Glucocorticoid receptor pathway (Homo sapiens)
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Description
The glucocorticoid receptor (GR, a.k.a. NR3C1) is a nuclear receptor that is activated upon binding of cortisol or glucocorticoids. It mainly regulates gene expression of several groups of genes in two ways. It can stimulate anti-inflammatory genes, or inhibit the transcription of pro-inflammatory genes.
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ABHD2 | GeneProduct | 11057 (Entrez Gene) ![]() | abhydrolase domain containing 2 |
AKAP13 | GeneProduct | 11214 (Entrez Gene) ![]() | A kinase (PRKA) anchor protein 13 |
ALOX5AP | GeneProduct | 241 (Entrez Gene) ![]() | arachidonate 5-lipoxygenase-activating protein |
AMIGO2 | GeneProduct | 347902 (Entrez Gene) ![]() | adhesion molecule with Ig-like domain 2 |
ANGPTL4 | GeneProduct | 51129 (Entrez Gene) ![]() | angiopoietin-like 4 |
ANKRD1 | GeneProduct | 27063 (Entrez Gene) ![]() | ankyrin repeat domain 1 (cardiac muscle) |
ARL5B | GeneProduct | 221079 (Entrez Gene) ![]() | ADP-ribosylation factor-like 5B |
B3GNT5 | GeneProduct | 84002 (Entrez Gene) ![]() | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 |
BHLHE40 | GeneProduct | 8553 (Entrez Gene) ![]() | basic helix-loop-helix family, member e40 |
BIRC2 | GeneProduct | 329 (Entrez Gene) ![]() | baculoviral IAP repeat containing 2 |
BIRC3 | GeneProduct | 330 (Entrez Gene) ![]() | baculoviral IAP repeat containing 3 |
CCL20 | GeneProduct | 6364 (Entrez Gene) ![]() | chemokine (C-C motif) ligand 20 |
CCL2 | GeneProduct | 6347 (Entrez Gene) ![]() | chemokine (C-C motif) ligand 2 |
CDC42EP3 | GeneProduct | 10602 (Entrez Gene) ![]() | CDC42 effector protein (Rho GTPase binding) 3 |
CDKN1C | GeneProduct | 1028 (Entrez Gene) ![]() | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
CPEB4 | GeneProduct | 80315 (Entrez Gene) ![]() | cytoplasmic polyadenylation element binding protein 4 |
CUL1 | GeneProduct | 8454 (Entrez Gene) ![]() | cullin 1 |
CXCR7 | GeneProduct | 57007 (Entrez Gene) ![]() | atypical chemokine receptor 3 |
DNAJC15 | GeneProduct | 29103 (Entrez Gene) ![]() | DnaJ (Hsp40) homolog, subfamily C, member 15 |
DNER | GeneProduct | 92737 (Entrez Gene) ![]() | delta/notch-like EGF repeat containing |
EDN2 | GeneProduct | 1907 (Entrez Gene) ![]() | endothelin 2 |
ENC1 | GeneProduct | 8507 (Entrez Gene) ![]() | ectodermal-neural cortex 1 (with BTB domain) |
EPB41L4B | GeneProduct | 54566 (Entrez Gene) ![]() | erythrocyte membrane protein band 4.1 like 4B |
ETNK2 | GeneProduct | 55224 (Entrez Gene) ![]() | ethanolamine kinase 2 |
FGD4 | GeneProduct | 121512 (Entrez Gene) ![]() | FYVE, RhoGEF and PH domain containing 4 |
FGFBP1 | GeneProduct | 9982 (Entrez Gene) ![]() | fibroblast growth factor binding protein 1 |
GADD45B | GeneProduct | 4616 (Entrez Gene) ![]() | growth arrest and DNA-damage-inducible, beta |
GPR115 | GeneProduct | 221393 (Entrez Gene) ![]() | adhesion G protein-coupled receptor F4 |
GPR153 | GeneProduct | 387509 (Entrez Gene) ![]() | G protein-coupled receptor 153 |
GR ligand | Metabolite | CHEBI:63562 (ChEBI) ![]() | |
HSP90AA1 | GeneProduct | 3320 (Entrez Gene) ![]() | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
IL11 | GeneProduct | 3589 (Entrez Gene) ![]() | interleukin 11 |
JUN | GeneProduct | 3725 (Entrez Gene) ![]() | jun proto-oncogene |
KTN1 | GeneProduct | 3895 (Entrez Gene) ![]() | kinectin 1 (kinesin receptor) |
