Calcium mediated T-cell apoptosis involved in inclusion body myositis (Homo sapiens)

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1CytoplasmEndoplasmic reticulumNucleusExtracellular spaceCalcium channelSupervises intracellular Ca levelsApoptosisPKCCa2+TCRNFATC2PIP2CALM1DAGITPRIPIP3NR4A1NFATC2CAPN2MHC class I/CD8APPP3CCMEF2DPPP3CAHDAC1Ca2+Ca2+CRACZAP70Ca2+PPP3CBMHC class I/CD8BEP300ATP2A1MHC class II/CD4CABIN1PLCG1LCKLegendBindingConversionStimulation/ActivasionInhibitionCellular location changeCatalysisPhosphorylation stateHDAC2NFATC2CABIN1


Description

Inclusion body myositis is a late onset disease of the muscles. It shares both degenerative and autoimmune features, as well as genetic factors, and also is resistant to classical treatments of immunosuppressive drugs. This pathway is based on Figure 3 of Johari M. et al. 2021.

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Ontology Terms

 

Bibliography

  1. Johari M.; ''Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositis''; , 2021

History

View all...
CompareRevisionActionTimeUserComment
128174view19:23, 28 January 2024EweitzAdd space around slash
128173view19:11, 28 January 2024EweitzAlign transmembranes
128172view19:08, 28 January 2024EweitzFix label truncation (affects site, but not PathVisio)
128171view19:07, 28 January 2024EweitzSoften part label color, copyedit note, remove extraneous anchor
128170view18:52, 28 January 2024EweitzShow receptors as transmembrane, remove extraneous graphics
128169view18:45, 28 January 2024EweitzUpgrade, internally align legend
128168view18:25, 28 January 2024EweitzFurther economize layout
128166view17:57, 28 January 2024EweitzRefine ER placement
128165view17:56, 28 January 2024EweitzFurther economize layout
128164view17:36, 28 January 2024EweitzEconomize layout
128163view17:17, 28 January 2024EweitzOntology Term : 'apoptotic cell death pathway' added !
128046view08:35, 23 January 2024FehrhartAnnotated missing nodes and changed data nodes to graphical elements
122437view08:06, 6 April 2022FehrhartOntology Term : 'disease pathway' added !
120439view13:05, 2 December 2021TheodorosZarotiadisCalcineurin catalytic subunit genes added
120435view22:54, 1 December 2021TheodorosZarotiadisHistone deacetylases 1&2 added
120421view13:48, 30 November 2021Fehrhartexpert curation workshop updates
120419view12:56, 30 November 2021TheodorosZarotiadisCalcineurin stimulation arrow added
120364view08:09, 29 November 2021TheodorosZarotiadis
120297view14:11, 26 November 2021TheodorosZarotiadisMinor changes in MIM interactions
120296view21:27, 25 November 2021TheodorosZarotiadisConversion added
120295view21:23, 25 November 2021TheodorosZarotiadisPhosphorylation state added
120294view15:44, 25 November 2021TheodorosZarotiadisCellural compartments added Proteins identifiers changed
120284view08:40, 24 November 2021TheodorosZarotiadisCellular compartments added
120282view23:09, 23 November 2021TheodorosZarotiadisCompounds annotations and identifiers changes
120260view10:07, 22 November 2021FehrhartOntology Term : 'inclusion body myositis' added !
120259view10:06, 22 November 2021Fehrhartconverted protein to metabolite
120232view11:29, 17 November 2021EweitzModified title
120224view10:45, 15 November 2021TheodorosZarotiadisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProduct
ATP2A1GeneProductENSG00000196296 (Ensembl)
  • SERCA
  • Calcium channel - Supervises intracellular Ca levels
ApoptosisPathwayWP254 (WikiPathways)
CABIN1GeneProductENSG00000099991 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl) Refers to the calmodulin family of genes
CAPN2GeneProductENSG00000162909 (Ensembl)
CRACGeneProduct
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DAGMetabolite6026790 (PubChem-compound)
EP300GeneProductENSG00000100393 (Ensembl)
HDAC1ProteinQ13547 (Uniprot-TrEMBL)
HDAC2ProteinQ92769 (Uniprot-TrEMBL)
IP3Metabolite55310 (PubChem-compound)
ITPRIPGeneProductENSG00000148841 (Ensembl) IP3 receptor for the calcium channel
LCKGeneProductENSG00000182866 (Ensembl)
Legend

Binding Conversion Stimulation/Activasion Inhibition Cellular location change Catalysis

Phosphorylation state
MEF2DGeneProductENSG00000116604 (Ensembl)
MHC class I/CD8AGeneProductENSG00000153563 (Ensembl) CD8 glycoprotein co-receptor for the T cell receptor (TCR). This is the alpha isoform of the protein.
MHC class I/CD8BGeneProductENSG00000172116 (Ensembl) CD8 glycoprotein co-receptor for the T cell receptor (TCR). This is the beta isoform of the protein.
MHC class II/CD4GeneProductENSG00000010610 (Ensembl) CD4 glycoprotein co-receptor for the T cell receptor (TCR).
NFATC2GeneProductENSG00000101096 (Ensembl)
NR4A1GeneProductENSG00000123358 (Ensembl) NUR77
PIP2MetaboliteQ3083814 (Wikidata)
PKCProteinPF00433 (Pfam)
PLCG1GeneProductENSG00000124181 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl) calcineurin
PPP3CBGeneProductENSG00000107758 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
TCRProteinPF11628 (Pfam) T cell receptor (TCR) complex
ZAP70GeneProductENSG00000115085 (Ensembl)

Annotated Interactions

No annotated interactions

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