Biosynthesis of the three types of mycolic acids (Mycobacterium tuberculosis)

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1Malonyl-AcpMFadD32acetyl coenzyme aAccD4AcpMCarbon dioxidemtFabHMalonyl-CoAKetomycolateFAS IKasAMeromycolates (C56)FabG1methoxy mycolic acidFatty acids (C26)Rv0636Rv0635Rv0637α-mycolic acidInhARv2425cFAS IIKasBPks13


Description

Pathway leading to the biosynthesis of the three types of mycolic acids in M. tuberculosis, as published in: "Virulence factors of the Mycobacterium tuberculosis complex" (PMID: 23076359)

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Quality Tags

Ontology Terms

 

Bibliography

  1. Forrellad MA, Klepp LI, Gioffré A, Sabio y García J, Morbidoni HR, de la Paz Santangelo M, Cataldi AA, Bigi F; ''Virulence factors of the Mycobacterium tuberculosis complex.''; Virulence, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129332view09:06, 27 March 2024MkutmonOntology Term : 'classic metabolic pathway' added !
116588view11:42, 8 May 2021EweitzModified title
101921view13:29, 17 November 2018EgonwReplaced old Uniprot data sources with the new ones.
95615view20:13, 9 January 2018AndraModified description
95614view20:11, 9 January 2018AndraCompletion of drawing from original source
95613view20:03, 9 January 2018Andraintermediate save
95612view13:41, 9 January 2018AndraOntology Term : 'tuberculosis' added !
95611view13:40, 9 January 2018Andrainternediate save...
95610view12:37, 9 January 2018AndraInitial stub
95609view12:34, 9 January 2018AndraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AccD4Protein
AcpMGeneProduct888272 (Entrez Gene)
Carbon dioxideMetabolite280 (PubChem-compound)
FabG1Protein
FadD32ProteinO53580 (Uniprot-TrEMBL)
Fatty acids (C26)Metabolite
InhAGeneProduct886523 (Entrez Gene)
KasAProteinA5U4S7 (Uniprot-TrEMBL)
KasBProteinP9WQD6 (Uniprot-TrEMBL)
KetomycolateMetabolite
Malonyl-AcpMMetabolite
Malonyl-CoAMetabolite869 (PubChem-compound)
Meromycolates (C56)Metabolite
Pks13Protein
Rv0635ProteinI6Y8B9 (Uniprot-TrEMBL)
Rv0636ProteinI6WYY7 (Uniprot-TrEMBL)
Rv0637ProteinI6Y4B3 (Uniprot-TrEMBL)
Rv2425cProteinP71923 (Uniprot-TrEMBL)
acetyl coenzyme aMetabolite444493 (PubChem-compound)
methoxy mycolic acidMetaboliteCHEBI:59233 (ChEBI)
mtFabHProteinP9WNG3 (Uniprot-TrEMBL)
α-mycolic acidMetaboliteCHEBI:59235 (ChEBI)

Annotated Interactions

No annotated interactions

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