Methylation (Canis familiaris)

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1, 2S-methylationO-methylationSAM synthesis (co-substrate)N-methylationS-AdenosylhomocysteineS-AdenosylmethionineS-AdenosylmethionineSubstratePhosphateS-AdenosylhomocysteineMAT2ANP_001004074.1PhosphateATPO-methylated substratePNMTMAT1AMAT2BN-methylated substrateS-AdenosylmethionineS-AdenosylhomocysteineINMTNNMTS-methylated substrateL-MethionineHNMTTPMT_CANFA


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP704(r30265) with a 88% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia
  2. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118131view10:35, 25 May 2021EweitzModified title
106035view11:56, 16 August 2019MaintBotHMDB identifier normalization
87825view11:43, 25 July 2016ElisaOntology Term : 'classic metabolic pathway' added !
87824view11:42, 25 July 2016ElisaOntology Term : 'PW:0000003' removed !
87823view11:41, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
68601view23:27, 5 July 2013MaintBotUpdated to 2013 gpml schema
58857view23:35, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40761view21:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
34032view18:49, 9 December 2009MaintBotAutomatic update of empty xrefs
31734view11:58, 14 August 2009MaintBotFixed group labels
30678view22:42, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB0000538 (HMDB)
HNMTGeneProductENSCAFG00000005178 (Ensembl)
INMTGeneProduct489397 (Entrez Gene)
L-MethionineMetaboliteHMDB0000696 (HMDB)
MAT1AGeneProductENSCAFG00000015807 (Ensembl)
MAT2AGeneProductENSCAFG00000007755 (Ensembl)
MAT2BGeneProductENSCAFG00000017181 (Ensembl)
N-methylated substrateMetabolite
NNMTGeneProductENSCAFG00000013523 (Ensembl)
NP_001004074.1GeneProductENSCAFG00000014253 (Ensembl)
O-methylated substrateMetabolite
PNMTGeneProductENSCAFG00000016368 (Ensembl)
PhosphateMetaboliteHMDB0001429 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TPMT_CANFAGeneProductENSCAFG00000010160 (Ensembl)

Annotated Interactions

No annotated interactions
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