Focal adhesion (Rattus norvegicus)
From WikiPathways
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
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Ontology Terms
Bibliography
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- Turner CE; ''Paxillin and focal adhesion signalling.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
- Lee JW, Juliano R; ''Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.''; Mol Cells, 2004 PubMed Europe PMC Scholia
- Schmitz AA, Govek EE, Böttner B, Van Aelst L; ''Rho GTPases: signaling, migration, and invasion.''; Exp Cell Res, 2000 PubMed Europe PMC Scholia
- Schlaepfer DD, Mitra SK; ''Multiple connections link FAK to cell motility and invasion.''; Curr Opin Genet Dev, 2004 PubMed Europe PMC Scholia
- Nicholson KM, Anderson NG; ''The protein kinase B/Akt signalling pathway in human malignancy.''; Cell Signal, 2002 PubMed Europe PMC Scholia
- Comoglio PM, Boccaccio C, Trusolino L; ''Interactions between growth factor receptors and adhesion molecules: breaking the rules.''; Curr Opin Cell Biol, 2003 PubMed Europe PMC Scholia
- Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
- Guo W, Giancotti FG; ''Integrin signalling during tumour progression.''; Nat Rev Mol Cell Biol, 2004 PubMed Europe PMC Scholia
- Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z; ''The mechanism of action of the tumour suppressor gene PTEN.''; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2003 PubMed Europe PMC Scholia
- Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC Scholia
- Petit V, Thiery JP; ''Focal adhesions: structure and dynamics.''; Biol Cell, 2000 PubMed Europe PMC Scholia
- Danen EH, Yamada KM; ''Fibronectin, integrins, and growth control.''; J Cell Physiol, 2001 PubMed Europe PMC Scholia
- Oloumi A, McPhee T, Dedhar S; ''Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.''; Biochim Biophys Acta, 2004 PubMed Europe PMC Scholia
- Berman AE, Kozlova NI, Morozevich GE; ''Integrins: structure and signaling.''; Biochemistry (Mosc), 2003 PubMed Europe PMC Scholia
- Parsons JT; ''Focal adhesion kinase: the first ten years.''; J Cell Sci, 2003 PubMed Europe PMC Scholia
- Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.''; Biochem J, 2000 PubMed Europe PMC Scholia
- Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase: in command and control of cell motility.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Actb | GeneProduct | 81822 (Entrez Gene) | actin, beta |
Actg1 | GeneProduct | 287876 (Entrez Gene) | actin, gamma 1 |
Actn1 | GeneProduct | 81634 (Entrez Gene) | actinin, alpha 1 |
Akt1 | GeneProduct | 24185 (Entrez Gene) | v-akt murine thymoma viral oncogene homolog 1 |
Akt2 | GeneProduct | 25233 (Entrez Gene) | v-akt murine thymoma viral oncogene homolog 2 |
Akt3 | GeneProduct | 29414 (Entrez Gene) | v-akt murine thymoma viral oncogene homolog 3 |
Araf | GeneProduct | 64363 (Entrez Gene) | ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-] |
Arhgap5 | GeneProduct | 299012 (Entrez Gene) | Rho GTPase activating protein 5 |
Bad | GeneProduct | 64639 (Entrez Gene) | BCL2-associated agonist of cell death |
Bcar1 | GeneProduct | 25414 (Entrez Gene) | breast cancer anti-estrogen resistance 1 |
Bcl2 | GeneProduct | 24224 (Entrez Gene) | B-cell CLL/lymphoma 2 |
