Wnt signaling pathway (Pan troglodytes)

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InhibitionCY->PMSumoylationProteins in a complex interactionDMTEndosomeDCYRecruitmentDDDCY->PMECPhosphorylationLigandERMolecular AssociationUbiquitinationTranslocationGene SymbolCY->PMCY->NUDemethylationComplex formationCytoplasmAcetylationDeacetylationDPM->CYControlAutophosphorylationMitochondrionCY->NUNUMolecule in the pathwayCY->NUNU->CYDDephosphorylationProteolytic cleavageGolgi apparatusDActivationPalmitoylationGlycosylationGOCY->NU(Protein-protein interaction)DPlasma membraneEndoplasmic reticulumMethylationReceptorNucleusCY->NUExtracellularReaction through unknowm mechanisms/moleculesENCY->PMEnzyme ComplexPMAccession Number: NetPath_8; cellmap:8DeubiquitinationDesumoylationMAPK3DVL3DVL1MAPK8IP1CXXC4ANKRD6FZD1PIN1EP300ROR2MAPK8MARK2APCPRKCGCSNK2A2MAP1BFZD1FHL2CRYBB2FZD4WNT1TBPAXIN1SFRP1CSNK1ELEF1CSNK2A2CCND1WNT5ACTBP2GSK3BDLG2SMAD3DAAM1AXIN1ARRB1CSNK1DCAMK2BRUVBL1FZD5FRAT2PRKCABCL9CDH1PPP2CACDC25CVANGL2PAX2WNT4DVL2SUMO2LRP6AXIN2CTNNB1RUNX2DVL1ARRB2SUMO1CSNK1A1DVL2DVL1SOX9WNT2DLG1WNT1APCBTRCCTNNB1CTBP1FZD7NKD1GSK3BARRB2MYBSOX1MAPK9WNT3FZD6APCNLKTCF3CUL1FZD8TAX1BP3AXIN1CSNK2BFRAT1LEF1CDC2BTRCMAP3K7FZD4FZD1SFRP2AKT1PIAS4RAC1MAPK1JUPSKP1FZD1WNT1TFAP2AWNT1HIPK2CAMK2DLRP6WNT7ADKK1FZD9WNT2WNT3AWNT4LRP1NR5A1DAB2SENP2CSNK2A1PRKCB1RAF1RHOAFZD2CAMK2GMAP3K7SALL1AKT1CDC2SMAD4DLG4WNT3ACTNNBIP1APCAPCLRP5MAGI3TCF4JUNCSNK2A1WNT1BRD7CTNNB1CAMK2A


