Amino acid metabolism (Homo sapiens)

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Revision as of 14:23, 16 May 2021 by Eweitz (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

Description

A complete overview of the metabolism of all 20 amino acids. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper: This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP662 revision 71177, with a 99.0% conversion rate.

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Quality Tags

Ontology Terms

Bibliography

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History

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Revision	Action	Time	User	Comment
123124	view	18:51, 4 July 2022	Egonw	Made three pathways clickable
117062	view	14:23, 16 May 2021	Eweitz	Modified title
115752	view	11:42, 9 March 2021	Egonw	Replaced the WP id of a mouse pathway with the matching human pathway
107149	view	14:23, 17 September 2019	MaintBot	ChEBI identifier normalization
106767	view	13:24, 17 September 2019	MaintBot	HMDB identifier normalization
105878	view	04:51, 16 August 2019	Khanspers	Modified description
105525	view	05:59, 9 August 2019	Khanspers	Modified description
96439	view	07:56, 15 March 2018	Egonw	Replaced secondary ChEBI identifiers with primary identifiers.
90737	view	23:26, 13 December 2016	Khanspers	updated link to source pathway
90730	view	22:40, 13 December 2016	Khanspers	Ontology Term : 'amino acid metabolic pathway' added !
90729	view	22:38, 13 December 2016	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
2-oxo-glutarate	Metabolite	CHEBI:16810 (ChEBI)
5-OH-Trp	Metabolite	HMDB0000472 (HMDB)
AC007325.2	GeneProduct	ENSG00000277196 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19125
AC068533.7	GeneProduct	ENSG00000249319 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88084
ACAA1	GeneProduct	ENSG00000060971 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2148491
ACADM	GeneProduct	ENSG00000117054 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87867
ACLY	GeneProduct	ENSG00000131473 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:103251
ACO2	GeneProduct	ENSG00000100412 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87880
ACSS1	GeneProduct	ENSG00000154930 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915988
ADH1C	GeneProduct	ENSG00000248144 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87921
ADH4	GeneProduct	ENSG00000198099 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1349472
ADH5	GeneProduct	ENSG00000197894 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87929
ADH7	GeneProduct	ENSG00000196344 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87926
ALDH18A1	GeneProduct	ENSG00000059573 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1888908
ALDH1A1	GeneProduct	ENSG00000165092 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1353450
ALDH7A1	GeneProduct	ENSG00000164904 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:108186
AOC3	GeneProduct	ENSG00000131471 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1306797
AP002884.2	GeneProduct	ENSG00000255292 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914175
ARG1	GeneProduct	ENSG00000118520 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88070
ARG2	GeneProduct	ENSG00000081181 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1330806
ASNS	GeneProduct	ENSG00000070669 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1350929
ASS1	GeneProduct	ENSG00000130707 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88090
AUH	GeneProduct	ENSG00000148090 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1338011
Acetyl-CoA	Metabolite	HMDB0001206 (HMDB)
Aconitate	Metabolite	HMDB0000072 (HMDB)
Ala-tRNA	Metabolite	CHEBI:17732 (ChEBI)
Alanine	Metabolite	HMDB0000161 (HMDB)
Arg-tRNA	Metabolite	CHEBI:18366 (ChEBI)