Birc2 | GeneProduct | 60371 (Entrez Gene) | baculoviral IAP repeat-containing 2 |
Birc3 | GeneProduct | 78971 (Entrez Gene) | baculoviral IAP repeat-containing 3 |
Birc4 | GeneProduct | 63879 (Entrez Gene) | X-linked inhibitor of apoptosis, also known as Birc4, Api3, riap3 |
Blk | GeneProduct | 364403 (Entrez Gene) | BLK proto-oncogene, Src family tyrosine kinase |
Braf | GeneProduct | ENSRNOG00000010957 (Ensembl) | B-Raf proto-oncogene, serine/threonine kinase |
Capn1 | GeneProduct | 29153 (Entrez Gene) | calpain 1, (mu/I) large subunit |
Cav2 | GeneProduct | 363425 (Entrez Gene) | CAV2; caveolin 2 |
Cav | GeneProduct | 25404 (Entrez Gene) | CAV1; caveolin 1 caveolae protein 22kD |
Cav3 | GeneProduct | 29161 (Entrez Gene) | CAV3; caveolin 3 |
Ccnd1 | GeneProduct | 58919 (Entrez Gene) | cyclin D1 |
Ccnd2 | GeneProduct | 64033 (Entrez Gene) | cyclin D2 |
Ccnd3 | GeneProduct | 25193 (Entrez Gene) | cyclin D3 |
Cdc42 | GeneProduct | 64465 (Entrez Gene) | cell division cycle 42 |
Chad | GeneProduct | 29195 (Entrez Gene) | chondroadherin |
Col11a1 | GeneProduct | 25654 (Entrez Gene) | collagen, type XI, alpha 1 |
Col11a2 | GeneProduct | 294279 (Entrez Gene) | |
Col1a1 | GeneProduct | 29393 (Entrez Gene) | collagen, type I, alpha 1 |
Col1a2 | GeneProduct | 84352 (Entrez Gene) | |
Col2a1 | GeneProduct | 25412 (Entrez Gene) | collagen, type II, alpha 1 |
Col3a1 | GeneProduct | 84032 (Entrez Gene) | collagen, type III, alpha 1 |
Col4a1 | GeneProduct | 290905 (Entrez Gene) | collagen, type IV, alpha 1 |
Col4a2 | GeneProduct | 306628 (Entrez Gene) | |
Col4a4 | GeneProduct | 301562 (Entrez Gene) | collagen, type IV, alpha 4 |
Col4a6 | GeneProduct | 363458 (Entrez Gene) | collagen, type IV, alpha 6 |
Col5a1 | GeneProduct | 85490 (Entrez Gene) | collagen, type V, alpha 1 |
Col5a2 | GeneProduct | 85250 (Entrez Gene) | collagen, type V, alpha 2 |
Col5a3 | GeneProduct | 60379 (Entrez Gene) | |
Col6a2 | GeneProduct | 361821 (Entrez Gene) | collagen, type VI, alpha 2 |
Comp | GeneProduct | 25304 (Entrez Gene) | |
Crk1 | GeneProduct | 81649 (Entrez Gene) | mitogen activated protein kinase 14, synonym: Mapk14, RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha |
Crk | GeneProduct | 54245 (Entrez Gene) | v-crk avian sarcoma virus CT10 oncogene homolog |
Ctnnb1 | GeneProduct | 84353 (Entrez Gene) | |
Diap1 | GeneProduct | 307483 (Entrez Gene) | |
Dock1 | GeneProduct | 309081 (Entrez Gene) | DOCK1; dedicator of cyto-kinesis |
Egf | GeneProduct | 25313 (Entrez Gene) | |
Egfr | GeneProduct | 24329 (Entrez Gene) | epidermal growth factor receptor |
Elk1 | GeneProduct | 314436 (Entrez Gene) | ELK1, member of ETS oncogene family |
Erbb2 | GeneProduct | 24337 (Entrez Gene) | v-erb-b2 avian erythroblastic leukemia viral oncogene 2 |
Farp2 | GeneProduct | 316639 (Entrez Gene) | |
Fgr | GeneProduct | 79113 (Entrez Gene) | FGR proto-oncogene, Src family tyrosine kinase |
Figf | GeneProduct | 360457 (Entrez Gene) | |
Flna | GeneProduct | 293860 (Entrez Gene) | filamin A, alpha |
Flt1 | GeneProduct | 54251 (Entrez Gene) | FMS-related tyrosine kinase 1 |
Fn1 | GeneProduct | 25661 (Entrez Gene) | fibronectin 1 |
Fyn | GeneProduct | 25150 (Entrez Gene) | FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112] |
Grb2 | GeneProduct | 81504 (Entrez Gene) | GRB2; growth factor receptor-bound protein 2 |
