Alzheimer's disease (Homo sapiens)

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IRS2ATG14NeuronER2-6, 8-10, 13...2117LegendMicrotubuleMicrogliaAnterograde cargoATP depletionNonamyloidogenic APP processingMPTPImpaired neuronal insulin signalingCell deathReduction in LTPMitochondiral dysfunctionAPP Intracellular domainDecreased energy production?Neuronal InjuryAmyloid BetaNeurofibrillary tanglesImpairement of autophagyCalcium overloadDefective insulin signalingOligomeric Amyloid BetaAntioxidant responsesAmino acid metabolismDecreased AB clearanceGene mutated in Alzheimer'sKinesin 1Insulin resistanceULK complexMitochondrial dysfunctionER chaperonesPI3K complexFragmentationInduction of ApoptosisProtein oxidationp50 ATF6AGEsCu+Ca2+NAE1TNFRSF1ACalcium Signaling PathwayApoptosisRAGEAPPHydrogen peroxideIP3NAC fragmentP3 peptidePI3PMAPTAPP intracellular domainRTN3Modulation of gene expressionbeta-amyloid protein 40NOFe2+superoxideOxidative PhosphorylationWnt signaling pathway24APBB1GAPDHADAM10BACE1PSENENPSEN1NCSTNAPH1AIDEMMELPLAPOELRP1FASTNFRSF1AFADDCASP8Cx ICx IICx IIICx IVCx VAPP processingHSD17B10Fall in mitochondrialmembrane potentialIncreased ROSDegredationBIDCYCSCALM1BADCALM2PCALM3CALML3CALML5PPP3CAPPP3CBPPP3CCPPP3R1PPP3R2ADAM17PSEN2APAF1CASP9CASP3AB AggregationSNCASenile plaqueGPCRGRIN1CACNA1CGRIN2AGRIN2BGRIN2CGRIN2DCACNA1DCACNA1FCACNA1SGNAQPLCB1PLCB2PLCB3PLCB4Aggr. amyloidTNFIL1BMAPK1MAPK3CASP12ApoptosisRYR3ATP2A2ATP2A1ATP2A3EIF2AK3ERN1ATF6ITPR1ITPR2ITPR3Ca2+Ca2+ER stressCAPN1CAPN2CDK5R1 / p35CDK5R1 / p25NOS1CDK5MAPTPCASP3CASP7Paired helical filamentsNeurofibrillarytanglesApoptosisDNA damageInflammationLipid peroxidationONOO-RTN4HyperinsulinemiaSequestration of IDEConcentrated intoendosome/lysosomeINSINSRIRS1PPPIRS4PPIDMCUCa2+Ca2+Ca2+beta-amyloid protein 42beta-amyloid protein 40beta-amyloid protein 42AKT1AKT2AKT3PIK3CAPIK3R1PIK3R2PIK3CBPIK3CDPIK3R3PIP3EIF2AK2MAPK8MAPK9MAPK10GPR83CHUKIKBKBSynaptic dysfunctionImpaired memoryCHRNA7CYBBNOX1NOX4NFKB1RELA(Tau-p)nNRASKRASHRASRAF1ARAFBRAFNOS2TNFIL1AIL1BPTGS2IL6CSF1DKK1DKK212DKK4MTORULK2ULK1ATG13PPATG101RB1CC1BECN1PBECN2PIK3R4NRBF2PIK3C3PAMBRA1ATG2AATG2BWIPI1WIPI2PSEN1GSK3Bbeta-amyloid protein 40beta-amyloid protein 42Ca2+Ca2+KLC3KIF5AKIF5BKIF5CKLC1KLC2KLC4PTUBA1BTUBA3ETUBA3DTUBA8TUBA4ATUBA3CTUBA1ATUBAL3TUBA1CTUBB3TUBB4ATUBB4BTUBBTUBB8TUBB2BTUBB2ATUBB1TUBB6Axonal transport defectsWntWNT3AWNT7AWNT11WNT1WNT5BWNT2WNT2BWNT6WNT5AWNT16WNT4WNT3WNT10BWNT7BWNT10AWNT16FZD3FZD8LRP5FZD10FZD7FZD4FZD1LRP6FZD6FZD5FZD9FZD2DVL3FRAT1CSNK1EDVL2DVL1FRAT2TPTEP2-CSNK1EGSK3BCSNK2BCSNK2A1CSNK2A3CSNK2A2APCCSNK1A1AXIN1CSNK1A1LAXIN2APC2CSNK1A1CSNK1A1LCTNNB1PPPPPP3CAPPP3CBPPP3CCPPP3R1PPP3R2GSK3BsAPP alphaAPP-C83APP-C99sAPP betaEIF2S1ATF4DDIT3TRAF2MAP3K5MAP2K7MAPK8MAPK10PPPMAPK9PPPXBP1ER chaperonesERADDDIT3XBP1Proteasome 20SCatalytic Core (p45)PSMA2PSMB1PSMA5PSMB4PSMB2PSMA3PSMA7PSMA1PSMB6PSMA6PSMB5PSMA4PSMB7PSMB3PSMA819S regulatorPSMD8SEM1PSMD1PSMC6PSMC5PSMC4PSMC3PSMC2PSMC1PSMD7PSMD6ADRM1PSMD4PSMD3PSMD2PSMD14PSMD13PSMD12PSMD9PPIFSLC25A4SLC25A5SLC25A6VDAC1VDAC2VDAC3SLC25A31CALML4CALML6APH1BAmyloidogenic APP processingbeta-amyloid protein 40beta-amyloid protein 42Oligomeric Intracellular ABCa2+MAP2K1PPMAP2K2PPMAPK1PPMAPK3PPbeta-amyloid protein 40beta-amyloid protein 42PSEN1PSEN2


Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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  15. Abdelmohsen K, Hutchison ER, Lee EK, Kuwano Y, Kim MM, Masuda K, Srikantan S, Subaran SS, Marasa BS, Mattson MP, Gorospe M; ''miR-375 inhibits differentiation of neurites by lowering HuD levels.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
128389view03:01, 4 February 2024EweitzFix typos, standard case
123917view17:08, 30 August 2022KhanspersModified description
123916view17:07, 30 August 2022KhanspersModified description
123915view17:05, 30 August 2022KhanspersModified description
