Fluoropyrimidine activity (Bos taurus)

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4, 5, 10, 11, 14...2420Liver cellApical membraneCancer cellEffluxDrug resistanceDNA IncorporationRNA IncorporationBasolateral membraneReuptake9CES1CES2FUTPERCC2TP53dTMPDHFUUMPSApoptosisCDAUPP1FURDihydrofolateTYMPFUPAMTHFRdUMPRRM2TK15-fluorouracil (5-FU)5-dFCR5-FUFPGSLeucovorinUCK25-FUDNA Repair5-dFURFdUDPUPP1CYP2A6RRM15-FUPPATFdUTPSLC22A7FUMPFdUMPUCK1FBALFdUTPTYMSTDGSMUG1SLC29A1ABCC4CapecitabineUPP2ABCC4XRCC35-hydroxytegafurTegafurGGHMIR29CFUDPTYMPFUDRABCC3FdUMP5,10-MethylenetetrahydrofolateFUTPFolate CycleUPP2UPB1DHFRDPYSABCG2DPYDABCC5182538, 2641231121, 28, 3430, 362, 7, 196, 9, 13, 29, 3337517


Description

The main mechanism of 5-FU activation is conversion to fluorodeoxyuridine monophosphate (FdUMP) which inhibits the enzyme thymidylate synthase (TYMS), an important part of the folate-homocysteine cycle and purine and pyrimidine synthesis The conversion of 5-FU to FdUMP can occur via thymidylate phosphorylase (TYMP) to fluorodeoxyuridine (FUDR) and then by the action of thymidine kinase to FdUMP or indirectly via fluorouridine monophosphate (FUMP) or fluroridine (FUR) to fluorouridine diphosphate (FUDP) and then ribonucleotide reductase action to FdUDP and FdUMP. FUDP and FdUDP can also be converted to FUTP and FdUTP and incorporated into RNA and DNA respectively which also contributes to the pharmacodynamic actions of fluoropyrimidines. Sources: PharmGKB:Fluoropyrimidine Pharmacokinetics, PharmGKB:Fluoropyrimidine Pharmacodynamics, Wikipedia:Fluorouracil

Comments

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This pathway was inferred from Homo sapiens pathway WP1601(80157) with a 89.0% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117513view11:06, 21 May 2021EweitzModified title
108137view10:32, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
107075view14:16, 17 September 2019MaintBotChEBI identifier normalization
105995view11:52, 16 August 2019MaintBotHMDB identifier normalization
80928view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5,10-MethylenetetrahydrofolateMetabolite97272 (Chemspider)
5-FUMetaboliteCHEBI:46345 (ChEBI)
5-dFCRMetabolite
5-dFURMetabolite
5-fluorouracil (5-FU)MetaboliteCHEBI:46345 (ChEBI)
5-hydroxytegafurMetabolite
ABCC3GeneProduct
ABCC4GeneProductENSBTAG00000046611 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10257
ABCC5GeneProductENSBTAG00000017666 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10057
ABCG2GeneProductENSBTAG00000017704 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9429
ApoptosisPathwayWP254 (WikiPathways)
CDAGeneProductENSBTAG00000006136 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:978
CES1GeneProductENSBTAG00000011021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1066
CES2GeneProductENSBTAG00000005093 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8824
CYP2A6GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1548
CapecitabineMetaboliteCHEBI:31348 (ChEBI)
DHFRGeneProductENSBTAG00000007681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1719
DHFUMetabolite
DNA RepairPathwayWP1805 (WikiPathways)
DPYDGeneProductENSBTAG00000031358 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1806
DPYSGeneProductENSBTAG00000021887 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1807
DihydrofolateMetaboliteHMDB0001056 (HMDB)
ERCC2GeneProductENSBTAG00000002072 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2068
FBALMetabolite
FPGSGeneProductENSBTAG00000008994 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2356
FUDPMetabolite
FUDRMetabolite
FUMPMetabolite796-66-7 (CAS)
FUPAMetabolite
FURMetabolite
FUTPMetabolite
FUTPMetabolite8430967 (Chemspider)
FdUDPMetabolite
FdUMPMetabolite
FdUTPMetabolite
Folate CyclePathway
GGHGeneProductENSBTAG00000007534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8836
LeucovorinMetabolite
MIR29CRna
MTHFRGeneProductENSBTAG00000020698 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4524
PPATGeneProductENSBTAG00000010571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5471
RRM1GeneProductENSBTAG00000013111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6240
RRM2GeneProductENSBTAG00000008216 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6241
SLC22A7GeneProductENSBTAG00000006350 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10864
SLC29A1GeneProductENSBTAG00000015131 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2030
SMUG1GeneProductENSBTAG00000021974 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23583
TDGGeneProductENSBTAG00000021633 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6996
TK1GeneProductENSBTAG00000007121 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7083
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
TYMPGeneProduct
TYMSGeneProductENSBTAG00000007003 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7298
TegafurMetabolite5193 (Chemspider)
UCK1GeneProductENSBTAG00000010810 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83549
UCK2GeneProductENSBTAG00000044150 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7371
UMPSGeneProductENSBTAG00000013727 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7372
UPB1GeneProductENSBTAG00000001325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51733
UPP1GeneProductENSBTAG00000008428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7378
UPP2GeneProductENSBTAG00000012801 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:151531
XRCC3GeneProductENSBTAG00000009966 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7517
dTMPMetaboliteHMDB0001056 (HMDB)
dUMPMetaboliteHMDB0001409 (HMDB)

Annotated Interactions

No annotated interactions
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