J Allergy Clin Immunol, 2018 PubMed Europe PMC Scholia
  24. Chen BC, Liao CC, Hsu MJ, Liao YT, Lin CC, Sheu JR, Lin CH; ''Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B.''; J Immunol, 2006 PubMed Europe PMC Scholia
  25. Siu KL, Yuen KS, Castaño-Rodriguez C, Ye ZW, Yeung ML, Fung SY, Yuan S, Chan CP, Yuen KY, Enjuanes L, Jin DY; ''Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC.''; FASEB J, 2019 PubMed Europe PMC Scholia
  26. Gustafsson K, Junevik K, Werlenius O, Holmgren S, Karlsson-Parra A, Andersson PO; ''Tumour-loaded α-type 1-polarized dendritic cells from patients with chronic lymphocytic leukaemia produce a superior NK-, NKT- and CD8+ T cell-attracting chemokine profile.''; Scand J Immunol, 2011 PubMed Europe PMC Scholia
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  30. Cho JS, Han IH, Lee HR, Lee HM; ''Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-κB Pathways in Nasal Polyp-Derived Fibroblasts.''; Allergy Asthma Immunol Res, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128022view16:11, 21 January 2024EweitzOntology Term : 'plasmacytoid dendritic cell' added !
128021view16:10, 21 January 2024EweitzOntology Term : 'natural killer cell' added !
128020view16:10, 21 January 2024EweitzOntology Term : 'T-helper 17 cell' added !
128019view16:10, 21 January 2024EweitzOntology Term : 'fibroblast' added !
128018view16:09, 21 January 2024EweitzOntology Term : 'macrophage' added !
128017view16:09, 21 January 2024EweitzOntology Term : 'monocyte' added !
127698view00:21, 23 November 2023EweitzFurther optimize layout of components
127697view23:03, 22 November 2023EweitzTrim more empty space, further standardize font size, etc.
127696view21:52, 22 November 2023EweitzCenter-align components
127695view21:46, 22 November 2023EweitzOptimize component offsets
127692view20:59, 22 November 2023EweitzShift diagram left, to trim excess negative space
127690view13:11, 22 November 2023EweitzOptimize layout in T cell function component
127689view12:58, 22 November 2023EweitzOptimize layout in NK cell functions component
127688view12:47, 22 November 2023EweitzOptimize layout in NF-kB signaling component
127687view12:30, 22 November 2023EweitzStandardize case
127685view12:20, 22 November 2023EweitzModified description
119639view06:34, 27 July 2021EgonwNot a conversion
119319view13:32, 23 June 2021AriajadhavUpdated and restructured pathway. Added legend
119018view19:19, 9 June 2021EgonwNot a human gene id
118971view12:33, 5 June 2021EgonwNot a human gene ID
117086view20:38, 16 May 2021AriajadhavMade the pathway compact
116865view14:51, 14 May 2021AriajadhavConnected lines
116773view00:28, 14 May 2021AriajadhavUpdated pathway, added references
116698view18:38, 9 May 2021AriajadhavModified description
116418view09:09, 7 May 2021EweitzModified title
116320view11:27, 30 April 2021Marvin M2Ontology Term : 'prostaglandin I2 signaling pathway' added !
116319view11:25, 30 April 2021Marvin M2Ontology Term : 'prostaglandin E2 signaling pathway' added !
116318view11:25, 30 April 2021Marvin M2Ontology Term : 'COVID-19' added !
116317view11:23, 30 April 2021Marvin M2connected lines
116312view15:10, 29 April 2021AriajadhavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHR ProteinENSG00000106546 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
COX2 GeneProductENSSSCG00000018078 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL9GeneProductENSG00000138755 (Ensembl)
Ca2+ effluxMetaboliteCHEBI:29108 (ChEBI)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNGProteinIFNG (HGNC)
IL12AGeneProductENSG00000168811 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL8 GeneProductENSG00000169429 (Ensembl)
IP-activated cAMPMetaboliteHMDB0000058 (HMDB)
IRF7GeneProductENSG00000185507 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
Natural killer cells antigen CD94ProteinE9PCX9 (Uniprot-TrEMBL)
PKAProteinEC 2.7.11.11 (KEGG Genes)
Prostaglandin E receptor 4ProteinENSG00000171522 (Ensembl)
Prostaglandin E2 receptor EP2 subtypeProteinG3V2Y6 (Uniprot-TrEMBL)
Prostaglandin E2Metabolite363-24-6 (CAS)
Prostaglandin I2Metabolite35121-78-9 (CAS)
TGFB1GeneProductTGFB1 (HGNC)
TNFGeneProductENSG00000232810 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions

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