Toll-like receptor signaling pathway (Pan troglodytes)

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IKKDNA+pImidazoquinolinCpG DNAChemotactic+p(T cell)Autocrine / Paracrine(Mycobacteria)+p+p+pbiosynthesisMyD88-dependent pathwayLipoproteinCytokine-effectsdsRNALipopolysaccharideeffectsCostimulatory molecules+++p+pcytokine receptorPeptidoglycan(G+)Complement andApoptosisLPS(G-)interaction(Neutrophil, immature DC,T cell stimulationcoagulation cascadesFlagellar assembly+pUbiquitin mediated proteolysisChemotacticeffects(anti-viral compounds)ProinflammatoryInflammatory cytokines+pNK cell)DegradationssRNAEndosome+pJak-STAT signaling pathway+p+pAntiviral effectsFlagellinUnmethylated+pSpecific pathwayin pDCsInflammatory cytokinesMyD88-independent pathwayZymosan (Yeast)MAPK signaling pathwayLipoarabinomannan+p+pIRF3IKBKBIL12BMAPK3IRAK1MAP2K6MAP2K2TOLLIPIL12ACXCL11NFKB1NFKB1LOC473198AKT2SPP1TIRAPIL1BCXCL10IRF5PIK3CGMYD88IL8TICAM2MAPK1RELATIRAPCCL5MAP3K7IP1IFNA5MAP3K8TICAM1IFNAR1LOC473191CASP8STAT1CCL4PIK3R1IFNA8IFNA6CHUKRIPK1IKBKECD80LOC473193LOC473185TLR2CXCL9MAP3K7IP2CCL3LBPMAP3K7RAC1TLR6AKT1IRF7LOC473183FOSTLR4MAPK11TLR2MAPK8MAP2K3IKBKGIFNA7MAP2K4LY96TLR8LOC473183MYD88MYD88IFNA10FADDTBK1PIK3R3LOC473183IRAK4TRAF3MYD88JUNCD86MAPK14MAPK13CD40CHUKIFNA4IRAK1PIK3R2NFKBIAMAPK12LOC741978IFNAR2TRAF6TLR1TRAF6TRAF6PIK3CDMAP2K7IL6CD14PIK3R5IRAK4TLR3TLR7TLR5MAP2K1IFNA1TNFPIK3CAMAPK10AKT3IFNA13TLR9NFKB2PIK3CBMAPK9


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 85% conversion rate.

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
118911view21:53, 3 June 2021EweitzOntology Term : 'signaling pathway pertinent to development' added !
118910view21:53, 3 June 2021EweitzOntology Term : 'Toll-like receptor signaling pathway' added !
87798view11:17, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69220view18:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
41522view01:56, 2 March 2011MaintBotRemoved redundant pathway information and comments
34261view21:51, 9 December 2009MaintBotAutomatic update of empty xrefs
33598view09:56, 1 December 2009MaintBotRemoved group label
31619view22:18, 13 August 2009MaintBotFixed text labels
30518view21:48, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct456035 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT3GeneProduct735718 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CASP8GeneProduct746477 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL3GeneProduct454592 (Entrez Gene) Original kegg element: gene;44;hsa:6348
CCL4GeneProduct455004 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct747004 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct462118 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD40GeneProductOriginal kegg element: gene;29;hsa:958
CD80GeneProduct470892 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct470900 (Entrez Gene) Original kegg element: gene;28;hsa:942
CHUKGeneProduct450673 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CXCL10GeneProduct461242 (Entrez Gene) Original kegg element: gene;25;hsa:3627
CXCL11GeneProduct739195 (Entrez Gene) Original kegg element: gene;23;hsa:6373
CXCL9GeneProduct471200 (Entrez Gene) Original kegg element: gene;24;hsa:4283
FADDGeneProduct451389 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FOSGeneProduct453047 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA1GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA10GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct742651 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct744748 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct473195 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct473196 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct741747 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProduct473199 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct458516 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct473965 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IKBKBGeneProduct472749 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct742813 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct743415 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IL12AGeneProduct460816 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct471723 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct450200 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct463288 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct471205 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProduct465935 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK4GeneProduct466962 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProduct747565 (Entrez Gene) Original kegg element: gene;67;hsa:3661
IRF5GeneProduct472512 (Entrez Gene) Original kegg element: gene;21;hsa:3663
IRF7GeneProduct450927 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JUNGeneProduct456893 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LBPGeneProduct458239 (Entrez Gene) Original kegg element: gene;77;hsa:3929
LOC473183GeneProduct473183 (Entrez Gene) Original kegg element: gene;1;hsa:3456
LOC473185GeneProduct473185 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
LOC473191GeneProduct473191 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
LOC473193GeneProduct473193 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
LOC473198GeneProduct473198 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
LOC741978GeneProduct741978 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
LY96GeneProduct746178 (Entrez Gene) Original kegg element: gene;71;hsa:23643
MAP2K1GeneProduct450188 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct456390 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K3GeneProduct454515 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K4GeneProduct455065 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProduct468310 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProduct743199 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct462888 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct458845 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProduct463057 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct450384 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct461358 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProductOriginal kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProductOriginal kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK13GeneProduct462644 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct450161 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct458680 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK3GeneProduct454037 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct450445 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct462336 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MYD88GeneProduct460269 (Entrez Gene) Original kegg element: gene;47;hsa:4615
NFKB1GeneProduct461406 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct450697 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct467426 (Entrez Gene) Original kegg element: gene;64;hsa:4792
PIK3CAGeneProduct460858 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct471079 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct457922 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct463649 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct461836 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct455855 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct456565 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct455085 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
RAC1GeneProductOriginal kegg element: gene;48;hsa:5879
RELAGeneProduct466665 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct462397 (Entrez Gene) Original kegg element: gene;17;hsa:8737
SPP1GeneProduct461366 (Entrez Gene) Original kegg element: gene;15;hsa:6696
STAT1GeneProduct459834 (Entrez Gene) Original kegg element: gene;62;hsa:6772
TBK1GeneProduct452047 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct468677 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2GeneProductOriginal kegg element: gene;80;hsa:353376
TIRAPGeneProduct451654 (Entrez Gene) Original kegg element: gene;83;hsa:114609
TLR1GeneProduct461167 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR2GeneProduct471325 (Entrez Gene) Original kegg element: gene;74;hsa:7097
TLR3GeneProduct471374 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct743242 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR5GeneProduct457762 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProduct471167 (Entrez Gene) Original kegg element: gene;76;hsa:10333
TLR7GeneProduct473521 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProduct473522 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct470827 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TNFGeneProduct744399 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TOLLIPGeneProduct450943 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct453178 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProduct451702 (Entrez Gene) Original kegg element: gene;53;hsa:7189

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP949"
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