Gsk3b | GeneProduct | 84027 (Entrez Gene) | glycogen synthase kinase 3 beta |
Ha-Ras | GeneProduct | 293621 (Entrez Gene) | Harvey rat sarcoma virus oncogene, also known as H-ras, HRAS1, c-H-ras |
Hck | GeneProduct | 25734 (Entrez Gene) | hemopoietic cell kinase |
Hgf | GeneProduct | 24446 (Entrez Gene) | |
Ibsp | GeneProduct | 24477 (Entrez Gene) | integrin-binding sialoprotein |
Igf1 | GeneProduct | 24482 (Entrez Gene) | |
Igf1r | GeneProduct | 25718 (Entrez Gene) | insulin-like growth factor 1 receptor |
Ilk | GeneProduct | 170922 (Entrez Gene) | ILK; integrin-linked kinase [EC:2.7.1.-] |
Itga10 | GeneProduct | 310683 (Entrez Gene) | |
Itga11 | GeneProduct | 315744 (Entrez Gene) | |
Itga2 | GeneProduct | 685269 (Entrez Gene) | integrin, alpha 2B |
Itga2b | GeneProduct | 685269 (Entrez Gene) | integrin, alpha 2B |
Itga3 | GeneProduct | 360606 (Entrez Gene) | |
Itga4 | GeneProduct | 311144 (Entrez Gene) | |
Itga5 | GeneProduct | 315346 (Entrez Gene) | |
Itga6 | GeneProduct | 114517 (Entrez Gene) | integrin, alpha 6 |
Itga7 | GeneProduct | 81008 (Entrez Gene) | integrin, alpha 7 |
Itga8 | GeneProduct | 364786 (Entrez Gene) | integrin, alpha 8 |
Itga9 | GeneProduct | 685004 (Entrez Gene) | integrin, alpha 9 |
Itgad | GeneProduct | 64350 (Entrez Gene) | integrin, alpha D |
Itgae | GeneProduct | 83577 (Entrez Gene) | integrin, alpha E |
Itgal | GeneProduct | 308995 (Entrez Gene) | integrin, alpha L |
Itgam | GeneProduct | 25021 (Entrez Gene) | integrin, alpha M |
Itgav | GeneProduct | 296456 (Entrez Gene) | integrin, alpha V |
Itgax | GeneProduct | 499271 (Entrez Gene) | |
Itgb1 | GeneProduct | 24511 (Entrez Gene) | integrin, beta 1 |
Itgb2 | GeneProduct | 309684 (Entrez Gene) | integrin, beta 2 |
Itgb3 | GeneProduct | 29302 (Entrez Gene) | integrin, beta 3 |
Itgb4 | GeneProduct | 3691 (Entrez Gene) | |
Itgb5 | GeneProduct | ENSRNOG00000001795 (Ensembl) | integrin, beta 5 |
Itgb6 | GeneProduct | 311061 (Entrez Gene) | integrin, beta 6 |
Itgb7 | GeneProduct | 25713 (Entrez Gene) | integrin, beta 7 |
Itgb8 | GeneProduct | 362800 (Entrez Gene) | |
Jun | GeneProduct | 24516 (Entrez Gene) | jun proto-oncogene |
Kdr | GeneProduct | 25589 (Entrez Gene) | kinase insert domain receptor |
LOC235580 | GeneProduct | unknown gene product, LOC235580 was replaced by Col6a4 collagen, type VI, alpha 4 (M. musculus), Gene ID: 68553, updated on 17-Mar-2015 | |
Lama1 | GeneProduct | 316758 (Entrez Gene) | |
Lama2 | GeneProduct | ENSRNOG00000011134 (Ensembl) | |
Lama3 | GeneProduct | 307582 (Entrez Gene) | laminin, alpha 3 |
Lama4 | GeneProduct | 309816 (Entrez Gene) | laminin, alpha 4 |
Lama5 | GeneProduct | 140433 (Entrez Gene) | laminin, alpha 5 |
Lamb1 | GeneProduct | 298941 (Entrez Gene) | |
Lamb2 | GeneProduct | 25473 (Entrez Gene) | laminin, beta 2 |
Lamb3 | GeneProduct | 305078 (Entrez Gene) | laminin, beta 3 |
Lamc1 | GeneProduct | 117036 (Entrez Gene) | |
Lamc2 | GeneProduct | 192362 (Entrez Gene) | laminin, gamma 2 |
Lamc3 | GeneProduct | 311862 (Entrez Gene) | |
Map2k1 | GeneProduct | 170851 (Entrez Gene) | MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-] |
Map2k2 | GeneProduct | 58960 (Entrez Gene) | MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-] |
Map2k3 | GeneProduct | 303200 (Entrez Gene) | MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-] |