Description

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NethPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the Cancer Cell Map and NetPath websites until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP363(r28127) with a 78% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
120583view18:12, 17 December 2021EweitzModified title
118709view07:49, 1 June 2021EgonwModified description
117980view11:20, 23 May 2021EweitzModified title
86973view14:29, 15 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
69290view18:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
41600view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
35031view09:18, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35023view09:13, 11 February 2010ThomasModified description
34329view22:15, 9 December 2009MaintBotAutomatic update of empty xrefs
31566view21:57, 13 August 2009MaintBotFixed text labels
30431view21:19, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
ANKRD6GeneProduct462885 (Entrez Gene)
APCGeneProduct461999 (Entrez Gene)
ARRB1GeneProduct451424 (Entrez Gene)
ARRB2GeneProduct454450 (Entrez Gene)
AXIN1GeneProduct453789 (Entrez Gene)
AXIN2GeneProduct468301 (Entrez Gene)
BCL9GeneProduct457248 (Entrez Gene)
BRD7GeneProduct
BTRCGeneProduct450685 (Entrez Gene)
CAMK2AGeneProduct462189 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct461445 (Entrez Gene)
CAMK2GGeneProduct738330 (Entrez Gene)
CCND1GeneProduct747688 (Entrez Gene)
CDC2GeneProduct450481 (Entrez Gene)
CDC25CGeneProduct746151 (Entrez Gene)
CDH1GeneProduct468009 (Entrez Gene)
CRYBB2GeneProduct
CSNK1A1GeneProduct462182 (Entrez Gene)
CSNK1DGeneProduct454989 (Entrez Gene)
CSNK1EGeneProduct458829 (Entrez Gene)
CSNK2A1GeneProduct
CSNK2A2GeneProduct454131 (Entrez Gene)
CSNK2BGeneProduct
CTBP1GeneProduct738792 (Entrez Gene)
CTBP2GeneProduct450810 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
CTNNBIP1GeneProduct749394 (Entrez Gene)
CUL1GeneProduct463821 (Entrez Gene)
CXXC4GeneProduct471261 (Entrez Gene)
DAAM1GeneProduct
DAB2GeneProduct461905 (Entrez Gene)
DKK1GeneProduct450465 (Entrez Gene)
DLG1GeneProduct460968 (Entrez Gene)
DLG2GeneProduct466728 (Entrez Gene)
DLG4GeneProduct468444 (Entrez Gene)
DVL1GeneProduct457191 (Entrez Gene)
DVL2GeneProduct455236 (Entrez Gene)
DVL3GeneProduct460882 (Entrez Gene)
EP300GeneProduct458862 (Entrez Gene)
FHL2GeneProduct459469 (Entrez Gene)
FRAT1GeneProduct466169 (Entrez Gene)
FRAT2GeneProduct466170 (Entrez Gene)
FZD1GeneProduct463524 (Entrez Gene)
FZD2GeneProduct
FZD4GeneProduct466732 (Entrez Gene)
FZD5GeneProduct470627 (Entrez Gene)
FZD6GeneProduct464327 (Entrez Gene)
FZD7GeneProduct459881 (Entrez Gene)
FZD8GeneProduct466040 (Entrez Gene)
FZD9GeneProduct472405 (Entrez Gene)
GSK3BGeneProduct470896 (Entrez Gene)
HIPK2GeneProduct463772 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
JUPGeneProduct
LEF1GeneProduct461425 (Entrez Gene)
LRP1GeneProduct452006 (Entrez Gene)
LRP5GeneProduct451380 (Entrez Gene)
LRP6GeneProduct465295 (Entrez Gene)
MAGI3GeneProduct457133 (Entrez Gene)
MAP1BGeneProduct450137 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPK8IP1GeneProduct451148 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MARK2GeneProduct
MYBGeneProduct463016 (Entrez Gene)
NKD1GeneProduct465164 (Entrez Gene)
NLKGeneProduct739132 (Entrez Gene)
NR5A1GeneProduct464724 (Entrez Gene)
PAX2GeneProduct744540 (Entrez Gene)
PIAS4GeneProduct736762 (Entrez Gene)
PIN1GeneProduct745021 (Entrez Gene)
PPP2CAGeneProduct471633 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCB1GeneProduct
PRKCGGeneProduct456276 (Entrez Gene)
RAC1GeneProduct
RAF1GeneProduct460182 (Entrez Gene)
RHOAGeneProduct461014 (Entrez Gene)
ROR2GeneProduct464589 (Entrez Gene)
RUNX2GeneProduct472017 (Entrez Gene)
RUVBL1GeneProduct460670 (Entrez Gene)
SALL1GeneProduct473281 (Entrez Gene)
SENP2GeneProduct460902 (Entrez Gene)
SFRP1GeneProduct736186 (Entrez Gene)
SFRP2GeneProduct742398 (Entrez Gene)
SKP1GeneProduct462063 (Entrez Gene)
SMAD3GeneProduct748161 (Entrez Gene)
SMAD4GeneProduct468537 (Entrez Gene)
SOX1GeneProduct
SOX9GeneProduct450101 (Entrez Gene)
SUMO1GeneProduct459882 (Entrez Gene)
SUMO2GeneProduct454875 (Entrez Gene)
TAX1BP3GeneProduct454432 (Entrez Gene)
TBPGeneProduct738472 (Entrez Gene)
TCF3GeneProduct
TCF4GeneProduct
TFAP2AGeneProduct462426 (Entrez Gene)
VANGL2GeneProduct
WNT1GeneProduct742674 (Entrez Gene)
WNT2GeneProduct463673 (Entrez Gene)
WNT3GeneProduct468297 (Entrez Gene)
WNT3AGeneProduct469698 (Entrez Gene)
WNT4GeneProduct469212 (Entrez Gene)
WNT5AGeneProduct
WNT7AGeneProduct

Annotated Interactions

No annotated interactions
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