Aryl hydrocarbon receptor (Bos taurus)

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359, 282734233111, 25, 4513234026, 36745224, 3933STAT119CyNuHSP9017ActivationTCDD28CyNuNEDD8SUMO7CyNuCyNuNucleusProteinProteinDRE regionKLF6NQO1proliferation and tumorigenesis EGFRCYP1A1PAHAIPEBNA-3ARNTESR1HSP90AA1RETRB1TCDDEP300Calcium ChannelVEGFAXRECCL1CDKN1BPLAGL1NFE2L26, 154346AIP3747, 563111, 48, 509, 28, 555744, 524947P16, 35, 54L30AHRAIPAHR3, 17AHRHSP90AA128HSP90AA141, 4232MYC53TATAEGFR PathwayTNF25CDC37SRC26PRAF1PMAP2K1MAPK1PPGHS-233PSRC1RELANFKB1RELANFKB1EP300PSRC12AngiogenesisNCOA7NRIP1CYP1A1CD36LPLNFE2L222FGF21HPGDSGCLCOxidative StressNRIP1NF1NCOA75NCOR2CYP1A22021CYP1B118, 29Estrogen Metabolism and modulation of Estrogen receptor signallingEnzyme ComplexProteinReceptorLigandmRNASmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeCDKN1ACDK210, 51RB1E2F1Cell cycle inhibitionDetoxification of Xenobiotics and metabolism of xenobioticsCell SurvivalAHRREP30012FAS/ FAS-L (Apoptosis)NRASHRASKRASTCDD16, 35, 54PAH6, 15Cell Survival1


Description

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g. immunosuppression, carcinogenesis and hepatotoxicity.

AhR is a member of basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. In the absence of ligand, the AhR can be found in the cytosol, bound to a dimer of the heat shock protein of 90 kDa (Hsp90) and the immunophilin-like protein, AIP (also known as XAP2 and ARA9). Upon ligand binding, the AHR translocates to the nucleus and binds with ARNT. The AHR/ARNT heterodimer binds to xenobiotic response elements and regulates a diverse set of genes

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2586(79995) with a 96.0% conversion rate.

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Ontology Terms

 

Bibliography

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  39. Miao W, Hu L, Scrivens PJ, Batist G; ''Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
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  42. Soshilov A, Denison MS; ''Ligand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligand-binding domain.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
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  44. Elferink CJ, Ge NL, Levine A; ''Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein.''; Mol Pharmacol, 2001 PubMed Europe PMC Scholia
  45. Biscardi JS, Maa MC, Tice DA, Cox ME, Leu TH, Parsons SJ; ''c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  46. N'Diaye M, Le Ferrec E, Lagadic-Gossmann D, Corre S, Gilot D, Lecureur V, Monteiro P, Rauch C, Galibert MD, Fardel O; ''Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  47. Klinge CM, Kaur K, Swanson HI; ''The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.''; Arch Biochem Biophys, 2000 PubMed Europe PMC Scholia
  48. Riese DJ 2nd, Stern DF; ''Specificity within the EGF family/ErbB receptor family signaling network.''; Bioessays, 1998 PubMed Europe PMC Scholia
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  50. Madhukar BV, Ebner K, Matsumura F, Bombick DW, Brewster DW, Kawamoto T; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an increase in protein kinases associated with epidermal growth factor receptor in the hepatic plasma membrane.''; J Biochem Toxicol, 1988 PubMed Europe PMC Scholia
  51. Kwon TK, Nordin AA; ''Identification of cdk2 binding sites on the p27Kip1 cyclin-dependent kinase inhibitor.''; Oncogene, 1998 PubMed Europe PMC Scholia
  52. Ge NL, Elferink CJ; ''A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  53. Kim DW, Gazourian L, Quadri SA, Romieu-Mourez R, Sherr DH, Sonenshein GE; ''The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells.''; Oncogene, 2000 PubMed Europe PMC Scholia
  54. Poland A, Glover E, Kende AS; ''Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.''; J Biol Chem, 1976 PubMed Europe PMC Scholia
  55. Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y; ''Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.''; Biochem Biophys Res Commun, 1998 PubMed Europe PMC Scholia
  56. Ahmed S, Valen E, Sandelin A, Matthews J; ''Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters.''; Toxicol Sci, 2009 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
117477view10:59, 21 May 2021EweitzModified title
107071view14:15, 17 September 2019MaintBotChEBI identifier normalization
89410view20:18, 10 September 2016AlexanderPicoOntology Term : 'signaling pathway' added !
89133view21:49, 22 August 2016AriuttaOntology Term : 'regulatory pathway' added !
85345view10:13, 9 May 2016EgonwReplaced a mim-conversion with Arrow.
80830view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHRGeneProductENSBTAG00000007746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196
AHRRGeneProductENSBTAG00000026527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57491
AIPGeneProductENSBTAG00000010478 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110711
ARNTGeneProductENSBTAG00000021037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:405
AngiogenesisPathway
CCL1GeneProductENSBTAG00000008832 (Ensembl)
  • PMID: 16679317 PAHs induce expression of the chemokine CCL1 in an AhR- and calcium-dependent manner.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6346
CD36GeneProductENSBTAG00000014220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:948
CDC37GeneProductENSBTAG00000011699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11140
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CYP1A1ProteinENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1543
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1544
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1545
Calcium Channel
Cell SurvivalPathway
Cell Survival Pathway
Cell cycle inhibitionPathway
DRE regionComplex
Detoxification of Xenobiotics and metabolism of xenobiotics Pathway
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
EBNA-3Protein
EGFR Pathway
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
EP300ProteinENSBTAG00000016198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
ESR1ProteinENSBTAG00000007159 (Ensembl)
  • Estrogen Receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2099
Estrogen Metabolism and modulation of Estrogen receptor signallingPathway
FAS/ FAS-L (Apoptosis)Pathway
FGF21ProteinENSBTAG00000011624 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26291
GCLCProteinENSBTAG00000015571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2729
HPGDSProteinENSBTAG00000017073 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27306
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174775
HSP90AA1GeneProductENSBTAG00000006270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3320
KLF6GeneProductENSBTAG00000015188 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1316
KRASGeneProduct
LPLProteinENSBTAG00000012855 (Ensembl)
  • lipoprotein lipase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MYCProteinENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NCOA7ProteinENSBTAG00000011911 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:135112
NCOR2ProteinENSBTAG00000024603 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9612
NF1ProteinENSBTAG00000011829 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4763
NFE2L2GeneProductENSBTAG00000019255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4780
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NQO1ProteinENSBTAG00000020632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1728
NRASGeneProductENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213281
NRIP1ProteinENSBTAG00000047293 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8204
Oxidative Stress Pathway
PAHMetaboliteCHEBI:33848 (ChEBI)
PGHS-2GeneProductENSBTAG00000014127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
PLAGL1ProteinENSBTAG00000026523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5325
PSRC1GeneProductENSBTAG00000018806 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84722
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RELAGeneProductENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
RETProteinENSBTAG00000000570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5979
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
TATAComplex
TCDDMetaboliteCHEBI:28119 (ChEBI)
TNFGeneProductENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7422
XRExenobiotic responsive element
proliferation and tumorigenesis Pathway

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3226"
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