Arginine	Metabolite	HMDB0000517 (HMDB)
Arginino-succinate	Metabolite	HMDB0000052 (HMDB)
Asparagine	Metabolite	HMDB0000168 (HMDB)
Aspartate	Metabolite	HMDB0000191 (HMDB)
B-OH-butyrate	Metabolite	HMDB0000011 (HMDB)
BCAT1	GeneProduct	ENSG00000060982 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104861
BHMT	GeneProduct	ENSG00000145692 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339972
CAD	GeneProduct	ENSG00000084774 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1916969
CBS	GeneProduct	ENSG00000160200 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88285
CPS1	GeneProduct	ENSG00000021826 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:891996
CS	GeneProduct	ENSG00000062485 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88529
CTH	GeneProduct	ENSG00000116761 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339968
Carbamoyl-aspartate	Metabolite	HMDB0000828 (HMDB)
Citrate	Metabolite	HMDB0000094 (HMDB)
Citrulline	Metabolite	HMDB0000904 (HMDB)
Creatine P	Metabolite	HMDB0001511 (HMDB)
Cystathionine	Metabolite	HMDB0000099 (HMDB)
Cysteine	Metabolite	HMDB0000574 (HMDB)
DBH	GeneProduct	ENSG00000123454 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94864
DDC	GeneProduct	ENSG00000132437 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94876
DLD	GeneProduct	ENSG00000091140 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107450
DLST	GeneProduct	ENSG00000119689 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1926170
Dihydro-orotate	Metabolite	HMDB0003349 (HMDB)
Dopamine	Metabolite	HMDB0000073 (HMDB)
EHHADH	GeneProduct	ENSG00000113790 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1277964
EPRS	GeneProduct	ENSG00000136628 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97838
Epinephrine	Metabolite	HMDB0000068 (HMDB)
Ethanol	Metabolite	HMDB0000108 (HMDB)
FAH	GeneProduct	ENSG00000103876 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95482
FARSB	GeneProduct	ENSG00000116120 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1346035
FH	GeneProduct	ENSG00000091483 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14194
FTCD	GeneProduct	ENSG00000160282 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962
Fatty acid metabolism	Pathway	WP357 (WikiPathways)
Fumarate	Metabolite	HMDB0000134 (HMDB)
G6PC2	GeneProduct	ENSG00000152254 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.140768
GCLM	GeneProduct	ENSG00000023909 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104995
GLS	GeneProduct	ENSG00000115419 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95752
GLUD1	GeneProduct	ENSG00000148672 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753
GLUL	GeneProduct	ENSG00000135821 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95739
GOT1	GeneProduct	ENSG00000120053 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95791
GOT2	GeneProduct	ENSG00000125166 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95792
GPT2	GeneProduct	ENSG00000166123 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391
GSR	GeneProduct	ENSG00000104687 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95804
GSS	GeneProduct	ENSG00000100983 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95852
Glu-tRNA	Metabolite	CHEBI:29157 (ChEBI)
Glucose	Metabolite	HMDB0000122 (HMDB)
Glutamate	Metabolite	HMDB0000148 (HMDB)
Glutamine	Metabolite	HMDB0000641 (HMDB)
Glycine	Metabolite	HMDB0000123 (HMDB)
Gst	GeneProduct		No homologues found for original id M:MGI:1309515
Guanidinoacetate P	Metabolite	HMDB0003705 (HMDB)
Guanidinoacetate	Metabolite	HMDB0000128 (HMDB)
HADH	GeneProduct	ENSG00000138796 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96009
HAL	GeneProduct	ENSG00000084110 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010
HCO3	Metabolite	HMDB0003538 (HMDB)
