Eukaryotic transcription initiation (Bos taurus)

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1, 2TFIIH55cell growth53(large ribosomal RNAs)TFIIFTFIIDRNA polymerase IIIRNA polymerase IRNA polymerase II5TFIIA355TATATFIIE(small stable RNAs)TFIIDTFIIB35(mRNA, snRNPs)TATA Box bindingprotein53Gene Regulatory Proteins3(recognize surface DNA geometry)TFIIF33Steps 2) Association of TIFs and RNA polymeraseSteps 5) RNA elongation with CDT phosphorylationTFIIETATATFIIH33RNA pol IISteps 3) DNA melting by association with TFIIHSteps 1) TBP binds TATA boxPrimary RNA transcriptdsDNA5TFIIATFIIFTATATranscription Initiation Factors (TIFs)5TFIIBSteps 4) Transcription elongation by NTPsPOLR2HGTF2H1POLR2BPOLR3KMNAT1GTF2H3TAF5CDK7GTF2A2GTF2E1POLR3EPOLR2GPOLR2ICCNHPOLR1BGTF2BERCC3TAF12POLR2APOLR1DGTF2F2ERCC2GTF2E2POLR3BAK6GTF2H4TBPPOLR3DPOLR2EPOLR1EPOLR2KTAF6ILKPOLR2CPOLR2FPOLR3HTAF7POLR2JTAF13GTF2H2POLR1A


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(73594) with a 97.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118352view13:31, 27 May 2021EweitzOntology Term : 'RNA polymerase I transcription initiation pathway' added !
118350view13:31, 27 May 2021EweitzOntology Term : 'RNA polymerase II transcription initiation pathway' added !
118349view13:30, 27 May 2021EweitzOntology Term : 'RNA polymerase III transcription initiation pathway' added !
117508view11:05, 21 May 2021EweitzModified title
80704view15:22, 30 June 2015Mkutmonhomology conversion
79155view05:06, 6 March 2015MaintBotUpdated conversion from Hs
67208view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
63323view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
48132view05:51, 9 May 2012MaintBotUpdating from human to fix xref duplication
40504view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35525view13:56, 12 February 2010Thomasadded literature
35512view13:49, 12 February 2010ThomasModified description
33747view23:57, 8 December 2009MaintBotAutomatic update of empty xrefs
32524view12:57, 17 August 2009MaintBotFixed text labels
32210view12:42, 15 August 2009MaintBotFixed text labels
31698view11:49, 14 August 2009MaintBotFixed group labels
31222view19:42, 13 August 2009MaintBotFixed text labels
30635view22:27, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AK6GeneProductENSBTAG00000046192 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6880
CCNHGeneProductENSBTAG00000009566 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:902
CDK7GeneProductENSBTAG00000011046 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1022
ERCC2GeneProductENSBTAG00000002072 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2068
ERCC3GeneProductENSBTAG00000020777 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2071
GTF2A2GeneProductENSBTAG00000010298 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2958
GTF2BGeneProductENSBTAG00000000504 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2959
GTF2E1GeneProductENSBTAG00000016848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2960
GTF2E2GeneProductENSBTAG00000012691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2961
GTF2F2GeneProductENSBTAG00000034495 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2963
GTF2H1GeneProductENSBTAG00000005160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2965
GTF2H2GeneProductENSBTAG00000027983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2966
GTF2H3GeneProductENSBTAG00000007270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2967
GTF2H4GeneProductENSBTAG00000046757 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2968
ILKGeneProductENSBTAG00000000696 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611
MNAT1GeneProductENSBTAG00000030801 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4331
POLR1AGeneProductENSBTAG00000006481 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25885
POLR1BGeneProductENSBTAG00000014166 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84172
POLR1DGeneProductENSBTAG00000008642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51082
POLR1EGeneProductENSBTAG00000012243 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64425
POLR2AGeneProductENSBTAG00000046765 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5430
POLR2BGeneProductENSBTAG00000019366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5431
POLR2CGeneProductENSBTAG00000001856 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5432
POLR2EGeneProductENSBTAG00000020776 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5434
POLR2FGeneProductENSBTAG00000004820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5435
POLR2GGeneProductENSBTAG00000009483 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5436
POLR2HGeneProductENSBTAG00000040199 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5437
POLR2IGeneProductENSBTAG00000015002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5438
POLR2JGeneProduct
POLR2KGeneProductENSBTAG00000022539 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5440
POLR3BGeneProductENSBTAG00000004781 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55703
POLR3DGeneProductENSBTAG00000010036 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:661
POLR3EGeneProductENSBTAG00000018044 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55718
POLR3HGeneProductENSBTAG00000005311 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:171568
POLR3KGeneProductENSBTAG00000019803 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51728
TAF12GeneProductENSBTAG00000026660 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6883
TAF13GeneProductENSBTAG00000031656 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6884
TAF5GeneProductENSBTAG00000009709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6877
TAF6GeneProductENSBTAG00000030966 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6878
TAF7GeneProductENSBTAG00000011945 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6879
TBPGeneProductENSBTAG00000002545 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6908

Annotated Interactions

No annotated interactions
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