Sphingolipid metabolism in senescence (Homo sapiens)

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SASPCytokine releaseTelomere maintainanceDNA damageSenescenceSenescence escapeSenescenceProliferationMAPK1PKC α/βp53 Retinoblastoma protein!CDK4SPHK1Palmitoyl-CoADEGS1Ceramide synthase 1DihydroceramidesTelomerase reverse transcriptasePLC !3-ketodihydrosphingosinep21Neutral ceramidasePP2P38sphingomyelinsSerine palmitoyltransferase 1C18-dihydrosphingosineGLB1Sphingosine SNS2MTORE2F1lactosylceramideGlucosylceramidaseRetinoblastoma protein!Neutral sphingomyelinaseS1PR2diacylglycerolsPhosphatidylcholinesceramides3-ketodihydrosphingosine reductaseGlucosylceramide synthase Glucosylceramide (d18:1/9Z-18:1)S1PR5S1PR1PP1serineCDK2Sphingosine-1-phosphateProliferation


Description

Sphingolipid metabolism in senescence

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM; ''Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides.''; Cell Death Dis, 2021 PubMed Europe PMC Scholia
  2. Gault CR, Obeid LM, Hannun YA; ''An overview of sphingolipid metabolism: from synthesis to breakdown.''; Adv Exp Med Biol, 2010 PubMed Europe PMC Scholia
  3. Trayssac M, Hannun YA, Obeid LM; ''Role of sphingolipids in senescence: implication in aging and age-related diseases.''; J Clin Invest, 2018 PubMed Europe PMC Scholia
  4. Deevska G, Dotson PP 2nd, Mitov M, Butterfield DA, Nikolova-Karakashian M; ''Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane.''; Cells, 2021 PubMed Europe PMC Scholia
  5. Dix FL; ''Ceramide synthase 4: a novel metabolic regulator of oncogene-induced senescence''; The University of Edinburgh [PhD thesis], 2018
  6. Hannun YA, Obeid LM; ''The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  7. Munk R, Anerillas C, Rossi M, Tsitsipatis D, Martindale JL, Herman AB, Yang JH, Roberts JA, Varma VR, Pandey PR, Thambisetty M, Gorospe M, Abdelmohsen K; ''Acid ceramidase promotes senescent cell survival.''; Aging (Albany NY), 2021 PubMed Europe PMC Scholia
  8. Millner A, Atilla-Gokcumen GE; ''Lipid Players of Cellular Senescence.''; Metabolites, 2020 PubMed Europe PMC Scholia
  9. Flor AC, Wolfgeher D, Wu D, Kron SJ; ''A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.''; Cell Death Discov, 2017 PubMed Europe PMC Scholia
  10. Weinstein IB; ''Cell culture studies on the mechanism of action of chemical carcinogens and tumor promoters.''; Carcinog Compr Surv, 1985 PubMed Europe PMC Scholia
  11. Kim MK, Lee W, Yoon GH, Chang EJ, Choi SC, Kim SW; ''Links between accelerated replicative cellular senescence and down-regulation of SPHK1 transcription.''; BMB Rep, 2019 PubMed Europe PMC Scholia
  12. Jeffries KA, Krupenko NI; ''Ceramide Signaling and p53 Pathways.''; Adv Cancer Res, 2018 PubMed Europe PMC Scholia
  13. Dix FL; ''Ceramide synthase 4: a novel metabolic regulator of oncogene-induced senescence.''; The University of Edinburgh [PhD thesis], 2018
  14. Gey C, Seeger K; ''Metabolic Changes Investigated by Proton NMR Spectroscopy in Cells Undergoing Oncogene-Induced Senescence.''; Methods Mol Biol, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125321view21:54, 31 January 2023LarsgwFix references
119472view08:00, 30 June 2021TadeIdowuDeletion additional p53