HDC	GeneProduct	ENSG00000140287 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96062
HIBADH	GeneProduct	ENSG00000106049 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1889802
HIBCH	GeneProduct	ENSG00000198130 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1923792
HMGCL	GeneProduct	ENSG00000117305 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96158
HMGCS2	GeneProduct	ENSG00000134240 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:101939
HNMT	GeneProduct	ENSG00000150540 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2153181
His-tRNA	Metabolite	CHEBI:29155 (ChEBI)
Histamine	Metabolite	HMDB0000870 (HMDB)
Histidine	Metabolite	HMDB0000177 (HMDB)
Homocysteine	Metabolite	HMDB0000742 (HMDB)
IARS	GeneProduct	ENSG00000196305 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2145219
IDH1	GeneProduct	ENSG00000138413 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96413
Ile-tRNA	Metabolite	CHEBI:29160 (ChEBI)
Imidazole acetaldehyde	Metabolite	HMDB0003905 (HMDB)
Indoleacetaldehyde	Metabolite	HMDB0001190 (HMDB)
Indoleacetate	Metabolite	HMDB0000197 (HMDB)
Isoleucine	Metabolite	HMDB0000172 (HMDB)
Isovaleryl-CoA	Metabolite	HMDB0001113 (HMDB)
LARS2	GeneProduct	ENSG00000011376 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2142973
LDHA	GeneProduct	ENSG00000134333 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96759
Lactate	Metabolite	HMDB0000190 (HMDB)
Leu-tRNA	Metabolite	CHEBI:16624 (ChEBI)
Leucine	Metabolite	HMDB0000687 (HMDB)
MAOA	GeneProduct	ENSG00000189221 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96915
MARS2	GeneProduct	ENSG00000247626 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2444136
MCCC1	GeneProduct	ENSG00000078070 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1919289
MDH1	GeneProduct	ENSG00000014641 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97051
MDH2	GeneProduct	ENSG00000146701 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97050
MPST	GeneProduct	ENSG00000128309 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2179733
MUT	GeneProduct	ENSG00000146085 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97239
Malate	Metabolite	HMDB0000156 (HMDB)
Melanin	Metabolite	HMDB0004068 (HMDB)
Met-tRNA	Metabolite	CHEBI:16635 (ChEBI)
Methionine	Metabolite	HMDB0000696 (HMDB)
Methyl-OH-butyryl-CoA	Metabolite	HMDB0001356 (HMDB)
Methylacetoacetyl-CoA	Metabolite	HMDB0001157 (HMDB)
Methylbutyryl-CoA	Metabolite	HMDB0001041 (HMDB)
Methylcrotonyl-CoA	Metabolite	HMDB0001493 (HMDB)
Methylglutaconyl-CoA	Metabolite	HMDB0001057 (HMDB)
N-Formylkynurenine	Metabolite	HMDB0001200 (HMDB)
NADP	Metabolite	HMDB0000217 (HMDB)
Norepinephrine	Metabolite	HMDB0000216 (HMDB)
OAT	GeneProduct	ENSG00000065154 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97394
ODC1	GeneProduct	ENSG00000115758 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97402
OGDH	GeneProduct	ENSG00000105953 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18293
OH-indoleacetate	Metabolite	HMDB0000763 (HMDB)
OH-isobutyrate	Metabolite	CHEBI:19641 (ChEBI)
OH-isobutyryl-CoA	Metabolite	HMDB0001052 (HMDB)
OH-isovaleryl-CoA	Metabolite	HMDB0006870 (HMDB)
OH-methylglutaryl-CoA	Metabolite	HMDB0001375 (HMDB)
OTC	GeneProduct	ENSG00000036473 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97448
Ornithine	Metabolite	HMDB0000214 (HMDB)
Ox. glutathione	Metabolite	HMDB0003337 (HMDB)
Oxaloacetate	Metabolite	HMDB0000223 (HMDB)
Oxobutyrate	Metabolite	HMDB0000005 (HMDB)
P-enolpyruvate	Metabolite	HMDB0000263 (HMDB)
P4HA2	GeneProduct	ENSG00000072682 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:894286
PC	GeneProduct	ENSG00000173599 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97520
PCK1	GeneProduct	ENSG00000124253 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97501
PDHA1	GeneProduct	ENSG00000131828 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775
