DNA replication (Rattus norvegicus)

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1-3Cdc6Mcm6Processive complexMcm7Orc2Mcm2Mcm5Mcm6Orc complexRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerCdc6Phosphorylated Cdc6DNAPolymerase AOrc4Cdt1Orc4p180Cdc6Degraded byproteasomein cytosol3. DNA replication initiationRFC37Orc2RFC Heteropentamer:RNA primer-DNA primerOrc complexRFC140Cdt1Cdt1Phosphorylated Orc1Orc complex5. Leading/lagging strand synthesisMcm10PrimaseDNA polymerase alpha:primase: origin complexRFC36Mcm3Mcm5Ubiquitinated Cdc6GemininDegraded by proteasome in cytosolOrc2Cdt1RNA primer-DNA primerRFC40Pre-replicative complexp49Ubiquitin4. Switching of origins to post-replicative statep58Orc3Mcm7Mcm 4,6,7 trimer forms andassociates with the replication forkMcm3Mcm4Orc5RNA PrimerOriginOrc1DNA polymerase alpha:primase: origin complexOrc3Cdc6Ubiquitinated Orc1Phosphorylation ofMcm 2-7 complex2. Activation of the pre-replicative complexp70Mcm4Orc3Orc complexRNA primer-DNA primerCdt1Orc5Pre-replicative complexMcm10RNA primer-DNA primer:origin duplex:PCNAOrc31. Assembly of the pre-replicative complexRFC38Orc complexUbiquitinMcm2Orc2Orc5Cdt1GTPOrc6lRfc2Pola2Pole2PcnaATPdCTPRfc3Pold1RPA4POLARfc1dUTPATPCdc45lOrc3lUTPADPATPUba52Mcm6PoleCdk2Mcm10Prim2Rfc4Cdc6Mcm2Rpa2Orc1lCdc7Orc5lMcm5CTPPold2UbcPold4Orc4ldGTPdATPMcm7ATPOrc2lRpa3Dbf4Rpa1Mcm3Mcm4GmnnPold3PRIM1ADPRfc5


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 70% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116954view10:07, 16 May 2021EweitzModified title
71773view20:30, 17 October 2013MaintBotAutomated update of data sources
69342view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67163view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41654view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
35215view15:47, 11 February 2010Thomasadded literature
35214view15:46, 11 February 2010ThomasModified description
35200view15:39, 11 February 2010ThomasModified description
34052view19:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32445view17:19, 15 August 2009MaintBotFixed text labels
32119view13:51, 14 August 2009MaintBotFixed group labels
31462view21:16, 13 August 2009MaintBotFixed text labels
30930view00:37, 30 July 2009MaintBotConverted from Homo sapiens
21698view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:DNA replication Reactome]] moved to [[Pathway:WP484]]: Moved to stable identifier
10211view18:29, 16 January 2008MaintBotSpecify description
10047view15:05, 11 January 2008MaintBot
7994view13:46, 7 January 2008MaintBot[[Pathway:Rat:DNA replication Reactome]] moved to [[Pathway:Rattus norvegicus:DNA replication Reactome]]: Renaming species
7211view12:33, 4 November 2007MaintBotAdded categories to GPML
19419view22:19, 22 May 2007D.Korengpml file for [[Rat:DNA_replication_Reactome]]
6530view22:19, 22 May 2007Kdahlquistgpml file for [[Rat:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CTPMetabolite
Cdc45lGeneProduct287961 (Entrez Gene)
Cdc6GeneProduct360621 (Entrez Gene)
Cdc7GeneProduct360908 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene)
Cdt1GeneProduct292071 (Entrez Gene)
Dbf4GeneProduct312046 (Entrez Gene)
GTPMetabolite
GmnnGeneProduct291137 (Entrez Gene)
Mcm10GeneProduct307126 (Entrez Gene)
Mcm2GeneProduct312538 (Entrez Gene)
Mcm3GeneProduct316273 (Entrez Gene)
Mcm4GeneProduct29728 (Entrez Gene)
Mcm5GeneProduct291885 (Entrez Gene)
Mcm6GeneProduct29685 (Entrez Gene)
Mcm7GeneProduct288532 (Entrez Gene)
Orc1lGeneProduct313479 (Entrez Gene)
Orc2lGeneProduct301430 (Entrez Gene)
Orc3lGeneProduct313138 (Entrez Gene)
Orc4lGeneProduct295596 (Entrez Gene)
Orc5lGeneProduct362304 (Entrez Gene)
Orc6lGeneProduct291927 (Entrez Gene)
POLAGeneProduct
PRIM1GeneProduct246327 (Entrez Gene)
PcnaGeneProduct25737 (Entrez Gene)
Pola2GeneProduct85242 (Entrez Gene)
Pold1GeneProduct59294 (Entrez Gene)
Pold2GeneProduct289758 (Entrez Gene)
Pold3GeneProduct293144 (Entrez Gene)
Pold4GeneProduct361698 (Entrez Gene)
Pole2GeneProduct299112 (Entrez Gene)
PoleGeneProduct304573 (Entrez Gene)
Prim2GeneProduct301323 (Entrez Gene)
RPA4GeneProduct
Rfc1GeneProduct89809 (Entrez Gene)
Rfc2GeneProduct116468 (Entrez Gene)
Rfc3GeneProduct288414 (Entrez Gene)
Rfc4GeneProduct288003 (Entrez Gene)
Rfc5GeneProduct304528 (Entrez Gene)
Rpa1GeneProduct287524 (Entrez Gene)
Rpa2GeneProduct59102 (Entrez Gene)
Rpa3GeneProduct296883 (Entrez Gene)
UTPMetabolite
Uba52GeneProduct64156 (Entrez Gene)
UbcGeneProduct50522 (Entrez Gene)
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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