Overview of proinflammatory and profibrotic mediators (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cytokine stormIL2CSF3CSF2CXCL10IL-6IL-1 BetaIL-8CCL2TNF alphaIL-12IL-8MMP3CCL2TNF alphaIL-12IL-1 BetaMMP1IL-6ROSNF-kappa-BVEGFAMMP9TGFB1CXCL1CSF1AREGIL17FIL17AIL22CXCL9IFNGIFNA1Prostaglandin E2Prostaglandin E2Name: Inflammatory Mediators leading to Cytokine StormOrganism: Homo sapiens


Description

Inflammatory cytokines leading to cytokine storm after NF-kappa-B activation. KEGG pathway 05171 was referenced for the pathway development.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Turner MD, Nedjai B, Hurst T, Pennington DJ; ''Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.''; Biochim Biophys Acta, 2014 PubMed Europe PMC Scholia
  2. Robb CT, Goepp M, Rossi AG, Yao C; ''Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.''; Br J Pharmacol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128722
Approved
view02:09, 21 February 2024EweitzEconomize layout
128721view01:58, 21 February 2024EweitzColor metabolites, standardize font, ecoonomize layout
120801view12:31, 10 January 2022DuyguddOntology Term : 'pro-inflammatory cytokine mediated pathway' added !
116868view20:50, 14 May 2021Marvin M2Added chemokines
116764view09:58, 12 May 2021Marvin M2Added cytokines
116697view18:36, 9 May 2021AriajadhavModified description
116696view18:31, 9 May 2021AriajadhavAdded references to Prostaglandin pathways
116695view18:27, 9 May 2021AriajadhavAdded Prostaglandin mediated cytokine release to pathway
116384view11:18, 6 May 2021RaatsSModified description
116383view11:17, 6 May 2021RaatsSchanged title format. capitalized letters.
116382view11:16, 6 May 2021RaatsSAdded upstream genes and metabolites
116381view11:14, 6 May 2021RaatsSNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AREGGeneProductENSG00000109321 (Ensembl)
CCL2GeneProduct6347 (Entrez Gene)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL9GeneProductENSG00000138755 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IL-1 BetaGeneProductENSG00000125538 (Ensembl)
IL-12GeneProductIL12A (HGNC)
IL-6GeneProductENSG00000136244 (Ensembl)
IL-8GeneProductENSG00000169429 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL22GeneProductIL22 (HGNC)
IL2GeneProductENSG00000109471 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NF-kappa-B ProteinD6RC45 (Uniprot-TrEMBL)
Prostaglandin E2Metabolite15551 (ChEBI)
Prostaglandin E2Metabolite35121-78-9 (CAS)
ROSMetaboliteCHEBI:26523 (ChEBI)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNF alphaGeneProductENSG00000232810 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)

Annotated Interactions

No annotated interactions

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