123914view17:05, 30 August 2022Khanspersremoved old comments
119432view00:38, 29 June 2021Khanspersadded literature references
119431view23:52, 28 June 2021KhanspersModified description
119430view23:51, 28 June 2021KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProductENSG00000137845 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
ADRM1GeneProductENSG00000130706 (Ensembl)
AGEsMetaboliteCHEBI:84123 (ChEBI)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AMBRA1GeneProductENSG00000110497 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
APAF1GeneProductENSG00000120868 (Ensembl)
APBB1GeneProductENSG00000166313 (Ensembl)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProduct324 (Entrez Gene)
APH1AGeneProductENSG00000117362 (Ensembl)
APH1BGeneProductENSG00000138613 (Ensembl)
APOEGeneProductENSG00000130203 (Ensembl)
APP intracellular domainGeneProductP05067 (Uniprot-TrEMBL)
APP processingPathway
APP-C83GeneProductP05067 (Uniprot-TrEMBL)
APP-C99GeneProductP05067 (Uniprot-TrEMBL)
APPGeneProductENSG00000142192 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
ATF4GeneProductENSG00000128272 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ATG101GeneProductENSG00000123395 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG13GeneProductENSG00000175224 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG14GeneProductENSG00000126775 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2AGeneProductENSG00000110046 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2BGeneProductENSG00000066739 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATP2A1GeneProductENSG00000196296 (Ensembl)
ATP2A2GeneProductENSG00000174437 (Ensembl)
ATP2A3GeneProductENSG00000074370 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProductENSG00000168646 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BACE1GeneProductENSG00000186318 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BECN2GeneProductENSG00000196289 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BIDGeneProductENSG00000015475 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
CACNA1CGeneProductENSG00000151067 (Ensembl)
CACNA1DGeneProductENSG00000157388 (Ensembl)
CACNA1FGeneProductENSG00000102001 (Ensembl)
CACNA1SGeneProductENSG00000081248 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CALML4GeneProductENSG00000129007 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
CALML6GeneProductENSG00000169885 (Ensembl)
CAPN1GeneProductENSG00000014216 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDK5R1 / p25GeneProductENSG00000176749 (Ensembl)
CDK5R1 / p35GeneProductENSG00000176749 (Ensembl)
CHRNA7GeneProductENSG00000175344 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CYBBGeneProductENSG00000165168 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Ca2+MetaboliteHMDB0000464 (HMDB)
Calcium Signaling PathwayPathway
Cu+MetaboliteHMDB0000657 (HMDB)
Cx IGeneProduct
Cx IIGeneProduct
Cx IIIGeneProduct
Cx IVGeneProduct
Cx VGeneProduct
DDIT3GeneProductENSG00000175197 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK2GeneProductENSG00000155011 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK4GeneProductENSG00000104371 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DNA damagePathway
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
Fe2+MetaboliteHMDB0000692 (HMDB)
GAPDHGeneProductENSG00000111640 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GPCRGeneProduct
GPR83GeneProductENSG00000123901 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
GSK3BGeneProductENSG00000082701 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
HRASGeneProductENSG00000174775 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
HSD17B10GeneProductENSG00000072506 (Ensembl)
Hydrogen peroxideMetaboliteHMDB0003125 (HMDB)
IDEGeneProductENSG00000119912 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
