EPO receptor signaling (Gallus gallus)

From WikiPathways

Revision as of 10:33, 18 May 2021 by Eweitz (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
EPORJAK2SRCEPOR1, 2PBox-1PPPPPPPPPPY343Y479Box-2Cell membraneDNAY343Y460PPBox-2Box-1PY431RCJMB04_17i9RCJMB04_4o20AKT1SHC1ERK1MAPK1MAP2K2MAP2K1GRB2PIK3CGEPOEPOSOCS1STAT5BCISHSTAT5ASTAT3STAT3RCJMB04_17i9PTPRCPTPRUPPPGRB2RAF1SOS1IRS2JAK2IRS1RASA1RAF1SOS1RASA1


Description

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia This pathway is based on ScienceSlides.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP581(r22574) with a 74% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed Europe PMC Scholia
  2. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117198view10:33, 18 May 2021EweitzModified title
68838view17:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
67200view10:20, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
40975view22:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
35093view12:54, 11 February 2010Thomasadded literature
33900view17:59, 9 December 2009MaintBotAutomatic update of empty xrefs
33451view15:00, 30 November 2009MaintBotRemoved group label
30337view20:48, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
CISHGeneProduct395335 (Entrez Gene)
EPOGeneProduct
EPORGeneProduct
ERK1GeneProduct
GRB2GeneProduct386572 (Entrez Gene)
IRS1GeneProduct429126 (Entrez Gene)
IRS2GeneProduct428017 (Entrez Gene)
JAK2GeneProduct374199 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
PIK3CGGeneProduct417706 (Entrez Gene)
PTPRCGeneProduct386580 (Entrez Gene)
PTPRUGeneProduct395153 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RASA1GeneProduct427327 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_4o20GeneProduct425972 (Entrez Gene)
SHC1GeneProduct395934 (Entrez Gene)
SOCS1GeneProduct416630 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene)
SRCGeneProduct396442 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
STAT5AGeneProduct
STAT5BGeneProduct395556 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools