Exercise-induced circadian regulation (Homo sapiens)
From WikiPathways
Description
Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianally regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianally regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianally regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.
Based on Zambon et al, Genome Biol. 2003;4(10):R61.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, Weitz CJ; ''Extensive and divergent circadian gene expression in liver and heart.''; Nature, 2002 PubMed Europe PMC Scholia
- Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB; ''Coordinated transcription of key pathways in the mouse by the circadian clock.''; Cell, 2002 PubMed Europe PMC Scholia
- Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, Takahashi JS, Schambelan M, Conklin BR; ''Time- and exercise-dependent gene regulation in human skeletal muscle.''; Genome Biol, 2003 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ARNTL | GeneProduct | 406 (Entrez Gene) | |
AZIN1 | GeneProduct | 51582 (Entrez Gene) | 101002 at |
BTG1 | GeneProduct | 694 (Entrez Gene) | 93104 at |
CAST | GeneProduct | 26059 (Entrez Gene) | 93829 at |
CBX3 | GeneProduct | 11335 (Entrez Gene) | 100405 at |
CEBPB | GeneProduct | 1051 (Entrez Gene) | 92925 at |
CLDN5 | GeneProduct | 7122 (Entrez Gene) | 104516 at |
CLOCK | GeneProduct | 9575 (Entrez Gene) | |
CRY1 | GeneProduct | 1407 (Entrez Gene) | |
CRY2 | GeneProduct | 1408 (Entrez Gene) | |
DAZAP2 | GeneProduct | 9802 (Entrez Gene) | 94454 at |
DNAJA1 | GeneProduct | 3301 (Entrez Gene) | 97261 at |
EIF4G2 | GeneProduct | 1982 (Entrez Gene) | 100535 at |
ETV6 | GeneProduct | 2120 (Entrez Gene) | 93866 s at |
G0S2 | GeneProduct | 50486 (Entrez Gene) | 97531 at |
GENX-3414 | GeneProduct | 8987 (Entrez Gene) | 104116 at |
GFRA1 | GeneProduct | 2674 (Entrez Gene) | 93872 at |
GSTM3 | GeneProduct | 2947 (Entrez Gene) | 97681 f at |
GSTP1 | GeneProduct | 2950 (Entrez Gene) | 99583 at |
HERPUD1 | GeneProduct | 9709 (Entrez Gene) | 95057 at |
HIST1H2BN | GeneProduct | 8341 (Entrez Gene) | 93833 s at |
HLA-DMA | GeneProduct | 3108 (Entrez Gene) | 162346 f at |
HSPA8 | GeneProduct | 3312 (Entrez Gene) | 96564 at |
IDI1 | GeneProduct | 3422 (Entrez Gene) | 96269 at |
KLF9 | GeneProduct | 687 (Entrez Gene) | 93527 at |
MAP3K7IP2 | GeneProduct | 23118 (Entrez Gene) | 160309 at |
MYF6 | GeneProduct | 4618 (Entrez Gene) | 102265 at |
NCKAP1 | GeneProduct | 10787 (Entrez Gene) | 95508 at |
NCOA4 | GeneProduct | 8031 (Entrez Gene) | 97843 at |
NR1D2 | GeneProduct | 9975 (Entrez Gene) | 99076 at |
PER1 | GeneProduct | 5187 (Entrez Gene) | |
PER2 | GeneProduct | 8864 (Entrez Gene) | |
PIGF | GeneProduct | 5281 (Entrez Gene) | 104725 at |
PPP1R3C | GeneProduct | 5507 (Entrez Gene) | 93933 at |
PPP2CB | GeneProduct | 5516 (Entrez Gene) | 101101 at |
PSMA4 | GeneProduct | 5685 (Entrez Gene) | 97459 at |
PURA | GeneProduct | 5813 (Entrez Gene) | 103501 at |
QKI | GeneProduct | 9444 (Entrez Gene) | 95096 at (mouse) |
RBPMS | GeneProduct | 11030 (Entrez Gene) | 103888 at |
SF3A3 | GeneProduct | 10946 (Entrez Gene) | 96029 at |
SUMO1 | GeneProduct | 7341 (Entrez Gene) | 101091 at |
SUMO3 | GeneProduct | 6612 (Entrez Gene) | 95424 at |
TOB1 | GeneProduct | 10140 (Entrez Gene) | 99532 at |
TUBB3 | GeneProduct | 10381 (Entrez Gene) | 94835 f at |
UCP3 | GeneProduct | 7352 (Entrez Gene) | 93392 at |
UGP2 | GeneProduct | 7360 (Entrez Gene) | 94481 at |
VAPA | GeneProduct | 9218 (Entrez Gene) | 94889 at |
ZFR | GeneProduct | 51663 (Entrez Gene) | 104050 at |
Annotated Interactions
No annotated interactions