PDHX	GeneProduct	ENSG00000110435 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351627
PDK4	GeneProduct	ENSG00000004799 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351481
PKM	GeneProduct	ENSG00000067225 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97591
PNMT	GeneProduct	ENSG00000141744 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97724
PPM1L	GeneProduct	ENSG00000163590 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.40577
PYCR1	GeneProduct	ENSG00000183010 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2384795
Phe-tRNA	Metabolite	CHEBI:29153 (ChEBI)
Phenylalanine	Metabolite	HMDB0000159 (HMDB)
Proline	Metabolite	HMDB0000162 (HMDB)
Propionyl-CoA	Metabolite	HMDB0001275 (HMDB)
Putrescine	Metabolite	HMDB0001414 (HMDB)
Pyruvate	Metabolite	HMDB0000243 (HMDB)
R-S-glutathione	Metabolite	CHEBI:17021 (ChEBI)
RARS	GeneProduct	ENSG00000113643 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914297
Red. Glutathione	Metabolite	HMDB0000125 (HMDB)
SDHA	GeneProduct	ENSG00000073578 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914195
SDS	GeneProduct	ENSG00000135094 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98270
SMS	GeneProduct	ENSG00000102172 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:109490
SRM	GeneProduct	ENSG00000116649 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:102690
SUCLG1	GeneProduct	ENSG00000163541 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1927234
Serine	Metabolite	HMDB0000187 (HMDB)
Serotonin	Metabolite	HMDB0000259 (HMDB)
Spermidine	Metabolite	HMDB0001257 (HMDB)
Spermine	Metabolite	HMDB0001256 (HMDB)
Succinate	Metabolite	HMDB0000254 (HMDB)
Succinyl-CoA	Metabolite	HMDB0001022 (HMDB)
TAT	GeneProduct	ENSG00000198650 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98487
TDO2	GeneProduct	ENSG00000151790 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1928486
TH	GeneProduct	ENSG00000180176 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98735
TPH1	GeneProduct	ENSG00000129167 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98796
TPO	GeneProduct	ENSG00000115705 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98813
Threonine	Metabolite	HMDB0000167 (HMDB)
Thyroxine	Metabolite	HMDB0000248 (HMDB)
Tiglyl-CoA	Metabolite	HMDB0002054 (HMDB)
Trp-tRNA	Metabolite	CHEBI:29159 (ChEBI)
Tryptamine	Metabolite	HMDB0000303 (HMDB)
Tryptophan	Metabolite	HMDB0000929 (HMDB)
Tyr-tRNA	Metabolite	CHEBI:29161 (ChEBI)
Tyrosine	Metabolite	HMDB0000158 (HMDB)
Urea	Metabolite	HMDB0000294 (HMDB)
VARS	GeneProduct	ENSG00000204394 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:90675
Val-tRNA	Metabolite	CHEBI:29164 (ChEBI)
WARS	GeneProduct	ENSG00000140105 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104630
carbamoyl-P	Metabolite	HMDB0001096 (HMDB)
glutamate semialdehyde	Metabolite	CHEBI:15757 (ChEBI)
glutamyl-P	Metabolite	CHEBI:21314 (ChEBI)
glutamyl-cysteine	Metabolite	CHEBI:17515 (ChEBI)
glycolysis & gluconeogenesis	Pathway	WP157 (WikiPathways)
homogentisate	Metabolite	CHEBI:16169 (ChEBI)
hydroxy-proline	Metabolite	HMDB0000725 (HMDB)
isobutyryl-CoA	Metabolite	CHEBI:15479 (ChEBI)
isocitrate	Metabolite	HMDB0000193 (HMDB)
mercaptopyruvate	Metabolite	HMDB0001368 (HMDB)
methacrylyl-CoA	Metabolite	CHEBI:27754 (ChEBI)
methylhistamine	Metabolite	HMDB0000898 (HMDB)
methylmalonate semialdehyde	Metabolite	CHEBI:16256 (ChEBI)
methylmalonyl-CoA	Metabolite	CHEBI:15465 (ChEBI)
oxo-isocaproate	Metabolite	CHEBI:17865 (ChEBI)
oxo-isovalerate	Metabolite	CHEBI:11851 (ChEBI)
oxo-methyl-valerate	Metabolite	CHEBI:35146 (ChEBI)
pyrroline carboxylate	Metabolite	HMDB0006875 (HMDB)
valine	Metabolite	HMDB0000883 (HMDB)

Annotated Interactions

No annotated interactions

Amino acid metabolism (Homo sapiens)

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