INSGeneProduct3630 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IP3MetaboliteHMDB0001498 (HMDB)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
IRS4GeneProductENSG00000133124 (Ensembl)
ITPR1GeneProductENSG00000150995 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
KIF5AGeneProductENSG00000155980 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5BGeneProductENSG00000170759 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5CGeneProductENSG00000168280 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC1GeneProductENSG00000126214 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC2GeneProductENSG00000174996 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC3GeneProductENSG00000104892 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC4GeneProductENSG00000137171 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KRASGeneProductENSG00000133703 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
LPLGeneProductENSG00000175445 (Ensembl)
LRP1GeneProductENSG00000123384 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
Lipid peroxidationPathwayWP1878 (WikiPathways)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K7GeneProductENSG00000076984 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAPTGeneProductENSG00000186868 (Ensembl)
MCUGeneProductENSG00000156026 (Ensembl)
MMEGeneProductENSG00000196549 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
Modulation of gene expressionPathwayWP1821 (WikiPathways)
NAC fragmentProteinP37840 (Uniprot-TrEMBL)
NAE1GeneProductENSG00000159593 (Ensembl)
NCSTNGeneProductENSG00000162736 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NOMetaboliteHMDB0003378 (HMDB)
NOS1GeneProductENSG00000089250 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
NOX1GeneProductENSG00000007952 (Ensembl)
NOX4GeneProductENSG00000086991 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176
NRBF2GeneProductENSG00000148572 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ONOO-MetaboliteHMDB0002179 (HMDB)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
P3 peptideGeneProductP05067 (Uniprot-TrEMBL)
PI3PMetaboliteCHEBI:17283 (ChEBI)
PIK3C3GeneProductENSG00000078142 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
PIK3CAGeneProductENSG00000121879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CBGeneProductENSG00000051382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CDGeneProductENSG00000171608 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3R1GeneProductENSG00000145675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2GeneProductENSG00000105647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PIK3R4GeneProductENSG00000196455 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
PIP3MetaboliteHMDB0004249 (HMDB)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PPIDGeneProductENSG00000171497 (Ensembl)
PPIFGeneProductENSG00000108179 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
PPP3CBGeneProductENSG00000107758 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
PPP3R1GeneProductENSG00000221823 (Ensembl)
PPP3R2GeneProductENSG00000188386 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
PSEN2GeneProductENSG00000143801 (Ensembl)
PSENENGeneProductENSG00000205155 (Ensembl)
PSMA1GeneProduct5682 (Entrez Gene)
PSMA2GeneProduct5683 (Entrez Gene)
PSMA3GeneProduct5684 (Entrez Gene)
PSMA4GeneProduct5685 (Entrez Gene)
PSMA5GeneProduct5686 (Entrez Gene)
PSMA6GeneProduct5687 (Entrez Gene)
PSMA7GeneProduct5688 (Entrez Gene)
PSMA8GeneProductENSG00000154611 (Ensembl)
PSMB1GeneProduct5689 (Entrez Gene)
PSMB2GeneProduct5690 (Entrez Gene)
PSMB3GeneProduct5691 (Entrez Gene)
PSMB4GeneProduct5692 (Entrez Gene)
PSMB5GeneProduct5693 (Entrez Gene)
PSMB6GeneProduct5694 (Entrez Gene) U13393
PSMB7GeneProduct5695 (Entrez Gene)
PSMC1GeneProduct5700 (Entrez Gene)