Map2k5 | GeneProduct | 29568 (Entrez Gene) | MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-] |
Map2k6 | GeneProduct | 114495 (Entrez Gene) | MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.- |
Mapk1 | GeneProduct | 116590 (Entrez Gene) | MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-] |
Mapk12 | GeneProduct | 60352 (Entrez Gene) | MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-] |
Mapk4 | GeneProduct | 54268 (Entrez Gene) | MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-] |
Mapk6 | GeneProduct | 58840 (Entrez Gene) | MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-] |
Mapk7 | GeneProduct | 114509 (Entrez Gene) | MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.- |
Mapk8 | GeneProduct | 116554 (Entrez Gene) | mitogen-activated protein kinase 8 |
Mapk9 | GeneProduct | 50658 (Entrez Gene) | mitogen-activated protein kinase 9 |
Met | GeneProduct | 24553 (Entrez Gene) | MET proto-oncogene, receptor tyrosine kinase |
Myl6 | GeneProduct | 362816 (Entrez Gene) | |
Mylk2 | GeneProduct | 117558 (Entrez Gene) | myosin light chain kinase 2 |
Mylk | GeneProduct | 288057 (Entrez Gene) | |
Pak1 | GeneProduct | 29431 (Entrez Gene) | p21 protein (Cdc42/Rac)-activated kinase 1 |
Pak2 | GeneProduct | 29432 (Entrez Gene) | p21 protein (Cdc42/Rac)-activated kinase 2 |
Pak3 | GeneProduct | 29433 (Entrez Gene) | p21 protein (Cdc42/Rac)-activated kinase 3 |
Pak4 | GeneProduct | 292756 (Entrez Gene) | |
Pak6 | GeneProduct | 296078 (Entrez Gene) | |
Pak7 | GeneProduct | 311450 (Entrez Gene) | |
Parvb | GeneProduct | 362973 (Entrez Gene) | |
Pdgfa | GeneProduct | 25266 (Entrez Gene) | |
Pdgfb | GeneProduct | 24628 (Entrez Gene) | platelet-derived growth factor beta polypeptide |
Pdgfc | GeneProduct | 79429 (Entrez Gene) | platelet derived growth factor C |
Pdgfd | GeneProduct | 66018 (Entrez Gene) | platelet derived growth factor D |
Pdgfra | GeneProduct | 25267 (Entrez Gene) | platelet derived growth factor receptor, alpha polypeptide |
Pdgfrb | GeneProduct | 24629 (Entrez Gene) | platelet derived growth factor receptor, beta polypeptide |
Pdpk1 | GeneProduct | 81745 (Entrez Gene) | 3-phosphoinositide dependent protein kinase-1 |
Pelo | GeneProduct | 294754 (Entrez Gene) | |
Pgf | GeneProduct | 94203 (Entrez Gene) | |
Pik3ca | GeneProduct | 170911 (Entrez Gene) | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
Pik3cb | GeneProduct | 85243 (Entrez Gene) | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Pik3cd | GeneProduct | 366508 (Entrez Gene) | |
Pik3cg | GeneProduct | 298947 (Entrez Gene) | |
Pik3r1 | GeneProduct | 25513 (Entrez Gene) | phosphoinositide-3-kinase, regulatory subunit 1 |
Pik3r2 | GeneProduct | 29741 (Entrez Gene) | phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
Pik3r4 | GeneProduct | 363131 (Entrez Gene) | |
Pik3r5 | GeneProduct | 497931 (Entrez Gene) | |
Pip5k1c | GeneProduct | 314641 (Entrez Gene) | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma |
Ppp1r12a | GeneProduct | 116670 (Entrez Gene) | protein phosphatase 1, regulatory subunit 12A |
Pten | GeneProduct | 50557 (Entrez Gene) | phosphatase and tensin homolog |
Ptk2 | GeneProduct | 25614 (Entrez Gene) | PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112 |
