Colchicine metabolic pathway (Bos taurus)

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Description

P450-mediated biotransformation pathway of colchicine with the CYP3A4, while colchicine inhibits the expression of this enzyme.

HomologyConvert: This pathway was inferred from Homo sapiens pathway WP2536(74479) with a 100.0% conversion rate.

View approved pathways at the new wikipathways.org.

Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ; ''Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.''; Biochem Pharmacol, 1997 PubMed Europe PMC Scholia
Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, Maurel P, Pascussi JM; ''Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia

Name	Type	Database reference	Comment
2DMC	Metabolite	22210 (Chemspider)
3DMC	Metabolite	264748 (Chemspider)
CYP3A4	Protein	ENSBTAG00000047379 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08684
Colchicine	Metabolite	5933 (Chemspider)

No annotated interactions

Compare	Revision	Action	Time	User	Comment
	117489	view	11:01, 21 May 2021	Eweitz	Modified title
	80769	view	15:25, 30 June 2015	Mkutmon	New pathway