PSMC2GeneProduct5701 (Entrez Gene)
PSMC3GeneProduct5702 (Entrez Gene)
PSMC4GeneProduct5704 (Entrez Gene)
PSMC5GeneProduct5705 (Entrez Gene)
PSMC6GeneProduct5706 (Entrez Gene)
PSMD12GeneProduct5718 (Entrez Gene)
PSMD13GeneProduct5719 (Entrez Gene)
PSMD14GeneProduct10213 (Entrez Gene)
PSMD1GeneProduct5707 (Entrez Gene)
PSMD2GeneProduct5708 (Entrez Gene)
PSMD3GeneProduct5709 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PSMD6GeneProduct9861 (Entrez Gene)
PSMD7GeneProduct5713 (Entrez Gene)
PSMD8GeneProduct5714 (Entrez Gene)
PSMD9GeneProduct5715 (Entrez Gene)
PTGS2GeneProductENSG00000073756 (Ensembl)
Protein oxidationPathway
RAF1GeneProductENSG00000132155 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
RAGEProteinQ15109 (Uniprot-TrEMBL)
RB1CC1GeneProductENSG00000023287 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
RELAGeneProduct5970 (Entrez Gene)
RTN3GeneProductENSG00000133318 (Ensembl)
RTN4GeneProductENSG00000115310 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
SEM1GeneProductENSG00000127922 (Ensembl)
SLC25A31GeneProductENSG00000151475 (Ensembl)
SLC25A4GeneProductENSG00000151729 (Ensembl)
SLC25A5GeneProductENSG00000005022 (Ensembl)
SLC25A6GeneProductENSG00000169100 (Ensembl)
SNCAGeneProductENSG00000145335 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFRSF1AGeneProductENSG00000067182 (Ensembl)
TPTEP2-CSNK1EGeneProduct1454 (Entrez Gene)
TRAF2GeneProductENSG00000127191 (Ensembl)
TUBA1AGeneProductENSG00000167552 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA1BGeneProductENSG00000123416 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA1CGeneProductENSG00000167553 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3CGeneProductENSG00000198033 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3DGeneProductENSG00000075886 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3EGeneProductENSG00000152086 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA4AGeneProductENSG00000127824 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA8GeneProductENSG00000183785 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBAL3GeneProductENSG00000178462 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB1GeneProductENSG00000101162 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB2AGeneProductENSG00000137267 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB2BGeneProductENSG00000137285 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB3GeneProductENSG00000258947 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB4AGeneProductENSG00000104833 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB4BGeneProductENSG00000188229 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB6GeneProductENSG00000176014 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB8GeneProductENSG00000261456 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBBGeneProductENSG00000196230 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ULK1GeneProductENSG00000177169 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ULK2GeneProductENSG00000083290 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
VDAC1GeneProductENSG00000213585 (Ensembl)
VDAC2GeneProductENSG00000165637 (Ensembl)
VDAC3GeneProductENSG00000078668 (Ensembl)
WIPI1GeneProductENSG00000070540 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
WIPI2GeneProductENSG00000157954 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
Wnt signaling pathwayPathwayWP428 (WikiPathways)
XBP1GeneProductENSG00000100219 (Ensembl)
beta-amyloid protein 40MetaboliteCHEBI:64646 (ChEBI)
beta-amyloid protein 42MetaboliteCHEBI:64647 (ChEBI)
p50 ATF6GeneProductENSG00000118217 (Ensembl)
sAPP alphaGeneProductP05067 (Uniprot-TrEMBL)
sAPP betaGeneProductP05067 (Uniprot-TrEMBL)
superoxideMetaboliteCHEBI:18421 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5124"
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