119413view11:16, 28 June 2021DKalbeGrouping
119409view14:21, 27 June 2021TadeIdowuNF-κB
119383view12:50, 25 June 2021DKalbeLayout
119382view12:48, 25 June 2021DKalbecolor coding
119381view12:00, 25 June 2021TadeIdowuArrangment
119377view11:48, 25 June 2021TadeIdowuAnnotation
119375view10:48, 25 June 2021EweitzOntology Term : 'aging pathway' added !
119371view10:40, 25 June 2021EweitzOntology Term : 'sphingolipid metabolic pathway' added !
119370view10:34, 25 June 2021EweitzModified title
119338view08:59, 24 June 2021DKalbeData nodes
119336view08:30, 24 June 2021DKalbeDescription
119335view08:26, 24 June 2021DKalbeDescription
119334view08:19, 24 June 2021DKalbeReferencing
119325view15:14, 23 June 2021DKalbeCorrecting references
119324view15:05, 23 June 2021DKalbeCorrecting errors
119323view14:50, 23 June 2021JDoreenModified description
119219view16:18, 22 June 2021TadeIdowuModified description
119218view15:09, 22 June 2021DKalbeadjusting references in description
119217view15:06, 22 June 2021TadeIdowuModified description
119216view14:49, 22 June 2021DKalbeDescription layout
119215view14:46, 22 June 2021DKalbeDescription of the pathway
119211view14:14, 22 June 2021Mario5181Modified title
119208view14:08, 22 June 2021DKalbeRearranging, adding references and correcting
119207view12:21, 22 June 2021TadeIdowuModified title
119206view12:20, 22 June 2021TadeIdowuNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3-ketodihydrosphingosine reductaseProteinQ06136 (Uniprot-TrEMBL)
3-ketodihydrosphingosineMetaboliteCHEBI:17862 (ChEBI)
C18-dihydrosphingosineMetaboliteCHEBI:16566 (ChEBI)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
Ceramide synthase 1ProteinA0A024R7N8 (Uniprot-TrEMBL)
DEGS1GeneProductENSG00000143753 (Ensembl)
DihydroceramidesMetaboliteCHEBI:139048 (ChEBI)
E2F1GeneProductENSG00000101412 (Ensembl)
GLB1GeneProductENSG00000170266 (Ensembl)
GlucosylceramidaseProteinA0A068F658 (Uniprot-TrEMBL)
Glucosylceramide (d18:1/9Z-18:1)MetaboliteCHEBI:139140 (ChEBI)
Glucosylceramide synthase Protein
MAPK1GeneProduct5594 (Entrez Gene)
MTORGeneProductENSG00000198793 (Ensembl)
Neutral ceramidaseProteinQ9NR71 (Uniprot-TrEMBL)
Neutral sphingomyelinaseProtein
P38GeneProductENSG00000152464 (Ensembl)
PKC α/βProtein
PLC !GeneProduct
PP1ProteinQ27088427 (Wikidata)
PP2ProteinQ7120082 (Wikidata)
Palmitoyl-CoAMetaboliteCHEBI:15525 (ChEBI)
PhosphatidylcholinesMetaboliteCHEBI:49183 (ChEBI)
Retinoblastoma protein!Protein
S1PR1GeneProductENSG00000170989 (Ensembl)
S1PR2GeneProductENSG00000267534 (Ensembl)
S1PR5GeneProductENSG00000180739 (Ensembl)
SNS2Protein
SPHK1GeneProductENSG00000176170 (Ensembl)
Serine palmitoyltransferase 1ProteinO15269 (Uniprot-TrEMBL)
Sphingosine MetaboliteCHEBI:45719 (ChEBI)
Sphingosine-1-phosphateMetaboliteCHEBI:37550 (ChEBI)
Telomerase reverse transcriptaseProteinO14746 (Uniprot-TrEMBL)
ceramidesMetaboliteCHEBI:17761 (ChEBI)
diacylglycerolsMetaboliteCHEBI:18035 (ChEBI)
lactosylceramideMetaboliteCHEBI:134507 (ChEBI)
p21ProteinA0A024RCX5 (Uniprot-TrEMBL)
p53 MetaboliteCHEBI:77731 (ChEBI)
serineMetaboliteCHEBI:17822 (ChEBI)
sphingomyelinsMetaboliteCHEBI:62490 (ChEBI)

Annotated Interactions

No annotated interactions

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