Ptk6 | GeneProduct | 366275 (Entrez Gene) | |
Pxn | GeneProduct | 360820 (Entrez Gene) | paxillin |
Rac1 | GeneProduct | 363875 (Entrez Gene) | ras-related C3 botulinum toxin substrate 1 |
Rac2 | GeneProduct | 366957 (Entrez Gene) | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
Rac3 | GeneProduct | ENSRNOG00000048172 (Ensembl) | also known as LOC688319, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
Raf1 | GeneProduct | 24703 (Entrez Gene) | RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-] |
Rap1a | GeneProduct | 295347 (Entrez Gene) | RAP1A; RAP1A member of RAS oncogene family |
Rap1b | GeneProduct | 171337 (Entrez Gene) | RAP1B; RAP1B member of RAS oncogene family |
Rapgef1 | GeneProduct | 63881 (Entrez Gene) | Rap guanine nucleotide exchange factor |
Reln | GeneProduct | 24718 (Entrez Gene) | reelin |
Rhoa | GeneProduct | 117273 (Entrez Gene) | ras homolog family member A |
Rhob | GeneProduct | 64373 (Entrez Gene) | ras homolog family member B |
Rock1 | GeneProduct | 81762 (Entrez Gene) | Rho-associated coiled-coil containing protein kinase 1 |
Rock2 | GeneProduct | 25537 (Entrez Gene) | Rho-associated coiled-coil containing protein kinase 2 |
Sepp1 | GeneProduct | 29360 (Entrez Gene) | SEPP1; selenoprotein P plasma |
Shc1 | GeneProduct | 85385 (Entrez Gene) | SHC1; SHC (Src homology 2 domain containing) transforming protein 1 |
Shc3 | GeneProduct | 114858 (Entrez Gene) | SHC3; neuronal Sh |
Sos1 | GeneProduct | 313845 (Entrez Gene) | SOS1; son of sevenless homolog 1 (Drosophila) |
Spp1 | GeneProduct | 25353 (Entrez Gene) | secreted phosphoprotein 1 |
Src | GeneProduct | 83805 (Entrez Gene) | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] |
Srms | GeneProduct | 296472 (Entrez Gene) | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites |
Styk1 | GeneProduct | 500340 (Entrez Gene) | |
Tesk2 | GeneProduct | 170908 (Entrez Gene) | testis-specific kinase 2 |
Thbs1 | GeneProduct | 445442 (Entrez Gene) | thrombospondin 1 |
Thbs2 | GeneProduct | 292406 (Entrez Gene) | thrombospondin 2 |
Thbs3 | GeneProduct | 681309 (Entrez Gene) | thrombospondin 3 |
Thbs4 | GeneProduct | 29220 (Entrez Gene) | |
Tln1 | GeneProduct | 313494 (Entrez Gene) | talin 1 |
Tnc | GeneProduct | 116640 (Entrez Gene) | tenascin C |
Tnk1 | GeneProduct | 303247 (Entrez Gene) | |
Tnk2 | GeneProduct | 303882 (Entrez Gene) | tyrosine kinase, non-receptor, 2 |
Tnn | GeneProduct | 304913 (Entrez Gene) | |
Tnr | GeneProduct | 25567 (Entrez Gene) | tenascin R |
Tnxb | GeneProduct | 415089 (Entrez Gene) | tenascin XB |
Txk | GeneProduct | 305311 (Entrez Gene) | TXK tyrosine kinase |
Vasp | GeneProduct | 361517 (Entrez Gene) | VASP; vasodilator-stimulated phosphoprotein |
Vav1 | GeneProduct | 25156 (Entrez Gene) | vav 1 guanine nucleotide exchange factor |
Vcl | GeneProduct | 305679 (Entrez Gene) | VCL; vinculin |
Vegfa | GeneProduct | 83785 (Entrez Gene) | vascular endothelial growth factor A |
Vegfb | GeneProduct | 89811 (Entrez Gene) | vascular endothelial growth factor B |
Vegfc | GeneProduct | 114111 (Entrez Gene) | vascular endothelial growth factor C |
Vtn | GeneProduct | 29169 (Entrez Gene) | vitronectin |
Vwf | GeneProduct | 116669 (Entrez Gene) | |
Zyx | GeneProduct | 114636 (Entrez Gene) | ZYX; zyxin |
Annotated Interactions
No annotated interactions