LRRC8A | GeneProduct | 56262 (Entrez Gene) ![]() | leucine rich repeat containing 8 family, member A |
Ligand | Metabolite | CHEBI:63562 (ChEBI) ![]() | |
MFGE8 | GeneProduct | 4240 (Entrez Gene) ![]() | milk fat globule-EGF factor 8 protein |
MGAM | GeneProduct | 8972 (Entrez Gene) ![]() | maltase-glucoamylase |
MT1IP | GeneProduct | 644314 (Entrez Gene) ![]() | metallothionein 1I, pseudogene |
NAV3 | GeneProduct | 89795 (Entrez Gene) ![]() | neuron navigator 3 |
NFKB2 | GeneProduct | 4791 (Entrez Gene) ![]() | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
NR1I2 | GeneProduct | 8856 (Entrez Gene) ![]() | nuclear receptor subfamily 1, group I, member 2 |
NR1I3 | GeneProduct | 9970 (Entrez Gene) ![]() | nuclear receptor subfamily 1, group I, member 3 |
NR3C1 | GeneProduct | 2908 (Entrez Gene) ![]() | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
PDE4B | GeneProduct | 5142 (Entrez Gene) ![]() | phosphodiesterase 4B, cAMP-specific |
PLK2 | GeneProduct | 10769 (Entrez Gene) ![]() | polo-like kinase 2 |
PMP2 | GeneProduct | 5375 (Entrez Gene) ![]() | peripheral myelin protein 2 |
POU5F1 | GeneProduct | 5460 (Entrez Gene) ![]() | POU class 5 homeobox 1 |
PPP1R14C | GeneProduct | 81706 (Entrez Gene) ![]() | protein phosphatase 1, regulatory (inhibitor) subunit 14C |
PRRG4 | GeneProduct | 79056 (Entrez Gene) ![]() | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) |
PTGES3 | GeneProduct | 10728 (Entrez Gene) ![]() | prostaglandin E synthase 3 (cytosolic) |
PTGS2 | GeneProduct | 5743 (Entrez Gene) ![]() | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
RGS2 | GeneProduct | 5997 (Entrez Gene) ![]() | regulator of G-protein signaling 2 |
RXRA | GeneProduct | 6256 (Entrez Gene) ![]() | retinoid X receptor, alpha |
S100P | GeneProduct | 6286 (Entrez Gene) ![]() | S100 calcium binding protein P |
SCNN1A | GeneProduct | 6337 (Entrez Gene) ![]() | sodium channel, non voltage gated 1 alpha subunit |
SDPR | GeneProduct | 8436 (Entrez Gene) ![]() | serum deprivation response |
SEC14L1 | GeneProduct | 6397 (Entrez Gene) ![]() | SEC14-like 1 (S. cerevisiae) |
SERPINB9 | GeneProduct | 5272 (Entrez Gene) ![]() | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
SERTAD2 | GeneProduct | 9792 (Entrez Gene) ![]() | SERTA domain containing 2 |
SLC19A2 | GeneProduct | 10560 (Entrez Gene) ![]() | solute carrier family 19 (thiamine transporter), member 2 |
SLC26A2 | GeneProduct | 1836 (Entrez Gene) ![]() | solute carrier family 26 (anion exchanger), member 2 |
SNAI2 | GeneProduct | 6591 (Entrez Gene) ![]() | snail family zinc finger 2 |
SPINK13 | GeneProduct | 153218 (Entrez Gene) ![]() | serine peptidase inhibitor, Kazal type 13 (putative) |
SPRY1 | GeneProduct | 10252 (Entrez Gene) ![]() | sprouty homolog 1, antagonist of FGF signaling (Drosophila) |
SRGN | GeneProduct | 5552 (Entrez Gene) ![]() | serglycin |
STOM | GeneProduct | 2040 (Entrez Gene) ![]() | stomatin |
TGFBR3 | GeneProduct | 7049 (Entrez Gene) ![]() | transforming growth factor, beta receptor III |
THBD | GeneProduct | 7056 (Entrez Gene) ![]() | thrombomodulin |
TNFAIP3 | GeneProduct | 7128 (Entrez Gene) ![]() | tumor necrosis factor, alpha-induced protein 3 |
TNS4 | GeneProduct | 84951 (Entrez Gene) ![]() | tensin 4 |
TSC22D3 | GeneProduct | 1831 (Entrez Gene) ![]() | TSC22 domain family, member 3 |
ZIC2 | GeneProduct | 7546 (Entrez Gene) ![]() | Zic family member 2 |
Annotated Interactions
No annotated interactions