MAPK cascade (Bos taurus)

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1, 2GqNucleusGrowth and MitogenesisStress Activated PathwaysActivatedRap1GAPGiComplexp38 MAPK PathwayGb and GgMAP2K7MAP3K12SIPA1MAPK14MAP2MAPK1MAPK10MAPK12GDPMAP2K4MAP2K6MAP3K1MAP2K3MBPMAP2K1MAP2K2RapGAPIIPLCB3MAP3K3MAP3K2ELK1NRASKRASJUNHRASGTPRASA3MAPK3MAP2K4ARAFRAF1BRAFApoptosisRRAS


Description

The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP422 (r95146) with a 96.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  2. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120345view07:25, 27 November 2021EgonwMade a pathway clickable
116824view10:17, 14 May 2021EweitzModified title
95769view14:24, 19 January 2018MkutmonHomology conversion update
86847view14:54, 13 July 2016MkutmonOntology Term : 'mitogen activated protein kinase signaling pathway' added !
86841view13:33, 13 July 2016Mkutmonontology tag fix
80699view15:22, 30 June 2015Mkutmonhomology conversion
71415view19:01, 17 October 2013MaintBotAutomated update of data sources
63370view23:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
62705view23:17, 1 May 2013MaintBotUpdated UniProt data source
40542view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33783view00:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32488view12:45, 17 August 2009MaintBotFixed text labels
32183view12:32, 15 August 2009MaintBotFixed text labels
31654view11:37, 14 August 2009MaintBotFixed group labels
31186view19:28, 13 August 2009MaintBotFixed text labels
30578view22:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARAFGeneProductENSBTAG00000005039 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:369
ApoptosisPathwayWP254 (WikiPathways)
BRAFGeneProductENSBTAG00000021761 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:673
ELK1GeneProductENSBTAG00000015817 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2002
GDPMetabolite146-91-8 (CAS)
GTPMetabolite2564-35-4 (CAS)
HRASGeneProductENSBTAG00000046644 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3265
JUNGeneProductENSBTAG00000004037 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3725
KRASGeneProductENSBTAG00000009778 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3845
MAP2GeneProductENSBTAG00000018130 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4133
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5608
MAP2K7GeneProductENSBTAG00000010639 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5609
MAP3K12GeneProductENSBTAG00000020758 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7786
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4214
MAP3K2GeneProductENSBTAG00000004216 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10746
MAP3K3GeneProductENSBTAG00000008151 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4215
MAPK10GeneProductENSBTAG00000020048 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5602
MAPK12GeneProductENSBTAG00000019574 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6300
MAPK14GeneProductENSBTAG00000020783 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5595
MBPGeneProductENSBTAG00000022890 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4155
NRASGeneProductENSBTAG00000046797 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4893
PLCB3GeneProductENSBTAG00000012510 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5331
RAF1GeneProductENSBTAG00000004514 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5894
RASA3GeneProductENSBTAG00000019967 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22821
RRASGeneProductENSBTAG00000020983 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6237
RapGAPIIGeneProduct
SIPA1GeneProductENSBTAG00000013884 (Ensembl)
  • not confirmed SwissProt ID - mu: SPA1 MOUSE
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6494

Annotated Interactions

No annotated interactions
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