Toll-like receptor signaling pathway (Canis familiaris)

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MyD88-dependent pathway(Neutrophil, immature DC,Specific pathwayin pDCsCpG DNA(T cell)Proinflammatory+peffects+pPeptidoglycan(G+)+pCytokine-+p(anti-viral compounds)LPS(G-)Zymosan (Yeast)Ubiquitin mediated proteolysisChemotacticLipoarabinomannanDNAInflammatory cytokinesT cell stimulation+p+pDegradation+pbiosynthesisImidazoquinolinInflammatory cytokinesFlagellar assemblyUnmethylatedcoagulation cascadesCostimulatory moleculeseffectsLipopolysaccharide+pJak-STAT signaling pathwayinteractionEndosomedsRNANK cell)Antiviral effects+cytokine receptor+pChemotacticMyD88-independent pathwayMAPK signaling pathway+pComplement andAutocrine / ParacrineIKK+p(Mycobacteria)Flagellin+p+peffects+pssRNAApoptosisLipoprotein+p+TLR2CCL4MYD88MAP2K2IL8IRF3NFKB1TIRAPTIRAPCXCL10RELATRAF3IFNA5STAT1RIPK1IKBKGTRAF6IFNA1CXCL9PIK3R2NFKB1IL12ATICAM1MAP2K1MAPK3RAC1AKT3AKT1IFNA7SPP1CHUKCD14MAPK8CD86MAP2K4TLR8PIK3R3IFNA13IFNA8IRAK1IRF5PIK3CALY96IFNA17CD40TLR5IFNB1MAP2K7IL12BTLR4TLR7IFNAR2TLR9MAP3K7IP2CXCL11IFNA2IKBKBTOLLIPMAPK12TLR6TRAF6MAPK10TNFCASP8IFNA10MAP2K3TLR3MAPK11IFNAR1TRAF6IFNA14CCL5IKBKEIL6MYD88IRF7MYD88MAP3K7IFNB1FOSMAPK13IRAK1JUNLOC480600IFNA6MYD88FADDMAP2K6CHUKIFNA21MAPK9PIK3R5LBPIRAK4NFKB2PIK3R1NFKBIAMAP3K7IP1IRAK4PIK3CBIFNB1TLR1MAPK14TLR2MAP3K8IFNA4CD80PIK3CDTBK1AKT2IFNA16TICAM2MAPK1PIK3CGIL1B


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 77% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
118909view21:52, 3 June 2021EweitzOntology Term : 'Toll-like receptor signaling pathway' added !
118908view21:51, 3 June 2021EweitzOntology Term : 'signaling pathway pertinent to development' added !
87794view11:16, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68519view22:02, 5 July 2013MaintBotUpdated to 2013 gpml schema
40673view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
33963view18:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32266view13:03, 15 August 2009MaintBotFixed text labels
31793view12:16, 14 August 2009MaintBotFixed group labels
31294view20:08, 13 August 2009MaintBotFixed text labels
30752view23:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct449021 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT3GeneProduct442964 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CASP8GeneProduct488473 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL4GeneProduct448786 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct403522 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct607076 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD40GeneProduct403469 (Entrez Gene) Original kegg element: gene;29;hsa:958
CD80GeneProduct403765 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct403764 (Entrez Gene) Original kegg element: gene;28;hsa:942
CHUKGeneProduct477796 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CXCL10GeneProduct478432 (Entrez Gene) Original kegg element: gene;25;hsa:3627
CXCL11GeneProductOriginal kegg element: gene;23;hsa:6373
CXCL9GeneProductOriginal kegg element: gene;24;hsa:4283
FADDGeneProductOriginal kegg element: gene;56;hsa:8772
FOSGeneProduct490792 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA1GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA10GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct442934 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct444848 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct474181 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProduct474182 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct609830 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct487737 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProduct481558 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IKBKBGeneProduct482839 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct478950 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProductOriginal kegg element: gene;85;hsa:8517
IL12AGeneProduct403977 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct403976 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct403974 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct403985 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct403850 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProduct492247 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK4GeneProduct486601 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProduct476412 (Entrez Gene) Original kegg element: gene;67;hsa:3661
IRF5GeneProduct482264 (Entrez Gene) Original kegg element: gene;21;hsa:3663
IRF7GeneProductOriginal kegg element: gene;20;hsa:3665
JUNGeneProduct609429 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LBPGeneProduct485869 (Entrez Gene) Original kegg element: gene;77;hsa:3929
LOC480600GeneProduct480600 (Entrez Gene) Original kegg element: gene;44;hsa:6348
LY96GeneProduct610524 (Entrez Gene) Original kegg element: gene;71;hsa:23643
MAP2K1GeneProduct478347 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct611939 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K3GeneProduct489547 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K4GeneProduct489508 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProduct480454 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProduct485004 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct474996 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct481245 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProduct484028 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct487085 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct478464 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProduct607019 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProduct607023 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK13GeneProduct612821 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct403856 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct477575 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK3GeneProduct486758 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct477746 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct474652 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MYD88GeneProduct477024 (Entrez Gene) Original kegg element: gene;47;hsa:4615
NFKB1GeneProduct442859 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct486858 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct480291 (Entrez Gene) Original kegg element: gene;64;hsa:4792
PIK3CAGeneProduct488084 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct477085 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct489644 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct483266 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct487235 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct609956 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct482512 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct612805 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
RAC1GeneProduct403955 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RELAGeneProduct483729 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct488195 (Entrez Gene) Original kegg element: gene;17;hsa:8737
SPP1GeneProduct478471 (Entrez Gene) Original kegg element: gene;15;hsa:6696
STAT1GeneProduct488449 (Entrez Gene) Original kegg element: gene;62;hsa:6772
TBK1GeneProduct481145 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct611852 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2GeneProductOriginal kegg element: gene;80;hsa:353376
TIRAPGeneProduct609544 (Entrez Gene) Original kegg element: gene;83;hsa:114609
TLR1GeneProduct488834 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR2GeneProduct448807 (Entrez Gene) Original kegg element: gene;74;hsa:7097
TLR3GeneProduct482905 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct403417 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR5GeneProduct488605 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProductOriginal kegg element: gene;76;hsa:10333
TLR7GeneProduct491743 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProductOriginal kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct403502 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TNFGeneProduct403922 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TOLLIPGeneProduct483657 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct490867 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProductOriginal kegg element: gene;53;hsa:7189

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1183"
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